[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07253285":3,"trial-entities:NCT07253285":1149,"trial-summary:NCT07253285":1152},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":26,"interventions":29,"primary_outcomes":49,"secondary_outcomes":54,"sex":228,"minimum_age":229,"maximum_age":230,"healthy_volunteers":15,"eligibility_criteria":231,"std_ages":264,"locations":267,"central_contacts":1137,"overall_officials":1143,"references":1147,"see_also_links":1148},"NCT07253285","NN9838-4968","A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight","Efficacy, Safety and Pharmacokinetics of Cagrilintide s.c. 2.4 mg as Monotherapy and in Combination With Semaglutide s.c. 2.4 mg (CagriSema) Once Weekly for Weight Management in Chidren and Adolescents With Overweight or Obesity","RECRUITING","2033-09-20","2026-07","2026-07-17","2026-01-08","Novo Nordisk A\u002FS","INDUSTRY",false,"This study will look at how well CagriSema and cagrilintide help children and adolescents with excess body weight lose weight. The study has 2 parts: main and extension study. In the main study, participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide (a drug that doctors can already prescribe to adolescents and adults) or placebo (a placebo looks like the treatment being tested, but doesn't have any active ingredients in it). Which treatment participants will get is decided by chance. Participants who get semaglutide in the main study will not take part in the extension study. If participants take part in the extension study, they will get either CagriSema or cagrilintide in this part of the study. Like all drugs, the study drugs may have side effects. The total time participants will be in the main study is about 1 year and 6 months. If participants take part in the extension study, the total time is about 4 years and 10 months.",null,[19,20],"Overweight","Obesity",[],"INTERVENTIONAL","TREATMENT",[25],"PHASE3",{"count":27,"type":28},460,"ESTIMATED",[30,36,40,45],{"type":31,"name":32,"description":33,"armGroupLabels":34},"DRUG","Cagrilintide","Participants will receive cagrilintide subcutaneously.",[35,32],"CagriSema",{"type":31,"name":37,"description":38,"armGroupLabels":39},"Semaglutide","Participants will receive semaglutide subcutaneously.",[35,37],{"type":31,"name":41,"description":42,"armGroupLabels":43},"Placebo cagrilintide","Participants will receive placebo matched to cagrilintide subcutaneously.",[35,32,44],"Placebo",{"type":31,"name":46,"description":47,"armGroupLabels":48},"Placebo semaglutide","Participants will receive placebo matched to semaglutide subcutaneously.",[35,44,37],[50],{"measure":51,"description":52,"timeFrame":53},"Relative change in body mass index (BMI)","Measured in percentage (%).","Baseline (week 0), week 68",[55,58,61,64,67,69,71,73,75,77,79,81,83,85,87,89,91,94,97,100,102,105,108,110,112,114,116,119,121,123,126,128,130,132,134,136,138,140,142,144,146,148,150,153,156,159,161,163,166,169,172,174,177,179,181,183,185,187,189,192,194,196,198,200,203,206,209,211,213,216,219,222,225],{"measure":56,"description":57,"timeFrame":53},"Relative change in body weight","Measured in %.",{"measure":59,"description":60,"timeFrame":53},"Change in BMI Standard Deviation Score (SDS)","Measured as SDS score.",{"measure":62,"description":57,"timeFrame":63},"Relative change in BMI","Baseline (week 0), week 68 and week 224",{"measure":65,"description":66,"timeFrame":53},"Number of participants in weight category reduction","Measured as count of participants.",{"measure":68,"description":66,"timeFrame":53},"Number of participants who achieved greater than or equal to (>=) 5 percent (%) reduction of body weight (yes\u002Fno)",{"measure":70,"description":66,"timeFrame":53},"Number of participants who achieved >=10% reduction of body weight (yes\u002Fno)",{"measure":72,"description":66,"timeFrame":53},"Number of participants who achieved >=15% reduction of body weight (yes\u002Fno)",{"measure":74,"description":66,"timeFrame":53},"Number of participants who achieved >=20% reduction of body weight (yes\u002Fno)",{"measure":76,"description":66,"timeFrame":53},"Number