[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07015190":3,"trial-entities:NCT07015190":1074,"trial-summary:NCT07015190":1077},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":34,"primary_purpose":35,"phases":36,"enrollment_info":38,"interventions":41,"primary_outcomes":54,"secondary_outcomes":63,"sex":64,"minimum_age":65,"maximum_age":66,"healthy_volunteers":67,"eligibility_criteria":68,"std_ages":81,"locations":84,"central_contacts":1063,"overall_officials":1071,"references":1072,"see_also_links":1073},"NCT07015190","IDE196-010","Neoadjuvant Darovasertib in Primary Uveal Melanoma","A Randomized, Phase 3, Open-label Study of Neoadjuvant Darovasertib in Subjects With Primary Non-metastatic Uveal Melanoma (OptimUM-10)","RECRUITING","2031-03","2025-09","2026-05-06","2026-01-25","IDEAYA Biosciences","INDUSTRY",true,"This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)","The study is divided into 2 cohorts of patients with primary uveal melanoma requiring either plaque brachytherapy or enucleation.\n\nIn cohort 1, patients in the treatment arm will receive neoadjuvant darovasertib followed by plaque brachytherapy compared to immediate plaque brachytherapy (control arm).\n\nIn cohort 2, the treatment arm will receive neoadjuvant darovasertib followed by definitive primary local therapy (i.e., plaque brachytherapy, proton beam radiation, or enucleation). Subjects in the control arm will go onto immediate enucleation.\n\nSubjects will then receive primary local therapy following neoadjuvant darovasertib.\n\nAll patients will be followed for up to 3 years to assess longer term outcomes such as vision and tumor recurrence.",[19],"Uveal Melanoma",[19,21,22,23,24,25,26,27,28,29,30,31,32,33],"Plaque Brachytherapy","Enucleation","Neoadjuvant","Darovasertib","IDE 196","Ocular Melanoma","Choroidal Melanoma","Ophthalmology","Ocular Oncology","Melanoma","Protein Kinase C","GNAQ","GNA11","INTERVENTIONAL","TREATMENT",[37],"PHASE3",{"count":39,"type":40},520,"ESTIMATED",[42,48],{"type":43,"name":24,"description":44,"armGroupLabels":45,"otherNames":47},"DRUG","Dosed orally, twice daily (28-day\u002F cycle",[46],"Treatment Arm",[25],{"type":49,"name":50,"description":51,"armGroupLabels":52},"PROCEDURE","Primary Local Therapy","Plaque Brachytherapy or Enucleation",[53],"Control Arm",[55,59],{"measure":56,"description":57,"timeFrame":58},"Cohort 1: To demonstrate that the proportion of subjects with vision loss is lower for subjects in the Treatment Arm vs the Control Arm","Loss of Best Corrected Visual Acuity (BCVA) of ≥ 15 letters using Early Treatment Diabetic Retinopathy Study (ETDRS) BCVA","Approximately 3 years",{"measure":60,"description":61,"timeFrame":62},"Cohort 2: To demonstrate the ability to salvage the eye and prevent enucleation in the Treatment Arm","Eye preservation rate","Approximately 2 years",[],"ALL","18 Years",null,false,{"inclusion":69,"exclusion":74,"raw_text":80},[70,71,72,73],"Primary non-metastatic uveal melanoma","Able and willing to provide written, informed consent before initiation of any study-related procedures, and in the opinion of the Investigator, to comply with all study requirements","ECOG 0 or 1","Adequate organ function",[75,76,77,78,79],"Previous treatment for UM","Evidence of metastatic UM","Attributes that necessitate enucleation regardless of response to therapy","Evidence of progressive secondary underlying ocular disease that would confound longitudinal VA assessments","Presence of a malignant disease other than the one being treated in this study","Inclusion Criteria:\n\n* Primary non-metastatic uveal melanoma\n* Able and willing to provide written, informed consent before initiation of any study-related procedures, and in the opinion of the Investigator, to comply with all study requirements\n* ECOG 0 or 1\n* Adequate organ function\n\nExclusion Criteria:\n\n* Previous treatment for UM\n* Evidence of metastatic UM\n* Attributes that necessitate enucleation regardless of response to therapy\n* Evidence of progressive secondary underlying ocular disease that would confound