[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06907173":3,"trial-entities:NCT06907173":750,"trial-summary:NCT06907173":753},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":42,"secondary_outcomes":47,"sex":79,"minimum_age":80,"maximum_age":81,"healthy_volunteers":82,"eligibility_criteria":83,"std_ages":105,"locations":109,"central_contacts":740,"overall_officials":745,"references":748,"see_also_links":749},"NCT06907173","HSR231657","Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)","RECRUITING","2029-12","2026-04","2026-05-14","2026-03-06","University of Virginia","OTHER",true,"The goal of this clinical trial is to determine if treatment of patients with two doses of ketamine plus levetiracetam versus levetiracetam alone leads to more effective control of status epilepticus.","KESETT is a multicenter, randomized, blinded study to determine whether adding 1 mg\u002Fkg or 3 mg\u002Fkg dose of KET to 60 mg\u002Fkg LEV can terminate status epilepticus (SE) in a larger fraction of subjects with benzodiazepine-refractory SE than those treated with LEV (60 mg\u002Fkg) alone.\n\nThe primary outcome is termination of SE from 15 minutes after starting the study drug infusion, sustained until 60 minutes from enrollment without using additional anti-seizure medication. Termination of SE is determined by (1) improving consciousness and absence of clinically apparent seizures at 60 minutes or (2) absence of any electrographic SE after 15 minutes in those with EEG monitoring and no improvement in consciousness.\n\nSecondary objectives include determining the relative safety of the treatment arms on defined safety outcomes and all adverse events, analysis of secondary\u002Fexploratory efficacy outcomes, and evaluation of both effectiveness and safety in the pediatric subpopulation.\n\nThe trial will initially allocate subjects equally (1:1:1) for the first 350 participants (burn-in period) before transitioning to response-adaptive randomization. Interim analyses will be conducted for efficacy and futility beginning when 350 subjects have been randomized, and will occur every 100 subjects thereafter. A maximum of 770 participants will be enrolled.",[18],"Status Epilepticus",[],"INTERVENTIONAL","TREATMENT",[23],"PHASE3",{"count":25,"type":26},770,"ESTIMATED",[28,34,38],{"type":29,"name":30,"description":31,"armGroupLabels":32},"DRUG","Levetiracetam (LEV) (60 mg\u002FKg) + 1 mg\u002Fkg Ketamine (KET)","The study drug will be produced at the central pharmacy, a GMP facility at the University of California, Davis. Diluted formulations are expected to remain stable for months when stored at room temperature. Expiration dates for study drugs will be determined and adjusted based on ongoing stability testing performed on study drugs prepared at the GMP facility for the study.\n\nAll three formulations will be transparent solutions. None of the formulations are reported to consistently cause adverse effects at the infusion site. The method of drug administration, including volume and rate of infusion, is identical for all three drugs. These factors ensure that drug administration will be blinded.",[33],"Levetiracetam + low dose Ketamine",{"type":29,"name":35,"description":31,"armGroupLabels":36},"Levetiracetam (LEV) (60 mg\u002FKg) + 3 mg\u002Fkg Ketamine (KET)",[37],"Levetiracetam + high dose Ketamine",{"type":29,"name":39,"description":31,"armGroupLabels":40},"Levetiracetam (LEV) (60 mg\u002FKg)",[41],"Levetiracetam",[43],{"measure":44,"description":45,"timeFrame":46},"Termination of SE","Termination of SE from 15 minutes after starting the study drug infusion, sustained for 60 minutes without using additional anti-seizure medication.