[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07023757":3,"trial-entities:NCT07023757":85,"trial-summary:NCT07023757":89},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":35,"secondary_outcomes":43,"sex":58,"minimum_age":59,"maximum_age":60,"healthy_volunteers":14,"eligibility_criteria":61,"std_ages":65,"locations":68,"central_contacts":78,"overall_officials":79,"references":83,"see_also_links":84},"NCT07023757","HUM00264197","Effect of Age on PRF Quality; Assessed by Evaluating Healing Outcomes of ARP","ENROLLING_BY_INVITATION","2027-07-01","2026-07","2026-07-15","2025-06-12","University of Michigan","OTHER",false,"This study will examine whether using PRF and your age are going to affect the healing and regeneration benefits gained from PRF.","Platelet-rich fibrin (PRF) is commonly used to enhance gum tissue healing and reducing pain after tooth extraction and before placing a dental implant. 44 patients requiring a tooth extraction will be recruited and randomized to receive a collagen plug with or without platelet-rich fibrin.",[18],"Healing Wound",[],"INTERVENTIONAL","TREATMENT",[23],"NA",{"count":25,"type":26},44,"ESTIMATED",[28],{"type":29,"name":30,"description":31,"armGroupLabels":32},"PROCEDURE","Socket preservation","After tooth extraction, the extraction socket will be filled with a collagen plug in one group or a platelet-rich fibrin plug in the other.",[33,34],"Collagen plug only","Platelet-rich fibrin group.",[36,40],{"measure":37,"description":38,"timeFrame":39},"Alveolar ridge dimension changes","Digitally measured alveolar ridge dimension changes in mm\\^2 using cone-beam computed tomography","4 months",{"measure":41,"description":42,"timeFrame":39},"Soft tissue dimension changes","Digitally measured soft tissue changes in mm\\^2 using intraoral scans",[44,47,50,54],{"measure":45,"description":46,"timeFrame":39},"Histological bone density.","Histomorphometry.",{"measure":48,"description":49,"timeFrame":39},"Presence of bone turnover proteins.","Immunohistochemistry.",{"measure":51,"description":52,"timeFrame":53},"Amount of growth factors","Growth factors (PDGF, VEGF and TGF b1) from PRF obtained from drawn blood","At baseline surgery",{"measure":55,"description":56,"timeFrame":57},"Wound healing index","Wound healing index (WHI) according to the following scheme: Score \"1\" for uneventful wound healing with no gingival edema, erythema, suppuration, discomfort or barrier exposure; Score \"2\" for uneventful wound healing with slight gingival edema, erythema, or discomfort but no suppuration; Score \"3\" for poor wound healing with significant gingival edema, erythema, discomfort, loss of barrier or any suppuration.","1 week, 2 weeks, 4 weeks, and 8 weeks","ALL","20 Years","80 Years",{"inclusion":62,"exclusion":63,"raw_text":64},[],[],"Inclusion Criteria:\n\n1. Age range: 20 to 80 years.\n2. Patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable.\n3. Non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers)\n4. Patients interested in implant placement following tooth extraction.\n\nExclusion Criteria:\n\n1. Allergies or hypersensitivities to study related medications.\n2. Hematologic disorders\u002Fblood dyscrasias.\n3. Active infectious diseases of any kind.\n4. Liver or kidney dysfunction\u002Ffailure.\n5. Uncontrolled diabetes (HbA1c \\> 8).\n6. Active cancer treatment - such as active chemotherapy or radiation therapy.\n7. Taking medications that will affect their bone healing (for example, bisphosphonates, Long-term NSAIDs use, Steroid).\n8. Metabolic bone diseases that affect bone healing such as osteoporosis.\n9. Pregnant or lactating women (self-reported).\n10. Smoke 10 or more cigarettes per day (self-reported).\n11. Poor oral hygiene.\n12. Systemic diseases that compromise the immune system\n13. Anti-coagulant therapy",[66,67],"ADULT","OLDER_ADULT",[69],{"facility":70,"city":71,"state":72,"zip":73,"country":74,"geoPoint":75},"University of Michigan School of Dentistry","Ann Arbor","Michigan","48109","United States",{"lat":76,"lon":77},42.27756,-83.74088,[],[80],{"name":81,"affiliation":12,"role":82},"Muhammad Saleh, BDS, MSD","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":86,"biomarkers":88},[87],"Wound healed",[],{"nct_id":4,"found":14,"summary":90,"prompt_version":90},null]