[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06912841":3,"trial-entities:NCT06912841":84,"trial-summary:NCT06912841":102},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":35,"study_type":41,"primary_purpose":42,"phases":43,"enrollment_info":44,"interventions":47,"primary_outcomes":48,"secondary_outcomes":56,"sex":57,"minimum_age":42,"maximum_age":42,"healthy_volunteers":14,"eligibility_criteria":58,"std_ages":64,"locations":68,"central_contacts":77,"overall_officials":78,"references":79,"see_also_links":80},"NCT06912841","IRB-A00047069","Deep Brain Stimulation (DBS) MatchMaker","ENROLLING_BY_INVITATION","2030-12-01","2026-04","2026-04-13","2024-12-01","Boston Children's Hospital","OTHER",false,"DBS Matchmaker (https:\u002F\u002Fwww.dbsmatchmaker.com) is a platform designed to connect clinicians worldwide who are treating rare movement disorders with deep brain stimulation (DBS). It facilitates global collaboration and knowledge sharing to enhance patient care by improving patient selection, counseling, treatment, and outcomes for individuals with movement disorders.","Deep brain stimulation (DBS) is an effective treatment for childhood-onset dystonia and other hyperkinetic disorders, with emerging evidence supporting its use in an expanding range of monogenic movement disorders. While some conditions, such as TOR1A-related dystonia, are well-established indications for DBS, many rare and ultra-rare movement disorders are also being considered for treatment. However, individual centers often have limited experience with these conditions, leading to mostly anecdotal observations. Furthermore, the published literature is often scarce or not up to date.\n\nTo bridge this gap, DBSMatchMaker (https:\u002F\u002Fwww.dbsmatchmaker.com) was developed both as a tool to assist clinicians in determining the appropriateness of DBS for their patients, and in supporting therapy adjustments for patients who already have an implant. By connecting specialists worldwide, DBSMatchMaker seeks to improve patient selection, counseling, treatment, and outcomes for individuals with rare movement disorders, ultimately enhancing care for this underserved patient population.\n\nBy connecting specialists worldwide, the platform aims to:\n\nImprove patient selection and counseling; Enhance treatment strategies and outcomes for individuals with rare movement disorders; Ultimately, DBSMatchmaker seeks to elevate the standard of care for this underserved patient population.\n\nKey Features:\n\nGlobal Collaboration: Enables clinicians to connect with peers treating similar conditions with DBS, fostering a worldwide network of specialists.\n\nKnowledge Sharing: Facilitates the exchange of experiences and expertise in DBS treatment, promoting collaborative learning.\n\nEnhanced Patient Care: Aims to improve treatment outcomes through shared insights and collective knowledge.\n\nHow It Works:\n\nClinicians can submit information about their cases to DBS Matchmaker. The platform adheres to strict safety and privacy protocols; it does not collect identifiable data, and the database is not searchable by users. Submitted data may be shared with potential collaborators to facilitate connections between medical centers treating similar cases.\n\nDeveloped by the Ebrahimi-Fakhari Laboratory at Boston Children's Hospital, DBS Matchmaker is committed to advancing the care of individuals treated with DBS for rare movement disorders.",[18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34],"TOR1A","PANK2","HPRT1","EIF2AK2","SOX2","KMT2B","GABRB2","ADCY5","UBA5","GNAO1","SGCE","TNPO2","GNB1","PLA2G6","Movement Disorders","Dystonia","Chorea",[36,37,38,39,40],"Deep Brain Stimulation","DBS","movement disorders","dystonia","genetic","OBSERVATIONAL",null,[],{"count":45,"type":46},500,"ESTIMATED",[],[49,53],{"measure":50,"description":51,"timeFrame":52},"Identify Potential Matches","Clinicians can submit their DBS cases through a secure platform (https:\u002F\u002Fwww.dbsmatchmaker.com\u002F), which are then reviewed to identify potential matches with other centers treating similar cases. When a match is found, direct connections between medical teams are facilitated to promote collaboration and knowledge sharing.","5 years",{"measure":54,"description":55,"timeFrame":52},"Connect Clinicians & Facilitate Collaboration","DBS Matchmaker is a platform designed to connect clinicians worldwide who are treating rare movement disorders with deep brain stimulation (DBS). It facilitates global collaboration and knowledge sharing to enhance patient care.",[],"ALL",{"inclusion":59,"exclusion":61,"raw_text":63},[60],"Individuals of all ages with genetic movement disorders, who are undergoing or being considered for DBS treatment.",[62],"Individuals who have not undergone DBS treatment.","Inclusion Criteria:\n\n* Individuals of all ages with genetic movement disorders, who are undergoing or being considered for DBS treatment.\n\nExclusion Criteria:\n\n* Individuals who have not undergone DBS treatment.",[65,66,67],"CHILD","ADULT","OLDER_ADULT",[69],{"facility":12,"city":70,"state":71,"zip":72,"country":73,"geoPoint":74},"Boston","Massachusetts","02115","United States",{"lat":75,"lon":76},42.35843,-71.05977,[],[],[],[81],{"label":82,"url":83},"Related Info","https:\u002F\u002Fwww.dbsmatchmaker.com\u002F",{"nct_id":4,"conditions":85,"biomarkers":87},[34,33,86],"Movement Disorder",[88,89,90,91,92,93,94,95,96,97,98,99,100,101],"85 kDa Calcium-Independent Phospholipase A2","ADCY5 Gene","EIF2AK2 Gene","GAMMA-AMINOBUTYRIC ACID RECEPTOR, BETA-2","GNAO1 Gene","GNB1 Gene","HPRT1 Gene","KMT2B Gene","PANK2 Gene","SGCE Gene","SOX2 Gene","Torsin-1A","TRANSPORTIN 2","UBA5 Gene",{"nct_id":4,"found":14,"summary":42,"prompt_version":42}]