\n\nTermination of SE is determined by (1) improving consciousness and absence of clinically apparent seizures at 60 minutes or (2) absence of any electrographic status epilepticus (ESE) after 15 minutes in those with EEG monitoring and no improvement in consciousness.","From 15 minutes after starting the study drug infusion, sustained for 60 minutes without using additional anti-seizure medication.",[48,52,56,60,63,67,71,75],{"measure":49,"description":50,"timeFrame":51},"Desirability of response (DOOR) outcome","One secondary outcome will be a desirability of response (DOOR) outcome which is a composite efficacy measure evaluated on a graded scale from 1 to 5 at 60 minutes, as follows:\n\n* No clinically evident or electrographic seizures after 15 minutes, no rescue drugs, and improving mental status by 60 minutes\n* No clinically evident or electrographic seizures after 15 minutes, not intubated, but not improving mental status at 60 minutes\n* No clinically evident or electrographic seizures after 15 minutes, but intubated or use of additional seizures medications (including medications used for intubation)\n* Any clinically evident seizure or electrographic seizure requiring rescue medicine within the timeframe between 15 and 60 minutes\n* Life-threatening hypotension or cardiac arrhythmia or death within 60 minutes\n\nThe Central Adjudication Core will determine the DOOR grade (1-5) based on clinical outcome data provided by the site and EEG data provided by the Central EEG Core.","60 minutes after starting the study drug infusion",{"measure":53,"description":54,"timeFrame":55},"Endotracheal intubation","Endotracheal intubation within 60 minutes of randomization (start of study drug infusion) and duration","Within 60 minutes after start of the study drug infusion",{"measure":57,"description":58,"timeFrame":59},"ICU duration","ICU duration during the study period for those that are admitted to the ICU as abstracted from the hospital admission record","Up to 30 days after enrollment",{"measure":61,"description":62,"timeFrame":59},"Hospital length-of-stay (LOS)","Hospital length-of-stay (LOS) from the ED as abstracted from the hospital admission record",{"measure":64,"description":65,"timeFrame":66},"Late recurrent seizure","Number of participants with late recurrent seizure between 60 minutes and 4 hours after the start of the study drug infusion","Between 60 minutes and 4 hours after the start of the study drug infusion",{"measure":68,"description":69,"timeFrame":70},"Time to termination of seizures","The interval from the start of infusion of study drug to the cessation of electrographic seizure in those who meet the primary outcome","From the start of infusion of study drug to the cessation of electrographic seizure assessed up to 60 minutes from study drug initiation",{"measure":72,"description":73,"timeFrame":74},"Late seizures after requiring an anesthetic","Number of participants with late seizures after requiring an anesthetic between 60 minutes and 24 hours after start of study drug infusion","Between 60 minutes and 24 hours after start of study drug infusion",{"measure":76,"description":77,"timeFrame":78},"All cause mortality","All cause mortality to end of study","From the start of study drug infusion to hospital discharge or day 30","ALL","1 Year",null,false,{"inclusion":84,"exclusion":91,"raw_text":104},[85,86,87,88,89,90],"The patient was witnessed to have a convulsive seizure for greater than 5-minute duration","The patient received