[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT06977581":3,"trial-entities:NCT06977581":1038,"trial-summary:NCT06977581":1041},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":29,"primary_purpose":30,"phases":31,"enrollment_info":33,"interventions":36,"primary_outcomes":50,"secondary_outcomes":68,"sex":101,"minimum_age":102,"maximum_age":103,"healthy_volunteers":104,"eligibility_criteria":105,"std_ages":112,"locations":115,"central_contacts":1024,"overall_officials":1030,"references":1033,"see_also_links":1034},"NCT06977581","C4531029","A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma","A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-group, Dose-Ranging Study to Investigate the Efficacy and Safety of PF-07275315 in Adult Participants With Inadequately Controlled Moderate-to-Severe Asthma","RECRUITING","2027-05-31","2026-04","2026-05-04","2025-05-20","Pfizer","INDUSTRY",true,"The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected.\n\nThis study is seeking participants who:\n\n* Are 18 to 70 years old\n* Have had moderate-to-severe asthma for at least 12 months that is not well controlled\n* Have been taking their regular maintenance treatment(s) for asthma over the last 12 months\n\nAll participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied.\n\nPF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective.\n\nParticipants will be involved in this study for about 7.5 months. During this time, they will have 9 visits at the study clinic.",null,[19],"Asthma",[21,22,23,24,25,26,27,28,19],"Pulmonary","Wheezing","Respiratory hypersensitivity","Airway Inflammation","Airway Obstruction","Dyspnea","Lung Diseases","Respiratory Tract Diseases","INTERVENTIONAL","TREATMENT",[32],"PHASE2",{"count":34,"type":35},252,"ESTIMATED",[37,45],{"type":38,"name":39,"description":40,"armGroupLabels":41},"DRUG","PF-07275315","subcutaneous injection",[42,43,44],"Treatment Arm A","Treatment Arm B","Treatment Arm C",{"type":46,"name":47,"description":40,"armGroupLabels":48},"OTHER","Placebo",[49],"Treatment Arm D",[51,55,59,62,65],{"measure":52,"description":53,"timeFrame":54},"Change from baseline in pre-bronchodilator Forced Expiratory Volume in 1 Second (FEV1) at Week 12","FEV1 is the maximal volume of air exhaled in the first second of a forced expiration from a position of full inspiration. FEV1 is obtained from spirometry.","Week 12",{"measure":56,"description":57,"timeFrame":58},"Treatment-Emergent Adverse Events (AEs), Serious AEs (SAEs), and AEs\u002FSAEs leading to treatment discontinuation","Incidence of treatment-emergent AEs, treatment-emergent SAEs, and treatment-emergent AEs\u002FSAEs leading to treatment discontinuation","Baseline through Week 24",{"measure":60,"description":61,"timeFrame":58},"Clinically significant, treatment-related laboratory abnormalities","Incidence of clinically significant changes in laboratory tests",{"measure":63,"description":64,"timeFrame":58},"Clinically significant, treatment-related abnormalities in vital signs","Incidence of clinically significant changes in vital signs",{"measure":66,"description":67,"timeFrame":58},"Clinically significant, treatment-related electrocardiogram (ECG) abnormalities","Incidence of clinically significant changes in ECG",[69,71,73,75,77,79,81,83,85,87,89,91,93,95,97,99],{"measure":70,"timeFrame":54},"Change from baseline in pre-bronchodilator Percent (%) Predicted FEV1 at Week 