[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07165795":3,"trial-entities:NCT07165795":88,"trial-summary:NCT07165795":92},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":24,"primary_purpose":25,"phases":26,"enrollment_info":28,"interventions":31,"primary_outcomes":38,"secondary_outcomes":46,"sex":62,"minimum_age":63,"maximum_age":16,"healthy_volunteers":64,"eligibility_criteria":65,"std_ages":72,"locations":75,"central_contacts":84,"overall_officials":85,"references":86,"see_also_links":87},"NCT07165795","2288149-1","Pilot Study to Evaluate the Effect of Transcendental Meditation on Telomere Activity and Well-Being Among Nurse Managers","ENROLLING_BY_INVITATION","2027-05","2025-09","2025-09-10","2025-05-18","Sarasota Memorial Health Care System","OTHER",false,"The objective of this study is to evaluate the impact of a health and coping strategy (Transcendental Meditation, or TM) on Telomere Length and Telomerase Activity (known markers of physiological and psychological stress and aging), Perceived Stress, Work Life Balance, Flourishing, Power as Knowing Participation in Change, and Burnout, among nurse managers.\n\nAim 1: To evaluate the effects of TM compared to usual care delayed instruction on TL and TA.\n\nAim 2: To evaluate the effects of TM compared to usual care delayed instruction on work life climate, flourishing, perceived stress, burnout, and power as knowing participation in change.",null,[18],"Meditation",[20,21,22,23],"nurse manager","well-being","telomere","meditation","INTERVENTIONAL","SUPPORTIVE_CARE",[27],"NA",{"count":29,"type":30},30,"ESTIMATED",[32],{"type":33,"name":34,"description":35,"armGroupLabels":36},"BEHAVIORAL","Transcendental Meditation","Standard TM instruction by certified TM teachers, including 4 days of initial training (60-90 min\u002Fday), then follow-up sessions (60-90 min) every 2-4 weeks.",[37],"Immediate TM Instruction",[39,43],{"measure":40,"description":41,"timeFrame":42},"Telomere Length","T\u002FS ratio; processed by UCSF Blackburn Labs SOP #104D","baseline, 1-month, 4-months",{"measure":44,"description":45,"timeFrame":42},"Telomerase Activity","(# positive copies\u002F10,000 input cells) ; processed by UCSF Blackburn Labs SOP #104D",[47,50,53,56,59],{"measure":48,"description":49,"timeFrame":42},"Work-Life Climate Scale","(Sexton, et al., 2017); measures work\u002Flife balance; responses range from 0-4; survey scores range 0-32, with lower scores reflecting better work\u002Flife balance.",{"measure":51,"description":52,"timeFrame":42},"Secure Flourishing Index, SFI","(Weziak-Bialowolska et al., 2019); measures multidimensional well-being; survey scores range from 0-120, with higher scores reflecting a higher level of flourishing.",{"measure":54,"description":55,"timeFrame":42},"Perceived Stress Scale-10 (PSS10)","(Cohen, 1988); measures the perception of stressful thoughts and feelings in preceding month; responses range from 0-40 with higher scores indicating higher levels of stress.",{"measure":57,"description":58,"timeFrame":42},"Maslach Burnout Inventory Human Services Survey for Medical Personnel","(Maslach \\& Jackson, 1984); Consists of three subscales: Emotional Exhaustion (9-items, score range 0-54, higher scores indicate more emotional exhaustion); Depersonalization (5-items, score range 0-18, higher scores indicate more depersonalization); and Personal Accomplishment (8-items, score range 0-48, higher scores indicate higher level of personal accomplishment).",{"measure":60,"description":61,"timeFrame":42},"Power as Knowing Participation in Change (PKPCT)","Barrett (1983, 1984, 2010); Scores range from 48-336 in four subscales with higher scores indicating higher levels of perceived power.","ALL","18 Years",true,{"inclusion":66,"exclusion":69,"raw_text":71},[67,68],"Nurse managers within the Sarasota Memorial Health Care System (SMHCS);","Stable for at least two months on any prescribed medications (for example, anti-anxiety or anti-depressant medications)",[70],"prior instruction in the TM technique","Inclusion Criteria:\n\n* Nurse managers within the Sarasota Memorial Health Care System (SMHCS);\n* Stable for at least two months on any prescribed medications (for example, anti-anxiety or anti-depressant medications)\n\nExclusion Criteria:\n\n* prior instruction in the TM technique",[73,74],"ADULT","OLDER_ADULT",[76],{"facility":12,"city":77,"state":78,"zip":79,"country":80,"geoPoint":81},"Sarasota","Florida","34239","United States",{"lat":82,"lon":83},27.33643,-82.53065,[],[],[],[],{"nct_id":4,"conditions":89,"biomarkers":91},[90],"Nurse Manager",[],{"nct_id":4,"found":14,"summary":16,"prompt_version":16}]