[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07227402":3,"trial-entities:NCT07227402":1427,"trial-summary:NCT07227402":1430},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":49,"secondary_outcomes":57,"sex":95,"minimum_age":96,"maximum_age":17,"healthy_volunteers":97,"eligibility_criteria":98,"std_ages":119,"locations":122,"central_contacts":1410,"overall_officials":1415,"references":1419,"see_also_links":1420},"NCT07227402","6482-033","A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)","A Phase 3, Randomized, Open-label Study of Belzutifan + Zanzalintinib Versus Cabozantinib in Participants With Advanced RCC Who Experienced Disease Recurrence During or After Prior Adjuvant Anti-PD-1\u002FL1 Therapy (LITESPARK-033)","RECRUITING","2032-02-27","2026-07","2026-08-03","2025-11-26","Merck Sharp & Dohme LLC","INDUSTRY",true,"Researchers are looking for more ways to treat advanced renal cell carcinoma (RCC) that is recurrent. Researchers want to learn if recurrent advanced renal cell carcinoma (RCC) responds (gets smaller or goes away) after treatment with belzutifan (MK-6482) and zanzalintinib compared to cabozantinib.\n\nThe goal of this study is to learn if:\n\nPeople who take belzutifan and zanzalintinib live longer overall and without the cancer getting worse than people who take cabozantinib.",null,[19],"Renal Cell Carcinoma",[21,22,23,24],"Carcinoma","Renal cell","Belzutifan","Zanzalintinib","INTERVENTIONAL","TREATMENT",[28],"PHASE3",{"count":30,"type":31},904,"ESTIMATED",[33,42,46],{"type":34,"name":23,"description":35,"armGroupLabels":36,"otherNames":38},"DRUG","Administered orally QD",[37],"Belzutifan plus Zanzalintinib",[39,40,41],"MK-6482","PT2977","WELIREG™",{"type":34,"name":24,"description":35,"armGroupLabels":43,"otherNames":44},[37],[45],"XL092",{"type":34,"name":47,"description":35,"armGroupLabels":48},"Cabozantinib",[47],[50,54],{"measure":51,"description":52,"timeFrame":53},"Progression Free Survival (PFS)","PFS is defined as the time from randomization to the first documented progressive disease (PD) or death due to any cause, whichever occurs first. PD will be assessed by Response Criteria in Solid Tumors Version 1.1 (RECIST 1.1). PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD. PFS as assessed by blinded independent central review (BICR) will be presented.","Up to approximately 73 months",{"measure":55,"description":56,"timeFrame":53},"Overall Survival (OS)","OS is defined as the time from randomization to death due to any cause.",[58,61,64,67,70,74,77,80,83,86,89,92],{"measure":59,"description":60,"timeFrame":53},"Objective Response Rate (ORR)","ORR is defined as the percentage of participants with Complete Response (CR: disappearance of all target lesions) or Partial Response (PR: at least a 30% decrease in the sum of diameters of target lesions) per Response Evaluation Criteria In Solid Tumors Version 1.1 (RECIST 1.1). The percentage of participants who experience CR or PR as assessed by Blinded Independent Central Review (BICR) will be presented.",{"measure":62,"description":63,"timeFrame":53},"Duration of Response (DOR)","For participants who demonstrate a confirmed Complete Response (CR: disappearance of all target lesions) or Partial Response (PR: at least a 30% decrease in the sum of diameters of target lesions) per Response Evaluation Criteria In Solid Tumors Version 1.1 (RECIST 1.1), DOR is defined as the time from first documented evidence of CR or PR until progressive disease (PD) or death. Per RECIST 1.1, PD is defined as at least a 20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. The appearance of one or more new lesions is also considered PD. DOR as assessed by Blinded Independent Central Review (BICR) will be presented.",{"measure":65,"description":66,"timeFrame":53},"Number of Participants