12",{"measure":72,"timeFrame":58},"Change from baseline in pre-bronchodilator FEV1 at all time points",{"measure":74,"timeFrame":58},"Change from baseline in pre-bronchodilator % Predicted FEV1 at all time points",{"measure":76,"timeFrame":58},"Change from baseline in pre-bronchodilator Forced Vital Capacity (FVC) at all time points",{"measure":78,"timeFrame":58},"Change from baseline in pre-bronchodilator % Predicted FVC at all time points",{"measure":80,"timeFrame":58},"Change from baseline in pre-bronchodilator FEV1\u002FFVC Ratio at all time points",{"measure":82,"timeFrame":58},"Change from baseline in post-bronchodilator FEV1 at all time points",{"measure":84,"timeFrame":58},"Change from baseline in post-bronchodilator % Predicted FEV1 at all time points",{"measure":86,"timeFrame":58},"Change from baseline in post-bronchodilator FVC at all time points",{"measure":88,"timeFrame":58},"Change from baseline in post-bronchodilator % Predicted FVC at all time points",{"measure":90,"timeFrame":58},"Change from baseline in post-bronchodilator FEV1\u002FFVC Ratio at all time points",{"measure":92,"timeFrame":58},"Percentage change from baseline in pre-bronchodilator FEV1 at all time points",{"measure":94,"timeFrame":54},"Change from baseline in pre-bronchodilator FEV1 at Week 12",{"measure":96,"timeFrame":54},"Change from baseline in Asthma Control Questionnaire-5 (ACQ-5) total score at Week 12",{"measure":98,"timeFrame":54},"Change from baseline in Asthma Quality of Life Questionnaire (AQLQ) global score at Week 12",{"measure":100,"timeFrame":54},"Change from baseline in pre-bronchodilator FEV1 at Week 12 in participants with Fractional Concentration of Exhaled Nitric Oxide (FeNO) ≥25 ppb and \u003C25 ppb","ALL","18 Years","70 Years",false,{"inclusion":106,"exclusion":107,"raw_text":111},[],[108,109,110],"Active helminth or parasitic infection requiring treatment within 2 weeks prior to screening;","Infection requiring hospitalization or systemic (parenteral) antimicrobial therapy within 60 days prior to Day 1;","Any infection judged to be an opportunistic infection or clinically significant by the investigator, within 6 months prior to Day 1.","Inclusion Criteria:\n\nMust meet the following asthma criteria:\n\n1. History of persistent, moderate-to-severe asthma for at least 12 months prior to screening.\n2. Must have experienced at least 1 asthma exacerbation requiring treatment with systemic steroids (oral or parenteral) for 3 days or more within 12 months of the screening visit.\n3. At least 2 of the 3 pre-bronchodilator FEV1 values collected in the run-in period and the mean of the of pre-bronchodilator FEV1 values collected in the run-in period are ≥30% to \\\u003C80% of predicted normal values.\n4. Positive bronchodilator responsiveness as evidenced by increase in FEV1 of at least 12% and 200 mL for spirometry conducted during screening period.\n5. Maintenance (controller) treatment that minimally includes a medium to high dose ICS - LABA combination consistent with GINA Step 4\u002F5 (either Track 1 or Track 2) for 12 months prior to the screening visit and at a stable dose for at least 3 months prior to the screening visit.\n6. ACQ-5 score of ≥1.5 at screening visit and prior to randomization.\n\n   Other Inclusion Criteria:\n7. Body mass index between 18 40 kg\u002Fm2 at screening.\n\nExclusion Criteria:\n\nMedical Conditions:\n\n1. Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation\u002Fbehavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.\n2. Evidence of lung disease(s) other than asthma, either clinical evidence, spirometry, or imaging (Chest X-ray, CT, MRI) within 12 months of the screening visit, as per local standard of care, including but not limited to: Chronic obstructive pulmonary disease, Other emphysematous lung disease such as alpha-1 antitrypsin disease, Cystic fibrosis, Emphysema, Idiopathic pulmonary fibrosis, Churg-Strauss syndrome, Allergic bronchopulmonary aspergillosis, Sarcoidosis\n3. Diagnosed with any of the following acute or chronic infections or infection history:\n\n   * Active helminth or parasitic infection requiring treatment within 2 weeks prior to screening;\n   * Infection requiring hospitalization or systemic (parenteral) antimicrobial therapy within 60 days prior to Day 1;\n   * Any infection judged to be an opportunistic infection or clinically significant by the investigator, within 6 months prior to Day 1.\n\n   Prior\u002FConcomitant Therapy:\n4. Prior or current use of any prohibited concomitant medication(s) or unwillingness or inability to use a required concomitant medication(s).\n5. Prior or concurrent treatment with either approved or experimental biologic treatment (such as inhibitors of IL-4, IL-13, IL-33\u002FST2, IL-4Rα, TSLP, IL-5, OX40\u002FOX40L or IgE) or targeted synthetic drugs (such as JAK inhibitors) for the treatment of asthma or other type 2 inflammatory diseases, including but not limited to: AD, EoE, CRS.\n6. Treatment with any dose level of systemic (oral, injectable, or intraarticular) corticosteroids within 28 days of the screening visit.\n7. Prior (within 12 weeks prior to screening) or planned concomitant treatment with immunoglobulin supplementation (eg, IV Ig or SC Ig).\n8. History of anaphylaxis to antibody therapeutic or to PF-07275315 or to the excipients of the formulated drug products.\n9. Bronchial thermoplasty within the previous 24 months.\n\n   Prior\u002FConcurrent Clinical Study Experience:\n10. Administration of an investigational drug product within 30 days or 5 half lives preceding the screening visit (whichever is longer). Participation in studies of other investigational products (drug or vaccine) at any time during participation in this study.",[113,114],"ADULT","OLDER_ADULT",[116,125,133,141,148,155,162,169,177,186,194,197,201,209,217,220,228,236,244,251,259,266,273,281,289,296,303,311,319,327,335,342,349,356,360,368,376,382,389,397,403,410,413,422,430,436,445,452,456,463,472,476,484,492,499,503,508,515,522,526,534,542,550,558,562,565,573,581,584,591,600,605,612,619,628,636,644,652,659,668,676,684,692,700,707,713,721,729,736,744,751,756,763,770,776,785,789,797,804,812,820,828,837,840,844,853,861,869,873,877,881,885,889,893,897,906,914,921,928,932,938,946,953,960,967,974,983,987,995,1003,1010,1017],{"facility":117,"status":8,"city":118,"state":119,"zip":120,"country":121,"geoPoint":122},"Velocity Clinical Research, Mobile","Mobile","Alabama","36608","United States",{"lat":123,"lon":124},30.69436,-88.04305,{"facility":126,"status":8,"city":127,"state":128,"zip":129,"country":121,"geoPoint":130},"Chandler Clinical Trials","Chandler","Arizona","85224",{"lat":131,"lon":132},33.30616,-111.84125,{"facility":134,"status":8,"city":135,"state":136,"zip":137,"country":121,"geoPoint":138},"Antelope Valley Clinical