longitudinal VA assessments\n* Presence of a malignant disease other than the one being treated in this study",[82,83],"ADULT","OLDER_ADULT",[85,98,110,120,127,137,147,157,167,178,188,199,209,216,227,238,249,259,270,281,291,298,305,316,326,337,348,358,369,376,387,397,404,414,425,436,448,459,470,480,491,501,511,522,532,544,555,566,575,586,598,610,621,632,642,649,661,671,682,693,704,714,724,734,744,754,766,776,787,796,806,818,828,837,848,857,867,879,890,902,913,924,935,946,958,969,980,990,1000,1010,1021,1031,1043,1053],{"facility":86,"status":8,"city":87,"state":88,"zip":89,"country":90,"contacts":91,"geoPoint":95},"Mayo Clinic Scottsdale - PPDS","Scottsdale","Arizona","85259","United States",[92],{"name":93,"role":94},"Odette Houghton, MD Principal Investigator","CONTACT",{"lat":96,"lon":97},33.50921,-111.89903,{"facility":99,"status":100,"city":101,"state":102,"zip":103,"country":90,"contacts":104,"geoPoint":107},"UCSD Moores Cancer Center","NOT_YET_RECRUITING","La Jolla","California","92093",[105],{"name":106,"role":94},"Gregory Daniels, MD Principal Investigator",{"lat":108,"lon":109},32.84727,-117.2742,{"facility":111,"status":100,"city":112,"state":102,"zip":113,"country":90,"contacts":114,"geoPoint":117},"Jules Stein Eye Institute","Los Angeles","90024",[115],{"name":116,"role":94},"Tara McCannel, MD Principal Investigator",{"lat":118,"lon":119},34.05223,-118.24368,{"facility":121,"status":100,"city":112,"state":102,"zip":122,"country":90,"contacts":123,"geoPoint":126},"USC Norris Comprehensive Cancer Center","90033",[124],{"name":125,"role":94},"Gino In, MD, Principal Investigator",{"lat":118,"lon":119},{"facility":128,"status":100,"city":129,"state":102,"zip":130,"country":90,"contacts":131,"geoPoint":134},"University of California Irvine Medical Center","Orange","92868",[132],{"name":133,"role":94},"Poorva Vaidya, MD Principal Investigator",{"lat":135,"lon":136},33.78779,-117.85311,{"facility":138,"status":8,"city":139,"state":102,"zip":140,"country":90,"contacts":141,"geoPoint":144},"Stanford Comprehensive Cancer Center","Palo Alto","94304",[142],{"name":143,"role":94},"Pauline Funchain, MD Principal Investigator",{"lat":145,"lon":146},37.44188,-122.14302,{"facility":148,"status":8,"city":149,"state":102,"zip":150,"country":90,"contacts":151,"geoPoint":154},"Kaiser Permanente-Riverside Medical Center","Riverside","92505-3043",[152],{"name":153,"role":94},"Helen Moon, MD Principal Investigator",{"lat":155,"lon":156},33.95335,-117.39616,{"facility":158,"status":100,"city":159,"state":102,"zip":160,"country":90,"contacts":161,"geoPoint":164},"UCSF Wayne and Gladys Valley Center for Vision","San Francisco","94143",[162],{"name":163,"role":94},"Armin Afshar, MD, Principal Investigator",{"lat":165,"lon":166},37.77493,-122.41942,{"facility":168,"status":8,"city":169,"state":170,"zip":171,"country":90,"contacts":172,"geoPoint":175},"University of Colorado Hospital","Aurora","Colorado","80045",[173],{"name":174,"role":94},"Sapna Patel, MD Principal Investigator",{"lat":176,"lon":177},39.72943,-104.83192,{"facility":179,"status":100,"city":180,"state":170,"zip":181,"country":90,"contacts":182,"geoPoint":185},"The Melanoma and Skin Cancer Institute","Englewood","80113-2791",[183],{"name":184,"role":94},"Ryan Weight, MD Principal Investigator",{"lat":186,"lon":187},39.64777,-104.98776,{"facility":189,"status":8,"city":190,"state":191,"zip":192,"country":90,"contacts":193,"geoPoint":196},"Mayo Clinic Jacksonville","Jacksonville","Florida","32224",[194],{"name":195,"role":94},"Bently Doonan, MD Principal Investigator",{"lat":197,"lon":198},30.33218,-81.65565,{"facility":200,"status":100,"city":201,"state":191,"zip":202,"country":90,"contacts":203,"geoPoint":206},"USF Health Eye Institute","Tampa","33612-6601",[204],{"name":205,"role":94},"Jorge Agi, MD Principal Investigator",{"lat":207,"lon":208},27.94752,-82.45843,{"facility":210,"status":100,"city":201,"state":191,"zip":211,"country":90,"contacts":212,"geoPoint":215},"Moffit Cancer Center","33612",[213],{"name":214,"role":94},"Nikhil Khushalani, MD, Principal