Who Experience One or More Adverse Events (AEs)","An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention. The number of participants who experienced an AE will be reported.",{"measure":68,"description":69,"timeFrame":53},"Number of Participants Who Discontinue Study Treatment due to an AE","An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention. The number of participants who discontinue the study treatment due to an AE will be reported.",{"measure":71,"description":72,"timeFrame":73},"Change From Baseline in European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) Global Health\u002FHealth-Related Quality of Life (HRQoL) Items 29 and 30 Combined Score","The EORTC QLQ-C30 is a cancer specific health-related quality-of life (QoL) questionnaire. Participant responses to the questions regarding Global Health Status (GHS; \"How would you rate your overall health during the past week?\") and Quality of Life (QoL; \"How would you rate your overall quality of life during the past week?\") are scored on a 7-point scale (1= Very poor to 7=Excellent), then summed. Summed raw scores are standardized by linear transformation so that scores ranged from 0 to 100, with a higher score indicating a better overall outcome.","Up to approximately 25 months",{"measure":75,"description":76,"timeFrame":73},"Change From Baseline in EORTC QLC-C30 Physical Functioning Items 1-5 Score","The EORTC QLQ-C30 is a cancer specific health-related quality-of life (QoL) questionnaire. Participant responses to 5 questions about their physical functioning (Items 1-5) are scored on a 4-point scale (1=Not at All to 4=Very Much). The combined score of items 1 to 5 was computed by averaging the raw scores of the 5 items and then applying a linear transformation to standardize the average score, so that the combined scores range from 0-100. A higher score indicates a better outcome.",{"measure":78,"description":79,"timeFrame":73},"Change From Baseline in EORTC QLQ-C30 Role Functioning Items 6-7 Score","The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to 2 questions about their role functioning are scored on a 4-point scale (1=Not at All to 4=Very Much). Summed raw scores are standardized by linear transformation so that scores ranged from 0 to 100, with a higher score indicating a better level of functioning.",{"measure":81,"description":82,"timeFrame":73},"Change From Baseline in Functional Assessment of Cancer Therapy-Kidney Symptom Index-Disease-related Symptoms (FKSI-DRS) Items 1-9 Score","The FKSI-DRS index consists of a 9-item questionnaire that assesses the extent of participant symptoms from kidney cancer. Responses are scored on a 5-point scale (0=Not at all to 4=Very much) and summed to generate an index symptom score. These scores can range from 0 to 36, with a higher score indicating more favorable kidney cancer symptom status.",{"measure":84,"description":85,"timeFrame":73},"Time From Baseline to First Deterioration in EORTC-QLC-C30 Global Health\u002FHRQoL Score","Time to True Deterioration (TTD) is defined as the time from baseline to the first onset of a ≥10-point decrease with confirmation by the subsequent visit of a ≥10-point decrease in Items 29 and 30 scale scores. A longer TTD indicates a better outcome. TTD is reported based on the product-limit (Kaplan-Meier) method for censored data.",{"measure":87,"description":88,"timeFrame":73},"Time From Baseline to First Deterioration in EORTC-QLC-C30 Physical Functioning Score","TTD is defined as the time from baseline to the first onset of a ≥10-point deterioration (decrease) from baseline in physical functioning score (EORTC QLQ-C30 Items 1-5). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. The TTD, as assessed based on a ≥10-point negative change (decrease) from baseline in physical functioning score will be presented. A longer TTD indicates a better outcome.",{"measure":90,"description":91,"timeFrame":73},"Time From Baseline to First Deterioration in EORTC-QLC-C30 Role Functioning Score","TTD is defined as the time from baseline to the first onset of a ≥10-point negative change (decrease) from baseline in role functioning (EORTC QLQ-C30 Items 6 and 7) score. Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. The TTD, as assessed based on a ≥10 point negative change (decrease) from baseline in role functioning score, will be presented. A longer TTD indicates a better outcome.",{"measure":93,"description":94,"timeFrame":73},"Time From Baseline to First Deterioration in FKSI-DRS Score","TTD is defined as time from the first dose of study treatment to the date of deterioration of FKSI-DRS Score. Each item is scored on a 5-point scale (0=not at all to 4=very much). FKSI-DRS total score ranged from 0 (most severe symptoms) to 36 (no symptoms) with a higher score indicating a better outcome. Deterioration is defined as a 3-point decrease (i.e. lower score) in symptom score and the time to true deterioration is the time to first onset of 3 or more decreases from baseline with confirmation under right-censoring rule (the last observation). A longer TTD indicates a better outcome.","ALL","18 Years",false,{"inclusion":99,"exclusion":104,"raw_text":118},[100,101,102,103],"Has a histologically confirmed diagnosis of unresectable, advanced renal cell cancer (RCC) with clear cell component (with or without sarcomatoid features) i.e., Stage IV renal cell cancer per American Joint Committee on Cancer (AJCC) (8th Edition)","Has measurable disease per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1)","Has disease recurrence during adjuvant anti-programmed cell death 1\u002Fprogrammed cell death ligand 1 (PD-1\u002FL1) therapy or recurrence ≤24 months following the last dose of adjuvant anti-PD-1\u002FL1 therapy","Has received no other prior systemic therapy for their RCC except for their adjuvant anti-PD-1\u002FL1 therapy",[105,106,107,108,109,110,111,112,113,114,115,116,117],"Has clinically significant cardiovascular disease within 12 months from first dose of study intervention, including New York Heart Association Class III or IV congestive heart failure, unstable angina, new-onset angina, pulmonary embolism, myocardial infarction, cerebral vascular accident, or cardiac arrhythmia associated with hemodynamic instability","Had deep vein thrombosis within 3 months before randomization unless stable, asymptomatic, and treated with therapeutic anticoagulation for at least 4 weeks before randomization","Has a left ventricular ejection fraction ≤50% or below the institutional (or local laboratory) normal range as determined by multigated acquisition or echocardiogram","Has had major surgery within 8 weeks before randomization or has not adequately recovered from major surgery or has ongoing surgical complications","Has current pneumonitis\u002Finterstitial lung disease","Has symptomatic pleural effusion (for example cough, dyspnea, pleuritic chest pain), ascites, or pericardial fluid requiring drainage within 4 weeks prior to randomization","Has a gastrointestinal disorder including those associated with a high risk of perforation or fistula formation","Has a serious active nonhealing wound\u002Fulcer\u002Fbone fracture","Has a requirement for hemodialysis or peritoneal dialysis","Has history of human immunodeficiency virus infection","Has hepatitis B or hepatitis C virus","Has pharmacologically uncompensated, symptomatic hypothyroidism","Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has a histologically confirmed diagnosis of unresectable, advanced renal cell cancer (RCC) with clear cell component (with or without sarcomatoid features) i.e., Stage IV