Trials","Lancaster","California","93534",{"lat":139,"lon":140},34.69804,-118.13674,{"facility":142,"status":8,"city":143,"state":136,"zip":144,"country":121,"geoPoint":145},"NewportNativeMD, Inc.","Newport Beach","92663",{"lat":146,"lon":147},33.61891,-117.92895,{"facility":149,"status":8,"city":150,"state":136,"zip":151,"country":121,"geoPoint":152},"California Medical Research Associates","Northridge","91324",{"lat":153,"lon":154},34.22834,-118.53675,{"facility":156,"status":8,"city":157,"state":136,"zip":158,"country":121,"geoPoint":159},"Allergy and Asthma Associates of Santa Clara Valley Research Center","San Jose","95117",{"lat":160,"lon":161},37.33939,-121.89496,{"facility":163,"status":8,"city":164,"state":136,"zip":165,"country":121,"geoPoint":166},"Allergy & Asthma Clinical Research","Walnut Creek","94598",{"lat":167,"lon":168},37.90631,-122.06496,{"facility":170,"status":8,"city":171,"state":172,"zip":173,"country":121,"geoPoint":174},"Colorado ENT & Allergy","Colorado Springs","Colorado","80923",{"lat":175,"lon":176},38.83388,-104.82136,{"facility":178,"status":179,"city":180,"state":181,"zip":182,"country":121,"geoPoint":183},"Cpcc-Research Llc","NOT_YET_RECRUITING","East Point","Georgia","30344",{"lat":184,"lon":185},33.67955,-84.43937,{"facility":187,"status":8,"city":188,"state":189,"zip":190,"country":121,"geoPoint":191},"Christie Clinic - University","Champaign","Illinois","61820",{"lat":192,"lon":193},40.11642,-88.24338,{"facility":195,"status":8,"city":188,"state":189,"zip":190,"country":121,"geoPoint":196},"Innovo Research - Christie Clinic",{"lat":192,"lon":193},{"facility":198,"status":8,"city":188,"state":189,"zip":199,"country":121,"geoPoint":200},"Christie Clinic - Windsor","61822",{"lat":192,"lon":193},{"facility":202,"status":8,"city":203,"state":204,"zip":205,"country":121,"geoPoint":206},"University of Kansas Medical Center","Kansas City","Kansas","66160",{"lat":207,"lon":208},39.11417,-94.62746,{"facility":210,"status":8,"city":211,"state":212,"zip":213,"country":121,"geoPoint":214},"North Ingalls Building","Ann Arbor","Michigan","48109",{"lat":215,"lon":216},42.27756,-83.74088,{"facility":218,"status":8,"city":211,"state":212,"zip":213,"country":121,"geoPoint":219},"University of Michigan",{"lat":215,"lon":216},{"facility":221,"status":8,"city":222,"state":223,"zip":224,"country":121,"geoPoint":225},"Washington University School of Medicine","St Louis","Missouri","63110",{"lat":226,"lon":227},38.62727,-90.19789,{"facility":229,"status":8,"city":230,"state":231,"zip":232,"country":121,"geoPoint":233},"Henderson Clinical Trials","Henderson","Nevada","89052",{"lat":234,"lon":235},36.0397,-114.98194,{"facility":237,"status":8,"city":238,"state":239,"zip":240,"country":121,"geoPoint":241},"Rutgers, Robert Wood Johnson Medical School","New Brunswick","New Jersey","08901",{"lat":242,"lon":243},40.48622,-74.45182,{"facility":245,"status":8,"city":246,"state":239,"zip":247,"country":121,"geoPoint":248},"Circuit Clinical \u002F Impact Medical Allergy, Asthma & Immunology","Riverdale","07457",{"lat":249,"lon":250},40.99399,-74.30348,{"facility":252,"status":8,"city":253,"state":254,"zip":255,"country":121,"geoPoint":256},"American Health Research","Charlotte","North Carolina","28277",{"lat":257,"lon":258},35.22709,-80.84313,{"facility":260,"status":179,"city":261,"state":254,"zip":262,"country":121,"geoPoint":263},"Clinical Research Of Gastonia","Gastonia","28054",{"lat":264,"lon":265},35.26208,-81.1873,{"facility":267,"status":8,"city":268,"state":254,"zip":269,"country":121,"geoPoint":270},"Stern