[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06823115":3,"trial-entities:NCT06823115":679,"trial-summary:NCT06823115":684},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":26,"study_type":32,"primary_purpose":33,"phases":34,"enrollment_info":35,"interventions":38,"primary_outcomes":39,"secondary_outcomes":44,"sex":63,"minimum_age":64,"maximum_age":65,"healthy_volunteers":15,"eligibility_criteria":66,"std_ages":70,"locations":72,"central_contacts":675,"overall_officials":676,"references":677,"see_also_links":678},"NCT06823115","23847","Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0","Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0: Towards Expanding Our Understanding of Neonatal Acute Kidney Injury","ENROLLING_BY_INVITATION","2026-12","2026-04","2026-04-17","2025-03-01","Indiana University","OTHER",false,"There is a growing focus on short- and long-term kidney health in neonates, including those with acute kidney injury (AKI). AKI occurs commonly in the Neonatal Intensive Care Unit (NICU) and is associated with adverse outcomes. In addition to poor outcomes during the hospitalization, infants discharged from the NICU may have an increased burden of kidney disease during childhood. Studies of long-term kidney function in children born prematurely show a fourfold increase in chronic kidney disease (CKD) by adolescence and into adulthood.\n\nDespite the landmark findings of the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) study, the limitations of this study are notable. First, the AWAKEN study enrolled infants admitted in 2014, making the data now over 10 years old. Much has changed in neonatal practice (e.g. increased AKI awareness, treatment strategies). Secondly, the findings of the AWAKEN study were geographically limited. While the AWAKEN study was multi-national and multi-center, it represented only 24 centers (22 from North America, 1 from India and 1 from Australia). Finally, information collected from AWAKEN ended at hospital discharge.\n\nThe investigators seek to leverage the strength of the Neonatal Kidney Collaborative along with other organizations and collaboratives interested in neonatal kidney health to address these gaps. Therefore, the investigators are conducting a second, modified iteration of this study entitled \"AWAKEN 2.0\". AWAKEN 2.0 will be a multi-center multi-national retrospective analysis utilizing similar methodology to the AWAKEN study.","AWAKEN 2.0 is a multi-center multi-national retrospective analysis utilizing similar methodology to the AWAKEN study. The investigators will capture information on all infants admitted to participating level 3 and 4 NICUs between January 1-March 31, 2019, to answer specific hypothesis regarding the following three inter-connected but independent specific aims:\n\nSpecific Aim 1. Describe prevalence of AKI in a multi-national multi-center retrospective cohort, 5 years after the original AWAKEN study.\n\n1. Primary hypothesis: The investigators hypothesize that rates of neonatal AKI are higher than the rate described in the original AWAKEN study.\n2. Population:\n\n   1. Inclusion Criteria include all infants admitted to participating NICUs between 1\u002F1\u002F19- 3\u002F31\u002F19 and receiving \\> 48 hours of IV fluids\n   2. Exclusion Criteria include age \\> 14 days at admission, congenital heart disease requiring transfer for escalation of CHD care and\u002For surgery within the first 7 days, lethal chromosomal anomalies and\u002For neonatal mortality \\\u003C48 hours\n3. Primary Outcome - Neonatal AKI\n4. Potential confounders - gestational age, birth weight, 5 minute APGAR score, multiple gestation, significant renal anomalies, site characteristics.\n\nSpecific Aim 2. Determine if AKI is independently associated with mortality, length of stay, and discharge serum creatinine (SCr).\n\n1. The investigators hypothesize that higher stages of AKI are associated with higher mortality, longer lengths of stay and higher serum creatinine at discharge, even after controlling for confounding factors.