renal cell cancer per American Joint Committee on Cancer (AJCC) (8th Edition)\n* Has measurable disease per Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1)\n* Has disease recurrence during adjuvant anti-programmed cell death 1\u002Fprogrammed cell death ligand 1 (PD-1\u002FL1) therapy or recurrence ≤24 months following the last dose of adjuvant anti-PD-1\u002FL1 therapy\n* Has received no other prior systemic therapy for their RCC except for their adjuvant anti-PD-1\u002FL1 therapy\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Has clinically significant cardiovascular disease within 12 months from first dose of study intervention, including New York Heart Association Class III or IV congestive heart failure, unstable angina, new-onset angina, pulmonary embolism, myocardial infarction, cerebral vascular accident, or cardiac arrhythmia associated with hemodynamic instability\n* Had deep vein thrombosis within 3 months before randomization unless stable, asymptomatic, and treated with therapeutic anticoagulation for at least 4 weeks before randomization\n* Has a left ventricular ejection fraction ≤50% or below the institutional (or local laboratory) normal range as determined by multigated acquisition or echocardiogram\n* Has had major surgery within 8 weeks before randomization or has not adequately recovered from major surgery or has ongoing surgical complications\n* Has current pneumonitis\u002Finterstitial lung disease\n* Has symptomatic pleural effusion (for example cough, dyspnea, pleuritic chest pain), ascites, or pericardial fluid requiring drainage within 4 weeks prior to randomization\n* Has a gastrointestinal disorder including those associated with a high risk of perforation or fistula formation\n* Has a serious active nonhealing wound\u002Fulcer\u002Fbone fracture\n* Has a requirement for hemodialysis or peritoneal dialysis\n* Has history of human immunodeficiency virus infection\n* Has hepatitis B or hepatitis C virus\n* Has pharmacologically uncompensated, symptomatic hypothyroidism\n* Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention",[120,121],"ADULT","OLDER_ADULT",[123,137,148,158,165,176,187,198,209,220,231,240,247,253,259,269,277,288,295,305,317,329,339,351,362,373,384,396,407,418,429,438,450,461,468,480,486,497,509,520,530,540,550,560,567,579,590,600,612,623,634,645,656,667,678,689,700,711,722,734,744,755,766,777,786,797,808,818,828,838,850,857,867,876,882,893,903,915,926,937,947,958,966,977,988,998,1008,1018,1028,1038,1048,1060,1071,1082,1092,1102,1114,1125,1136,1143,1154,1164,1175,1186,1197,1204,1213,1224,1235,1245,1252,1259,1271,1282,1293,1304,1315,1324,1331,1340,1347,1353,1360,1371,1378,1388,1398],{"facility":124,"status":8,"city":125,"state":126,"zip":127,"country":128,"contacts":129,"geoPoint":134},"Alaska Oncology and Hematology ( Site 0133)","Anchorage","Alaska","99508","United States",[130],{"name":131,"role":132,"phone":133},"Study Coordinator","CONTACT","907-257-9851",{"lat":135,"lon":136},61.21806,-149.90028,{"facility":138,"status":8,"city":139,"state":140,"zip":141,"country":128,"contacts":142,"geoPoint":145},"Providence Medical Foundation ( Site 0141)","Fullerton","California","92835",[143],{"name":131,"role":132,"phone":144},"714-446-5900",{"lat":146,"lon":147},33.87029,-117.92534,{"facility":149,"status":8,"city":150,"state":140,"zip":151,"country":128,"contacts":152,"geoPoint":155},"USC Norris Comprehensive Cancer Center ( Site 0126)","Los Angeles","90033",[153],{"name":131,"role":132,"phone":154},"800-872-2273",{"lat":156,"lon":157},34.05223,-118.24368,{"facility":159,"status":8,"city":150,"state":140,"zip":160,"country":128,"contacts":161,"geoPoint":164},"Cedars-Sinai Medical Center ( Site 0112)","90048",[162],{"name":131,"role":132,"phone":163},"310-423-3227",{"lat":156,"lon":157},{"facility":166,"status":8,"city":167,"state":168,"zip":169,"country":128,"contacts":170,"geoPoint":173},"New