Research Partners, LLC","Huntersville","28078",{"lat":271,"lon":272},35.41069,-80.84285,{"facility":274,"status":8,"city":275,"state":276,"zip":277,"country":121,"geoPoint":278},"Toledo Institute of Clinical Research Inc.","Toledo","Ohio","43617",{"lat":279,"lon":280},41.66394,-83.55521,{"facility":282,"status":8,"city":283,"state":284,"zip":285,"country":121,"geoPoint":286},"OK Clinical Research","Edmond","Oklahoma","73034",{"lat":287,"lon":288},35.65283,-97.4781,{"facility":290,"status":179,"city":291,"state":284,"zip":292,"country":121,"geoPoint":293},"Allergy, Asthma and Clinical Research","Oklahoma City","73120",{"lat":294,"lon":295},35.46756,-97.51643,{"facility":297,"status":8,"city":298,"state":284,"zip":299,"country":121,"geoPoint":300},"Layrek Clinical Research","Tulsa","74133",{"lat":301,"lon":302},36.15398,-95.99277,{"facility":304,"status":8,"city":305,"state":306,"zip":307,"country":121,"geoPoint":308},"Clinical Research Associates of Central PA, LLC","DuBois","Pennsylvania","15801",{"lat":309,"lon":310},41.11923,-78.76003,{"facility":312,"status":8,"city":313,"state":314,"zip":315,"country":121,"geoPoint":316},"Clinical Research of Rock Hill","Rock Hill","South Carolina","29732",{"lat":317,"lon":318},34.92487,-81.02508,{"facility":320,"status":8,"city":321,"state":322,"zip":323,"country":121,"geoPoint":324},"Premier Research Center, LLC","Hendersonville","Tennessee","37075",{"lat":325,"lon":326},36.30477,-86.62,{"facility":328,"status":8,"city":329,"state":330,"zip":331,"country":121,"geoPoint":332},"South Texas Medical Research Institute, Inc., DBA TTS Research","Boerne","Texas","78006",{"lat":333,"lon":334},29.79466,-98.73197,{"facility":336,"status":8,"city":337,"state":330,"zip":338,"country":121,"geoPoint":339},"Horizon Clinical Research Group","Cypress","77429",{"lat":340,"lon":341},29.96911,-95.69717,{"facility":343,"status":8,"city":344,"state":330,"zip":345,"country":121,"geoPoint":346},"Alina Clinical Trials, LLC.","Dallas","75209",{"lat":347,"lon":348},32.78306,-96.80667,{"facility":350,"status":8,"city":351,"state":330,"zip":352,"country":121,"geoPoint":353},"Greater Heights & Memorial Pulmonary and Sleep","Houston","77008",{"lat":354,"lon":355},29.76328,-95.36327,{"facility":357,"status":8,"city":351,"state":330,"zip":358,"country":121,"geoPoint":359},"Houston Pulmonary Sleep and Allergy Associates","77065",{"lat":354,"lon":355},{"facility":361,"status":362,"city":363,"state":330,"zip":364,"country":121,"geoPoint":365},"Metroplex Pulmonary and Sleep Center","ACTIVE_NOT_RECRUITING","McKinney","75069",{"lat":366,"lon":367},33.19762,-96.61527,{"facility":369,"status":8,"city":370,"state":371,"zip":372,"country":121,"geoPoint":373},"Clinical Research Partners, LLC","Richmond","Virginia","23226",{"lat":374,"lon":375},37.55376,-77.46026,{"facility":377,"status":8,"city":378,"state":379,"zip":380,"country":381},"Fundación Respirar","Ciudad Autónoma de Buenos Aires","Buenos Aires","C1426ABP","Argentina",{"facility":383,"status":8,"city":384,"state":379,"zip":385,"country":381,"geoPoint":386},"Instituto Ave Pulmo","Mar del Plata","7600",{"lat":387,"lon":388},-38.00042,-57.5562,{"facility":390,"status":8,"city":391,"state":392,"zip":393,"country":381,"geoPoint":394},"Investigaciones en Patologias Respiratorias","San Miguel de Tucumán","Tucumán