an adequate dose of benzodiazepines. The doses may be divided.","The last dose of a benzodiazepine was administered 5-30 minutes before study drug administration.","Continued or recurring seizures in the Emergency Department.","Age 1 years or older","Known or estimated weight ≥10 Kg",[92,93,94,95,96,97,98,99,100,101,102,103],"Known pregnancy","Prisoner","Opt-out identification or otherwise known to be previously enrolled in KESETT","Treatment with a second line anticonvulsant (FOS, PHT, VPA, LEV, phenobarbital, or other agents defined in the MoP) for this episode of SE","Treatment with sedatives with anticonvulsant properties other than benzodiazepines for this episode of SE(propofol, etomidate, ketamine or other agents defined in the MoP)","Endotracheal intubation prior to enrollment","Acute traumatic brain injury clearly precedes seizures","Scalp injury or burn preventing EEG placement","Known allergy or other known contraindication to KET or LEV","Hypoglycemia \\\u003C 50 mg\u002FdL","Hyperglycemia \\> 400 mg\u002FdL","Cardiac arrest \u002F post-anoxic seizures","Inclusion Criteria:\n\n* The patient was witnessed to have a convulsive seizure for greater than 5-minute duration\n* The patient received an adequate dose of benzodiazepines. The doses may be divided.\n* The last dose of a benzodiazepine was administered 5-30 minutes before study drug administration.\n* Continued or recurring seizures in the Emergency Department.\n* Age 1 years or older\n* Known or estimated weight ≥10 Kg\n\nExclusion Criteria:\n\n* Known pregnancy\n* Prisoner\n* Opt-out identification or otherwise known to be previously enrolled in KESETT\n* Treatment with a second line anticonvulsant (FOS, PHT, VPA, LEV, phenobarbital, or other agents defined in the MoP) for this episode of SE\n* Treatment with sedatives with anticonvulsant properties other than benzodiazepines for this episode of SE(propofol, etomidate, ketamine or other agents defined in the MoP)\n* Endotracheal intubation prior to enrollment\n* Acute traumatic brain injury clearly precedes seizures\n* Scalp injury or burn preventing EEG placement\n* Known allergy or other known contraindication to KET or LEV\n* Hypoglycemia \\\u003C 50 mg\u002FdL\n* Hyperglycemia \\> 400 mg\u002FdL\n* Cardiac arrest \u002F post-anoxic seizures",[106,107,108],"CHILD","ADULT","OLDER_ADULT",[110,127,142,152,165,178,191,197,211,225,238,252,266,280,290,304,314,320,334,343,357,371,385,399,412,421,431,445,455,462,476,490,496,510,524,534,548,562,568,578,588,601,611,624,639,652,666,676,690,703,717,731],{"facility":111,"status":7,"city":112,"state":113,"zip":114,"country":115,"contacts":116,"geoPoint":124},"Banner University Medical Center - Tucson Campus","Tucson","Arizona","85724","United States",[117,122],{"name":118,"role":119,"phone":120,"email":121},"Aaron Leetch, MD","CONTACT","520-621-8752","aleetch@arizona.edu",{"name":118,"role":123},"PRINCIPAL_INVESTIGATOR",{"lat":125,"lon":126},32.22174,-110.92648,{"facility":128,"status":129,"city":130,"state":131,"zip":132,"country":115,"contacts":133,"geoPoint":139},"Ronald Reagan UCLA Medical Center","NOT_YET_RECRUITING","Los Angeles","California","90024",[134,138],{"name":135,"role":119,"phone":136,"email":137},"Richelle Cooper, MD","424-440-0486","rcooper@mednet.ucla.edu",{"name":135,"role":123},{"lat":140,"lon":141},34.05223,-118.24368,{"facility":143,"status":129,"city":130,"state":131,"zip":144,"country":115,"contacts":145,"geoPoint":151},"Children's Hospital Los Angeles","90027",[146,150],{"name":147,"role":119,"phone":148,"email":149},"Ara