[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06745895":3,"trial-entities:NCT06745895":127,"trial-summary:NCT06745895":132},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":27,"primary_purpose":28,"phases":29,"enrollment_info":31,"interventions":34,"primary_outcomes":40,"secondary_outcomes":45,"sex":61,"minimum_age":62,"maximum_age":63,"healthy_volunteers":64,"eligibility_criteria":65,"std_ages":83,"locations":86,"central_contacts":110,"overall_officials":114,"references":118,"see_also_links":123},"NCT06745895","MCC-23232","Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening","Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES)","RECRUITING","2028-04-30","2024-12","2024-12-20","2024-10-21","H. Lee Moffitt Cancer Center and Research Institute","OTHER",false,"This innovative Multilevel Action Toward Colorectal Cancer (CRC) and Hepatitis C Virus (HCV) Education and Screening (MATCHES) intervention aims to promote concurrent HCV and CRC screening among FQHC patients ages 45-75.","While this is a multi-level intervention study, only information related to the patient-level intervention is being reported for the purposes ClinicalTrials.gov.",[19,20],"Colorectal Cancer Screening","Hepatitis C Virus",[22,23,24,25,26],"Screening","HCV Screening","CRC Screening","Colorectal Cancer (CRC)","Hepatitis C Virus (HCV)","INTERVENTIONAL","SCREENING",[30],"NA",{"count":32,"type":33},350,"ESTIMATED",[35],{"type":36,"name":37,"description":38,"armGroupLabels":39},"BEHAVIORAL","MATCHES","Participants will be asked to complete a survey with specific topics including Hepatitis C (HCV) and Colorectal (CRC) knowledge and health beliefs, screening intentions and demographic characteristics.\n\nParticipants will be provided with education intervention materials (for example, a booklet) either in-person or via mail, access to free stool-based CRC screening, and access to free HCV screening.\n\nApproximately 1-2 weeks after receiving the education materials, participants will be asked to complete a post-intervention survey about the same specific topics (for example, HCV and CRC knowledge, HCV and CRC health beliefs, HCV and CRC screening intentions, healthcare experiences, perceptions of the educational materials) over the phone with a trained study staff.\n\nParticipants with a positive HCV screening and\u002For CRC screening result will be navigated to follow-up care as needed.",[7],[41],{"measure":42,"description":43,"timeFrame":44},"Screening Uptake for Hepatitis C Virus (HCV) and Colorectal Cancer (CRC)","Screening Uptake will be measured by the number of participants who complete both CRC and HCV screening documented via Electronic Health Record (EHR) at 12 months post-intervention.","Up to 12 Months",[46,50,53,56,58],{"measure":47,"description":48,"timeFrame":49},"Screening Completion for Hepatitis C Virus (HCV)","Screening Completion for HCV will be measured by the number of participants who complete HCV Screening at any time during the Study Period.","Up to 41 Months",{"measure":51,"description":52,"timeFrame":49},"Screening Completion for Colorectal Cancer (CRC)","Screening Completion for CRC will be measured by the number of participants who complete CRC Screening at any time during the Study Period.",{"measure":54,"description":55,"timeFrame":49},"Screening Test Results for Hepatitis C (HCV)","Screening Test Results will be measured as abnormal vs normal",{"measure":57,"description":55,"timeFrame":49},"Screening Test Results for Colorectal Cancer (CRC)",{"measure":59,"description":60,"timeFrame":49},"Completion of repeat CRC Screening","Completion of any repeat CRC Screening will be measured by the number of participants who repeat CRC Screening during the Study interval.","ALL","45 Years","75 Years",true,{"inclusion":66,"exclusion":80,"raw_text":82},[67,68,69,70,71,72,73,74,75,76,77,78,79],"Participants must be receiving care at one of the participating FQHC clinics.","Participants must be 45-75 years of age.","Participants must not be up to date with Colorectal Cancer (CRC) screening recommendations such as no colonoscopy in the past 10 years, occult blood test in the past 12 months.","Participants must never have had Hepatitis C Virus (HCV) antibody screening.","Participants must be able to read, write, and understand English or Spanish.","Participants must have no personal history of CRC or current presumptive CRC symptoms such as unresolved rectal bleeding or abdominal pain\u002Fbloating.","Participants must be at average risk for CRC (no hereditary CRC syndromes such as lower gastrointestinal (GI) bleeding, persistent diarrhea, bloating, or lower GI pain, no strong family history of CRC).","Participants must be asymptomatic for HCV.","Participants receiving intervention materials must be able and willing to complete surveys and receive the patient level intervention.","Participants completing qualitative interviews must be willing to complete a remote interview via phone or teleconference software such as ZOOM.","Participants completing qualitative interviews must be willing to be audio recorded.","Participants recruited for qualitative interviews only (did not receive MATCHES intervention materials) must have a clinic visit within prior two months.","All Participants must be able to provide informed consent.",[81],"Participants that do not meet all Inclusion Eligibility requirements will be excluded.","Inclusion Criteria:\n\n* Participants must be receiving care at one of the participating FQHC clinics.