[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07227298":3,"trial-entities:NCT07227298":592,"trial-summary:NCT07227298":598},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":30,"primary_purpose":31,"phases":32,"enrollment_info":35,"interventions":38,"primary_outcomes":59,"secondary_outcomes":71,"sex":93,"minimum_age":94,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":95,"std_ages":112,"locations":115,"central_contacts":578,"overall_officials":584,"references":587,"see_also_links":588},"NCT07227298","C6461020","Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers","AN INTERVENTIONAL OPEN-LABEL PHASE 1B\u002F2 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF PF-08634404 IN COMBINATION WITH DIFFERENT ANTICANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS","RECRUITING","2033-08-23","2026-07","2026-07-22","2026-01-30","Pfizer","INDUSTRY",false,"This study is being done to learn more about a new medicine called PF-08634404 and how it works when used with other cancer medicines in people who have advanced solid tumors. An advanced solid tumor is a type of cancer that has spread beyond its original location and cannot be removed by surgery or cured with standard treatments.\n\nTo join in the study, participants must:\n\n* Be 18 years or older\n* Participants with advanced non-small cell lung cancer (NSCLC), a type of lung cancer that has spread\n\nThe study will look at:\n\n* Whether PF-08634404 is safe to use with other cancer medicines.\n* What side effects may happen. A side effect is anything the medicine does to your body that is not part of treating your disease.\n* Whether the combination of PF-08634404 and other cancer medicines can help treat solid tumors.\n\nThe study has different parts, each testing PF-08634404 with a different cancer medicine:\n\n* Part A will test PF-08634404 with a medicine called sigvotatug vedotin.\n* Part B of the study will look at how well the new medicine PF-08634404 works when used together with another medicine.\n\nParticipants will receive the study medicines through an intravenous (IV) infusion (injected into the vein) at the study clinic. All treatments will take place at clinical trial sites, where trained medical staff will monitor participants during and after each visit.",null,[19,20,21],"Advanced\u002FMetastatic Non-Small Cell Lung Cancer","Carcinoma, Non-Small Cell Lung","Non-Small Cell Lung Cancer",[23,24,25,26,27,28,29],"non-small cell lung cancer","NSCLC","advanced solid tumors","metastatic non-small cell lung cancer","locally advanced non-small cell lung cancer","squamous non-small cell lung cancer","non-squamous non-small cell lung cancer","INTERVENTIONAL","TREATMENT",[33,34],"PHASE1","PHASE2",{"count":36,"type":37},162,"ESTIMATED",[39,48,55],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":46},"BIOLOGICAL","PF-08634404","-Concentrate for solution for infusion",[44,45],"PF-08634404 + Combination Agent 1 (Part B)","PF-08634404 + Sigvotatug Vedotin (Part A)",[47],"SSGJ-707",{"type":40,"name":49,"description":50,"armGroupLabels":51,"otherNames":52},"Sigvotatug Vedotin","-Powder for concentrate for solution for infusion. Single use vial",[45],[53,54],"SGN-B6A","PF-08046047",{"type":40,"name":56,"description":57,"armGroupLabels":58},"Combination Agent 1","-Powder for concentrate for solution for infusion. Single use vial.",[44],[60,64,67],{"measure":61,"description":62,"timeFrame":63},"Number of Participants with Treatment Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)","AEs as characterized by type, frequency, severity (as graded by NCI CTCAE version 5.0), timing, seriousness, and relationship to study intervention.","Through 90 days after the last study intervention; Up to approximately 5 years",{"measure":65,"description":66,"timeFrame":63},"Phase I: Number of participants with dose limiting toxicity (DLT)","Dose limiting toxicity based on dose limiting toxicity evaluable participants. The number of