\n2. Populations - Same as Specific Aim 1.\n3. Primary Exposure - Neonatal AKI definitions (table 3)\n4. Primary Outcome - Survival\n5. Secondary outcomes will include: Hospital length of stay, BPD.\n6. Potential confounders - gestational age, birth weight, 5 minute APGAR score, multiple gestation, significant renal anomalies,\n7. Exploratory outcomes - recognize that the proposed definition may not be the best definition to predict clinical outcomes. Also recognize that there may be a need to have different definitions for premature infants. The investigators plan to explore how other definitions reported in the literature can predict these outcomes (for example using the 90th % for normative values). In addition, this will have the largest comprehensive database to explore new definitions which could incorporate fluid balance and other factors.\n\nSpecific Aim 3. Determine if AKI can predict chronic kidney disease, recurrent AKI and hypertension during early childhood.\n\n1. The investigators hypothesize that higher stages of AKI are associated with chronic kidney disease and recurrent AKI during early childhood.\n2. Population - Same as Specific Aim 1\n3. Primary Exposure - Neonatal AKI definitions (table 3)\n4. Primary Outcome - Childhood CKD\n5. Secondary Outcomes - Childhood hypertension, recurrent AKI and childhood ESRD.\n\nEach participating site will screen all neonates admitted to the NICU during the 3 months of study and capture additional data on those who meet the same inclusion and exclusion criteria as the original cohort. There will be 6 different integrated forms.\n\n1. Screening form (all infants)\n2. Baseline form for included infants (maternal demographic data, admission indication)\n3. First 14 days form (i.e. urine output, medications and respiratory support)\n4. Serum creatinine data (all values from date of birth to date of IRB approval)\n5. Discharge form (discharge diagnoses, medications, follow-up anticipated)\n6. Follow-up Information (clinically obtained follow-up after discharge)",[19,20,21,22,23,24,25],"Acute Kidney Injury","Fluid Overload","Prematurity Complications","Risk Factors","Epidemiology","Chronic Kidney Disease(CKD)","Hypertension",[27,28,29,30,31],"acute kidney injury","chronic kidney disease","neonates","prematurity","hypertension","OBSERVATIONAL",null,[],{"count":36,"type":37},4000,"ESTIMATED",[],[40],{"measure":41,"description":42,"timeFrame":43},"Neonatal Acute Kidney Injury","The investigators will evaluate the rate of neonatal AKI among infants that meet inclusion criteria across all sites. Neonatal Acute Kidney Injury will be defined by the standard neonatal definitions, including serum creatinine values and urine output (when available). Furthermore, investigators will examine if different thresholds or definitions of AKI will better predict outcomes.","Up to 6 months or NICU discharge, whichever comes first",[45,48,51,54,58,60],{"measure":46,"description":47,"timeFrame":43},"Risk factors for Neonatal AKI","Define the major risk factors associated with neonatal AKI. The investigators will randomly split the cohort into two groups. The investigators will develop a risk factor prediction model with the first group, and test the ability of the model to predict AKI with the second group.",{"measure":20,"description":49,"timeFrame":50},"Fluid overload will be calculated based on daily weights and intake and output values. We will determine how fluid balance during the first few weeks of life relates to biochemical data and clinical outcomes.","NICU admission through discharge.",{"measure":52,"description":53,"timeFrame":43},"Mortality","Determine if the KDIGO AKI definition adapted to neonates can predict mortality. Investigators will also evaluate if other thresholds or proposed AKI definitions can better predict mortality.",{"measure":55,"description":56,"timeFrame":57},"Chronic Kidney Disease","In infants with available follow-up data clinically obtained, investigators