Festekjian, MD","323-804-8142","afestekjian@chla.usc.edu",{"name":147,"role":123},{"lat":140,"lon":141},{"facility":153,"status":129,"city":154,"state":131,"zip":155,"country":115,"contacts":156,"geoPoint":162},"Stanford University Medical Center","Palo Alto","94304",[157,161],{"name":158,"role":119,"phone":159,"email":160},"Alexandra June Gordon, MD","650-248-7701","ajgordon@stanford.edu",{"name":158,"role":123},{"lat":163,"lon":164},37.44188,-122.14302,{"facility":166,"status":7,"city":167,"state":131,"zip":168,"country":115,"contacts":169,"geoPoint":175},"UC Davis Medical Center","Sacramento","95817",[170,174],{"name":171,"role":119,"phone":172,"email":173},"Daniel Nishijima, MD","916-734-5010","dnishijima@ucdavis.edu",{"name":171,"role":123},{"lat":176,"lon":177},38.58157,-121.4944,{"facility":179,"status":129,"city":180,"state":131,"zip":181,"country":115,"contacts":182,"geoPoint":188},"San Francisco General Hospital","San Francisco","94143",[183,187],{"name":184,"role":119,"phone":185,"email":186},"Debbie Madhok, MD","415-601-6399","Debbie.madhok@ucsf.edu",{"name":184,"role":123},{"lat":189,"lon":190},37.77493,-122.41942,{"facility":192,"status":129,"city":180,"state":131,"zip":181,"country":115,"contacts":193,"geoPoint":196},"UCSF Medical Center",[194,195],{"name":184,"role":119,"phone":185,"email":186},{"name":184,"role":123},{"lat":189,"lon":190},{"facility":198,"status":7,"city":199,"state":200,"zip":201,"country":115,"contacts":202,"geoPoint":208},"Yale New Haven Hospital","New Haven","Connecticut","06519",[203,207],{"name":204,"role":119,"phone":205,"email":206},"Charles Wira, MD","203-785-5781","charles.wira@yale.edu",{"name":204,"role":123},{"lat":209,"lon":210},41.30815,-72.92816,{"facility":212,"status":129,"city":213,"state":214,"zip":215,"country":115,"contacts":216,"geoPoint":222},"Christiana Hospital","Newark","Delaware","19718",[217,221],{"name":218,"role":119,"phone":219,"email":220},"Jason Nomura, MD","302-733-4113","jnomura@christianacare.org",{"name":218,"role":123},{"lat":223,"lon":224},39.68372,-75.74966,{"facility":226,"status":129,"city":227,"state":214,"zip":228,"country":115,"contacts":229,"geoPoint":235},"Nemours Children's Hospital","Wilmington","19803",[230,234],{"name":231,"role":119,"phone":232,"email":233},"Amy Thompson, MD","302-490-4146","amy.thompson@nemours.org",{"name":231,"role":123},{"lat":236,"lon":237},39.74595,-75.54659,{"facility":239,"status":7,"city":240,"state":241,"zip":242,"country":115,"contacts":243,"geoPoint":249},"Children's National Medical Center","Washington D.C.","District of Columbia","20010",[244,248],{"name":245,"role":119,"phone":246,"email":247},"James Chamberlain, MD","202-476-8877","jchamber@childrensnational.org",{"name":245,"role":123},{"lat":250,"lon":251},38.89511,-77.03637,{"facility":253,"status":129,"city":254,"state":255,"zip":256,"country":115,"contacts":257,"geoPoint":263},"Orlando Regional Medical Center","Orlando","Florida","32806",[258,262],{"name":259,"role":119,"phone":260,"email":261},"Dipali Nemade, MD","321-841-1324","Dipali.Nemade@orlandohealth.com",{"name":259,"role":123},{"lat":264,"lon":265},28.53834,-81.37924,{"facility":267,"status":7,"city":268,"state":269,"zip":270,"country":115,"contacts":271,"geoPoint":277},"Grady Memorial Hospital","Atlanta","Georgia","30303",[272,276],{"name":273,"role":119,"phone":274,"email":275},"Jonathan Ratcliff, MD, MPH","404-778-1762","jonathan.ratcliff@emoryhealthcare.org",{"name":273,"role":123},{"lat":278,"lon":279},33.749,-84.38798,{"facility":281,"status":7,"city":268,"state":269,"zip":282,"country":115,"contacts":283,"geoPoint":289},"Arthur M. Blank