of participants who achieved >=25% reduction of body weight (yes\u002Fno)",{"measure":78,"description":66,"timeFrame":53},"Number of participants who achieved >=5% reduction of BMI (yes\u002Fno)",{"measure":80,"description":66,"timeFrame":53},"Number of participants who achieved >=10% reduction of BMI (yes\u002Fno)",{"measure":82,"description":66,"timeFrame":53},"Number of participants who achieved >=15% reduction of BMI (yes\u002Fno)",{"measure":84,"description":66,"timeFrame":53},"Number of participants who achieved >=20% reduction of BMI (yes\u002Fno)",{"measure":86,"description":66,"timeFrame":53},"Number of participants who achieved >=25% reduction of BMI (yes\u002Fno)",{"measure":88,"description":66,"timeFrame":53},"Number of participants who achieved normal BMI",{"measure":90,"description":66,"timeFrame":53},"Number of participants who shifted from obese to non-obese BMI class",{"measure":92,"description":93,"timeFrame":63},"Change in waist circumference","Measured in centimeter (cm).",{"measure":95,"description":96,"timeFrame":53},"Change in waist-to-height ratio","Measured as ratio.",{"measure":98,"description":99,"timeFrame":53},"Absolute change in total fat mass by dual energy X-ray absorption (DXA)","Measured in kilograms (kg).",{"measure":101,"description":57,"timeFrame":53},"Relative to baseline change in total fat mass by DXA",{"measure":103,"description":104,"timeFrame":53},"Relative to total body mass change in total fat mass by DXA","Measured in % points.",{"measure":106,"description":107,"timeFrame":53},"Absolute change in visceral fat mass by DXA","Measured in kg.",{"measure":109,"description":57,"timeFrame":53},"Relative to baseline change in visceral fat mass by DXA",{"measure":111,"description":104,"timeFrame":53},"Relative to total body mass change in visceral fat mass by DXA",{"measure":113,"description":107,"timeFrame":53},"Absolute change in lean body mass by DXA",{"measure":115,"description":104,"timeFrame":53},"Relative to total body mass change in lean body mass by DXA",{"measure":117,"description":118,"timeFrame":63},"Absolute change in total (neck-to-knee) muscle and fat volumes by Magnetic Resonance Imaging (MRI) - total muscle and total fat","Measured in liters (L).",{"measure":120,"description":57,"timeFrame":63},"Relative to baseline change in total (neck-to-knee) muscle and fat volumes by MRI - total muscle and total fat",{"measure":122,"description":104,"timeFrame":63},"Change in ectopic fat content by MRI - liver fat MRI-Proton Density Fat Fraction (MRI-PDFF), pancreatic fat, kidney fat and thigh muscle fat infiltration",{"measure":124,"description":125,"timeFrame":63},"Absolute change in abdominal fat volumes by MRI - subcutaneous fat and visceral fat","Measured in liters.",{"measure":127,"description":57,"timeFrame":63},"Relative to baseline change in abdominal fat volumes by MRI - subcutaneous fat and visceral fat",{"measure":129,"description":125,"timeFrame":63},"Absolute change in thigh muscle and fat volumes by MRI - thigh fat free muscle and thigh subcutaneous fat",{"measure":131,"description":57,"timeFrame":63},"Relative to baseline change in thigh muscle and fat volumes by MRI - thigh fat free muscle and thigh subcutaneous fat",{"measure":133,"description":96,"timeFrame":63},"Ratio to baseline in liver stiffness measured by Magnetic Resonance Elastography (MRE)",{"measure":135,"description":104,"timeFrame":53},"Change in BMI percentage of the 95th percentile",{"measure":137,"description":96,"timeFrame":53},"Ratio to baseline highly sensitive C-reactive protein (hs-CRP)",{"measure":139,"description":96,"timeFrame":63},"Ratio to baseline in lipids: Total cholesterol",{"measure":141,"description":96,"timeFrame":63},"Ratio to baseline in lipids: High Density Lipoprotein (HDL) cholesterol",{"measure":143,"description":96,"timeFrame":63},"Ratio to baseline in lipids: Low Density Lipoprotein (LDL) cholesterol",{"measure":145,"description":96,"timeFrame":63},"Ratio to baseline in lipids: Very Low Density Lipoprotein (VLDL) cholesterol",{"measure":147,"description":96,"timeFrame":63},"Ratio