participants who experienced DLTs during the DLT observation period.",{"measure":68,"description":69,"timeFrame":70},"Phase 2: Confirmed Objective Response Rate (ORR) per RECIST v1.1 by investigator","ORR is defined as the proportion of participants with a Best Overall Response (BOR) of confirmed Complete Response (CR) or confirmed Partial Response (PR) per RECIST v1.1.","Up to approximately 5 Years",[72,74,78,81,84,86,90],{"measure":73,"description":69,"timeFrame":70},"Phase I: Confirmed ORR per RECIST v1.1 by investigator",{"measure":75,"description":76,"timeFrame":77},"Disease Control Rate (DCR) per RECIST v1.1 by investigator","DCR by investigator assessment is defined as the proportion of participants with CR or PR with confirmation, or Stable Disease (SD) by investigator assessment per RECIST version 1.1.","Up to approximately 5 years",{"measure":79,"description":80,"timeFrame":77},"Duration of Response (DOR) per RECIST v1.1 by investigator","DOR is defined as the time from the first documentation of objective response (CR or PR that is subsequently confirmed) to the date of first documented disease progression per RECIST v1.1 or death due to any cause, whichever occurs first.",{"measure":82,"description":83,"timeFrame":77},"Progression Free Survival (PFS) per RECIST v1.1 by investigator","Progression-free survival is defined as the time from the date of randomization to the date of the first documentation of objective PD assessed by investigator per RECIST v1.1, or death due to any cause, whichever occurs first.",{"measure":85,"timeFrame":63},"Number of Participants With Clinical Laboratory Abnormalities",{"measure":87,"description":88,"timeFrame":89},"Pharmacokinetics (PK): Serum concentration of PF-08634404 with anticancer agents","To characterize the pharmacokinetics (PK) of PF-08634404 with anticancer agents.","Up to 37 days after the last dose of treatment",{"measure":91,"description":92,"timeFrame":89},"Incidence of Anti-Drug Antibody (ADA) against PF-08634404 with anticancer agents","To characterize the immunogenicity of PF-08634404 with anticancer agents.","ALL","18 Years",{"inclusion":96,"exclusion":103,"raw_text":111},[97,98,99,100,101,102],"Pathologically confirmed locally advanced (Stage IIIB\u002FIIIC) or metastatic (Stage IV) squamous or non-squamous NSCLC and are not a candidate for complete surgical resection and curative concurrent\u002Fsequential chemoradiotherapy","PD-L1 status available","Part B only: PD-L1 ≥ TPS 1%","Measurable disease based on RECIST v1.1 per investigator.","Eastern Cooperative Oncology Group performance status of 0 or 1.","Adequate organ function",[104,105,106,107,108,109,110],"Participants with known AGAs including EGFR, ALK and ROS1, NTRK, BRAF, and MET","History of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy","Known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression","Leptomeningeal disease","Active autoimmune diseases requiring systemic treatment within the past 2 years","Previous systemic anti-tumor therapy for locally advanced, unresectable, or metastatic NSCLC","Previous treatment with immunotherapy (exception is (neo)adjuvant anti-PD-(L)1), ADCs containing MMAE payload, systemic anti-angiogenic therapy, or prior radiotherapy to the lung within 6 months of first dose of study intervention","Inclusion Criteria:\n\n* Pathologically confirmed locally advanced (Stage IIIB\u002FIIIC) or metastatic (Stage IV) squamous or non-squamous NSCLC and are not a candidate for complete surgical resection and curative concurrent\u002Fsequential chemoradiotherapy\n* PD-L1 status available\n* Part B only: PD-L1 ≥ TPS 1%\n* Measurable disease based on RECIST v1.1 per investigator.\n* Eastern Cooperative Oncology Group performance status of 0 or 1.