Investigator",{"lat":207,"lon":208},{"facility":217,"status":8,"city":218,"state":219,"zip":220,"country":90,"contacts":221,"geoPoint":224},"Wilmer Eye Institute","Baltimore","Maryland","21287-0005",[222],{"name":223,"role":94},"James Handa, MD Principal Investigator",{"lat":225,"lon":226},39.29038,-76.61219,{"facility":228,"status":100,"city":229,"state":230,"zip":231,"country":90,"contacts":232,"geoPoint":235},"Massachusetts General Hospital","Boston","Massachusetts","02114",[233],{"name":234,"role":94},"Kamaneh Montazeri, MD Principal Investigator",{"lat":236,"lon":237},42.35843,-71.05977,{"facility":239,"status":100,"city":240,"state":241,"zip":242,"country":90,"contacts":243,"geoPoint":246},"W Kellogg Eye Center","Ann Arbor","Michigan","48105",[244],{"name":245,"role":94},"Hakan Demirci, MD Principal Investigator",{"lat":247,"lon":248},42.27756,-83.74088,{"facility":250,"status":8,"city":251,"state":241,"zip":252,"country":90,"contacts":253,"geoPoint":256},"The Cancer and Hematology Centers of West Michigan (CHCWM)","Grand Rapids","49503",[254],{"name":255,"role":94},"Sreenivasa Chandana, MD Principal Investigator",{"lat":257,"lon":258},42.96336,-85.66809,{"facility":260,"status":8,"city":261,"state":262,"zip":263,"country":90,"contacts":264,"geoPoint":267},"Mayo Clinic - PPDS","Rochester","Minnesota","55905",[265],{"name":266,"role":94},"Lauren Dalvin, MD Principal Investigator",{"lat":268,"lon":269},44.02163,-92.4699,{"facility":271,"status":100,"city":272,"state":273,"zip":274,"country":90,"contacts":275,"geoPoint":278},"TIERING Percentiles","Omaha","Nebraska","68105",[276],{"name":277,"role":94},"Pukhraj Rishi, MD Principal Investigator",{"lat":279,"lon":280},41.25626,-95.94043,{"facility":282,"status":8,"city":283,"state":283,"zip":284,"country":90,"contacts":285,"geoPoint":288},"Herbert Irving Comprehensive Cancer Center","New York","10032",[286],{"name":287,"role":94},"Benjamin Izar, MD Principal Investigator",{"lat":289,"lon":290},40.71427,-74.00597,{"facility":292,"status":100,"city":283,"state":283,"zip":293,"country":90,"contacts":294,"geoPoint":297},"Memorial Sloan Kettering Cancer Center - 1275 York Ave","10065-6635",[295],{"name":296,"role":94},"Jasmine Francis, MD Principal Investigator",{"lat":289,"lon":290},{"facility":299,"status":100,"city":283,"state":283,"zip":300,"country":90,"contacts":301,"geoPoint":304},"Northwell Health Cancer Institute","11042",[302],{"name":303,"role":94},"Shaheer Khan, MD Principal Investigator",{"lat":289,"lon":290},{"facility":306,"status":100,"city":307,"state":308,"zip":309,"country":90,"contacts":310,"geoPoint":313},"Cole Eye Institute-9500 Euclid Ave","Cleveland","Ohio","44195",[311],{"name":312,"role":94},"Lucy Kennedy, MD Principal Investigator",{"lat":314,"lon":315},41.4995,-81.69541,{"facility":317,"status":100,"city":318,"state":308,"zip":319,"country":90,"contacts":320,"geoPoint":323},"Ohio State Eye and Ear Institute","Columbus","43212",[321],{"name":322,"role":94},"Colleen Cebulla, MD Principal Investigator",{"lat":324,"lon":325},39.96118,-82.99879,{"facility":327,"status":100,"city":328,"state":329,"zip":330,"country":90,"contacts":331,"geoPoint":334},"Retina Consultants of Oklahoma","Oklahoma City","Oklahoma","73112",[332],{"name":333,"role":94},"Brian Firestone, MD, Principal Investigator",{"lat":335,"lon":336},35.46756,-97.51643,{"facility":338,"status":100,"city":339,"state":340,"zip":341,"country":90,"contacts":342,"geoPoint":345},"Jefferson Health Honickman Center","Philadelphia","Pennsylvania","19107",[343],{"name":344,"role":94},"Marlana Orloff, MD Principal Investigator",{"lat":346,"lon":347},39.95238,-75.16362,{"facility":349,"status":100,"city":350,"state":340,"zip":351,"country":90,"contacts":352,"geoPoint":355},"UPMC Hillman Cancer Center","Pittsburgh","15232",[353],{"name":354,"role":94},"Yana Najjar, MD Principal Investigator",{"lat":356,"lon":357},40.44062,-79.99589,{"facility":359,"status":8,"city":360,"state":361,"zip":362,"country":90,"contacts":363,"geoPoint":366},"SCRI Oncology Partners","Nashville","Tennessee","37203",[364],{"name":365,"role":94},"Meredith