to baseline in lipids: Triglycerides",{"measure":149,"description":96,"timeFrame":63},"Ratio to baseline in lipids: Non-HDL cholesterol",{"measure":151,"description":152,"timeFrame":63},"Change in Alanine Transaminase (ALT)","Measured in Units per Liter (U\u002FL).",{"measure":154,"description":155,"timeFrame":63},"Change in systolic blood pressure","Measured in millimeters of mercury (mmHg).",{"measure":157,"description":158,"timeFrame":63},"Change in diastolic blood pressure","Measured in mmHg.",{"measure":160,"description":96,"timeFrame":63},"Ratio to baseline in liver stiffness measured by ultrasonographic methods",{"measure":162,"description":104,"timeFrame":63},"Change in glycated haemoglobin (HbA1c) (% points)",{"measure":164,"description":165,"timeFrame":63},"Change in HbA1c (millimoles per mole [mmol\u002Fmol])","Measured in mmol\u002Fmol.",{"measure":167,"description":168,"timeFrame":53},"Change in Fasting Plasma Glucose (FPG) (millimoles per liter [mmol\u002FL])","Measured in mmol\u002FL.",{"measure":170,"description":171,"timeFrame":53},"Change in FPG (milligrams per deciliter [mg\u002FdL])","Measured in mg\u002FdL.",{"measure":173,"description":96,"timeFrame":63},"Ratio to baseline in fasting serum insulin",{"measure":175,"description":66,"timeFrame":176},"Number of participants with prediabetes who achieved HbA1c less than (\u003C) 5.7% (defined as 5.7 % less than or equal to [\u003C=] HbA1c \u003C6.5 %) at baseline","At week 68",{"measure":178,"description":66,"timeFrame":176},"Number of participants with normoglycemia (defined as HbA1c \u003C 5.7 %) at baseline, development of HbA1c greater than or equal to (>=) 5.7 %",{"measure":180,"description":66,"timeFrame":176},"Number of participants with prediabetes (5.7 % \u003C= HbA1c \u003C 6.5 %) at baseline, development of HbA1c >= 6.5%",{"measure":182,"description":66,"timeFrame":176},"Number of participants with HbA1c >=6.5% at baseline, achievement of HbA1c \u003C6.5%",{"measure":184,"description":66,"timeFrame":53},"Number of participants taking glucose lowering medication at baseline, stop or decrease",{"measure":186,"description":66,"timeFrame":53},"Number of participants taking antihypertensive medication at baseline, stop or decrease",{"measure":188,"description":66,"timeFrame":53},"Number of participants taking lipid lowering medication at baseline, stop or decrease",{"measure":190,"description":191,"timeFrame":63},"Impact of Weight on Quality of Life-Kids (IWQOL Kids) - Physical comfort domain score","Measured as score points. IWQOL-Kids measures weight-related quality of life in adolescents (ages 11-19 years) but will be administered to all study participants. The measure consists of 27-items yielding 4 sub-scale scores, and 1 total score. Higher scores indicate better weight-related quality of life. Subscale scores (score range): physical comfort (0-100), body esteem (0-100), social life (0-100), family relations (0-100) and total score (0-100).",{"measure":193,"description":191,"timeFrame":63},"IWQOL Kids - Body esteem domain score",{"measure":195,"description":191,"timeFrame":63},"IWQOL Kids - Social life domain score",{"measure":197,"description":191,"timeFrame":63},"IWQOL Kids - Family-relations score",{"measure":199,"description":191,"timeFrame":63},"IWQOL Kids - Total score",{"measure":201,"description":202,"timeFrame":63},"Control of Eating Questionnaire (COEQ)","Measured as score points. CoEQ is a 19-item multidimensional patient reported outcome (PRO) that assesses the experience of hunger, satiety, and severity and type of food cravings. CoEQ consists of 4 subscales that measure craving control (5 items), positive mood (4 items), craving for sweet (4 items), craving for savoury food (4 items), and 2 single items that address hunger and satiety. Each item is evaluated on a 0-10 (i.e., 11-point) numeric rating scale. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control 0-50\u002F5 = 0-10); Positive Mood (0-40\u002F4 = 0-10); Craving Sweet (0-40\u002F4 = 0-10); Craving Savoury food (0-40\u002F4 = 0-10); single items that address hunger and satiety (0-10). For the craving control subscale, the subscale score is reversed so that a higher score represents a greater level of craving control.",{"measure":204,"description":205,"timeFrame":63},"Change in proteomics-based serum biomarkers including biomarkers for metabolic dysfunction-associated steatohepatitis (MASH)","Measured as counts.",{"measure":207,"description":208,"timeFrame":63},"Number of treatment-emergent adverse events (TEAEs)","Measured as count of events.",{"measure":210,"description":208,"timeFrame":63},"Number of treatment-emergent serious adverse events (TESAEs)",{"measure":212,"description":208,"timeFrame":63},"Number of treatment-emergent hypoglycaemic episodes",{"measure":214,"description":215,"timeFrame":53},"Change in pulse rate","Measured in beats per minute (beats\u002Fmin).",{"measure":217,"description":218,"timeFrame":53},"Change in calcitonin","Measured in nanograms per liter (ng\u002FL).",{"measure":220,"description":221,"timeFrame":53},"Apparent clearance (CL\u002FF) of semaglutide and cagrilintide at steady state","Measured in liters per hour (L\u002Fh).",{"measure":223,"description":224,"timeFrame":53},"Average concentration (Cavg) of semaglutide and cagrilintide at steady state","Measured in nanomoles per liter (nmol\u002FL).",{"measure":226,"description":227,"timeFrame":53},"Area under the steady-state concentration-time curves (AUCt) in the dosing interval of semaglutide and cagrilintide","Measured in hours nanomoles per liter (h·nmol\u002FL).","ALL","8 Years","18 Years",{"inclusion":232,"exclusion":248,"raw_text":263},[233,234,235,236,237,238,239,240,241,242,243,244,245,246,247],"Informed consent of parent(s) or legally acceptable representative (LAR) of participant and child assent, as age-appropriate, obtained before any study related activities. Study related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.","The parent(s) or LAR of the child must sign and date the Informed Consent Form (according to local requirements)","The child must sign and date the Child Assent Form or provide oral assent (according to local requirements).","Male or female.","Aged 8 to less than (\\\u003C) 18 years at the time of signing the informed consent.","Body mass index (BMI), at screening, corresponding to:","Greater than or equal to (\\>=) 95th percentile for children aged 8 to \\\u003C 12 years (Tanner stage 1-5)","\\>= 95th percentile or \\>= 85th percentile with the presence of at least one obesity-related complication including, but not limited to, type 2 diabetes (T2D), hypertension, dyslipidaemia or obstructive sleep apnoea for adolescents aged 12 to \\\u003C 18 years (Tanner stage 2-5).","Laboratory parameters, as measured by the central lab at screening, within normal sex- and age-specific ranges of total calcium, phosphate, alkaline phosphatase, parathyroid hormone.","History of at least one unsuccessful effort to lose sufficient body weight after participation in a structured lifestyle modification programme (diet and exercise counselling) for at least 3 months.","Body weight greater than (\\>) 45 kilograms (kg) at screening.","Glycated haemoglobin (HbA1c) less than or equal to (\\\u003C=)10.0 percent (%) (86 millimoles per mole \\[mmol\u002Fmol\\]) as measured by central laboratory at screening.","Treatment with lifestyle intervention or treatment with metformin according to local label.","Treatment with metformin should be stable (same dose and dosing frequency) for at least 56 days before screening.","Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.",[249,250,251,252,253,254,255,256,257,258,259,260,261,262],"Treatment with any medication prescribed for obesity or weight management within 90 days before screening.","Previous or planned (during the study period) obesity treatment with surgery or a weight loss device. However, the following are allowed:","Liposuction and\u002For abdominoplasty, if performed \\> 1 year before screening.","Adjustable gastric banding, if the band has been removed \\> 1 year before screening.","Intragastric balloon, if the balloon has been removed \\> 1 year