\n* Adequate organ function\n\nExclusion Criteria:\n\n* Participants with known AGAs including EGFR, ALK and ROS1, NTRK, BRAF, and MET\n* History of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy\n* Known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression\n* Leptomeningeal disease\n* Active autoimmune diseases requiring systemic treatment within the past 2 years\n* Previous systemic anti-tumor therapy for locally advanced, unresectable, or metastatic NSCLC\n* Previous treatment with immunotherapy (exception is (neo)adjuvant anti-PD-(L)1), ADCs containing MMAE payload, systemic anti-angiogenic therapy, or prior radiotherapy to the lung within 6 months of first dose of study intervention",[113,114],"ADULT","OLDER_ADULT",[116,125,131,137,145,148,151,158,161,168,176,184,191,198,201,204,211,219,222,225,232,239,246,254,262,270,277,281,288,295,303,306,310,314,316,323,330,340,348,356,364,373,381,389,398,407,415,419,428,433,441,448,457,465,470,478,486,490,497,501,509,516,523,526,530,534,541,544,552,556,563,570,574],{"facility":117,"status":8,"city":118,"state":119,"zip":120,"country":121,"geoPoint":122},"Highlands Oncology Group, PA","Fayetteville","Arkansas","72703","United States",{"lat":123,"lon":124},36.06258,-94.15743,{"facility":117,"status":8,"city":126,"state":119,"zip":127,"country":121,"geoPoint":128},"Rogers","72758",{"lat":129,"lon":130},36.33202,-94.11854,{"facility":117,"status":8,"city":132,"state":119,"zip":133,"country":121,"geoPoint":134},"Springdale","72762",{"lat":135,"lon":136},36.18674,-94.12881,{"facility":138,"status":8,"city":139,"state":140,"zip":141,"country":121,"geoPoint":142},"Providence Medical Foundation","Fullerton","California","92835",{"lat":143,"lon":144},33.87029,-117.92534,{"facility":146,"status":8,"city":139,"state":140,"zip":141,"country":121,"geoPoint":147},"Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center and Infusion Center",{"lat":143,"lon":144},{"facility":149,"status":8,"city":139,"state":140,"zip":141,"country":121,"geoPoint":150},"Providence St. Jude Medical Center",{"lat":143,"lon":144},{"facility":152,"status":8,"city":153,"state":140,"zip":154,"country":121,"geoPoint":155},"Valkyrie Clinical Trials (Additional Site Pharmacy Storage Suite)","Los Angeles","90067",{"lat":156,"lon":157},34.05223,-118.24368,{"facility":159,"status":8,"city":153,"state":140,"zip":154,"country":121,"geoPoint":160},"Valkyrie Clinical Trials",{"lat":156,"lon":157},{"facility":162,"status":8,"city":163,"state":140,"zip":164,"country":121,"geoPoint":165},"Mission Community Hospital (Satellite Site)","Panorama City","91402",{"lat":166,"lon":167},34.22473,-118.44981,{"facility":169,"status":8,"city":170,"state":171,"zip":172,"country":121,"geoPoint":173},"Rocky Mountain Cancer Centers, LLP","Denver","Colorado","80218",{"lat":174,"lon":175},39.73915,-104.9847,{"facility":177,"status":8,"city":178,"state":179,"zip":180,"country":121,"geoPoint":181},"BRCR Medical Center Inc.","Coral Springs","Florida","33065",{"lat":182,"lon":183},26.27119,-80.2706,{"facility":185,"status":8,"city":186,"state":179,"zip":187,"country":121,"geoPoint":188},"Mid Florida Hematology and Oncology Center","Orange City","32763",{"lat":189,"lon":190},28.94888,-81.29867,{"facility":192,"status":8,"city":193,"state":179,"zip":194,"country":121,"geoPoint":195},"Orlando Health Ambulatory Care Center","Orlando","32806",{"lat":196,"lon":197},28.53834,-81.37924,{"facility":199,"status":8,"city":193,"state":179,"zip":194,"country":121,"geoPoint":200},"Orlando Health Cancer Institute",{"lat":196,"lon":197},{"facility":202,"status":8,"city":193,"state":179,"zip":194,"country":121,"geoPoint":203},"Orlando Health Orlando Regional Medical Center",{"lat":196,"lon":197},{"facility":205,"status":8,"city":206,"state":179,"zip":207,"country":121,"geoPoint":208},"BRCR Global - Tamarac","Tamarac","33321",{"lat":209,"lon":210},26.21286,-80.24977,{"facility":212,"status":8,"city":213,"state":214,"zip":215,"country":121,"geoPoint":216},"Hackensack University Medical Center","Hackensack","New Jersey","07601",{"lat":217,"lon":218},40.88593,-74.04347,{"facility":220,"status":8,"city":213,"state":214,"zip":215,"country":121,"geoPoint":221},"John