[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06953830":3,"trial-entities:NCT06953830":76,"trial-summary:NCT06953830":80},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":34,"secondary_outcomes":39,"sex":40,"minimum_age":41,"maximum_age":16,"healthy_volunteers":42,"eligibility_criteria":43,"std_ages":55,"locations":58,"central_contacts":68,"overall_officials":69,"references":74,"see_also_links":75},"NCT06953830","1766537-1","Optimal Measurement of Spleen Stiffness Among Veterans With Metabolic Dysfunction-Associated Steatotic Liver Disease","ENROLLING_BY_INVITATION","2026-07","2025-04","2025-05-01","2025-04-08","William Jennings Bryan Dorn VA Medical Center","FED",true,"A growing number of people are being diagnosed with fatty liver disease, also known as metabolic-dysfunction associated liver disease (MASLD). Fatty liver disease can unknowingly progress to serious liver disease and even permanent scarring (cirrhosis).The purpose of this research is to learn the best way to detect serious liver disease as early as possible in patients with fatty liver disease by measuring the stiffness of the spleen. Secondarily, the study hopes to understand how the stiffness of the spleen relates to the severity of liver disease.",null,[18],"Metabolic-dysfunction-associated Fatty Liver Disease (MAFLD)",[],"INTERVENTIONAL","DIAGNOSTIC",[23],"NA",{"count":25,"type":26},100,"ESTIMATED",[28],{"type":29,"name":30,"description":31,"armGroupLabels":32},"DEVICE","Vibration-controlled transient elastography","Liver and spleen stiffness measurements using vibration-controlled transient elastography",[33],"Spleen Stiffness Measurements",[35],{"measure":36,"description":37,"timeFrame":38},"Spleen Stiffness measurement","Percent of participants with valid spleen stiffness measurements using vibration controlled transient elastography","1 year",[],"ALL","18 Years",false,{"inclusion":44,"exclusion":48,"raw_text":54},[45,46,47],"Able to consent for participation in a clinical study","Able to read and comprehend English","Evidence of fatty liver disease on previous liver biopsy, imaging or clinical documentation",[49,50,51,52,53],"Pregnant","Known decompensated cirrhosis or hepatocellular carcinoma","Absence of spleen","Documentation of alcohol use disorder or alcohol use greater than 20g\u002Fday for women or greater than 30 g\u002Fday for men","Unable to provide informed consent","Inclusion Criteria:\n\n* Able to consent for participation in a clinical study\n* Able to read and comprehend English\n* Evidence of fatty liver disease on previous liver biopsy, imaging or clinical documentation\n\nExclusion Criteria:\n\n* Pregnant\n* Known decompensated cirrhosis or hepatocellular carcinoma\n* Absence of spleen\n* Documentation of alcohol use disorder or alcohol use greater than 20g\u002Fday for women or greater than 30 g\u002Fday for men\n* Unable to provide informed consent",[56,57],"ADULT","OLDER_ADULT",[59],{"facility":60,"city":61,"state":62,"zip":63,"country":64,"geoPoint":65},"WJB Dorn VA Medical Center 6439 Garners Ferry Road Columbia, South Carolina 29209","Columbia","South Carolina","29209","United States",{"lat":66,"lon":67},34.00071,-81.03481,[],[70],{"name":71,"affiliation":72,"role":73},"Nicholas Hoppmann, MD","Columbia VA Healthcare System","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":77,"biomarkers":79},[78],"Nonalcoholic Fatty Liver Disease",[],{"nct_id":4,"found":42,"summary":16,"prompt_version":16}]