before screening.","Duodenal-jejunal bypass liner (e.g., Endobarrier), if the sleeve has been removed \\>1 year before screening.","Uncontrolled thyroid disease.","Endocrine, hypothalamic, or syndromic obesity.","A self-reported (or by parent(s)\u002FLAR, where applicable) change in body weight \\> 5 % within 90 days before screening irrespective of medical records.","HbA1c greater than or equal to 6.5% (48 mmol\u002Fmol) as measured by the central laboratory at screening.","Treatment with glucose-lowering agent(s) prescribed for the indication of diabetes or pre-diabetes within 90 days before screening.","Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire.","Recurrent severe hypoglycaemic episodes within 1 year before screening, as judged by the investigator.","Positive insulinoma associated protein-2 (IA-2) antibodies or anti-glutamic acid decarboxylase (anti-GAD) antibodies.","Inclusion criteria:\n\n* Informed consent of parent(s) or legally acceptable representative (LAR) of participant and child assent, as age-appropriate, obtained before any study related activities. Study related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.\n* The parent(s) or LAR of the child must sign and date the Informed Consent Form (according to local requirements)\n* The child must sign and date the Child Assent Form or provide oral assent (according to local requirements).\n* Male or female.\n* Aged 8 to less than (\\\u003C) 18 years at the time of signing the informed consent.\n* Body mass index (BMI), at screening, corresponding to:\n* Greater than or equal to (\\>=) 95th percentile for children aged 8 to \\\u003C 12 years (Tanner stage 1-5)\n* \\>= 95th percentile or \\>= 85th percentile with the presence of at least one obesity-related complication including, but not limited to, type 2 diabetes (T2D), hypertension, dyslipidaemia or obstructive sleep apnoea for adolescents aged 12 to \\\u003C 18 years (Tanner stage 2-5).\n* Laboratory parameters, as measured by the central lab at screening, within normal sex- and age-specific ranges of total calcium, phosphate, alkaline phosphatase, parathyroid hormone.\n* History of at least one unsuccessful effort to lose sufficient body weight after participation in a structured lifestyle modification programme (diet and exercise counselling) for at least 3 months.\n* Body weight greater than (\\>) 45 kilograms (kg) at screening.\n\nFor participants with T2D at screening the following inclusion criteria also apply\n\n* Glycated haemoglobin (HbA1c) less than or equal to (\\\u003C=)10.0 percent (%) (86 millimoles per mole \\[mmol\u002Fmol\\]) as measured by central laboratory at screening.\n* Treatment with lifestyle intervention or treatment with metformin according to local label.\n* Treatment with metformin should be stable (same dose and dosing frequency) for at least 56 days before screening.\n\nKey exclusion criteria:\n\n* Treatment with any medication prescribed for obesity or weight management within 90 days before screening.\n* Previous or planned (during the study period) obesity treatment with surgery or a weight loss device. However, the following are allowed:\n* Liposuction and\u002For abdominoplasty, if performed \\> 1 year before screening.\n* Adjustable gastric banding, if the band has been removed \\> 1 year before screening.\n* Intragastric balloon, if the balloon has been removed \\> 1 year before screening.\n* Duodenal-jejunal bypass liner (e.g., Endobarrier), if the sleeve has been removed \\>1 year before screening.\n* Uncontrolled thyroid disease.\n* Endocrine, hypothalamic, or syndromic obesity.\n* A self-reported (or by parent(s)\u002FLAR, where applicable) change in body weight \\> 5 % within 90 days before screening irrespective of medical records.\n* Type 1 diabetes or monogenic diabetes. For participants without T2D at screening the following exclusion criteria also apply\n* HbA1c greater than or equal to 6.5% (48 mmol\u002Fmol) as measured by the central laboratory at screening.\n* Treatment with glucose-lowering agent(s) prescribed for the indication of diabetes or pre-diabetes within 90 days before screening.