will determine the rates of both clinically diagnosed (by ICD code or note) and laboratory determined Chronic Kidney Disease (using the CKID-U25 eGFR definitions).","NICU discharge to 5 year follow-up",{"measure":25,"description":59,"timeFrame":57},"In infants with available follow-up data clinically obtained, investigators will determine the rates of both clinically diagnosed (by ICD code or note) and value determined hypertension (using AAP Hypertension thresholds)",{"measure":61,"description":62,"timeFrame":57},"Proteinuria","In infants with available follow-up data clinically obtained, investigators will determine the rates of both clinically diagnosed (by ICD code or note) and laboratory determined proteinuria.","ALL","0 Minutes","2 Weeks",{"inclusion":67,"exclusion":68,"raw_text":69},[],[],"Inclusion Criteria:\n\n1. All infants born or admitted to a participating level 3 or 4 NICU between 1\u002F1\u002F19- 3\u002F31\u002F19 will be screened.\n2. Infants who received intravenous fluids for \\> 48 hours will be eligible.\n\nExclusion Criteria:\n\n1. Age \\> 14 days at admission\n2. Congenital heart disease requiring transfer for escalation of CHD care and\u002For surgery within the first 7 days\n3. Lethal chromosomal anomalies\n4. Neonatal mortality \\\u003C48 hours",[71],"CHILD",[73,82,90,98,105,113,121,129,137,144,152,160,167,175,178,186,194,201,209,213,221,229,237,245,252,260,268,275,282,289,296,300,308,315,323,330,337,345,353,361,369,377,384,391,398,406,414,422,430,438,445,453,459,466,472,480,486,492,498,504,507,510,517,523,529,536,543,550,556,562,565,572,579,585,591,598,605,612,619,625,628,635,642,649,655,661,668],{"facility":74,"city":75,"state":76,"zip":77,"country":78,"geoPoint":79},"University of Alabama at Birmingham","Birmingham","Alabama","35294","United States",{"lat":80,"lon":81},33.52066,-86.80249,{"facility":83,"city":84,"state":85,"zip":86,"country":78,"geoPoint":87},"University of Arkansas for Medical Sciences","Little Rock","Arkansas","72202",{"lat":88,"lon":89},34.74648,-92.28959,{"facility":91,"city":92,"state":93,"zip":94,"country":78,"geoPoint":95},"Stanford Children's","Palo Alto","California","94304",{"lat":96,"lon":97},37.44188,-122.14302,{"facility":99,"city":100,"state":93,"zip":101,"country":78,"geoPoint":102},"Rady Children's Hospital\u002FUCSD","San Diego","92123",{"lat":103,"lon":104},32.71571,-117.16472,{"facility":106,"city":107,"state":108,"zip":109,"country":78,"geoPoint":110},"Children's Hospital Colorado","Aurora","Colorado","80045",{"lat":111,"lon":112},39.72943,-104.83192,{"facility":114,"city":115,"state":116,"zip":117,"country":78,"geoPoint":118},"Yale University","New Haven","Connecticut","06511",{"lat":119,"lon":120},41.30815,-72.92816,{"facility":122,"city":123,"state":124,"zip":125,"country":78,"geoPoint":126},"Children's National Hospital","Washington D.C.","District of Columbia","20010",{"lat":127,"lon":128},38.89511,-77.03637,{"facility":130,"city":131,"state":132,"zip":133,"country":78,"geoPoint":134},"Miami Children's \u002F Nichlaus Children's Hospital","Miami","Florida","33155",{"lat":135,"lon":136},25.77427,-80.19366,{"facility":138,"city":139,"state":132,"zip":140,"country":78,"geoPoint":141},"Baptist Health South Florida\u002FSouth Miami Hospital","South Miami","33176",{"lat":142,"lon":143},25.7076,-80.29338,{"facility":145,"city":146,"state":147,"zip":148,"country":78,"geoPoint":149},"Emory Healthcare \u002F Children's Healthcare of Atlanta","Atlanta","Georgia","30322",{"lat":150,"lon":151},33.749,-84.38798,{"facility":153,"city":154,"state":155,"zip":156,"country":78,"geoPoint":157},"Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"lat":158,"lon":159},41.85003,-87.65005,{"facility":161,"city":162,"state":155,"zip":163,"country":78,"geoPoint":164},"SIU","Springfield","62702",{"lat":165,"lon":166},39.80172,-89.64371,{"facility":168,"city":169,"state":170,"zip":171,"country":78,"geoPoint":172},"Indiana University School of