Province","4000",{"lat":395,"lon":396},-26.81601,-65.21051,{"facility":398,"status":8,"city":379,"zip":399,"country":381,"geoPoint":400},"Centro de Investigaciones Metabólicas (CINME)","C1056ABI",{"lat":401,"lon":402},-34.61315,-58.37723,{"facility":404,"status":8,"city":405,"zip":406,"country":381,"geoPoint":407},"Fundacion Scherbovsky","Mendoza","5500",{"lat":408,"lon":409},-32.88946,-68.84582,{"facility":411,"status":8,"city":405,"zip":406,"country":381,"geoPoint":412},"Instituto de Salud Respiratoria",{"lat":408,"lon":409},{"facility":414,"status":8,"city":415,"state":416,"zip":417,"country":418,"geoPoint":419},"AZ Sint-Maarten","Mechelen","Antwerpen","2800","Belgium",{"lat":420,"lon":421},51.02574,4.47762,{"facility":423,"status":8,"city":424,"state":425,"zip":426,"country":418,"geoPoint":427},"UZ Gent","Ghent","Oost-vlaanderen","9000",{"lat":428,"lon":429},51.05,3.71667,{"facility":431,"status":8,"city":432,"zip":393,"country":418,"geoPoint":433},"Centre Hospitalier Régional de la Citadelle","Liège",{"lat":434,"lon":435},50.63373,5.56749,{"facility":437,"status":8,"city":438,"state":439,"zip":440,"country":441,"geoPoint":442},"Diagnostic Consultative Center Aleksandrovska","Sofia","Sofia (stolitsa)","1431","Bulgaria",{"lat":443,"lon":444},42.69751,23.32415,{"facility":446,"status":8,"city":447,"zip":448,"country":441,"geoPoint":449},"Medical Center Pulmo - 2018 EOOD","Haskovo","6300",{"lat":450,"lon":451},41.93415,25.55557,{"facility":453,"status":8,"city":438,"zip":454,"country":441,"geoPoint":455},"Medical Center Pulmovision","1756",{"lat":443,"lon":444},{"facility":457,"status":8,"city":458,"zip":459,"country":441,"geoPoint":460},"Medical Center New Rehabilitation Center EOOD","Stara Zagora","6001",{"lat":461,"lon":462},42.43205,25.64262,{"facility":464,"status":8,"city":465,"state":466,"zip":467,"country":468,"geoPoint":469},"Beijing Chao-Yang Hospital, Capital Medical University","Beijing","Beijing Municipality","100020","China",{"lat":470,"lon":471},39.9075,116.39723,{"facility":473,"status":179,"city":465,"state":466,"zip":474,"country":468,"geoPoint":475},"China-Japan Friendship Hospital","100029",{"lat":470,"lon":471},{"facility":477,"status":8,"city":478,"state":479,"zip":480,"country":468,"geoPoint":481},"The Third Affiliated Hospital of Guangzhou Medical University","Guangzhou","Guangdong","510150",{"lat":482,"lon":483},23.11667,113.25,{"facility":485,"status":179,"city":486,"state":487,"zip":488,"country":468,"geoPoint":489},"The First Affiliated Hospital of Baotou Medical College","Baotou","Inner Mongolia","014010",{"lat":490,"lon":491},40.6516,109.84389,{"facility":493,"status":8,"city":494,"state":487,"zip":495,"country":468,"geoPoint":496},"Inner Mongolia People's Hospital","Hohhot","010017",{"lat":497,"lon":498},40.81056,111.65222,{"facility":500,"status":8,"city":494,"state":487,"zip":501,"country":468,"geoPoint":502},"The Affiliated Hospital of Inner Mongolia Medical University","010050",{"lat":497,"lon":498},{"facility":504,"status":8,"city":505,"state":506,"zip":507,"country":468},"Nanjing First Hospital","Najing","Jiangsu","210001",{"facility":509,"status":179,"city":510,"state":506,"zip":511,"country":468,"geoPoint":512},"Jiangsu Province Hospital","Nanjing","210029",{"lat":513,"lon":514},32.06167,118.77778,{"facility":516,"status":8,"city":517,"state":506,"zip":518,"country":468,"geoPoint":519},"The Affiliated Hospital of Xuzhou Medical