\n\nFor participants with T2D at screening the following exclusion criteria also apply\n\n* Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire.\n* Recurrent severe hypoglycaemic episodes within 1 year before screening, as judged by the investigator.\n* Positive insulinoma associated protein-2 (IA-2) antibodies or anti-glutamic acid decarboxylase (anti-GAD) antibodies.\n* Treatment with any medication for the indication of diabetes other than those stated in the inclusion criteria within 90 days before screening.\n* Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.",[265,266],"CHILD","ADULT",[268,278,286,293,300,308,315,322,329,337,345,353,361,369,377,384,392,399,406,414,421,428,436,444,452,459,467,475,483,489,493,497,504,511,519,528,536,544,552,559,567,574,582,589,593,600,609,613,621,629,633,641,649,657,665,674,681,689,696,700,708,715,723,727,734,743,751,759,767,774,782,790,797,801,809,816,823,830,839,847,855,862,871,875,883,892,896,903,911,919,927,934,941,948,956,960,967,975,982,986,993,1001,1005,1012,1020,1027,1034,1042,1049,1056,1064,1071,1079,1086,1093,1100,1108,1115,1123,1130],{"facility":269,"status":270,"city":271,"state":272,"zip":273,"country":274,"geoPoint":275},"Neighborhood Healthcare","NOT_YET_RECRUITING","Escondido","California","92025","United States",{"lat":276,"lon":277},33.11921,-117.08642,{"facility":279,"status":8,"city":280,"state":281,"zip":282,"country":274,"geoPoint":283},"Encore Medical Research LLC","Hollywood","Florida","33024",{"lat":284,"lon":285},26.0112,-80.14949,{"facility":287,"status":270,"city":288,"state":281,"zip":289,"country":274,"geoPoint":290},"Jacksonville Ctr for Clin Res","Jacksonville","32216",{"lat":291,"lon":292},30.33218,-81.65565,{"facility":294,"status":8,"city":295,"state":281,"zip":296,"country":274,"geoPoint":297},"Encore Medical Research of Weston","Weston","33331",{"lat":298,"lon":299},26.10037,-80.39977,{"facility":301,"status":8,"city":302,"state":303,"zip":304,"country":274,"geoPoint":305},"Children's Healthcare Atlanta","Atlanta","Georgia","30329",{"lat":306,"lon":307},33.749,-84.38798,{"facility":309,"status":8,"city":310,"state":303,"zip":311,"country":274,"geoPoint":312},"Columbus Research Foundation","Columbus","31904",{"lat":313,"lon":314},32.46098,-84.98771,{"facility":316,"status":8,"city":317,"state":303,"zip":318,"country":274,"geoPoint":319},"Accel Research Sites-NeuroStudies","Decatur","30030",{"lat":320,"lon":321},33.77483,-84.29631,{"facility":323,"status":8,"city":324,"state":303,"zip":325,"country":274,"geoPoint":326},"Eastside Bariatric and Gen Surg","Snellville","30078",{"lat":327,"lon":328},33.85733,-84.01991,{"facility":330,"status":270,"city":331,"state":332,"zip":333,"country":274,"geoPoint":334},"Solaris Clinical Research","Meridian","Idaho","83646",{"lat":335,"lon":336},43.61211,-116.39151,{"facility":338,"status":8,"city":339,"state":340,"zip":341,"country":274,"geoPoint":342},"IU Health - Riley Physicians Endo-Diab","Indianapolis","Indiana","46202",{"lat":343,"lon":344},39.76838,-86.15804,{"facility":346,"status":270,"city":347,"state":348,"zip":349,"country":274,"geoPoint":350},"Cotton O'Neil Clinical Research Center","Topeka","Kansas","66606",{"lat":351,"lon":352},39.04833,-95.67804,{"facility":354,"status":8,"city":355,"state":356,"zip":357,"country":274,"geoPoint":358},"Pennington Biomed Res Ctr","Baton Rouge","Louisiana","70808-4124",{"lat":359,"lon":360},30.44332,-91.18747,{"facility":362,"status":270,"city":363,"state":364,"zip":365,"country":274,"geoPoint":366},"Barry J. Reiner, MD LLC","Baltimore","Maryland","21229",{"lat":367,"lon":368},39.29038,-76.61219,{"facility":370,"status":8,"city":371,"state":372,"zip":373,"country":274,"geoPoint":374},"University of Minnesota","Minneapolis","Minnesota","55455",{"lat":375,"lon":376},44.97997,-93.26384,{"facility":378,"status":270,"city":379,"state":372,"zip":380,"country":274,"geoPoint":381},"AES Minneapolis DRS","Richfield","55423",{"lat":382,"lon":383},44.8833,-93.283,{"facility":385,"status":270,"city":386,"state":387,"zip":388,"country":274,"geoPoint":389},"UBMD