McKean, MD Principal Investigator",{"lat":367,"lon":368},36.16589,-86.78444,{"facility":370,"status":100,"city":360,"state":361,"zip":371,"country":90,"contacts":372,"geoPoint":375},"Vanderbilt Eye Institute","37232",[373],{"name":374,"role":94},"Paul Sternberg, MD, Principal Investigator",{"lat":367,"lon":368},{"facility":377,"status":8,"city":378,"state":379,"zip":380,"country":90,"contacts":381,"geoPoint":384},"Austin Retina Associates - Central","Austin","Texas","78705",[382],{"name":383,"role":94},"Shelley Ghafoori, MD Principal Investigator",{"lat":385,"lon":386},30.26715,-97.74306,{"facility":388,"status":8,"city":389,"state":379,"zip":390,"country":90,"contacts":391,"geoPoint":394},"Texas Retina Associates - Dallas","Dallas","75231",[392],{"name":393,"role":94},"Timothy Fuller, MD Principal Investigator",{"lat":395,"lon":396},32.78306,-96.80667,{"facility":398,"status":8,"city":389,"state":379,"zip":399,"country":90,"contacts":400,"geoPoint":403},"University of Texas Southwestern Medical Center-5323 Harry Hines Blvd","75390-9057",[401],{"name":402,"role":94},"Sanjay Chandrasekaran, MD Principal Investigator",{"lat":395,"lon":396},{"facility":405,"status":100,"city":406,"state":379,"zip":407,"country":90,"contacts":408,"geoPoint":411},"Retina Consultants of Texas - (Houston)","Houston","77030-2727",[409],{"name":410,"role":94},"Amy Schefler, MD Principal Investigator",{"lat":412,"lon":413},29.76328,-95.36327,{"facility":415,"status":100,"city":416,"state":417,"zip":418,"country":90,"contacts":419,"geoPoint":422},"Augusta Health, Center for Cancer and Blood Disorders","Fishersville","Virginia","22939",[420],{"name":421,"role":94},"Kelvin Rayborn, MD Principal Investigator",{"lat":423,"lon":424},38.09902,-78.96919,{"facility":426,"status":100,"city":427,"state":428,"zip":429,"country":90,"contacts":430,"geoPoint":433},"University of Wisconsin Health","Madison","Wisconsin","53705-3644",[431],{"name":432,"role":94},"Michael Altaweel, MD Principal Investigator",{"lat":434,"lon":435},43.07305,-89.40123,{"facility":437,"status":100,"city":438,"state":439,"zip":440,"country":441,"contacts":442,"geoPoint":445},"Gallipoli Medical Research Foundation","Greenslopes","Queensland","QLD 4120","Australia",[443],{"name":444,"role":94},"Victoria Atkinson, MD, Principal Investigator",{"lat":446,"lon":447},-27.50815,153.04951,{"facility":449,"status":100,"city":450,"state":451,"zip":452,"country":441,"contacts":453,"geoPoint":456},"The Queen Elizabeth Hospital","Woodville South","South Australia","5011",[454],{"name":455,"role":94},"Rachel Roberts-Thomson, MD Principal Investigator",{"lat":457,"lon":458},-34.88186,138.53477,{"facility":460,"status":100,"city":461,"state":462,"zip":463,"country":441,"contacts":464,"geoPoint":467},"The Alfred Hospital","Melbourne","Victoria","3004",[465],{"name":466,"role":94},"Mark Shackleton, MD Principal Investigator",{"lat":468,"lon":469},-37.814,144.96332,{"facility":471,"status":100,"city":472,"zip":473,"country":441,"contacts":474,"geoPoint":477},"The Crown Princess Mary Cancer Centre (Westmead Hospital), NSW 214","Westmead","NSW 2145",[475],{"name":476,"role":94},"Matteo Carlino, MD, Principal Investigator",{"lat":478,"lon":479},-33.80383,150.98768,{"facility":481,"status":100,"city":482,"zip":483,"country":484,"contacts":485,"geoPoint":488},"LKH-Universitätsklinikum Graz","Graz","8036","Austria",[486],{"name":487,"role":94},"Thomas Georgi, MD Principal Investigator",{"lat":489,"lon":490},47.06733,15.44197,{"facility":492,"status":100,"city":493,"zip":494,"country":484,"contacts":495,"geoPoint":498},"Universitätsklinikum Innsbruck","Innsbruck","6020",[496],{"name":497,"role":94},"Matus Rehak, MD Principal Investigator",{"lat":499,"lon":500},47.26266,11.39454,{"facility":502,"status":100,"city":503,"zip":504,"country":484,"contacts":505,"geoPoint":508},"Universitätsklinikum AKH Wien","Vienna","1090",[506],{"name":507,"role":94},"Roman Dunavölgyi, MD Principal Investigator",{"lat":509,"lon":510},48.20849,16.37208,{"facility":512,"status":8,"city":513,"zip":514,"country":515,"contacts":516,"geoPoint":519},"Cliniques