[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07182045":3,"trial-entities:NCT07182045":83,"trial-summary:NCT07182045":87},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":20,"study_type":23,"primary_purpose":24,"phases":25,"enrollment_info":27,"interventions":30,"primary_outcomes":38,"secondary_outcomes":43,"sex":44,"minimum_age":45,"maximum_age":46,"healthy_volunteers":47,"eligibility_criteria":48,"std_ages":58,"locations":61,"central_contacts":77,"overall_officials":80,"references":81,"see_also_links":82},"NCT07182045","HSC-MS-25-0413","Impact of Uterine and Ovarian Vessel Occlusion on Blood Loss in High Burden Minimally Invasive Myomectomy.","RECRUITING","2029-09-30","2026-05","2026-05-14","2025-09-18","The University of Texas Health Science Center, Houston","OTHER",false,"This study hypothesizes that temporary bilateral uterine and utero-ovarian artery occlusion with laparoscopic clamps at time of minimally invasive myomectomy will lead to a decreased blood loss at time of myomectomy compared to minimally invasive myomectomy without temporary occlusion.","Background: Leiomyomas are the most common benign tumor of the uterus and affect approximately 70-80% of the population with a uterus . Patients who opt to undergo treatment for a fibroid uterus have a variety of options including medical management, embolization, or surgical management; Historically surgical management involved hysterectomy; however, myomectomy has become more popular as a uterine sparing option. Current data supports that minimally invasive myomectomy is associated with lower morbidity and blood loss than traditional abdominal surgery. With advances in Minimally invasive myomectomy (MIS). There continues to be interest in methods to better improve intraoperative and postoperative outcomes. There is currently support for universal use of intramural vasopressin at time of myomectomy and a growing body of evidence to support temporary bilateral occlusion of the uterine and\u002For uteroovarian arteries at time of myomectomy to decrease blood loss.\n\nHigh myoma burden is associated with an increased blood loss at time of surgical management.\n\nPrevious studies assessing the utility in temporary occlusion of the uterine and\u002For utero-ovarian vessels have not specifically evaluated the impact on high myoma burden individuals. As higher myoma burden is addressed in a minimally invasive fashion, it is important to specifically evaluate techniques to optimize these procedures. This study will specifically evaluate the effect of temporary bilateral uterine artery and utero-ovarian occlusion with laparoscopic clamps at the time of minimally invasive myomectomy.",[18,19],"Myoma","Surgery",[21,22],"myoma","blood loss","INTERVENTIONAL","TREATMENT",[26],"NA",{"count":28,"type":29},120,"ESTIMATED",[31],{"type":13,"name":32,"description":33,"armGroupLabels":34,"otherNames":36},"Temporary clamping of uterine and ovarian vessels","Surgeon will temporarily clamp uterine and ovarian vessels.",[35],"Temporary vessel clamps",[37],"Vessel occlusion",[39],{"measure":40,"description":41,"timeFrame":42},"Estimated blood loss","Estimated blood loss during the surgery between groups, calculated by suction prior to irrigation.","Intraoperative (during surgery, which is \u003C 24 hours)",[],"FEMALE","18 Years",null,true,{"inclusion":49,"exclusion":52,"raw_text":57},[50,51],"Patient undergoing minimally invasive myomectomy with either a single intramural or Submucosal fibroid =\u002F\\>5cm or","Patients undergoing minimally invasive Myomectomy with =\u002F\\> 5 fibroids",[53,54,55,56],"Pregnancy,","Age \\\u003C18yo,","Patients undergoing concomitant surgery such as endometriosis surgery,","Suspected malignancy","Inclusion Criteria:\n\n* Patient undergoing minimally invasive myomectomy with either a single intramural or Submucosal fibroid =\u002F\\>5cm or\n* Patients undergoing minimally invasive Myomectomy with =\u002F\\> 5 fibroids\n\nExclusion Criteria:\n\n* Pregnancy,\n* Age \\\u003C18yo,\n* Patients undergoing concomitant surgery such as endometriosis surgery,\n* Suspected malignancy",[59,60],"ADULT","OLDER_ADULT",[62],{"facility":63,"status":7,"city":64,"state":65,"zip":66,"country":67,"contacts":68,"geoPoint":74},"Memorial Hermann Hospital","Houston","Texas","77030","United States",[69],{"name":70,"role":71,"phone":72,"email":73},"Randa Jalloul, MD","CONTACT","713-486-7700","randa.j.jalloul@uth.tmc.edu",{"lat":75,"lon":76},29.76328,-95.36327,[78],{"name":70,"role":71,"phone":79,"email":73},"3137128603",[],[],[],{"nct_id":4,"conditions":84,"biomarkers":86},[85],"Uterine Corpus Leiomyoma",[],{"nct_id":4,"found":47,"summary":88,"prompt_version":98},{"design":89,"status":90,"heading":91,"summary":92,"follow_up":93,"word_count":94,"commitments":95,"compensation":96,"drugs_mentioned":97},"This is an interventional study planning to enroll 120 women. It compares temporary clamping of uterine and ovarian vessels during surgery to no clamping.","completed","Temporary Vessel Clamping for Myomectomy Blood Loss","This study is looking at whether temporarily clamping the blood vessels to the uterus and ovaries during a minimally invasive myomectomy (surgery to remove fibroids) can reduce blood loss. Doctors will temporarily clamp these vessels in some patients during their surgery. The study aims to see if this technique helps reduce the amount of blood lost during the procedure. You might be able to join if you are a woman aged 18 or older, having a minimally invasive myomectomy for a single fibroid 5cm or larger, or for five or more fibroids. You cannot participate if you are pregnant, under 18, having other surgeries at the same time, or have suspected cancer. The study is currently unclear on its recruitment status, but plans to enroll 120 participants.","The primary endpoint, estimated blood loss, is measured during surgery, which is less than 24 hours.",127,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]