[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06792695":3,"trial-entities:NCT06792695":576,"trial-summary:NCT06792695":581},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":28,"primary_purpose":29,"phases":30,"enrollment_info":32,"interventions":35,"primary_outcomes":53,"secondary_outcomes":61,"sex":85,"minimum_age":86,"maximum_age":87,"healthy_volunteers":15,"eligibility_criteria":88,"std_ages":113,"locations":116,"central_contacts":567,"overall_officials":573,"references":574,"see_also_links":575},"NCT06792695","D798VC00001","A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer","A Phase II, Open-label, Multicenter, Master Protocol to Evaluate the Safety and 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participants should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.",[102,103,104,105,106,107,108,109,110,111],"Central nervous system metastases or spinal cord compression","Known history of severe allergy to any monoclonal antibody or study intervention.","Any unresolved toxicity CTCAE Grade ≥ 2 from a previous anticancer therapy.","History of another primary malignancy.","Potentially resectable disease with multidisciplinary plan for radical surgery.","Active or prior documented autoimmune or inflammatory disorders or cardiac conditions.","Participants with a prior history of hypertensive crisis or hypertensive encephalopathy or bleeding risks.","Deep venous thrombosis, pulmonary embolism, arterial thrombosis, transient ischemic attack or cerebrovascular accident.","History of abdominal or tracheoesophageal fistula, GI perforation and\u002For fistulae, or intraabdominal abscess within 6 months prior to 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It is a multi-drug, multicenter study that will randomly assign participants to one of two treatment groups.","completed","Study of Volrustomig for Metastatic Colorectal Cancer","This study is looking at new ways to treat metastatic colorectal cancer (cancer that has spread). It tests a drug called Volrustomig in combination with standard treatments, FOLFIRI (a chemotherapy combination of Fluorouracil, leucovorin, and irinotecan) and Bevacizumab. You might be eligible if you have colorectal adenocarcinoma that has spread, meet certain health criteria like an ECOG performance status of 0 or 1, and have a life expectancy of at least 12 weeks. The study will measure how long people live without their cancer getting worse (Progression Free Survival) and track any side effects over about 3 years. This study is currently unclear on its recruitment status and plans to enroll 80 participants.","The study will follow participants for approximately 3 years to measure Progression Free Survival and adverse events.",113,"Not specified in the trial record.","Not stated in the trial record.",[38,50],"v2"]