Medicine","Indianapolis","Indiana","46202",{"lat":173,"lon":174},39.76838,-86.15804,{"facility":176,"city":169,"state":170,"zip":171,"country":78,"geoPoint":177},"Riley Hospital for Children",{"lat":173,"lon":174},{"facility":179,"city":180,"state":181,"zip":182,"country":78,"geoPoint":183},"University of Iowa","Iowa City","Iowa","52242",{"lat":184,"lon":185},41.66113,-91.53017,{"facility":187,"city":188,"state":189,"zip":190,"country":78,"geoPoint":191},"University of Kentucky","Lexington","Kentucky","40536",{"lat":192,"lon":193},37.98869,-84.47772,{"facility":195,"city":196,"state":189,"zip":197,"country":78,"geoPoint":198},"University of Louisville","Louisville","40202",{"lat":199,"lon":200},38.25424,-85.75941,{"facility":202,"city":203,"state":204,"zip":205,"country":78,"geoPoint":206},"University of Maryland","Baltimore","Maryland","21201",{"lat":207,"lon":208},39.29038,-76.61219,{"facility":210,"city":203,"state":204,"zip":211,"country":78,"geoPoint":212},"Johns Hopkins University\u002FHospital","21287",{"lat":207,"lon":208},{"facility":214,"city":215,"state":216,"zip":217,"country":78,"geoPoint":218},"Boston Children's Hospital","Boston","Massachusetts","02115",{"lat":219,"lon":220},42.35843,-71.05977,{"facility":222,"city":223,"state":224,"zip":225,"country":78,"geoPoint":226},"University of Michigan","Ann Arbor","Michigan","48109",{"lat":227,"lon":228},42.27756,-83.74088,{"facility":230,"city":231,"state":232,"zip":233,"country":78,"geoPoint":234},"University of Minnesota","Minneapolis","Minnesota","55455",{"lat":235,"lon":236},44.97997,-93.26384,{"facility":238,"city":239,"state":240,"zip":241,"country":78,"geoPoint":242},"Children's Mercy Hospital","Kansas City","Missouri","64108",{"lat":243,"lon":244},39.09973,-94.57857,{"facility":246,"city":247,"state":240,"zip":248,"country":78,"geoPoint":249},"Washington University","St Louis","63110",{"lat":250,"lon":251},38.62727,-90.19789,{"facility":253,"city":254,"state":255,"zip":256,"country":78,"geoPoint":257},"Children's Nebraska","Omaha","Nebraska","68114",{"lat":258,"lon":259},41.25626,-95.94043,{"facility":261,"city":262,"state":263,"zip":264,"country":78,"geoPoint":265},"Maimonides Medical Center","Brooklyn","New York","11219",{"lat":266,"lon":267},40.6501,-73.94958,{"facility":269,"city":270,"state":263,"zip":271,"country":78,"geoPoint":272},"Cohen Children's Hospital","Queens","11040",{"lat":273,"lon":274},40.68149,-73.83652,{"facility":276,"city":277,"state":263,"zip":278,"country":78,"geoPoint":279},"University of Rochester \u002F Golisano Children's Hospital","Rochester","14642",{"lat":280,"lon":281},43.15478,-77.61556,{"facility":283,"city":284,"state":263,"zip":285,"country":78,"geoPoint":286},"Stony Brook Medicine","Stony Brook","11794",{"lat":287,"lon":288},40.92565,-73.14094,{"facility":290,"city":291,"state":263,"zip":292,"country":78,"geoPoint":293},"Children's Hospital at Montefiore","The Bronx","10467",{"lat":294,"lon":295},40.84985,-73.86641,{"facility":297,"city":298,"state":263,"zip":299,"country":78},"Westchester Medical Center\u002FMaria Fareri Children's Hospital","Westchester","10595",{"facility":301,"city":302,"state":303,"zip":304,"country":78,"geoPoint":305},"UNC","Chapel Hill","North Carolina","27514",{"lat":306,"lon":307},35.9132,-79.05584,{"facility":309,"city":310,"state":303,"zip":311,"country":78,"geoPoint":312},"Wake Forest","Winston-Salem","27157",{"lat":313,"lon":314},36.09986,-80.24422,{"facility":316,"city":317,"state":318,"zip":319,"country":78,"geoPoint":320},"Akron Children's Hospital","Akron","Ohio","44308",{"lat":321,"lon":322},41.08144,-81.51901,{"facility":324,"city":325,"state":318,"zip":326,"country":78,"geoPoint":327},"Cincinnati Children's Hospital","Cincinnati","45229",{"lat":328,"lon":329},39.12711,-84.51439,{"facility":331,"city":332,"state":318,"zip":333,"country":78,"geoPoint":334},"Nationwide