Theurer Cancer Center at Hackensack University Medical Center",{"lat":217,"lon":218},{"facility":223,"status":8,"city":213,"state":214,"zip":215,"country":121,"geoPoint":224},"Newman Street Imaging",{"lat":217,"lon":218},{"facility":226,"status":8,"city":227,"state":214,"zip":228,"country":121,"geoPoint":229},"John Theurer Cancer Center at JSUMC","Neptune City","07753",{"lat":230,"lon":231},40.20011,-74.02792,{"facility":233,"status":8,"city":234,"state":214,"zip":235,"country":121,"geoPoint":236},"John Theurer Cancer Center at From Road","Paramus","07652",{"lat":237,"lon":238},40.94454,-74.07542,{"facility":240,"status":8,"city":241,"state":214,"zip":242,"country":121,"geoPoint":243},"Heart Center Glenpointe","Teaneck","07666",{"lat":244,"lon":245},40.8976,-74.01597,{"facility":247,"status":8,"city":248,"state":249,"zip":250,"country":121,"geoPoint":251},"Montefiore Medical Center- Montefiore Medical Park","The Bronx","New York","10461",{"lat":252,"lon":253},40.84985,-73.86641,{"facility":255,"status":8,"city":256,"state":257,"zip":258,"country":121,"geoPoint":259},"Oncology Associates of Oregon, P.C.","Eugene","Oregon","97401",{"lat":260,"lon":261},44.05207,-123.08675,{"facility":263,"status":8,"city":264,"state":265,"zip":266,"country":121,"geoPoint":267},"Dallas Cancer Specialists","Garland","Texas","75042",{"lat":268,"lon":269},32.91262,-96.63888,{"facility":271,"status":8,"city":272,"state":265,"zip":273,"country":121,"geoPoint":274},"Southwest Oncology Associates","Houston","77030",{"lat":275,"lon":276},29.76328,-95.36327,{"facility":278,"status":8,"city":272,"state":265,"zip":279,"country":121,"geoPoint":280},"Lumi Research","77090",{"lat":275,"lon":276},{"facility":282,"status":8,"city":283,"state":265,"zip":284,"country":121,"geoPoint":285},"US Oncology Investigational Products Center (IPC)","Irving","75063",{"lat":286,"lon":287},32.81402,-96.94889,{"facility":289,"status":8,"city":290,"state":265,"zip":291,"country":121,"geoPoint":292},"Voyage Clinical","Sugar Land","77479",{"lat":293,"lon":294},29.61968,-95.63495,{"facility":296,"status":8,"city":297,"state":298,"zip":299,"country":121,"geoPoint":300},"VCU Medical Center Gateway Building","Richmond","Virginia","23219",{"lat":301,"lon":302},37.55376,-77.46026,{"facility":304,"status":8,"city":297,"state":298,"zip":299,"country":121,"geoPoint":305},"Virginia Commonwealth University",{"lat":301,"lon":302},{"facility":307,"status":8,"city":297,"state":298,"zip":308,"country":121,"geoPoint":309},"VCU Health Stony Point","23235",{"lat":301,"lon":302},{"facility":311,"status":8,"city":297,"state":298,"zip":312,"country":121,"geoPoint":313},"Massey Cancer Center Clinical & Translational Research Lab","23298",{"lat":301,"lon":302},{"facility":304,"status":8,"city":297,"state":298,"zip":312,"country":121,"geoPoint":315},{"lat":301,"lon":302},{"facility":317,"status":8,"city":318,"state":298,"zip":319,"country":121,"geoPoint":320},"VCU Health Community Memorial Hospital","South Hill","23970",{"lat":321,"lon":322},36.72653,-78.12889,{"facility":324,"status":8,"city":325,"state":298,"zip":326,"country":121,"geoPoint":327},"VCU Health Tappahannock Hospital","Tappahannock","22560",{"lat":328,"lon":329},37.92541,-76.85913,{"facility":331,"status":332,"city":333,"state":334,"zip":335,"country":336,"geoPoint":337},"Beijing Cancer hospital","NOT_YET_RECRUITING","Beijing","Beijing Municipality","100142","China",{"lat":338,"lon":339},39.9075,116.39723,{"facility":341,"status":332,"city":342,"state":343,"zip":344,"country":336,"geoPoint":345},"Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology","Wuhan","Hubei","430030",{"lat":346,"lon":347},30.58333,114.26667,{"facility":349,"status":8,"city":350,"state":351,"zip":352,"country":336,"geoPoint":353},"Shanghai Chest Hospital","Shanghai","Shanghai Municipality","200030",{"lat":354,"lon":355},31.22222,121.45806,{"facility":357,"status":332,"city":358,"state":359,"zip":360,"country":336,"geoPoint":361},"Taizhou