[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07245420":3,"trial-entities:NCT07245420":97,"trial-summary:NCT07245420":100},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":24,"primary_purpose":14,"phases":25,"enrollment_info":27,"interventions":30,"primary_outcomes":42,"secondary_outcomes":50,"sex":51,"minimum_age":52,"maximum_age":53,"healthy_volunteers":15,"eligibility_criteria":54,"std_ages":66,"locations":69,"central_contacts":86,"overall_officials":88,"references":90,"see_also_links":91},"NCT07245420","ECHOS2","Evaluation Of Cardiovascular Health Outcomes Among Survivors 2","Evaluation Of Cardiovascular Health Outcomes Among Survivors 2 (ECHOS2)","RECRUITING","2030-12","2026-06","2026-06-26","2026-09","St. Jude Children's Research Hospital","OTHER",false,"Childhood cancer survivors who received certain treatments are at a higher risk of developing heart problems in the future. This study is looking at ways to educate childhood cancer survivors about that risk and encourage them to receive a recommended heart screening test.","Primary Objective:\n\n* To determine the efficacy of the Healthy Hearts eHealth intervention compared to standard of care for improving screening echocardiogram adherence in childhood cancer survivors.\n\nSecondary Objective\n\n* To determine the efficacy of the Healthy Hearts eHealth intervention compared to standard of care for improving mediators of screening echocardiogram adherence in childhood cancer survivors.\n\nAfter consenting, participants will complete a survey that will take about 15-20 minutes to complete. After this survey, they will be randomly assigned to participate in the Healthy Hearts eHealth Intervention or to receive standard educational materials about hearth health screening.\n\nAll participants will receive the Standard of Care (SOC) materials delivered via the Computerized Intervention Authoring System (CIAS) platform (i.e., a personalized survivorship care plan and educational materials regarding cardiomyopathy risk and need for screening). In addition to the SOC materials received by controls, the Healthy Hearts eHealth intervention arm will receive CIAS platform delivered Motivational Interview (MI), including scripted interaction with an avatar, video vignettes, and patient testimonials",[19],"Health Behavior",[21,22,23],"Childhood Cancer Survivors","Cardiomyopathy Screening","eHealth Intervention","INTERVENTIONAL",[26],"NA",{"count":28,"type":29},350,"ESTIMATED",[31,37],{"type":32,"name":33,"description":34,"armGroupLabels":35},"BEHAVIORAL","Survivorship Care Plan + Educational Materials (delivered via CIAS platform)","Participants receive a personalized survivorship care plan and educational materials about cardiomyopathy risk and screening recommendations. Materials are delivered via the CIAS platform and include infographics, treatment summaries, and general information about screening.",[36],"Standard of Care (SOC)",{"type":32,"name":38,"description":39,"armGroupLabels":40},"Healthy Hearts eHealth Program","Participants receive the same SOC materials plus a tailored, interactive eHealth intervention delivered via the CIAS platform. This includes avatar-led motivational interviewing (MI), survivor video vignettes, interactive modules addressing perceived barriers, self-efficacy, and goal setting. The intervention is designed to mimic MI counseling in a scalable format.",[41],"Healthy Hearts eHealth Intervention",[43,47],{"measure":44,"description":45,"timeFrame":46},"Number of Participants who Received Cardiomyopathy Screening at 12 months between Participants Randomized to the Healthy Hearts eHealth Intervention group as compared to the standard of care.","This outcome will be measured through self-reported questionnaire at 12 months along with confirmation through medical record review.","12 months",{"measure":48,"description":49,"timeFrame":46},"Difference in Precursors to Cardiomyopathy Screening at 12 months between Participants Randomized to the Healthy Hearts eHealth