Universitaires Saint-Luc - PPDS","Brussels","1200","Belgium",[517],{"name":518,"role":94},"Jean-Francois Baurain, MD Principal Investigator",{"lat":520,"lon":521},50.85045,4.34878,{"facility":523,"status":100,"city":524,"zip":525,"country":515,"contacts":526,"geoPoint":529},"UZ Leuven - PPDS","Leuven","3000",[527],{"name":528,"role":94},"Joachim Van Calster, MD Principal Investigator",{"lat":530,"lon":531},50.87959,4.70093,{"facility":533,"status":100,"city":534,"state":535,"zip":536,"country":537,"contacts":538,"geoPoint":541},"Cross Cancer Institute","Edmonton","Alberta","T6G 1Z2","Canada",[539],{"name":540,"role":94},"John Walker, MD, Principal Investigator",{"lat":542,"lon":543},53.55014,-113.46871,{"facility":545,"status":8,"city":546,"state":547,"zip":548,"country":537,"contacts":549,"geoPoint":552},"Princess Margaret Cancer Centre","Toronto","Ontario","M5G 2M9",[550],{"name":551,"role":94},"Marcus Butler, MD Principal Investigator",{"lat":553,"lon":554},43.70643,-79.39864,{"facility":556,"status":8,"city":557,"state":557,"zip":558,"country":559,"contacts":560,"geoPoint":563},"Ustredni vojenska nemocnice - Vojenska fakultni nemocnice Praha","Prague","169 02","Czechia",[561],{"name":562,"role":94},"Zuzana Hradcova, MD Principal Investigator",{"lat":564,"lon":565},50.08804,14.42076,{"facility":567,"status":100,"city":568,"state":569,"zip":570,"country":571,"contacts":572},"Rigshospitalet","Copenhagen O","Capital","2100","Denmark",[573],{"name":574,"role":94},"Jens Kiilgaard, MD Principal Investigator",{"facility":576,"status":100,"city":577,"state":578,"zip":579,"country":571,"contacts":580,"geoPoint":583},"Aarhus Universitetshospital","Aarhus","Central Jutland","8200",[581],{"name":582,"role":94},"Peter Skov Jensen, MD Principal Investigator",{"lat":584,"lon":585},56.15674,10.21076,{"facility":587,"status":100,"city":588,"state":589,"zip":590,"country":591,"contacts":592,"geoPoint":595},"East Tallinn Central Hospital-Pärnu road 104","Tallinn","Harju","11312","Estonia",[593],{"name":594,"role":94},"Elen Vettus, MD Principal Investigator",{"lat":596,"lon":597},59.43696,24.75353,{"facility":599,"status":100,"city":600,"state":601,"zip":602,"country":603,"contacts":604,"geoPoint":607},"CHU de Nice-Hôpital Pasteur","Nice","Alpes-Maritimes","6000","France",[605],{"name":606,"role":94},"Sacha Nahon-Estève, MD Principal Investigator",{"lat":608,"lon":609},43.70313,7.26608,{"facility":611,"status":100,"city":612,"state":613,"zip":614,"country":603,"contacts":615,"geoPoint":618},"Centre Retine Gallien - Bordeaux","Bordeaux","Gironde","33000",[616],{"name":617,"role":94},"Laurence Rosier, MD Principal Investigator",{"lat":619,"lon":620},44.84124,-0.58046,{"facility":622,"status":100,"city":623,"state":624,"zip":625,"country":603,"contacts":626,"geoPoint":629},"CHU de Rennes - Hôpital Pontchaillou","Rennes","Ille-et-Vilaine","35000",[627],{"name":628,"role":94},"Frederic Mouriaux, MD Principal Investigator",{"lat":630,"lon":631},48.11109,-1.67431,{"facility":633,"status":100,"city":634,"state":634,"zip":635,"country":603,"contacts":636,"geoPoint":639},"Institut Curie - Hôpital de Paris","Paris","75248",[637],{"name":638,"role":94},"Alexandre Matet, MD Principal Investigator",{"lat":640,"lon":641},48.85341,2.3488,{"facility":643,"status":100,"city":634,"zip":644,"country":603,"contacts":645,"geoPoint":648},"Centre Hospitalier National D'ophtalmologie Des Quinze Vingts","75571",[646],{"name":647,"role":94},"Sarah Tick, MD Principal Investigator",{"lat":640,"lon":641},{"facility":650,"status":100,"city":651,"state":652,"zip":653,"country":654,"contacts":655,"geoPoint":658},"Universitätsklinikum Tübingen","Tübingen","Baden-Wurttemberg","72076","Germany",[656],{"name":657,"role":94},"Daniela Süsskind, MD Principal Investigator",{"lat":659,"lon":660},48.52266,9.05222,{"facility":662,"status":100,"city":663,"state":652,"zip":664,"country":654,"contacts":665,"geoPoint":668},"Universitätsklinikum Ulm","Ulm","89075",[666],{"name":667,"role":94},"Armin Wolf, MD Principal