[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07094061":3,"trial-entities:NCT07094061":116,"trial-summary:NCT07094061":119},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":20,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":48,"secondary_outcomes":53,"sex":57,"minimum_age":58,"maximum_age":59,"healthy_volunteers":60,"eligibility_criteria":61,"std_ages":79,"locations":81,"central_contacts":110,"overall_officials":112,"references":114,"see_also_links":115},"NCT07094061","HUM00269332","Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model","RECRUITING","2028-08","2026-06","2026-06-10","2025-10-03","University of Michigan","OTHER",false,"This study seeks to understand individual differences in personality, brain function, and behavior.\n\nStudy hypothesis:\n\n\\- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.",null,[18,19],"Substance Use","Healthy",[21,22,23,24],"Functional magnetic resonance imaging (fMRI)","Questionnaires","Interviews","Behavioral tasks","INTERVENTIONAL","BASIC_SCIENCE",[28],"NA",{"count":30,"type":31},294,"ESTIMATED",[33,39,44],{"type":34,"name":35,"description":36,"armGroupLabels":37},"DEVICE","fMRI","Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.",[38],"Assessment group",{"type":40,"name":41,"description":42,"armGroupLabels":43},"BEHAVIORAL","Questionnaires and surveys","Participants will have multiple visits during this study and fill out various surveys at these visits.",[38],{"type":40,"name":45,"description":46,"armGroupLabels":47},"Behavioral tasks and eye tracking","Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.",[38],[49],{"measure":50,"description":51,"timeFrame":52},"Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score","PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with a cannabis use composite score based on the Substance Use History and Timeline Follow-Back.","Baseline",[54],{"measure":55,"description":56,"timeFrame":52},"Correlation between PavCA bias score (out-of-scanner) and activation from the Cannabis Cue Reactivity Task (P-CAN)","PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with the first principal component of average parameter estimates from the following regions extracted for the cannabis vs. neutral contrast: ventral striatum, anterior cingulate, posterior cingulate, insula, amygdala, orbitofrontal cortex, inferior occipital cortex, and inferior parietal cortex","ALL","18 Years","22 Years",true,{"inclusion":62,"exclusion":68,"raw_text":78},[63,64,65,66,67],"18-22 years old at baseline","Right-handed","Medically\u002Fphysically able to give informed consent","English-speaking","Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)",[69,70,71,72,73,74,75,76,77],"Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)","History of psychosis in self or first-degree relative","Current treatment for substance use disorder","Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)","Intelligence quotient (IQ) \\\u003C 70","Lifetime history of head trauma with loss of consciousness \\> 5 minutes","Reliance on glasses to be able to read small text at a distance of approximately 30 inches","Colorblindness","MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol","Inclusion Criteria:\n\n* 18-22 years old at baseline\n* Right-handed\n* Medically\u002Fphysically able to give informed consent\n* English-speaking\n* Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)\n\nExclusion Criteria:\n\n* Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)\n* History of psychosis in self or first-degree relative\n* Current treatment for substance use disorder\n* Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)\n* Intelligence quotient (IQ) \\\u003C 70\n* Lifetime history of head trauma with loss of consciousness \\> 5 minutes\n* Reliance on glasses to be able to read small text at a distance of approximately 30 inches\n* Colorblindness\n* MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol",[80],"ADULT",[82,100],{"facility":83,"status":7,"city":84,"state":85,"zip":86,"country":87,"contacts":88,"geoPoint":97},"Rachel Upjohn Building","Ann Arbor","Michigan","48109","United States",[89,94],{"name":90,"role":91,"phone":92,"email":93},"Loree Brennan O'Jack, CPA, MHSA","CONTACT","734-232-0227","loree@med.umich.edu",{"name":95,"role":96},"Lora M Cope, PhD","PRINCIPAL_INVESTIGATOR",{"lat":98,"lon":99},42.27756,-83.74088,{"facility":12,"status":101,"city":84,"state":85,"zip":86,"country":87,"contacts":102,"geoPoint":109},"NOT_YET_RECRUITING",[103,107],{"name":104,"role":91,"phone":105,"email":106},"Paul Holdefer, MPH","734-998-9239","holdefer@umich.edu",{"name":108,"role":96},"Lora Cope, PhD",{"lat":98,"lon":99},[111],{"name":104,"role":91,"phone":105,"email":106},[113],{"name":108,"affiliation":12,"role":96},[],[],{"nct_id":4,"conditions":117,"biomarkers":118},[18],[],{"nct_id":4,"found":60,"summary":120,"prompt_version":130},{"design":121,"status":122,"heading":123,"summary":124,"follow_up":125,"word_count":126,"commitments":127,"compensation":128,"drugs_mentioned":129},"This interventional study plans to enroll 294 participants. It is not specified if it is randomized or blinded.","completed","Understanding Brain Function and Behavior in Emerging Adults","This study aims to understand how personality, brain function, and behavior are connected in young adults aged 18-22. Researchers are looking at how different ways of processing information, called \"sign-tracking\" and \"goal-tracking,\" relate to attention, impulse control, and how the brain responds to rewards. You would have your brain scanned using an fMRI (functional magnetic resonance imaging), wear skin sensors, and complete questionnaires and behavioral tasks while your eye movements are tracked. The study is looking for a connection between a specific score related to how you respond to cues (Pavlovian conditioned approach bias score) and your cannabis use. The study is currently unclear about its recruitment status and plans to enroll 294 participants.","Not specified.",114,"You would have multiple visits, including an fMRI scan lasting about 90 minutes, and complete questionnaires and behavioral tasks with eye tracking.","Not stated in the trial record.",[35],"v2"]