[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06962995":3,"trial-entities:NCT06962995":130,"trial-summary:NCT06962995":134},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":16,"phases":21,"enrollment_info":22,"interventions":25,"primary_outcomes":41,"secondary_outcomes":57,"sex":58,"minimum_age":59,"maximum_age":16,"healthy_volunteers":60,"eligibility_criteria":61,"std_ages":75,"locations":78,"central_contacts":121,"overall_officials":123,"references":125,"see_also_links":126},"NCT06962995","24-000321","Multi-Cancer Detection Observational Cohort Study","RECRUITING","2029-06-30","2026-03","2026-04-06","2025-05-07","Mayo Clinic","OTHER",false,"This study assesses the incorporation of Multi-Cancer Detection (MCD) testing, designed to detect many types of cancer, into clinical practice to understand both its use and effect in real world practice conditions.",null,[18],"Cancer",[],"OBSERVATIONAL",[],{"count":23,"type":24},500,"ESTIMATED",[26,37],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":32},"PROCEDURE","Blood Sample","Up to 60 mL (about 4-5 Tbsp) of blood may be collected for an initial blood draw and up to 30 mL (about 2-3 Tbsp) may be collected for a second blood draw, 25-45 days after first blood draw. The research blood will be collected at the time of a clinical blood draw, if possible.",[31],"Observational",[33,34,35,36],"Biological Sample Collection","Biospecimen Collection","Specimen Collection","Blood Sample Collection",{"type":13,"name":38,"description":39,"armGroupLabels":40},"Surveys","Participants will complete surveys related to attitudes and beliefs around Multi-Cancer Detection testing.",[31],[42,46,49,53],{"measure":43,"description":44,"timeFrame":45},"Financial impact of MCD testing","Assessed by types of diagnostic studies ordered as a result of positive MCD test results (e.g., to establish or rule out a cancer diagnosis).","Up to 5 years",{"measure":47,"description":48,"timeFrame":45},"Positive actionable MCD results","Assessed by the number of participants who receive positive MCD results",{"measure":50,"description":51,"timeFrame":52},"Psychological Impact of MCD Testing","Assessed with the Multidimensional Impact of Cancer Risk Assessment (Adapted MICRA), which asks participants to evaluate their response to MCD test results over the past week. The MICRA consists of 20 items answered on a 4-point scale (Never, Rarely, Sometimes, Often). Higher scores generally indicate higher levels of distress or psychological impact.","Baseline (after receiving MCD results)",{"measure":54,"description":55,"timeFrame":56},"Change in Patient Satisfaction with MCD Test","Participants will complete a 3-question survey, \"Satisfaction with the Multi-Cancer Detection Test.\" Items are answered on a 5-point scale (not at all, a little, somewhat, very, extremely).","Baseline; After receiving MCD results (up to 5 years)",[],"ALL","21 Years",true,{"inclusion":62,"exclusion":68,"raw_text":74},[63,64,65,66,67],"Has Mayo Clinic medical record number","Has undergone (within last 6 months) or scheduled to undergo a multi-cancer detection test (MCD) as ordered by provider","Able to provide informed consent","≥ 21 years old","Ability to provide blood sample",[69,70,71,72,73],"Individuals who have situations that would limit compliance with the study requirements","Institutionalized (i.e. Federal Medical Prison)","Known pregnancy (self-reported)","Currently undergoing active cancer treatment other than adjuvant hormone therapy","Invasive cancer diagnosis within the last 3 years","Inclusion Criteria:\n\n* Has Mayo Clinic medical record number\n* Has undergone (within last 6 months) or scheduled to undergo a multi-cancer detection test (MCD) as ordered by provider\n* Able to provide informed consent\n* ≥ 21 years old\n* Ability to provide blood sample\n\nExclusion Criteria:\n\n* Individuals who have situations that would limit compliance with the study requirements\n* Institutionalized (i.e. Federal Medical Prison)\n* Known pregnancy (self-reported)\n* Currently undergoing active cancer treatment other than adjuvant hormone therapy\n* Invasive cancer diagnosis within the last 3 years",[76,77],"ADULT","OLDER_ADULT",[79,97,109],{"facility":80,"status":7,"city":81,"state":82,"zip":83,"country":84,"contacts":85,"geoPoint":94},"Mayo Clinic in Arizona","Scottsdale","Arizona","85259","United States",[86,91],{"name":87,"role":88,"phone":89,"email":90},"Clinical Trials Referral Office","CONTACT","855-776-0015","mayocliniccancerstudies@mayo.edu",{"name":92,"role":93},"Jewel Samadder, MD","PRINCIPAL_INVESTIGATOR",{"lat":95,"lon":96},33.50921,-111.89903,{"facility":98,"status":7,"city":99,"state":100,"zip":101,"country":84,"contacts":102,"geoPoint":106},"Mayo Clinic in Florida","Jacksonville","Florida","32224-9980",[103,104],{"name":87,"role":88,"phone":89,"email":90},{"name":105,"role":93},"R. John Presutti, DO",{"lat":107,"lon":108},30.33218,-81.65565,{"facility":110,"status":7,"city":111,"state":112,"zip":113,"country":84,"contacts":114,"geoPoint":118},"Mayo Clinic in Rochester","Rochester","Minnesota","55905",[115,116],{"name":87,"role":88,"phone":89,"email":90},{"name":117,"role":93},"Ryan Hurt, MD, PhD",{"lat":119,"lon":120},44.02163,-92.4699,[122],{"name":87,"role":88,"phone":89,"email":90},[124],{"name":92,"affiliation":12,"role":93},[],[127],{"label":128,"url":129},"Mayo Clinic Clinical Trials","https:\u002F\u002Fwww.mayo.edu\u002Fresearch\u002Fclinical-trials",{"nct_id":4,"conditions":131,"biomarkers":133},[132],"Malignant Neoplasm",[],{"nct_id":4,"found":60,"summary":135,"prompt_version":145},{"design":136,"status":137,"heading":138,"summary":139,"follow_up":140,"word_count":141,"commitments":142,"compensation":143,"drugs_mentioned":144},"This is an observational study, meaning researchers will watch and collect information without giving any specific treatment. The study plans to enroll 500 participants.","completed","Multi-Cancer Detection Observational Study","This study is looking at how Multi-Cancer Detection (MCD) tests, which are designed to find many types of cancer, are being used in real-world medical care. We want to understand both how these tests are used and what their effects are. You may be able to join if you have a Mayo Clinic medical record number, are at least 21 years old, and have recently had or are scheduled to have an MCD test ordered by your doctor. We will be collecting blood samples and asking you to complete surveys about your attitudes and beliefs regarding MCD testing. The study will look at the financial and psychological impact of MCD testing, and how often positive results lead to further action, over a period of up to 5 years.","Participants will be followed for up to 5 years to assess the financial impact, positive actionable MCD results, and psychological impact of MCD testing.",128,"You will provide up to two blood samples, one initially and another 25-45 days later. You will also complete surveys about your attitudes and beliefs regarding MCD testing.","Not stated in the trial record.",[28,38],"v2"]