Investigator",{"lat":669,"lon":670},48.39841,9.99155,{"facility":672,"status":100,"city":673,"state":674,"zip":675,"country":654,"contacts":676,"geoPoint":679},"Hautklinik Erlangen","Erlangen","Bavaria","91054",[677],{"name":678,"role":94},"Carola Berking, MD Principal Investigator",{"lat":680,"lon":681},49.59099,11.00783,{"facility":683,"status":100,"city":684,"state":685,"zip":686,"country":654,"contacts":687,"geoPoint":690},"Universitätsklinikum Essen","Essen","North Rhine-Westphalia","45147",[688],{"name":689,"role":94},"Halime Kalkavan, MD Principal Investigator",{"lat":691,"lon":692},51.45657,7.01228,{"facility":694,"status":100,"city":695,"state":696,"zip":697,"country":654,"contacts":698,"geoPoint":701},"Städtisches Klinikum Dessau","Dessau","Saxony-Anhalt","6847",[699],{"name":700,"role":94},"Lothar Krause, MD Principal Investigator",{"lat":702,"lon":703},51.83864,12.24555,{"facility":705,"status":100,"city":706,"zip":707,"country":654,"contacts":708,"geoPoint":711},"Charité - Universitätsmedizin Berlin","Berlin","12203",[709],{"name":710,"role":94},"Antonia Joussen, MD Principal Investigator",{"lat":712,"lon":713},52.52437,13.41053,{"facility":715,"status":100,"city":716,"zip":717,"country":654,"contacts":718,"geoPoint":721},"Universitätsklinikum Bonn","Bonn","53127",[719],{"name":720,"role":94},"Thomas Ach, MD Principal Investigator",{"lat":722,"lon":723},50.73438,7.09549,{"facility":725,"status":100,"city":726,"zip":727,"country":654,"contacts":728,"geoPoint":731},"Universitätsklinikum Schleswig-Holstein - Campus Lübeck","Lübeck","23562",[729],{"name":730,"role":94},"Svenja Sonntag, Principal Investigator, MD",{"lat":732,"lon":733},53.86893,10.68729,{"facility":735,"status":100,"city":736,"zip":737,"country":654,"contacts":738,"geoPoint":741},"Universitätsklinikum Giessen und Marburg - Marburg (UKGM)","Marburg","35043",[739],{"name":740,"role":94},"Walter Sekundo, MD Principal Investigator",{"lat":742,"lon":743},50.80904,8.77069,{"facility":745,"status":100,"city":746,"zip":747,"country":654,"contacts":748,"geoPoint":751},"Universitätsklinikum Würzburg","Würzburg","97080",[749],{"name":750,"role":94},"Andreas Berlin, MD Principal Investigator",{"lat":752,"lon":753},49.79391,9.95121,{"facility":755,"status":100,"city":756,"state":757,"zip":758,"country":759,"contacts":760,"geoPoint":763},"PAGNI-University General Hospital of Heraklion","Heraklion","Irakleio","715 00","Greece",[761],{"name":762,"role":94},"Efstathios Detorakis, MD Principal Investigator",{"lat":764,"lon":765},35.32787,25.14341,{"facility":767,"status":100,"city":768,"state":768,"zip":769,"country":759,"contacts":770,"geoPoint":773},"University General Hospital of Larissa","Larissa","41 110",[771],{"name":772,"role":94},"Sofia Androudi, MD Principal Investigator",{"lat":774,"lon":775},39.62847,22.42112,{"facility":777,"status":100,"city":778,"state":779,"zip":780,"country":759,"contacts":781,"geoPoint":784},"AHEPA University General Hospital of Thessaloniki","Thessaloniki","Thessaloníki","546 36",[782],{"name":783,"role":94},"Konstantinos Boboridis, MD Principal Investigator",{"lat":785,"lon":786},40.64072,22.93493,{"facility":788,"status":8,"city":789,"state":790,"zip":791,"country":792,"contacts":793},"The Chaim Sheba Medical Center - PPDS","Ramat Gan","Central District","5262100","Israel",[794],{"name":795,"role":94},"Vicktoria Vishnevskia-Dai, MD Principal Investigator",{"facility":797,"status":8,"city":798,"state":798,"zip":799,"country":792,"contacts":800,"geoPoint":803},"Hadassah Medical Center - PPDS","Jerusalem","91120",[801],{"name":802,"role":94},"Shahar Frenkel, MD Principal Investigator",{"lat":804,"lon":805},31.76904,35.21633,{"facility":807,"status":100,"city":808,"state":809,"zip":810,"country":811,"contacts":812,"geoPoint":815},"Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale","Naples","Campania","80131","Italy",[813],{"name":814,"role":94},"Paolo Ascierto, MD Principal Investigator",{"lat":816,"lon":817},40.85216,14.26811,{"facility":819,"status":100,"city":820,"state":820,"zip":821,"country":811,"contacts":822,"geoPoint":825},"ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco","Milan","20157",[823],{"name":824,"role":94},"Marco