Children's","Columbus","43205",{"lat":335,"lon":336},39.96118,-82.99879,{"facility":338,"city":339,"state":340,"zip":341,"country":78,"geoPoint":342},"OHSU","Portland","Oregon","97239",{"lat":343,"lon":344},45.52345,-122.67621,{"facility":346,"city":347,"state":348,"zip":349,"country":78,"geoPoint":350},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"lat":351,"lon":352},39.95238,-75.16362,{"facility":354,"city":355,"state":356,"zip":357,"country":78,"geoPoint":358},"Medical University of South Carolina","Charleston","South Carolina","29425",{"lat":359,"lon":360},32.77632,-79.93275,{"facility":362,"city":363,"state":364,"zip":365,"country":78,"geoPoint":366},"Monroe Carell Jr. Children's Hospital at Vanderbilt","Nashville","Tennessee","37232",{"lat":367,"lon":368},36.16589,-86.78444,{"facility":370,"city":371,"state":372,"zip":373,"country":78,"geoPoint":374},"UT Southwestern","Dallas","Texas","75235",{"lat":375,"lon":376},32.78306,-96.80667,{"facility":378,"city":379,"state":372,"zip":380,"country":78,"geoPoint":381},"Texas Children's Hospital","Houston","77030",{"lat":382,"lon":383},29.76328,-95.36327,{"facility":385,"city":386,"state":372,"zip":387,"country":78,"geoPoint":388},"Texas Tech","Lubbock","79415",{"lat":389,"lon":390},33.57786,-101.85517,{"facility":392,"city":393,"state":372,"zip":394,"country":78,"geoPoint":395},"Christus Children's Hospital","San Antonio","78207",{"lat":396,"lon":397},29.42412,-98.49363,{"facility":399,"city":400,"state":401,"zip":402,"country":78,"geoPoint":403},"Primary Children's Hospital","Salt Lake City","Utah","84113",{"lat":404,"lon":405},40.76078,-111.89105,{"facility":407,"city":408,"state":409,"zip":410,"country":78,"geoPoint":411},"Golisano Children's Hospital at University of Vermont Health","Burlington","Vermont","05401",{"lat":412,"lon":413},44.47588,-73.21207,{"facility":415,"city":416,"state":417,"zip":418,"country":78,"geoPoint":419},"University of Virginia","Charlottesville","Virginia","22930",{"lat":420,"lon":421},38.02931,-78.47668,{"facility":423,"city":424,"state":425,"zip":426,"country":78,"geoPoint":427},"Seattle Children's Hospital \u002F University of Washington","Seattle","Washington","98105",{"lat":428,"lon":429},47.60621,-122.33207,{"facility":431,"city":432,"state":433,"zip":434,"country":78,"geoPoint":435},"University of Wisconsin","Madison","Wisconsin","53792",{"lat":436,"lon":437},43.07305,-89.40123,{"facility":439,"city":440,"state":433,"zip":441,"country":78,"geoPoint":442},"Medical College of Wisconsin \u002F Children's Wisconsin","Milwaukee","53226",{"lat":443,"lon":444},43.0389,-87.90647,{"facility":446,"city":447,"state":448,"country":449,"geoPoint":450},"The Royal Children's Hospital Melbourne","Melbourne","Victoria","Australia",{"lat":451,"lon":452},-37.814,144.96332,{"facility":454,"city":455,"country":449,"geoPoint":456},"Perth Children's Hospital","Perth",{"lat":457,"lon":458},-31.95224,115.8614,{"facility":460,"city":461,"country":462,"geoPoint":463},"Joana de Gusmao Children's Hospital","Florianópolis","Brazil",{"lat":464,"lon":465},-27.59667,-48.54917,{"facility":467,"city":468,"country":462,"geoPoint":469},"Hospital de Clinicas de Porto Alegre","Porto Alegre",{"lat":470,"lon":471},-30.03283,-51.23019,{"facility":473,"city":474,"state":475,"country":476,"geoPoint":477},"The Hospital for Sick Children","Toronto","Ontario","Canada",{"lat":478,"lon":479},43.70643,-79.39864,{"facility":481,"city":482,"country":476,"geoPoint":483},"Alberta Children's Hospital\u002FUniversity of Calgary","Calgary",{"lat":484,"lon":485},51.05011,-114.08529,{"facility":487,"city":488,"country":476,"geoPoint":489},"Stollery Children's Hospital","Edmonton",{"lat":490,"lon":491},53.55014,-113.46871,{"facility":493,"city":494,"country":476,"geoPoint":495},"McMaster Children's Hospital","Hamilton",{"lat":496,"lon":497},43.25011,-79.84963,{"facility":499,"city":500,"country":476,"geoPoint":501},"McGill University","Montreal",{"lat":502,"lon":503},45.50884,-73.58781,{"facility":505,"city":474,"country":476,"geoPoint":506},"Mount Sinai Hospital",{"lat":478,"lon":479},{"facility":508,"city":474,"country":476,"geoPoint":509},"Sunnybrook Health Sciences Center",{"lat":478,"lon":479},{"facility":511,"city":512,"country":513,"geoPoint":514},"Hospital