Hospital","30329",[284,288],{"name":285,"role":119,"phone":286,"email":287},"Claudia Morris, MD","404-785-7070","claudia.r.morris@emory.edu",{"name":285,"role":123},{"lat":278,"lon":279},{"facility":291,"status":129,"city":292,"state":293,"zip":294,"country":115,"contacts":295,"geoPoint":301},"Northwestern Memorial Hospital","Chicago","Illinois","60611",[296,300],{"name":297,"role":119,"phone":298,"email":299},"Peter Pruitt, MD","312-694-7000","peter.pruitt@nm.org",{"name":297,"role":123},{"lat":302,"lon":303},41.85003,-87.65005,{"facility":305,"status":129,"city":292,"state":293,"zip":306,"country":115,"contacts":307,"geoPoint":313},"Comer Children's Hospital","60637",[308,312],{"name":309,"role":119,"phone":310,"email":311},"David Beiser, MD","773-834-4135","dbeiser@medicine.bsd.uchicago.edu",{"name":309,"role":123},{"lat":302,"lon":303},{"facility":315,"status":129,"city":292,"state":293,"zip":306,"country":115,"contacts":316,"geoPoint":319},"University of Chicago Medical Center",[317,318],{"name":309,"role":119,"phone":310,"email":311},{"name":309,"role":123},{"lat":302,"lon":303},{"facility":321,"status":129,"city":322,"state":323,"zip":324,"country":115,"contacts":325,"geoPoint":331},"IU Health Methodist Hospital","Indianapolis","Indiana","46202",[326,330],{"name":327,"role":119,"phone":328,"email":329},"Daniel Udrea, MD","317-274-0829","dudrea@iu.edu",{"name":327,"role":123},{"lat":332,"lon":333},39.76838,-86.15804,{"facility":335,"status":129,"city":322,"state":323,"zip":324,"country":115,"contacts":336,"geoPoint":342},"Riley Hospital for Children",[337,341],{"name":338,"role":119,"phone":339,"email":340},"Benjamin Nti, MD","317-416-7997","bnti@iu.edu",{"name":338,"role":123},{"lat":332,"lon":333},{"facility":344,"status":129,"city":345,"state":346,"zip":347,"country":115,"contacts":348,"geoPoint":354},"University of Iowa Medical Center","Iowa City","Iowa","52242",[349,353],{"name":350,"role":119,"phone":351,"email":352},"Brett Faine, MD","319-384-5228","brett-faine@uiowa.edu",{"name":350,"role":123},{"lat":355,"lon":356},41.66113,-91.53017,{"facility":358,"status":129,"city":359,"state":360,"zip":361,"country":115,"contacts":362,"geoPoint":368},"University of Maryland Medical Center","Baltimore","Maryland","21201",[363,367],{"name":364,"role":119,"phone":365,"email":366},"Jennifer Hopp, MD","410-328-7635","jhopp@som.umaryland.edu",{"name":364,"role":123},{"lat":369,"lon":370},39.29038,-76.61219,{"facility":372,"status":129,"city":373,"state":374,"zip":375,"country":115,"contacts":376,"geoPoint":382},"Massachusetts General Hospital","Boston","Massachusetts","02114",[377,381],{"name":378,"role":119,"phone":379,"email":380},"Michael Filbin, MD","617-724-4758","mfilbin@mgh.harvard.edu",{"name":378,"role":123},{"lat":383,"lon":384},42.35843,-71.05977,{"facility":386,"status":7,"city":387,"state":388,"zip":389,"country":115,"contacts":390,"geoPoint":396},"University of Michigan University Hospital","Ann Arbor","Michigan","48109",[391,395],{"name":392,"role":119,"phone":393,"email":394},"Mariama Runcie, MD","734-232-2145","runciema@med.umich.edu",{"name":392,"role":123},{"lat":397,"lon":398},42.27756,-83.74088,{"facility":400,"status":129,"city":401,"state":388,"zip":402,"country":115,"contacts":403,"geoPoint":409},"Detroit Receiving Hospital","Detroit","48201",[404,408],{"name":405,"role":119,"phone":406,"email":407},"Wazim Mohamed, MD","313-577-8824","wmohamed@med.wayne.edu",{"name":405,"role":123},{"lat":410,"lon":411},42.33143,-83.04575,{"facility":413,"status":129,"city":401,"state":388,"zip":402,"country":115,"contacts":414,"geoPoint":420},"Sinai-Grace