Pellegrini, MD Principal Investigator",{"lat":826,"lon":827},42.78235,12.59836,{"facility":829,"status":100,"city":830,"state":830,"country":811,"contacts":831,"geoPoint":834},"Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia","Perugia",[832],{"name":833,"role":94},"Mario Mandalà, MD Principal Investigator",{"lat":835,"lon":836},43.1122,12.38878,{"facility":838,"status":8,"city":839,"state":840,"zip":841,"country":811,"contacts":842,"geoPoint":845},"Azienda Ospedaliera Universitaria Careggi","Florence","Tuscany","50134",[843],{"name":844,"role":94},"Cinzia Mazzini, MD Principal Investigator",{"lat":846,"lon":847},43.77925,11.24626,{"facility":829,"status":100,"city":849,"zip":850,"country":811,"contacts":851,"geoPoint":854},"Pisa","56124",[852],{"name":853,"role":94},"Federica Genovesi Ebert, MD Principal Investigator",{"lat":855,"lon":856},43.70853,10.4036,{"facility":858,"status":100,"city":859,"zip":860,"country":811,"contacts":861,"geoPoint":864},"Fondazione Policlinico Universitario A Gemelli - Rome - PPDS","Rome","168",[862],{"name":863,"role":94},"Ernesto Rossi, MD Principal Investigator",{"lat":865,"lon":866},41.89193,12.51133,{"facility":868,"status":100,"city":869,"state":870,"zip":871,"country":872,"contacts":873,"geoPoint":876},"Erasmus MC","Rotterdam","South Holland","3015 GD","Netherlands",[874],{"name":875,"role":94},"Emine Kiliç-Ciğirci, MD Principal Investigator",{"lat":877,"lon":878},51.9225,4.47917,{"facility":880,"status":100,"city":881,"state":881,"zip":882,"country":883,"contacts":884,"geoPoint":887},"Auckland Eye","Auckland","1050","New Zealand",[885],{"name":886,"role":94},"Riyaz Bhikoo, MD Principal Investigator",{"lat":888,"lon":889},-36.84853,174.76349,{"facility":891,"status":100,"city":892,"state":893,"zip":894,"country":895,"contacts":896,"geoPoint":899},"Uniwersytecki Szpital Kliniczny w Poznaniu- Dluga 1\u002F2","Poznan","Greater Poland Voivodeship","61-848","Poland",[897],{"name":898,"role":94},"Iwona Rospond-Kubiak, MD Principal Investigator",{"lat":900,"lon":901},52.40692,16.92993,{"facility":903,"status":100,"city":904,"state":905,"zip":906,"country":895,"contacts":907,"geoPoint":910},"WIM-PIB, Centralny Szpital Kliniczny MON","Warsaw","Masovian Voivodeship","04-141",[908],{"name":909,"role":94},"Izabela Nowak-Gospodarowicz, MD Principal Investigator",{"lat":911,"lon":912},52.22977,21.01178,{"facility":914,"status":100,"city":915,"state":916,"zip":917,"country":895,"contacts":918,"geoPoint":921},"Uniwersyteckie Centrum Kliniczne w Gdansku - Debinki 7","Gdansk","Pomeranian Voivodeship","80-214",[919],{"name":920,"role":94},"Kamil Drucis, MD Principal Investigator",{"lat":922,"lon":923},54.35227,18.64912,{"facility":925,"status":100,"city":926,"zip":927,"country":928,"contacts":929,"geoPoint":932},"Fakultna nemocnica s poliklinikou F. D. Roosevelta","Banská Bystrica","975 17","Slovakia",[930],{"name":931,"role":94},"Ladislav Janco, MD Principal Investigator",{"lat":933,"lon":934},48.73947,19.14932,{"facility":936,"status":100,"city":937,"state":937,"zip":938,"country":939,"contacts":940,"geoPoint":943},"Institute of Oncology Ljubljana","Ljubljana","1000","Slovenia",[941],{"name":942,"role":94},"Janja Ocvirk, MD Principal Investiagtor",{"lat":944,"lon":945},46.05108,14.50513,{"facility":947,"status":8,"city":948,"state":949,"zip":950,"country":951,"contacts":952,"geoPoint":955},"Hospital Clinico Universitario de Santiago","Santiago de Compostela","A Coruña","15706","Spain",[953],{"name":954,"role":94},"Maria José Blanco Teijeiro, MD Principal Investigator",{"lat":956,"lon":957},42.88052,-8.54569,{"facility":959,"status":100,"city":960,"state":961,"zip":962,"country":951,"contacts":963,"geoPoint":966},"Hospital Universitario de Bellvitge","L'Hospitalet de Llobregat","Barcelona","8907",[964],{"name":965,"role":94},"Jose Maria Caminal Mitjana, MD Principal Investigator",{"lat":967,"lon":968},41.35967,2.10028,{"facility":970,"status":8,"city":971,"state":972,"zip":973,"country":951,"contacts":974,"geoPoint":977},"Clinica