Physicians Group - Pediatrics - Conventus","Buffalo","New York","14203",{"lat":390,"lon":391},42.88645,-78.87837,{"facility":393,"status":270,"city":394,"state":387,"zip":395,"country":274,"geoPoint":396},"SUNY Upstate Medical Univ - Syracuse","Syracuse","13210",{"lat":397,"lon":398},43.04812,-76.14742,{"facility":400,"status":270,"city":401,"state":387,"zip":402,"country":274,"geoPoint":403},"Advantage Clinical Trials","The Bronx","10467",{"lat":404,"lon":405},40.84985,-73.86641,{"facility":407,"status":270,"city":408,"state":409,"zip":410,"country":274,"geoPoint":411},"Valley Weight Loss Clinic","Fargo","North Dakota","58104",{"lat":412,"lon":413},46.87719,-96.7898,{"facility":415,"status":270,"city":310,"state":416,"zip":417,"country":274,"geoPoint":418},"Centricity Research - 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Dzieci Warszawy w Dziekanowie Lesnym","Dziekanów Leśny","05-092","Poland",{"lat":925,"lon":926},52.35243,20.85124,{"facility":928,"status":270,"city":929,"zip":930,"country":923,"geoPoint":931},"Uniwersytecki Szpital Kliniczny w Opolu","Opole","45-401",{"lat":932,"lon":933},50.67119,17.92604,{"facility":935,"status":270,"city":936,"zip":937,"country":923,"geoPoint":938},"Kliniczny Szpital Wojewodzki nr 2 im. Sw. Jadwigi Krolowej w Rzeszowie","Rzeszów","35-301",{"lat":939,"lon":940},50.04132,21.99901,{"facility":942,"status":270,"city":943,"zip":944,"country":923,"geoPoint":945},"Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Szyszko","Zabrze","41-800",{"lat":946,"lon":947},50.32492,18.78576,{"facility":949,"status":270,"city":950,"zip":951,"country":952,"geoPoint":953},"ULS De Santo António, E.P.E. _CMIN_Serviço de Pediatria","Porto","4050-651","Portugal",{"lat":954,"lon":955},41.1485,-8.61097,{"facility":957,"status":270,"city":950,"zip":958,"country":952,"geoPoint":959},"CUF Porto_Serviço de Pediatria","4100-180",{"lat":954,"lon":955},{"facility":961,"status":270,"city":962,"zip":963,"country":952,"geoPoint":964},"ULS De Gaia\u002FEspinho_H.Santos Silva_Unidade Ensaios Clínicos","Vila Nova de Gaia","4434-502",{"lat":965,"lon":966},41.12401,-8.61241,{"facility":968,"status":270,"city":969,"zip":970,"country":971,"geoPoint":972},"Spitalul Judetean de Urgenta Dr. Constantin Opris Baia Mare","Baia Mare","430031","Romania",{"lat":973,"lon":974},47.65729,23.56808,{"facility":976,"status":270,"city":977,"zip":978,"country":971,"geoPoint":979},"Kilostop Junior SRL","Bucharest","010073",{"lat":980,"lon":981},44.43225,26.10626,{"facility":983,"status":270,"city":977,"zip":984,"country":971,"geoPoint":985},"Spitalul Clinic de Urgenta pentru Copii \"M.S.Curie\"","041451",{"lat":980,"lon":981},{"facility":987,"status":270,"city":988,"zip":989,"country":971,"geoPoint":990},"Spitalul Clinic Judetean De Urgenta Pius Brinzeu Timisoara","Timișoara","300226",{"lat":991,"lon":992},45.75372,21.22571,{"facility":994,"status":270,"city":995,"zip":996,"country":997,"geoPoint":998},"University Children's Hospital Tirsova","Belgrade","11000","Serbia",{"lat":999,"lon":1000},44.80401,20.46513,{"facility":1002,"status":270,"city":995,"zip":1003,"country":997,"geoPoint":1004},"Institute for Mother and Child Health Care of Serbia","11070",{"lat":999,"lon":1000},{"facility":1006,"status":270,"city":1007,"zip":1008,"country":997,"geoPoint":1009},"Institute for Health Care of Children and Adolescents","Novi Sad","21000",{"lat":1010,"lon":1011},45.25167,19.83694,{"facility":1013,"status":270,"city":1014,"zip":1015,"country":1016,"geoPoint":1017},"Narodny Ustav Detskych Chorob","Bratislava","833 40","Slovakia",{"lat":1018,"lon":1019},48.14816,17.10674,{"facility":1021,"status":270,"city":1022,"zip":1023,"country":1016,"geoPoint":1024},"Detska Fakultna nemocnica Kosice","Košice","040 01",{"lat":1025,"lon":1026},48.71441,21.25802,{"facility":1028,"status":270,"city":1029,"zip":1030,"country":1016,"geoPoint":1031},"Narodny Endokrinologicky a diabetologicky ustav","Ľubochňa","03491",{"lat":1032,"lon":1033},49.12011,19.16891,{"facility":1035,"status":270,"city":1036,"zip":1037,"country":1038,"geoPoint":1039},"Hospital Vall d'Hebrón_Endocrinología