Hospital",[415,419],{"name":416,"role":119,"phone":417,"email":418},"Arun Sherma, MD","313-745-4238","arun@sherma.org",{"name":416,"role":123},{"lat":410,"lon":411},{"facility":422,"status":129,"city":401,"state":388,"zip":423,"country":115,"contacts":424,"geoPoint":430},"Henry Ford Hospital","48202",[425,429],{"name":426,"role":119,"phone":427,"email":428},"Joseph Miller, MD","313-404-9110","jmiller6@hfhs.org",{"name":426,"role":123},{"lat":410,"lon":411},{"facility":432,"status":129,"city":433,"state":434,"zip":435,"country":115,"contacts":436,"geoPoint":442},"University of Minnesota Masonic Children's Hospital","Minneapolis","Minnesota","55414",[437,441],{"name":438,"role":119,"phone":439,"email":440},"James Miner, MD","612-624-7426","miner015@umn.edu",{"name":438,"role":123},{"lat":443,"lon":444},44.97997,-93.26384,{"facility":446,"status":129,"city":433,"state":434,"zip":447,"country":115,"contacts":448,"geoPoint":454},"Hennepin County Medical Center","55415",[449,453],{"name":450,"role":119,"phone":451,"email":452},"Brian Driver, MD","612-873-7448","brian.driver@hcmed.org",{"name":450,"role":123},{"lat":443,"lon":444},{"facility":456,"status":129,"city":433,"state":434,"zip":457,"country":115,"contacts":458,"geoPoint":461},"University of Minnesota Medical Center","55455",[459,460],{"name":438,"role":119,"phone":439,"email":440},{"name":438,"role":123},{"lat":443,"lon":444},{"facility":463,"status":129,"city":464,"state":465,"zip":466,"country":115,"contacts":467,"geoPoint":473},"SUNY Upstate Medical University","Syracuse","New York","13210",[468,472],{"name":469,"role":119,"phone":470,"email":471},"Lindsay Nausin, DO","315-464-4363","nausinl@upstate.edu",{"name":469,"role":123},{"lat":474,"lon":475},43.04812,-76.14742,{"facility":477,"status":129,"city":478,"state":479,"zip":480,"country":115,"contacts":481,"geoPoint":487},"Duke Regional Hospital","Durham","North Carolina","27710",[482,486],{"name":483,"role":119,"phone":484,"email":485},"Alexander Limkakeng, MD","919-681-0908","alexander.limkakeng@duke.edu",{"name":483,"role":123},{"lat":488,"lon":489},35.99403,-78.89862,{"facility":491,"status":129,"city":478,"state":479,"zip":480,"country":115,"contacts":492,"geoPoint":495},"Duke University Hospital",[493,494],{"name":483,"role":119,"phone":484,"email":485},{"name":483,"role":123},{"lat":488,"lon":489},{"facility":497,"status":129,"city":498,"state":499,"zip":500,"country":115,"contacts":501,"geoPoint":507},"University of Cincinnati Medical Center","Cincinnati","Ohio","45267",[502,506],{"name":503,"role":119,"phone":504,"email":505},"Jason McMullan, MD","513-675-3072","jason.mcmullan@uc.edu",{"name":503,"role":123},{"lat":508,"lon":509},39.12711,-84.51439,{"facility":511,"status":7,"city":512,"state":499,"zip":513,"country":115,"contacts":514,"geoPoint":521},"Nationwide Children's Hospital","Columbus","43205",[515,519],{"name":516,"role":119,"phone":517,"email":518},"Aarti Gaglani Aarti Gaglani, MD","6147226910","kesett@nationwidechildrens.org",{"name":520,"role":123},"Aarti Gaglani, MD",{"lat":522,"lon":523},39.96118,-82.99879,{"facility":525,"status":129,"city":512,"state":499,"zip":526,"country":115,"contacts":527,"geoPoint":533},"OSU Wexner Medical Center","43210",[528,532],{"name":529,"role":119,"phone":530,"email":531},"Kirstin Acus, MD","614-293-6185","kirstin.acus@osumc.edu",{"name":529,"role":123},{"lat":522,"lon":523},{"facility":535,"status":7,"city":536,"state":537,"zip":538,"country":115,"contacts":539,"geoPoint":545},"Oregon Health & Science University