College","Xuzhou","221006",{"lat":520,"lon":521},34.20442,117.28386,{"facility":523,"status":179,"city":517,"state":506,"zip":524,"country":468,"geoPoint":525},"Xuzhou Central Hospital","221009",{"lat":520,"lon":521},{"facility":527,"status":8,"city":528,"state":529,"zip":530,"country":468,"geoPoint":531},"Jiangxi Provincial People's Hospital","Nanchang","Jiangxi","330006",{"lat":532,"lon":533},28.68396,115.85306,{"facility":535,"status":8,"city":536,"state":537,"zip":538,"country":468,"geoPoint":539},"The Second Hospital of Jilin University","Changchun","Jilin","130000",{"lat":540,"lon":541},43.88,125.32278,{"facility":543,"status":8,"city":544,"state":545,"zip":546,"country":468,"geoPoint":547},"The First Affiliated Hospital of Xi'an Medical University","Xi'an","Shaanxi","710077",{"lat":548,"lon":549},34.25833,108.92861,{"facility":551,"status":8,"city":552,"state":553,"zip":554,"country":468,"geoPoint":555},"Shanghai General Hospital","Shanghai","Shanghai Municipality","200080",{"lat":556,"lon":557},31.22222,121.45806,{"facility":559,"status":179,"city":552,"state":553,"zip":560,"country":468,"geoPoint":561},"Shanghai Pulmonary Hospital","200433",{"lat":556,"lon":557},{"facility":563,"status":179,"city":552,"state":553,"country":468,"geoPoint":564},"Ruijin Hospital Shanghai Jiaotong University School of Medicine",{"lat":556,"lon":557},{"facility":566,"status":179,"city":567,"state":568,"zip":569,"country":468,"geoPoint":570},"West China Hospital, Sichuan University","Chengdu","Sichuan","610041",{"lat":571,"lon":572},30.66667,104.06667,{"facility":574,"status":8,"city":575,"state":576,"zip":577,"country":468,"geoPoint":578},"Zhejiang Provincial People's Hospital","Hangzhou","Zhejiang","310014",{"lat":579,"lon":580},30.29365,120.16142,{"facility":582,"status":179,"city":575,"state":576,"country":468,"geoPoint":583},"The First People's Hospital of Hangzhou",{"lat":579,"lon":580},{"facility":585,"status":179,"city":586,"state":576,"zip":587,"country":468,"geoPoint":588},"Taizhou Central Hospital","Taizhou","318000",{"lat":589,"lon":590},28.66266,121.43312,{"facility":592,"status":8,"city":593,"state":594,"zip":595,"country":596,"geoPoint":597},"Mudr.I.Cierna Peterova s.r.o.","Brandýs nad Labem","Central Bohemia","25001","Czechia",{"lat":598,"lon":599},50.18356,14.67244,{"facility":601,"status":8,"city":602,"state":603,"zip":604,"country":596},"MEDITRIAL s.r.o.","Jindrichuv Hradec III","South Bohemian Region","377 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Participants will be randomly assigned to receive either PF-07275315 or a placebo.","completed","A Study of PF-07275315 for Moderate-To-Severe Asthma","This study is looking into the safety and effects of a medicine called PF-07275315 for people with moderate-to-severe asthma. Asthma makes it hard to breathe and can affect your daily life. We are looking for adults aged 18 to 70 who have had moderate-to-severe asthma for at least 12 months that isn't well controlled, even with their usual treatments. You will receive either PF-07275315 or a placebo (a substance with no medicine in it). The main goals are to see how much your breathing (measured by Forced Expiratory Volume in 1 Second or FEV1) improves after 12 weeks and to track any side effects up to 24 weeks. The current recruitment status is unclear.","Your safety and any side effects will be tracked from the beginning of the study through Week 24.",114,"Not specified in the trial record.","Not stated in the trial record.",[39,47],"v2"]