\n* Participants must be 45-75 years of age.\n* Participants must not be up to date with Colorectal Cancer (CRC) screening recommendations such as no colonoscopy in the past 10 years, occult blood test in the past 12 months.\n* Participants must never have had Hepatitis C Virus (HCV) antibody screening.\n* Participants must be able to read, write, and understand English or Spanish.\n* Participants must have no personal history of CRC or current presumptive CRC symptoms such as unresolved rectal bleeding or abdominal pain\u002Fbloating.\n* Participants must be at average risk for CRC (no hereditary CRC syndromes such as lower gastrointestinal (GI) bleeding, persistent diarrhea, bloating, or lower GI pain, no strong family history of CRC).\n* Participants must be asymptomatic for HCV.\n* Participants receiving intervention materials must be able and willing to complete surveys and receive the patient level intervention.\n* Participants completing qualitative interviews must be willing to complete a remote interview via phone or teleconference software such as ZOOM.\n* Participants completing qualitative interviews must be willing to be audio recorded.\n* Participants recruited for qualitative interviews only (did not receive MATCHES intervention materials) must have a clinic visit within prior two months.\n* All Participants must be able to provide informed consent.\n\nExclusion Criteria:\n\n* Participants that do not meet all Inclusion Eligibility requirements will be excluded.",[84,85],"ADULT","OLDER_ADULT",[87],{"facility":88,"status":8,"city":89,"state":90,"zip":91,"country":92,"contacts":93,"geoPoint":107},"Moffitt Cancer Center","Tampa","Florida","33612","United States",[94,99,102,105],{"name":95,"role":96,"phone":97,"email":98},"Carol Boxtha","CONTACT","813-745-8963","Carol.Boxtha@Moffitt.org",{"name":100,"role":101},"Christy Shannon, PhD","PRINCIPAL_INVESTIGATOR",{"name":103,"role":104},"Clement K Gwede, PhD, MPH, RN","SUB_INVESTIGATOR",{"name":106,"role":104},"Susan T Vadaparampil, PhD",{"lat":108,"lon":109},27.94752,-82.45843,[111,112],{"name":95,"role":96,"phone":97,"email":98},{"name":113,"role":96},"Shannon Christy, PhD",[115,116],{"name":113,"affiliation":88,"role":101},{"name":117,"affiliation":88,"role":101},"Clement K. Gwede, PhD, MPH, RN",[119],{"pmid":120,"type":121,"citation":122},"41692274","DERIVED","Abdulla R, Boxtha C, Courtney EP, Anyanwu OA, Sutton SK, Chung-Bridges K, Kassaye HG, Philippe E, Mudon KA, Frias E, Parras D, Avrilien N, Friedman M, Turner K, Coronado GD, Champion VL, Tobin JN, Vadaparampil ST, Gwede CK, Christy SM. Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES): Study protocol for a hybrid 1 stepped-wedge multibehavioral randomized trial. Contemp Clin Trials. 2026 Apr;163:108256. doi: 10.1016\u002Fj.cct.2026.108256. Epub 2026 Feb 13.",[124],{"label":125,"url":126},"Moffitt Cancer Center Clinical Trials website","http:\u002F\u002Fwww.moffitt.org\u002Fclinical-trials-research\u002Fclinical-trials\u002F",{"nct_id":4,"conditions":128,"biomarkers":131},[129,130],"Colorectal Carcinoma","Hepatitis C Infection",[],{"nct_id":4,"found":64,"summary":133,"prompt_version":143},{"design":134,"status":135,"heading":136,"summary":137,"follow_up":138,"word_count":139,"commitments":140,"compensation":141,"drugs_mentioned":142},"This is an interventional study, meaning participants will receive an intervention. It aims to enroll 350 participants.","completed","MATCHES: Colorectal Cancer and Hepatitis C Education and Screening","This study, called MATCHES, is testing an educational program to encourage screening for colorectal cancer (CRC) and Hepatitis C virus (HCV) among patients aged 45-75. You would complete a survey about your knowledge and beliefs regarding HCV and CRC, your intentions to get screened, and your background. Then, you would receive educational materials, like a booklet. The researchers want to see if this program increases the number of people who get screened for both conditions. You can join if you are 45-75 years old, receive care at a participating FQHC clinic, and are not up-to-date with your CRC screening (for example, no colonoscopy in the past 10 years). The study is currently unclear about its recruitment status and plans to enroll 350 participants.","Screening uptake for Hepatitis C Virus and Colorectal Cancer will be measured for up to 12 months.",123,"Participants will complete a survey and receive educational intervention materials, such as a booklet.","Not stated in the trial record.",[37],"v2"]