[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06700005":3,"trial-entities:NCT06700005":95,"trial-summary:NCT06700005":99},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":21,"study_type":30,"primary_purpose":16,"phases":31,"enrollment_info":32,"interventions":35,"primary_outcomes":36,"secondary_outcomes":48,"sex":49,"minimum_age":50,"maximum_age":16,"healthy_volunteers":51,"eligibility_criteria":52,"std_ages":67,"locations":70,"central_contacts":86,"overall_officials":88,"references":93,"see_also_links":94},"NCT06700005","ReadMap","ReadMap: Reading in Stroke Alexia and Typical Aging","RECRUITING","2028-08-31","2024-10","2024-11-21","2023-01-12","Georgetown University","OTHER",false,"Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email\u002Ftext, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.\n\nParticipants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.",null,[18,19,20],"Aphasia","Stroke","Alexia",[22,23,24,25,26,27,28,29],"aphasia","stroke","brain injury","speech","language","reading","alexia","apraxia","OBSERVATIONAL",[],{"count":33,"type":34},300,"ESTIMATED",[],[37,41,44],{"measure":38,"description":39,"timeFrame":40},"MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo)","Part of MRI sequence that measures deep grey matter structure.","Collected within 1 month of behavioral testing",{"measure":42,"description":43,"timeFrame":40},"DTI (Diffusion Tensor Imaging)","Part of MRI sequence that measures the rate of water diffusion between cells to understand and create a map of internal structures.",{"measure":45,"description":46,"timeFrame":47},"Behavioral testing","Battery of standard clinical and in-house behavioral tests to measure speech, language, and cognition. Final score is derived from principle components analysis.","Collected within 1 month of MRI",[],"ALL","18 Years",true,{"inclusion":53,"exclusion":57,"raw_text":66},[54,55,56,54,55],"Age \\>= 18","Learned English at 8 years or younger","Brain injury resulting from stroke",[58,59,60,61,62,63,64,65],"History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness)","Severe psychiatric condition that would interfere with participation in the study","History of diagnosed learning disorder","Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses\u002Fhearing aids.","Inability to follow study procedures despite maximal support","Presence of metal in the body that is incompatible with MRI","Pregnancy","Claustrophobia","Inclusion criteria:\n\nStroke Survivors:\n\n* Age \\>= 18\n* Learned English at 8 years or younger\n* Brain injury resulting from stroke\n\nControls:\n\n* Age \\>= 18\n* Learned English at 8 years or younger\n\nExclusion criteria for all groups:\n\n* History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness)\n* Severe psychiatric condition that would interfere with participation in the study\n* History of diagnosed learning disorder\n* Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses\u002Fhearing aids.\n* Inability to follow study procedures despite maximal support\n\nAdditional exclusion criteria for MRIs:\n\n* Presence of metal in the body that is incompatible with MRI\n* Pregnancy\n* Claustrophobia",[68,69],"ADULT","OLDER_ADULT",[71],{"facility":72,"status":7,"city":73,"state":74,"zip":75,"country":76,"contacts":77,"geoPoint":83},"Georgetown University Medical Center","Washington D.C.","District of Columbia","20057","United States",[78],{"name":79,"role":80,"phone":81,"email":82},"Alycia Laks, MS, CCC-SLP","CONTACT","202-687-5205","crlab@georgetown.edu",{"lat":84,"lon":85},38.89511,-77.03637,[87],{"name":79,"role":80,"phone":81,"email":82},[89],{"name":90,"affiliation":91,"role":92},"Peter Turkeltaub, MD,PhD","Georgetown University; MedStar National Rehabilitation Hospital","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":96,"biomarkers":98},[20,18,97,19],"Brain Injury",[],{"nct_id":4,"found":51,"summary":100,"prompt_version":110},{"design":101,"status":102,"heading":103,"summary":104,"follow_up":105,"word_count":106,"commitments":107,"compensation":108,"drugs_mentioned":109},"This is an observational study involving up to 300 participants. It compares stroke survivors with alexia to typical older adults.","completed","ReadMap: Understanding Reading After Stroke and in Aging","This study, called ReadMap, aims to better understand how the brain processes reading in people who have lost reading ability due to a stroke (alexia) and in typical older adults. Alexia can make everyday tasks like reading emails or signs very difficult. Researchers will conduct behavioral tests and brain imaging (MRI) to learn more about the brain and thinking processes involved in reading. You might be able to join if you are at least 18 years old and learned English by age 8. Stroke survivors who meet these criteria are welcome, as are healthy adults. The study will measure brain activity using MP-RAGE and DTI scans, and assess reading, speech, language, and thinking abilities. The goal is to improve diagnosis and treatment for reading difficulties.","Brain imaging and behavioral testing will be collected within one month of each other.",125,"You will complete a series of tests for reading, speech, language, and thinking. Some participants will also have an MRI scan.","Not stated in the trial record.",[],"v2"]