Hospital","Portland","Oregon","97239",[540,544],{"name":541,"role":119,"phone":542,"email":543},"Bory Kea, MD","503-494-8083","kea@ohsu.edu",{"name":541,"role":123},{"lat":546,"lon":547},45.52345,-122.67621,{"facility":549,"status":129,"city":550,"state":551,"zip":552,"country":115,"contacts":553,"geoPoint":559},"Hospital of the University of Pennsylvania","Philadelphia","Pennsylvania","19104",[554,558],{"name":555,"role":119,"phone":556,"email":557},"John Greenwood, MD","267-252-8741","john.greenwood@pennmedicine.upenn.edu",{"name":555,"role":123},{"lat":560,"lon":561},39.95238,-75.16362,{"facility":563,"status":129,"city":550,"state":551,"zip":552,"country":115,"contacts":564,"geoPoint":567},"Penn Presbyterian Medical Center",[565,566],{"name":555,"role":119,"phone":556,"email":557},{"name":555,"role":123},{"lat":560,"lon":561},{"facility":569,"status":7,"city":550,"state":551,"zip":570,"country":115,"contacts":571,"geoPoint":577},"Temple University Hospital","19140",[572,576],{"name":573,"role":119,"phone":574,"email":575},"Derek Isenberg, MD","215-707-0222","derek.isenberg@tuhs.temple.edu",{"name":573,"role":123},{"lat":560,"lon":561},{"facility":579,"status":129,"city":550,"state":551,"zip":580,"country":115,"contacts":581,"geoPoint":587},"Jefferson Einstein Philadelphia Hospital","19141",[582,586],{"name":583,"role":119,"phone":584,"email":585},"Joseph Herres, DO","215-457-5865","Joseph.herres@jefferson.edu",{"name":583,"role":123},{"lat":560,"lon":561},{"facility":589,"status":129,"city":590,"state":551,"zip":591,"country":115,"contacts":592,"geoPoint":598},"UPMC Presbyterian Hospital","Pittsburgh","15213",[593,597],{"name":594,"role":119,"phone":595,"email":596},"Adam Frisch, MD","412-647-9047","frischan@upmc.edu",{"name":594,"role":123},{"lat":599,"lon":600},40.44062,-79.99589,{"facility":602,"status":7,"city":590,"state":551,"zip":603,"country":115,"contacts":604,"geoPoint":610},"UPMC Children's Hospital of Pittsburgh","15224",[605,609],{"name":606,"role":119,"phone":607,"email":608},"Robert Hickey, MD","412-692-6567","robert.hickey@chp.edu",{"name":606,"role":123},{"lat":599,"lon":600},{"facility":612,"status":7,"city":613,"state":551,"zip":614,"country":115,"contacts":615,"geoPoint":621},"Reading Hospital","West Reading","19611",[616,620],{"name":617,"role":119,"phone":618,"email":619},"Adam Sigal, MD","484-628-7016","adam.sigal@towerhealth.org",{"name":617,"role":123},{"lat":622,"lon":623},40.3337,-75.94743,{"facility":625,"status":129,"city":626,"state":627,"zip":628,"country":115,"contacts":629,"geoPoint":636},"Children's Medical Center Dallas","Dallas","Texas","75235",[630,635],{"name":631,"role":119,"phone":632,"phoneExt":633,"email":634},"Pamela Okada, MD","214-456-7000","67102","pamela.okada@utsouthwestern.edu",{"name":631,"role":123},{"lat":637,"lon":638},32.78306,-96.80667,{"facility":640,"status":7,"city":641,"state":627,"zip":642,"country":115,"contacts":643,"geoPoint":649},"Memorial Hermann Texas Medical Center","Houston","77030",[644,648],{"name":645,"role":119,"phone":646,"email":647},"Kayleigh Fischer, MD","713-500-7803","Kayleigh.A.Fischer@uth.tmc.edu",{"name":645,"role":123},{"lat":650,"lon":651},29.76328,-95.36327,{"facility":653,"status":129,"city":654,"state":655,"zip":656,"country":115,"contacts":657,"geoPoint":663},"Primary Children's Hospital","Salt Lake City","Utah","84108",[658,662],{"name":659,"role":119,"phone":660,"email":661},"Maija Holsti, MD, MPH","801-656-8833","Maija.Holsti@hsc.utah.edu",{"name":659,"role":123},{"lat":664,"lon":665},40.76078,-111.89105,{"facility":667,"status":129,"city":654,"state":655,"zip":668,"country":115,"contacts":669,"geoPoint":675},"University