Hospital of Zhejiang Province","Taizhou","Zhejiang","317000",{"lat":362,"lon":363},28.66266,121.43312,{"facility":365,"status":8,"city":366,"state":367,"zip":368,"country":369,"geoPoint":370},"Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest","Bordeaux","Aquitaine","33076","France",{"lat":371,"lon":372},44.84124,-0.58046,{"facility":374,"status":8,"city":375,"state":376,"zip":377,"country":369,"geoPoint":378},"Centre Georges François Leclerc","Dijon","CÔTE D'OR","21079",{"lat":379,"lon":380},47.31344,5.01391,{"facility":382,"status":8,"city":383,"state":384,"zip":385,"country":369,"geoPoint":386},"Institut Paoli-Calmettes","Marseille","Provence-Alpes-Côte d'Azur Region","13273",{"lat":387,"lon":388},43.29695,5.38107,{"facility":390,"status":8,"city":391,"state":392,"zip":393,"country":394,"geoPoint":395},"Marien Hospital Düsseldorf","Düsseldorf","North Rhine-Westphalia","40479","Germany",{"lat":396,"lon":397},51.22319,6.77927,{"facility":399,"status":332,"city":400,"state":401,"zip":402,"country":403,"geoPoint":404},"Azienda Sanitaria Territoriale Pesaro Urbino (AST PU)","Fano","Pesaro AND Urbino","61032","Italy",{"lat":405,"lon":406},43.84052,13.01665,{"facility":408,"status":332,"city":409,"state":410,"zip":411,"country":403,"geoPoint":412},"IRCCS Istituto Nazionale dei Tumori Regina Elena","Roma","ROME","00144",{"lat":413,"lon":414},44.99364,11.10642,{"facility":416,"status":332,"city":409,"state":410,"zip":417,"country":403,"geoPoint":418},"Ospedale Isola Tiberina - Gemelli Isola","00186",{"lat":413,"lon":414},{"facility":420,"status":8,"city":421,"state":422,"zip":423,"country":424,"geoPoint":425},"Kansai Medical University Hospital","Hirakata","Osaka","573-1191","Japan",{"lat":426,"lon":427},34.81352,135.64914,{"facility":429,"status":8,"city":430,"state":431,"zip":432,"country":424},"Shizuoka Cancer Center","Nagaizumi-cho","Shizuoka","411-8777",{"facility":434,"status":8,"city":435,"zip":436,"country":437,"geoPoint":438},"Pan American Center for Oncology Trials, LLC","Rio Piedras","00935","Puerto Rico",{"lat":439,"lon":440},18.39745,-66.04989,{"facility":442,"status":8,"city":443,"zip":444,"country":437,"geoPoint":445},"BRCR Global Puerto Rico - Hato Rey","San Juan","00917",{"lat":446,"lon":447},18.46633,-66.10572,{"facility":449,"status":8,"city":450,"state":451,"zip":452,"country":453,"geoPoint":454},"HT Médica Jaen LAs Nieves","Jaén","Andalusia","23007","Spain",{"lat":455,"lon":456},37.76922,-3.79028,{"facility":458,"status":8,"city":459,"state":460,"zip":461,"country":453,"geoPoint":462},"Hospital Universitari Vall d'Hebron","Barcelona","Barcelona [barcelona]","08035",{"lat":463,"lon":464},41.38879,2.15899,{"facility":466,"status":8,"city":459,"state":467,"zip":468,"country":453,"geoPoint":469},"Hospital de la Santa Creu i Sant Pau","Catalunya [cataluña]","08041",{"lat":463,"lon":464},{"facility":471,"status":8,"city":472,"state":473,"zip":474,"country":453,"geoPoint":475},"Hospital Jerez de la Frontera","Jerez de la Frontera","Cádiz","11407",{"lat":476,"lon":477},36.68645,-6.13606,{"facility":479,"status":8,"city":480,"state":481,"zip":482,"country":453,"geoPoint":483},"Hospital Nuestra Señora del Rosario","Madrid","Madrid, Comunidad de","280006",{"lat":484,"lon":485},40.4165,-3.70256,{"facility":487,"status":8,"city":480,"state":481,"zip":488,"country":453,"geoPoint":489},"Hospital Universitario 12 de Octubre","28041",{"lat":484,"lon":485},{"facility":491,"status":8,"city":492,"state":492,"zip":493,"country":453,"geoPoint":494},"Hospital Universitario Virgen de la Victoria","Málaga","29010",{"lat":495,"lon":496},36.72016,-4.42034,{"facility":498,"status":8,"city":492,"state":492,"zip":499,"country":453,"geoPoint":500},"Clínica Radiólogica Mario Gallegos","29016",{"lat":495,"lon":496},{"facility":502,"status":332,"city":503,"state":504,"zip":505,"country":453,"geoPoint":506},"Fundación Instituto Valenciano de