England Cancer Specialists ( Site 0132)","Westbrook","Maine","04092",[171],{"name":131,"role":132,"phone":172},"207-303-3300",{"lat":174,"lon":175},43.67703,-70.37116,{"facility":177,"status":8,"city":178,"state":179,"zip":180,"country":128,"contacts":181,"geoPoint":184},"Greater Baltimore Medical Center ( Site 0145)","Baltimore","Maryland","21204",[182],{"name":131,"role":132,"phone":183},"443-849-8136",{"lat":185,"lon":186},39.29038,-76.61219,{"facility":188,"status":8,"city":189,"state":190,"zip":191,"country":128,"contacts":192,"geoPoint":195},"Metro-Minnesota Community Clinical Oncology ( Site 0144)","Saint Louis Park","Minnesota","55426",[193],{"name":131,"role":132,"phone":194},"952-993-1555",{"lat":196,"lon":197},44.9483,-93.34801,{"facility":199,"status":8,"city":200,"state":201,"zip":202,"country":128,"contacts":203,"geoPoint":206},"Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 0131)","Omaha","Nebraska","68130-2042",[204],{"name":131,"role":132,"phone":205},"402-691-6971",{"lat":207,"lon":208},41.25626,-95.94043,{"facility":210,"status":8,"city":211,"state":212,"zip":213,"country":128,"contacts":214,"geoPoint":217},"Carolina Oncology Specialists, PA ( Site 9002)","Charlotte","North Carolina","28207",[215],{"name":131,"role":132,"phone":216},"704-342-1900",{"lat":218,"lon":219},35.22709,-80.84313,{"facility":221,"status":8,"city":222,"state":223,"zip":224,"country":128,"contacts":225,"geoPoint":228},"Thompson Cancer Survival Center ( Site 0125)","Knoxville","Tennessee","37916",[226],{"name":131,"role":132,"phone":227},"865-331-1678",{"lat":229,"lon":230},35.96064,-83.92074,{"facility":232,"status":8,"city":233,"state":234,"zip":235,"country":236,"contacts":237},"Hospital Aleman ( Site 0204)","CABA","Buenos Aires","C1118AAT","Argentina",[238],{"name":131,"role":132,"phone":239},"+5448277000",{"facility":241,"status":8,"city":242,"state":234,"zip":243,"country":236,"contacts":244},"Hospital Italiano de Buenos Aires. ( Site 0203)","Caba","C1199ABB",[245],{"name":131,"role":132,"phone":246},"+541149590200",{"facility":248,"status":8,"city":242,"state":234,"zip":249,"country":236,"contacts":250},"Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)","C1419AHN",[251],{"name":131,"role":132,"phone":252},"+541145740870",{"facility":254,"status":8,"city":233,"state":234,"zip":255,"country":236,"contacts":256},"Instituto Alexander Fleming ( Site 0202)","C1426ANZ",[257],{"name":131,"role":132,"phone":258},"+541132218900",{"facility":260,"status":8,"city":261,"state":234,"zip":262,"country":236,"contacts":263,"geoPoint":266},"Hospital Universitario Austral ( Site 0212)","Pilar","B1629AHJ",[264],{"name":131,"role":132,"phone":265},"+542304387649",{"lat":267,"lon":268},-34.45867,-58.91398,{"facility":270,"status":8,"city":271,"state":272,"zip":273,"country":236,"contacts":274},"Centro de Educación Médica e Investigaciones clínicas \"Dr. Norberto Quirno\" (CEMIC) ( Site 0208)","Caba.","Buenos Aires F.D.","C1431FWO",[275],{"name":131,"role":132,"phone":276},"+541152990000",{"facility":278,"status":8,"city":279,"state":280,"zip":281,"country":236,"contacts":282,"geoPoint":285},"Sanatorio Parque ( Site 0201)","Rosario","Santa Fe Province","S2000DSV",[283],{"name":131,"role":132,"phone":284},"+5493416955611",{"lat":286,"lon":287},-32.94682,-60.63932,{"facility":289,"status":8,"city":279,"state":280,"zip":290,"country":236,"contacts":291,"geoPoint":294},"Instituto de Oncología de Rosario ( Site 0209)","S2000KZE",[292],{"name":131,"role":132,"phone":293},"+5493414218909",{"lat":286,"lon":287},{"facility":296,"status":8,"city":297,"zip":298,"country":236,"contacts":299,"geoPoint":302},"Hospital Privado Universitario de Córdoba ( Site 