pediatríca","Barcelona","08035","Spain",{"lat":1040,"lon":1041},41.38879,2.15899,{"facility":1043,"status":270,"city":1044,"zip":1045,"country":1038,"geoPoint":1046},"Hospital Sant Joan de Déu","Esplugues de Llobregat","08950",{"lat":1047,"lon":1048},41.37732,2.08809,{"facility":1050,"status":270,"city":1051,"zip":1052,"country":1038,"geoPoint":1053},"Hospital Universitario Virgen del Rocío","Seville","41013",{"lat":1054,"lon":1055},37.38283,-5.97317,{"facility":1057,"status":270,"city":1058,"zip":1059,"country":1060,"geoPoint":1061},"Barn och ungdomscentrum Västerbotten - NU","Umeå","907 37","Sweden",{"lat":1062,"lon":1063},63.82842,20.25972,{"facility":1065,"status":270,"city":1066,"zip":1067,"country":1060,"geoPoint":1068},"Akademiska barnsjukhuset - klinisk forskningsmottagning","Uppsala","75185",{"lat":1069,"lon":1070},59.85882,17.63889,{"facility":1072,"status":270,"city":1073,"zip":1074,"country":1075,"geoPoint":1076},"Chang Gung Memorial Hospital - Kaohsiung Branch","Kaohsiung City","833","Taiwan",{"lat":1077,"lon":1078},22.61626,120.31333,{"facility":1080,"status":270,"city":1081,"zip":1082,"country":1075,"geoPoint":1083},"Chung Shan Medical University Hospital","Taichung","402",{"lat":1084,"lon":1085},24.1469,120.6839,{"facility":1087,"status":270,"city":1088,"zip":1089,"country":1075,"geoPoint":1090},"Taipei Mackay Children's Hospital","Taipei","104",{"lat":1091,"lon":1092},25.05306,121.52639,{"facility":1094,"status":270,"city":1095,"zip":1096,"country":1075,"geoPoint":1097},"Chang Gung Memorial Hospital Linkou-Dept of Pediatrics","Taoyuan","333",{"lat":1098,"lon":1099},24.99368,121.29696,{"facility":1101,"status":270,"city":1102,"zip":1103,"country":1104,"geoPoint":1105},"King Chulalongkorn Memorial Hospital_Ped-Nutrition","Bangkok","10300","Thailand",{"lat":1106,"lon":1107},13.75398,100.50144,{"facility":1109,"status":270,"city":1110,"zip":1111,"country":1104,"geoPoint":1112},"Thammasat Hospital_CRC","Pathum Thani","12120",{"lat":1113,"lon":1114},14.01346,100.53049,{"facility":1116,"status":8,"city":1117,"zip":1118,"country":1119,"geoPoint":1120},"Birmingham Children's Hospital","Birmingham","B4 6NH","United Kingdom",{"lat":1121,"lon":1122},52.48142,-1.89983,{"facility":1124,"status":8,"city":1125,"zip":1126,"country":1119,"geoPoint":1127},"Alder Hey Children's Hospital","Liverpool","L12 2AP",{"lat":1128,"lon":1129},53.41058,-2.97794,{"facility":1131,"status":8,"city":1132,"zip":1133,"country":1119,"geoPoint":1134},"University College Hospital - Paediatric Services","London","NW1 1BU",{"lat":1135,"lon":1136},51.50853,-0.12574,[1138],{"name":1139,"role":1140,"phone":1141,"email":1142},"Novo Nordisk","CONTACT","(+1) 866-867-7178","clinicaltrials@novonordisk.com",[1144],{"name":1145,"affiliation":13,"role":1146},"Clinical Transparency (dept. 2834)","STUDY_DIRECTOR",[],[],{"nct_id":4,"conditions":1150,"biomarkers":1151},[20,19],[],{"nct_id":4,"found":1153,"summary":1154,"prompt_version":1164},true,{"design":1155,"status":1156,"heading":1157,"summary":1158,"follow_up":1159,"word_count":1160,"commitments":1161,"compensation":1162,"drugs_mentioned":1163},"This is an interventional study that will enroll about 460 participants. You will be randomly assigned to receive Cagrilintide, Semaglutide, CagriSema, or a placebo.","completed","Research Study on Cagrilintide and CagriSema for Children and Adolescents with Excess Body Weight","This research study is looking at how well two medications, Cagrilintide and CagriSema, help children and adolescents (ages 8 to 18) who have excess body weight. The study will compare these medications to Semaglutide (a drug already available) and a placebo (an inactive substance). You would be randomly assigned to one of these treatments. The main goal is to see how much your Body Mass Index (BMI) changes over 68 weeks. The study is currently unclear on its recruitment status and plans to enroll about 460 participants.","Your Body Mass Index (BMI) will be measured at the beginning of the study and again at week 68.",87,"Not specified in the trial record.","Not stated in the trial record.",[32,37],"v2"]