of Utah Healthcare","84112",[670,674],{"name":671,"role":119,"phone":672,"email":673},"Scott Youngquist, MD","801-349-0241","scott.youngquist@utah.edu",{"name":671,"role":123},{"lat":664,"lon":665},{"facility":677,"status":7,"city":678,"state":679,"zip":680,"country":115,"contacts":681,"geoPoint":687},"University of Virginia Medical Center","Charlottesville","Virginia","22908",[682,686],{"name":683,"role":119,"phone":684,"email":685},"Thomas Hartka, MD","434-924-2897","trh6u@uvahealth.org",{"name":683,"role":123},{"lat":688,"lon":689},38.02931,-78.47668,{"facility":691,"status":129,"city":692,"state":679,"zip":693,"country":115,"contacts":694,"geoPoint":700},"VCU Medical Center","Richmond","23298",[695,699],{"name":696,"role":119,"phone":697,"email":698},"Lisa Merck, MD, MPH, MHA","862-383-1688","Lisa.Merck@vcuhealth.org",{"name":696,"role":123},{"lat":701,"lon":702},37.55376,-77.46026,{"facility":704,"status":7,"city":705,"state":706,"zip":707,"country":115,"contacts":708,"geoPoint":714},"Harborview Medical Center","Seattle","Washington","98104",[709,713],{"name":710,"role":119,"phone":711,"email":712},"Vasisht Srinivasan, MD","585-730-3843","vasishts@uw.edu",{"name":710,"role":123},{"lat":715,"lon":716},47.60621,-122.33207,{"facility":718,"status":129,"city":719,"state":720,"zip":721,"country":115,"contacts":722,"geoPoint":728},"Children's Hospital of Wisconsin","Milwaukee","Wisconsin","53226",[723,727],{"name":724,"role":119,"phone":725,"email":726},"Keli Coleman, MD","414-266-2767","kcoleman@mcw.edu",{"name":724,"role":123},{"lat":729,"lon":730},43.0389,-87.90647,{"facility":732,"status":129,"city":719,"state":720,"zip":721,"country":115,"contacts":733,"geoPoint":739},"Froedtert Hospital",[734,738],{"name":735,"role":119,"phone":736,"email":737},"Jamie Jasti, MD","414-805-6493","jjasti@mcw.edu",{"name":735,"role":123},{"lat":729,"lon":730},[741],{"name":742,"role":119,"phone":743,"email":744},"Megan Wardius","434-243-6768","mew5j@virginia.edu",[746],{"name":747,"affiliation":12,"role":123},"Jaideep Kapur, MD, PhD",[],[],{"nct_id":4,"conditions":751,"biomarkers":752},[18],[],{"nct_id":4,"found":14,"summary":754,"prompt_version":764},{"design":755,"status":756,"heading":757,"summary":758,"follow_up":759,"word_count":760,"commitments":761,"compensation":762,"drugs_mentioned":763},"This is a multicenter, randomized, and blinded study, meaning participants are randomly assigned to a treatment group and neither you nor your doctors will know which treatment you are receiving. It aims to enroll up to 770 participants.","completed","Ketamine Add-on Therapy for Status Epilepticus (KESETT)","This study, called KESETT, is testing if adding ketamine to levetiracetam (LEV) can better stop ongoing seizures (status epilepticus) compared to levetiracetam alone. Researchers are comparing two different doses of ketamine (1 mg\u002Fkg or 3 mg\u002Fkg) along with levetiracetam (60 mg\u002Fkg) to just levetiracetam (60 mg\u002Fkg). The main goal is to see if seizures stop within 15 minutes of starting the study medicine and stay stopped for 60 minutes without needing more seizure medication. You might be able to join if you are at least 1 year old, have had a seizure lasting more than 5 minutes, received benzodiazepine medication, and are still having seizures in the emergency department. The study plans to enroll up to 770 participants, but its current recruitment status is unclear.","The primary outcome is measured for 60 minutes after starting the study drug infusion.",125,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]