Universidad Navarra","Pamplona","Navarre","31008",[975],{"name":976,"role":94},"Alfredo Garcia Layana, MD Principal Investigator",{"lat":978,"lon":979},42.81687,-1.64323,{"facility":981,"status":100,"city":982,"state":982,"zip":983,"country":951,"contacts":984,"geoPoint":987},"Hospital Universitari i Politecnic La Fe de Valencia","Valencia","46026",[985],{"name":986,"role":94},"Rafael Martínez-Costa Pérez, MD Principal Investigator",{"lat":988,"lon":989},39.47391,-0.37966,{"facility":991,"status":8,"city":992,"state":992,"zip":993,"country":951,"contacts":994,"geoPoint":997},"Hospital Clinico Universitario de Valladolid","Valladolid","47003",[995],{"name":996,"role":94},"Ciro Garcia-Alvarez, MD Principal Investigator",{"lat":998,"lon":999},41.65541,-4.72353,{"facility":1001,"status":8,"city":1002,"zip":1003,"country":951,"contacts":1004,"geoPoint":1007},"Hospital Universitario Virgen Macarena","Seville","41009",[1005],{"name":1006,"role":94},"Francisco Espejo-Arjona, MD Principal Investigator",{"lat":1008,"lon":1009},37.38283,-5.97317,{"facility":1011,"status":8,"city":1012,"zip":1013,"country":1014,"contacts":1015,"geoPoint":1018},"Universitätsspital Basel","Basel","4031","Switzerland",[1016],{"name":1017,"role":94},"Andreas Schmitt, MD Principal Investigator",{"lat":1019,"lon":1020},47.55839,7.57327,{"facility":1022,"status":8,"city":1023,"zip":1024,"country":1014,"contacts":1025,"geoPoint":1028},"Universitätsspital Zürich","Zurich","8091",[1026],{"name":1027,"role":94},"Egle Ramelyte, MD Principal Investigator",{"lat":1029,"lon":1030},47.36667,8.55,{"facility":1032,"status":100,"city":1033,"state":1034,"zip":1035,"country":1036,"contacts":1037,"geoPoint":1040},"Clatterbridge Cancer Centre - Liverpool - NWCRN - PPDS","Metropolitan Borough of Wirral","Merseyside","CH63 4JY","United Kingdom",[1038],{"name":1039,"role":94},"Joseph Sacco, MD Principal Investigator",{"lat":1041,"lon":1042},53.37616,-3.10501,{"facility":1044,"status":100,"city":1045,"zip":1046,"country":1036,"contacts":1047,"geoPoint":1050},"University College Hospital","London","NW1 2BU",[1048],{"name":1049,"role":94},"Heather Shaw, MD Principal Investigator",{"lat":1051,"lon":1052},51.50853,-0.12574,{"facility":1054,"status":100,"city":1055,"zip":1056,"country":1036,"contacts":1057,"geoPoint":1060},"Weston Park Cancer Centre - PPDS","Sheffield","S10 2TF",[1058],{"name":1059,"role":94},"Krishnakumar Garadi, MD Principal Investigator",{"lat":1061,"lon":1062},53.38297,-1.4659,[1064,1068],{"name":1065,"role":94,"phone":1066,"email":1067},"IDEAYA Clinical Trials","+1-855-433-2246","IDEAYAClinicalTrials@ideayabio.com",{"name":1069,"role":94,"email":1070},"Mwe Mwe Chao, MD","mchao@ideayabio.com",[],[],[],{"nct_id":4,"conditions":1075,"biomarkers":1076},[19],[],{"nct_id":4,"found":15,"summary":1078,"prompt_version":1088},{"design":1079,"status":1080,"heading":1081,"summary":1082,"follow_up":1083,"word_count":1084,"commitments":1085,"compensation":1086,"drugs_mentioned":1087},"This is a Phase 3, randomized, multi-center, open-label study. It will compare Darovasertib plus standard treatment to standard treatment alone.","completed","Darovasertib for Primary Uveal Melanoma","This study is testing a drug called Darovasertib for people with primary uveal melanoma (a type of eye cancer that hasn't spread). It's a Phase 3 study, meaning it's comparing Darovasertib to standard treatments to see if it's better. The study aims to see if Darovasertib can help preserve your vision or prevent the need to remove your eye (enucleation). You might be able to join if you have uveal melanoma that hasn't spread, are at least 18 years old, and are generally in good health. The study plans to enroll 520 participants.","All participants will be followed for up to 3 years to check on their vision and if the tumor returns.",93,"You would take Darovasertib orally twice daily for 28-day cycles, followed by a procedure like plaque brachytherapy or enucleation. You will be followed for up to 3 years.","Not stated in the trial record.",[24],"v2"]