Intervention group as Compared to the Standard of Care.","This outcome will use questions included in the baseline and 12 month questionnaire to calculate the differences in precursors to cardiomyopathy screening (perceived barriers, knowledge, motivation, beliefs, self-efficacy) at 12 months between participants randomized to Healthy Hearts eHealth Intervention vs participants assigned to standard care.",[],"ALL","26 Years",null,{"inclusion":55,"exclusion":64,"raw_text":65},[56,57,58,59,60,61,62,63],"Childhood Cancer Survivor Study (CCSS) Participants","Age ≥26 years","Treated with cumulative doxorubicin equivalent anthracycline doses ≥100 mg\u002Fm2 with any\u002Fno radiation, or ≥15 Gy chest radiation with any\u002Fno anthracyclines","No history of cardiomyopathy","Has not had an echocardiogram in the previous 5 years","Has a history of successful completion of CCSS surveys","English-Speaking","Has not been enrolled in ECHOS-1 (pilot)",[],"Inclusion Criteria:\n\n* Childhood Cancer Survivor Study (CCSS) Participants\n* Age ≥26 years\n* Treated with cumulative doxorubicin equivalent anthracycline doses ≥100 mg\u002Fm2 with any\u002Fno radiation, or ≥15 Gy chest radiation with any\u002Fno anthracyclines\n* No history of cardiomyopathy\n* Has not had an echocardiogram in the previous 5 years\n* Has a history of successful completion of CCSS surveys\n* English-Speaking\n* Has not been enrolled in ECHOS-1 (pilot)\n\nExclusion Criteria:\n\n• Currently participating in a long-term follow-up program that provides risk-based screening",[67,68],"ADULT","OLDER_ADULT",[70],{"facility":13,"status":8,"city":71,"state":72,"zip":73,"country":74,"contacts":75,"geoPoint":83},"Memphis","Tennessee","38105","United States",[76,81],{"name":77,"role":78,"phone":79,"email":80},"Matthew Ehrhardt, MD, MS, MPI","CONTACT","888-226-4343","referralinfo@stjude.org",{"name":77,"role":82},"PRINCIPAL_INVESTIGATOR",{"lat":84,"lon":85},35.14953,-90.04898,[87],{"name":77,"role":78,"phone":79,"email":80},[89],{"name":77,"affiliation":13,"role":82},[],[92,94],{"label":13,"url":93},"http:\u002F\u002Fwww.stjude.org",{"label":95,"url":96},"Clinical Trials Open at St. Jude","http:\u002F\u002Fwww.stjude.org\u002Fprotocols",{"nct_id":4,"conditions":98,"biomarkers":99},[21],[],{"nct_id":4,"found":101,"summary":102,"prompt_version":112},true,{"design":103,"status":104,"heading":105,"summary":106,"follow_up":107,"word_count":108,"commitments":109,"compensation":110,"drugs_mentioned":111},"This interventional study will randomly assign participants to either receive standard educational materials or the Healthy Hearts eHealth Program. It plans to enroll 350 participants.","completed","Cardiovascular Health for Childhood Cancer Survivors","This study, called \"Evaluation Of Cardiovascular Health Outcomes Among Survivors 2,\" is for childhood cancer survivors who received certain treatments that put them at higher risk for heart problems. It's testing two different approaches to help you understand this risk and encourage you to get a recommended heart screening test (echocardiogram). One approach is a \"Survivorship Care Plan + Educational Materials\" delivered through an online platform. The other, called \"Healthy Hearts eHealth Program,\" includes the same materials plus interactive online tools like avatar-led motivational interviewing. The study aims to see if the Healthy Hearts eHealth Program helps more people get their heart screening at 12 months compared to the standard educational materials. You can join if you are a Childhood Cancer Survivor Study (CCSS) participant, are 26 years or older, and meet specific treatment history and heart health criteria. The study is planning to enroll 350 participants, but its current status is unclear.","The study will measure outcomes at 12 months.",153,"You will complete a 15-20 minute survey at the beginning of the study. After that, you will receive either educational materials or an interactive eHealth program.","Not stated in the trial record.",[38],"v2"]