0207)","Córdoba","X5016KEH",[300],{"name":131,"role":132,"phone":301},"+543514688200",{"lat":303,"lon":304},-31.40648,-64.18853,{"facility":306,"status":8,"city":307,"state":308,"zip":309,"country":310,"contacts":311,"geoPoint":314},"Macquarie University-MQ Health Clinical Trials Unit ( Site 2100)","Sydney","New South Wales","2109","Australia",[312],{"name":131,"role":132,"phone":313},"+61 2 9812 3526",{"lat":315,"lon":316},-33.86785,151.20732,{"facility":318,"status":8,"city":319,"state":320,"zip":321,"country":322,"contacts":323,"geoPoint":326},"Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0600)","Linz","Upper Austria","4020","Austria",[324],{"name":131,"role":132,"phone":325},"+43 732 7676 4641",{"lat":327,"lon":328},48.30639,14.28611,{"facility":330,"status":8,"city":331,"zip":332,"country":322,"contacts":333,"geoPoint":336},"Medizinische Universitat Wien ( Site 0601)","Vienna","1090",[334],{"name":131,"role":132,"phone":335},"+43 1 40400 60430",{"lat":337,"lon":338},48.20849,16.37208,{"facility":340,"status":8,"city":341,"state":342,"zip":343,"country":344,"contacts":345,"geoPoint":348},"Cliniques Universitaires Saint-Luc ( Site 0703)","Brussels","Bruxelles-Capitale, Region de","1200","Belgium",[346],{"name":131,"role":132,"phone":347},"+3227643546",{"lat":349,"lon":350},50.85045,4.34878,{"facility":352,"status":8,"city":353,"state":354,"zip":355,"country":344,"contacts":356,"geoPoint":359},"Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 0701)","Genk","Limburg","3600",[357],{"name":131,"role":132,"phone":358},"+32 89 80 40 40",{"lat":360,"lon":361},50.965,5.50082,{"facility":363,"status":8,"city":364,"state":365,"zip":366,"country":344,"contacts":367,"geoPoint":370},"UZ Gent ( Site 0702)","Ghent","Oost-Vlaanderen","9000",[368],{"name":131,"role":132,"phone":369},"+32 (0)9 332 62 18",{"lat":371,"lon":372},51.05,3.71667,{"facility":374,"status":8,"city":375,"state":376,"zip":377,"country":344,"contacts":378,"geoPoint":381},"UZ Leuven ( Site 0700)","Leuven","Vlaams-Brabant","3000",[379],{"name":131,"role":132,"phone":380},"+32 (0)16 34 69 12",{"lat":382,"lon":383},50.87959,4.70093,{"facility":385,"status":8,"city":386,"state":387,"zip":388,"country":389,"contacts":390,"geoPoint":393},"IPC - MT Instituto de Pesquisas Clínicas do Mato Grosso ( Site 0305)","Cuiabá","Mato Grosso","78020-500","Brazil",[391],{"name":131,"role":132,"phone":392},"+5565999470522",{"lat":394,"lon":395},-15.59611,-56.09667,{"facility":397,"status":8,"city":398,"state":399,"zip":400,"country":389,"contacts":401,"geoPoint":404},"Liga Norte Riograndense Contra o Câncer ( Site 0307)","Natal","Rio Grande do Norte","59062-000",[402],{"name":131,"role":132,"phone":403},"+558440095595",{"lat":405,"lon":406},-5.795,-35.20944,{"facility":408,"status":8,"city":409,"state":410,"zip":411,"country":389,"contacts":412,"geoPoint":415},"Hospital Moinhos de Vento ( Site 0309)","Porto Alegre","Rio Grande do Sul","90560-032",[413],{"name":131,"role":132,"phone":414},"+5551980609999",{"lat":416,"lon":417},-30.03283,-51.23019,{"facility":419,"status":8,"city":420,"state":421,"zip":422,"country":389,"contacts":423,"geoPoint":426},"Fundação Faculdade Regional de Medicina de São José do Rio Preto ( Site 0302)","São José do Rio Preto","São Paulo","15090-000",[424],{"name":131,"role":132,"phone":425},"+551732015000",{"lat":427,"lon":428},-20.81972,-49.37944,{"facility":430,"status":8,"city":421,"state":421,"zip":431,"country":389,"contacts":432,"geoPoint":435},"Hospital Alemao Oswaldo Cruz ( Site 0311)","01327-001",[433],{"name":131,"role":132,"phone":434},"+551135490391",{"lat":436,"lon":437},-23.5475,-46.63611,{"facility":439,"status":8,"city":440,"state":441,"zip":442,"country":443,"contacts":444,"geoPoint":447},"Oncocentro Valdivia ( Site 0408)","Valdivia","Los Ríos 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