[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06960083":3,"trial-entities:NCT06960083":121,"trial-summary:NCT06960083":124},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":39,"secondary_outcomes":44,"sex":63,"minimum_age":64,"maximum_age":65,"healthy_volunteers":15,"eligibility_criteria":66,"std_ages":86,"locations":88,"central_contacts":108,"overall_officials":117,"references":119,"see_also_links":120},"NCT06960083","STUDY-24-00527","Transcranial Magnetic Stimulation in Misophonia","A Transcranial Magnetic Stimulation Approach to Treat Misophonia","RECRUITING","2026-12-31","2026-07","2026-07-21","2025-09-02","Icahn School of Medicine at Mount Sinai","OTHER",false,"The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.",null,[19],"Misophonia",[19,21,22,23,24],"Transcranial Magnetic Stimulation","Crossover trial","Single session","EEG","INTERVENTIONAL","TREATMENT",[28],"NA",{"count":30,"type":31},60,"ESTIMATED",[33],{"type":14,"name":34,"description":35,"armGroupLabels":36},"Transcranial Magnetic Stimulation (TMS)","Transcranial Magnetic Stimulation (TMS) is an FDA-approved non-invasive brain stimulation technology. It is currently used for treating depression. Applications to other disorders such as OCD and anxiety using TMS are currently under investigation. TMS will be administered for 25 minutes.",[37,38],"Excitatory-Inhibitory (EI) then Inhibitory-Excitatory (IE)","Inhibitory-Excitatory (IE) then Excitatory-Inhibitory (EI)",[40],{"measure":41,"description":42,"timeFrame":43},"Unpleasantness Rating Scale","Participants will be presented with a slider with extremes labelled as extremely unpleasant and extremely pleasant. Ratings will be provided for audio clips and visual cues. Full scale from 0-100, higher score indicates more unpleasantness","after each session, 72 hours apart (each session is 2 hours)",[45,48,51,54,57,60],{"measure":46,"description":47,"timeFrame":43},"Heart Rate","The heart rate (number of beats per minute) will be measured using a wristwatch worn by the participant.",{"measure":49,"description":50,"timeFrame":43},"Skin Conductance Response","Skin conductance, a measure capturing the amount of sweat, will be measured using a wristwatch worn by the participant.",{"measure":52,"description":53,"timeFrame":43},"EEG P1-N1-P2 Complex Peak Amplitude","Amplitude (microvolts) of P1, N1, and P2 peaks measured in the parietal region",{"measure":55,"description":56,"timeFrame":43},"EEG P1-N1-P2 Complex Peak Latency","Latency (milliseconds) of P1, N1, and P2 peaks measured in the parietal region",{"measure":58,"description":59,"timeFrame":43},"EEG Frequency Band Amplitude","Amplitude (decibel) in theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) frequency bands in the parietal region",{"measure":61,"description":62,"timeFrame":43},"EEG Frequency Band Inter-Trial Coherence","Coherence (unitless) across trials in theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) frequency bands in the parietal region","ALL","18 Years","55 Years",{"inclusion":67,"exclusion":71,"raw_text":85},[68,69,70],"Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger\u002Foutbursts, or fear.","Must be between the ages of 18 - 55.","Must be fluent in English since the study's instructions, surveys, and tasks will be in English.",[72,73,74,75,76,77,78,79,80,81,82,83,84],"Epilepsy or previous episode of convulsion or seizure.","Previous episode of fainting spell or syncope.","Head trauma.","Hearing problems.","Cochlear implant.","Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).","Implanted neurostimulator (e.g., DBS, epidural\u002Fsubdural, VNS).","Presence of cardiac pacemaker or intracardiac lines.","Presence of medication infusion device.","Use of pro-convulsant or epileptogenic medications.","Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.","Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.","Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.","Inclusion Criteria:\n\n* Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger\u002Foutbursts, or fear.\n* Must be between the ages of 18 - 55.\n* Must be fluent in English since the study's instructions, surveys, and tasks will be in English.\n\nExclusion Criteria:\n\n* Epilepsy or previous episode of convulsion or seizure.\n* Previous episode of fainting spell or syncope.\n* Head trauma.\n* Hearing problems.\n* Cochlear implant.\n* Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).\n* Implanted neurostimulator (e.g., DBS, epidural\u002Fsubdural, VNS).\n* Presence of cardiac pacemaker or intracardiac lines.\n* Presence of medication infusion device.\n* Use of pro-convulsant or epileptogenic medications.\n* Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.\n* Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.\n* Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.",[87],"ADULT",[89],{"facility":90,"status":8,"city":91,"state":91,"zip":92,"country":93,"contacts":94,"geoPoint":105},"Mount Sinai West","New York","10022","United States",[95,99,102],{"name":96,"role":97,"email":98},"Daniela Schiller, PhD","CONTACT","daniela.schiller@mssm.edu",{"name":100,"role":97,"email":101},"Martijn Figee, MD, PhD","martijn.figee@mssm.edu",{"name":103,"role":104},"Parul Jain","PRINCIPAL_INVESTIGATOR",{"lat":106,"lon":107},40.71427,-74.00597,[109,113],{"name":110,"role":97,"phone":111,"email":112},"Shama Patel","347-670-4878","shama.patel@mssm.edu",{"name":114,"role":97,"phone":115,"email":116},"Parul Jain, PhD","212-824-8992","parul.jain@mssm.edu",[118],{"name":114,"affiliation":13,"role":104},[],[],{"nct_id":4,"conditions":122,"biomarkers":123},[19],[],{"nct_id":4,"found":125,"summary":126,"prompt_version":136},true,{"design":127,"status":128,"heading":129,"summary":130,"follow_up":131,"word_count":132,"commitments":133,"compensation":134,"drugs_mentioned":135},"This study plans to enroll 60 participants. You will receive two types of Transcranial Magnetic Stimulation (TMS) sessions: one inhibitory and one excitatory.","completed","Transcranial Magnetic Stimulation for Misophonia","This study is testing if Transcranial Magnetic Stimulation (TMS), a non-invasive brain stimulation technology, can help people with misophonia. TMS is already approved for depression and is being studied for other conditions like OCD and anxiety. You might be able to join if you are 18-55 years old, fluent in English, and experience irritation, anger, or fear due to specific sounds. The study aims to see if TMS can improve your tolerance to these sounds. Researchers will measure your unpleasantness ratings after each TMS session to see if the treatment is successful. The current recruitment status is unclear.","Your unpleasantness rating will be measured after each session, which are 72 hours apart.",98,"You will undergo two Transcranial Magnetic Stimulation (TMS) sessions, each lasting 25 minutes. Each session is 2 hours long, and they are 72 hours apart. You will also complete computerized tasks and have your brain activity (EEG), heart rate, and skin temperature recorded.","Not stated in the trial record.",[34],"v2"]