Oncología","Valencia","Valenciana, Comunitat","46009",{"lat":507,"lon":508},39.47391,-0.37966,{"facility":510,"status":8,"city":511,"zip":512,"country":453,"geoPoint":513},"Hospital Universitario Puerta del Mar","Cadiz","11009",{"lat":514,"lon":515},36.52672,-6.2891,{"facility":517,"status":8,"city":518,"zip":519,"country":453,"geoPoint":520},"Hospital Universitario San Cecilio","Granada","18016",{"lat":521,"lon":522},37.18817,-3.60667,{"facility":524,"status":8,"city":450,"zip":452,"country":453,"geoPoint":525},"Hospital Universitario de Jaen",{"lat":455,"lon":456},{"facility":527,"status":8,"city":480,"zip":528,"country":453,"geoPoint":529},"Hospital Clinico San Carlos","28040",{"lat":484,"lon":485},{"facility":531,"status":8,"city":492,"zip":532,"country":453,"geoPoint":533},"Cadpet Malaga","29006",{"lat":495,"lon":496},{"facility":535,"status":8,"city":536,"zip":537,"country":453,"geoPoint":538},"Hospital Universitario Virgen Macarena","Seville","41009",{"lat":539,"lon":540},37.38283,-5.97317,{"facility":542,"status":8,"city":536,"zip":537,"country":453,"geoPoint":543},"VIVO Capuchinos",{"lat":539,"lon":540},{"facility":545,"status":8,"city":546,"zip":547,"country":548,"geoPoint":549},"Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung City","807","Taiwan",{"lat":550,"lon":551},22.61626,120.31333,{"facility":553,"status":8,"city":546,"zip":554,"country":548,"geoPoint":555},"Chang Gung Memorial Hospital at Kaohsiung","83301",{"lat":550,"lon":551},{"facility":557,"status":8,"city":558,"zip":559,"country":548,"geoPoint":560},"National Cheng Kung University Hospital","Tainan","704",{"lat":561,"lon":562},22.99083,120.21333,{"facility":564,"status":332,"city":565,"zip":566,"country":548,"geoPoint":567},"National Taiwan University Hospital","Taipei","100",{"lat":568,"lon":569},25.05306,121.52639,{"facility":571,"status":8,"city":565,"zip":572,"country":548,"geoPoint":573},"Mackay Memorial Hospital","10449",{"lat":568,"lon":569},{"facility":575,"status":8,"city":565,"zip":576,"country":548,"geoPoint":577},"Taipei Veterans General Hospital","11217",{"lat":568,"lon":569},[579],{"name":580,"role":581,"phone":582,"email":583},"Pfizer CT.gov Call Center","CONTACT","1-800-718-1021","ClinicalTrials.gov_Inquiries@pfizer.com",[585],{"name":580,"affiliation":13,"role":586},"STUDY_DIRECTOR",[],[589],{"label":590,"url":591},"To obtain contact information for a study center near you, click here.","https:\u002F\u002Fpmiform.com\u002Fclinical-trial-info-request?StudyID=C6461020",{"nct_id":4,"conditions":593,"biomarkers":596},[594,595],"Lung Non-Small Cell Carcinoma","Solid Neoplasm",[597],"Programmed Cell Death 1 Ligand 1",{"nct_id":4,"found":599,"summary":600,"prompt_version":610},true,{"design":601,"status":602,"heading":603,"summary":604,"follow_up":605,"word_count":606,"commitments":607,"compensation":608,"drugs_mentioned":609},"This is an interventional study, meaning participants will receive specific treatments. It plans to enroll 162 participants.","completed","Study of PF-08634404 with Other Cancer Agents in Advanced Cancers","This study is investigating PF-08634404, a biological medicine given as an infusion, in combination with other anti-cancer agents like Sigvotatug Vedotin, for people with advanced non-small cell lung cancer (NSCLC). Researchers want to learn if these combinations are safe and what side effects might occur. For some parts of the study, your cancer's PD-L1 status must be at least 1%. The study will also measure how many participants respond to the treatment. You may be eligible if you are 18 or older and have advanced NSCLC that cannot be surgically removed or cured with standard treatments. The study aims to enroll 162 participants, but its current status is unclear.","Participants will be followed for treatment-related events for up to approximately 5 years after their last study intervention.",109,"Not specified in the trial record.","Not stated in the trial record.",[41,49],"v2"]