[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06797752":3,"trial-entities:NCT06797752":84,"trial-summary:NCT06797752":89},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":23,"study_type":24,"primary_purpose":17,"phases":25,"enrollment_info":26,"interventions":29,"primary_outcomes":36,"secondary_outcomes":41,"sex":42,"minimum_age":43,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":44,"std_ages":53,"locations":56,"central_contacts":74,"overall_officials":76,"references":78,"see_also_links":83},"NCT06797752","STU-2024-1027","Effect of the Stellate Ganglion Block on the Retinal Microcirculation","Effect of the Stellate Ganglion Block on the Retinal Microcirculation: A Pilot Study","RECRUITING","2026-10-07","2025-11","2025-11-19","2024-10-07","University of Texas Southwestern Medical Center","OTHER",false,"Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke. It is hypothesized that these exaggerated increases in sympathetic nervous activity produce maladaptations that promote secondary brain injury. One of these possible mechanisms include diffuse vasospasm that cause cerebral ischemia. Hence, methods to abrogate the sympathetic nervous system in this context are under active investigation. One possible method is the regional anesthesia technique of the stellate ganglion nerve block, which is ordinarily used for complex regional pain syndrome, but has been shown to reduce cerebral sympathetic activity and reduces vasospasm in patients with subarachnoid hemorrhage. However, its effect on the microcirculation is not clear. Hence, we propose to study patients receiving the stellate ganglion nerve block as part of their standard medical care and to image their retinal microcirculation before and after the procedure using Optical Coherence Tomography Angiography (OCTA).",null,[19,20,21,22],"OCTA","Severe Brain Injury","Subarachnoid Hemorrhage","Intracerebral Hemorrhage",[],"OBSERVATIONAL",[],{"count":27,"type":28},50,"ESTIMATED",[30],{"type":31,"name":32,"description":33,"armGroupLabels":34},"DEVICE","OCTA Scan","Optical Coherence Tomography Angiography before and after receiving the stellate ganglion nerve block.",[35],"Intervention Group",[37],{"measure":38,"description":39,"timeFrame":40},"Vascular and Perfusion Density","Quantitative measure of retinal microperfusion","One day",[],"ALL","18 Years",{"inclusion":45,"exclusion":48,"raw_text":52},[46,47],"Age 18 years or older","Patients receiving the stellate ganglion nerve block for an approved indication, e.g. complex regional pain syndrome",[49,50,51],"Pregnancy","Non-English speaking","Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device","Inclusion Criteria:\n\n* Age 18 years or older\n* Patients receiving the stellate ganglion nerve block for an approved indication, e.g. complex regional pain syndrome\n\nExclusion Criteria:\n\n* Pregnancy\n* Non-English speaking\n* Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device",[54,55],"ADULT","OLDER_ADULT",[57],{"facility":58,"status":8,"city":59,"state":60,"zip":61,"country":62,"contacts":63,"geoPoint":71},"UT Southwestern Medical Center","Dallas","Texas","75235","United States",[64,69],{"name":65,"role":66,"phone":67,"email":68},"Noah Jouett, DO, PhD","CONTACT","214-645-7011","noah.jouett@utsouthwestern.edu",{"name":65,"role":70},"PRINCIPAL_INVESTIGATOR",{"lat":72,"lon":73},32.78306,-96.80667,[75],{"name":65,"role":66,"phone":67,"email":68},[77],{"name":65,"affiliation":13,"role":70},[79],{"pmid":80,"type":81,"citation":82},"15817102","BACKGROUND","Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat. 2005 Apr;206(4):319-48. doi: 10.1111\u002Fj.1469-7580.2005.00395.x.",[],{"nct_id":4,"conditions":85,"biomarkers":88},[86,87,20,21],"Cerebral Hemorrhage","Complex Regional Pain Syndrome",[],{"nct_id":4,"found":90,"summary":91,"prompt_version":101},true,{"design":92,"status":93,"heading":94,"summary":95,"follow_up":96,"word_count":97,"commitments":98,"compensation":99,"drugs_mentioned":100},"This is an observational study planning to include 50 participants. It is not a randomized trial.","completed","Observational Study of Stellate Ganglion Block on Retinal Microcirculation","This observational study is looking at how a stellate ganglion nerve block affects the tiny blood vessels in your retina (the back of your eye). Researchers want to see if this nerve block, which is sometimes used for conditions like complex regional pain syndrome, can improve blood flow in the eye. They believe that too much activity in a part of the nervous system (the sympathetic nervous system) after brain injuries like a stroke or bleeding in the brain might cause problems, including narrowing of blood vessels. You might be able to join if you are 18 or older, are receiving a stellate ganglion nerve block for a medical reason, and can sit up for an eye scan. The main goal is to measure changes in blood vessel density and blood flow one day after the nerve block. The current status of this study is unclear.","Vascular and perfusion density will be measured one day after the intervention.",146,"You would have an OCTA Scan (a special eye scan) before and after receiving the stellate ganglion nerve block.","Not stated in the trial record.",[],"v2"]