Occidente de Kennedy","Bogotá","Colombia",{"lat":515,"lon":516},4.60971,-74.08175,{"facility":518,"city":519,"country":513,"geoPoint":520},"Fundacion Valle del Lili Cali","Cali",{"lat":521,"lon":522},3.43054,-76.5199,{"facility":524,"city":525,"country":513,"geoPoint":526},"Clínica Universitaria Bolivariana","Medellín",{"lat":527,"lon":528},6.245,-75.57151,{"facility":530,"city":531,"country":532,"geoPoint":533},"Institute for the Care of Mother and Child","Prague","Czechia",{"lat":534,"lon":535},50.08804,14.42076,{"facility":537,"city":538,"country":539,"geoPoint":540},"University of Cologne","Cologne","Germany",{"lat":541,"lon":542},50.93333,6.95,{"facility":544,"city":545,"country":546,"geoPoint":547},"Aghia Sofia Children's Hospital","Athens","Greece",{"lat":548,"lon":549},37.98376,23.72784,{"facility":551,"city":552,"country":546,"geoPoint":553},"University Hospital of Heraklion","Heraklion",{"lat":554,"lon":555},35.32787,25.14341,{"facility":557,"city":558,"country":546,"geoPoint":559},"Aristotle University","Thessaloniki",{"lat":560,"lon":561},40.64072,22.93493,{"facility":563,"city":558,"country":546,"geoPoint":564},"Hippokration General Hospital of Thessaloniki",{"lat":560,"lon":561},{"facility":566,"city":567,"country":568,"geoPoint":569},"University of Szeged Children's Hospital","Szeged","Hungary",{"lat":570,"lon":571},46.253,20.14824,{"facility":573,"city":574,"country":575,"geoPoint":576},"St. John's Medical College Hospital","Bengaluru","India",{"lat":577,"lon":578},12.97194,77.59369,{"facility":580,"city":581,"country":575,"geoPoint":582},"Dr. Mehta's Hospitals","Chennai",{"lat":583,"lon":584},13.08784,80.27847,{"facility":586,"city":587,"country":575,"geoPoint":588},"Christian Medical College","Vellore",{"lat":589,"lon":590},12.9184,79.13255,{"facility":592,"city":593,"country":594,"geoPoint":595},"Centro de Alta Especialidad del Estado de Veracruz","Veracruz","Mexico",{"lat":596,"lon":597},19.18095,-96.1429,{"facility":599,"city":600,"country":601,"geoPoint":602},"Amalia Children's Hospital Radboudumc","Nijmegen","Netherlands",{"lat":603,"lon":604},51.8425,5.85278,{"facility":606,"city":607,"country":608,"geoPoint":609},"University of Ibadan","Ibadan","Nigeria",{"lat":610,"lon":611},7.37756,3.90591,{"facility":613,"city":614,"country":615,"geoPoint":616},"Hospital Santa Maria, Unidade Local de Saude de Santa Maria","Lisbon","Portugal",{"lat":617,"lon":618},38.72509,-9.1498,{"facility":620,"city":621,"country":615,"geoPoint":622},"Centro Materno Infantil de Norte Albino Aroso, Unidade Local de Saude de Santo Antonio","Porto",{"lat":623,"lon":624},41.1485,-8.61097,{"facility":626,"city":621,"country":615,"geoPoint":627},"ULS Sao Joan",{"lat":623,"lon":624},{"facility":629,"city":630,"country":631,"geoPoint":632},"University Medical Centre Ljubljana","Ljubljana","Slovenia",{"lat":633,"lon":634},46.05108,14.50513,{"facility":636,"city":637,"country":638,"geoPoint":639},"Puerta del Mar University Hospital","Cadiz","Spain",{"lat":640,"lon":641},36.52672,-6.2891,{"facility":643,"city":644,"country":645,"geoPoint":646},"Cukurova University","Adana","Turkey (Türkiye)",{"lat":647,"lon":648},36.98615,35.32531,{"facility":650,"city":651,"country":645,"geoPoint":652},"Ankara Bilkent City Hospital, Children Hospital","Ankara",{"lat":653,"lon":654},39.91987,32.85427,{"facility":656,"city":657,"country":645,"geoPoint":658},"Marmara University Pendik Research and Training Hospital","Istanbul",{"lat":659,"lon":660},41.01384,28.94966,{"facility":662,"city":663,"country":664,"geoPoint":665},"St Francis Nsambya","Kampala","Uganda",{"lat":666,"lon":667},0.31628,32.58219,{"facility":669,"city":670,"country":671,"geoPoint":672},"Bukovinian State Medical University","Chernivtsi","Ukraine",{"lat":673,"lon":674},48.29045,25.93241,[],[],[],[],{"nct_id":4,"conditions":680,"biomarkers":683},[681,55,682,20,25],"Acute Renal Failure","Complication of prematurity",[],{"nct_id":4,"found":15,"summary":33,"prompt_version":33}]