[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07296783":3,"trial-entities:NCT07296783":80,"trial-summary:NCT07296783":84},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":16,"phases":21,"enrollment_info":22,"interventions":25,"primary_outcomes":26,"secondary_outcomes":31,"sex":32,"minimum_age":33,"maximum_age":16,"healthy_volunteers":34,"eligibility_criteria":35,"std_ages":39,"locations":41,"central_contacts":62,"overall_officials":63,"references":67,"see_also_links":72},"NCT07296783","TRACK-GERI","Transforming Research and Clinical Knowledge in Geriatric Traumatic Brain Injury (TRACK-GERI)","ENROLLING_BY_INVITATION","2027-01","2025-12","2025-12-22","2019-09-02","University of California, San Francisco","OTHER",false,"The purpose of this study is to improve the diagnosis and prediction of recovery after traumatic brain injury (TBI) in adults age 65 years and older. The study will follow older adults who present to the emergency department after TBI, as well as matched control participants, and will measure clinical features, brain imaging, and blood-based biomarkers over 12 months to understand how recovery changes over time. Researchers will examine how pre-injury health, brain structure, and biological markers are related to disability and cognitive outcomes after TBI. Information from this study will be used to develop age-appropriate tools to better diagnose TBI and estimate long-term outcomes in older adults.",null,[18],"Traumatic Brain Injury",[],"OBSERVATIONAL",[],{"count":23,"type":24},1500,"ESTIMATED",[],[27],{"measure":28,"description":29,"timeFrame":30},"Functional Outcome at 6 Months Post-Injury as Assessed by the Glasgow Outcome Scale-Extended (GOSE)","Functional outcome after traumatic brain injury will be measured using the Glasgow Outcome Scale-Extended (GOSE). The score ranges from 1-8, with higher scores indicating better recovery. The primary outcome is GOSE assessed at 6 months post-injury.","6 months post-injury",[],"ALL","65 Years",true,{"inclusion":36,"exclusion":37,"raw_text":38},[],[],"TRACK-GERI\u002FVA TBI PATIENT INCLUSION\u002FEXCLUSION CRITERIA\n\nInclusion Criteria:\n\n1. Age 65 years and older, no upper age limit\n2. Reliable report or physical evidence of head trauma\n3. Injury occurred \\\u003C72 hours ago (within 14 days of injury for TRACK-VA TBI patients)\n4. Acute brain CT for clinical use\n5. Fluency in English\u002FChinese (UCSF only)\n6. Ability to obtain informed consent from subject or legally authorized representative\n7. Ability to be co-enrolled with a study partner who meets Study Partner enrollment criteria\n\nExclusion Criteria:\n\n1. Significant polytrauma that would interfere with follow-up and outcome assessment\n2. Prisoners or patients in custody\n3. Patients on psychiatric hold (e.g. 5150, 5250)\n4. Low likelihood follow-up (participant or family is indicating a low interest, homelessness, out of state\u002Fcountry)\n5. Current participation in an interventional trial\n6. Penetrating TBI\n7. Spinal cord injury with ASIA score of C or worse\n8. Acute disabling neurological injury (e.g. acute stroke, cardiac arrest concurrent with head trauma presentation)\n\nTRACK-GERI\u002FVA STUDY PARTNERS OF TBI PATIENTS INCLUSION\u002FEXCLUSION CRITERIA\n\nInclusion Criteria:\n\n1. Age 18 years or older\n2. Either designated by the patient, presents with patient to the Emergency Department, is listed in the patient's medical chart as an alternate\u002Femergency contact, or is the patient's case manager\u002Fsocial worker, and knows the patient well enough to comment on the patient's health and functional status (e.g. may be family member, friend, caregiver, case manager, etc).\n3. Ability to read, write, and speak English\u002FChinese (UCSF only)\n4. Ability to provide informed consent for self\n\nExclusion Criteria:\n\n1. Pre-existing and major disabling medical, psychiatric, or other neurological disease (e.g. dementia) that interferes with ability to provide evaluation of patient's health and functional status.\n2. Prisoners or patients in custody\n3. Patients on psychiatric hold (e.g. 5150, 5250)\n\nTRACK-GERI\u002FVA CONTROL SUBJECT INCLUSION\u002FEXCLUSION CRITERIA\n\nInclusion Criteria:\n\n1. Age 65 years or older, no upper age limit\n2. Visual acuity\u002Fhearing adequate for testing\n3. Fluency in English\u002FChinese (UCSF only)\n4. Ability to obtain informed consent from subject or legally authorized representative\n5. Ability to be co-enrolled with a study partner who meets study partner enrollment criteria (see control study partner enrollment criteria)\n6. For TRACK-VA patients only: Presentation to SFVAMC ED for acute care with planned discharge from ED.\n\nExclusion Criteria:\n\n1. Medically diagnosed with traumatic brain or orthopedic injury in the last year (TRACK-VA Control Subjects are not excluded for orthopedic injuries)\n2. Significant polytrauma that would interfere with follow-up and outcome assessment\n3. Prisoners or patients in custody\n4. Patients on psychiatric hold (e.g. 5150, 5250)\n5. Low likelihood follow-up (participant or family is indicating low interest, homelessness, out of state\u002Fcountry)\n6. Current participation in an interventional trial\n7. Penetrating TBI\n8. Spinal cord injury with ASIA score of C or worse\n9. Acute disabling neurological injury (e.g. acute stroke, cardiac arrest)\n\nTRACK-GERI\u002FVA STUDY PARTNERS OF CONTROL SUBJECTS INCLUSION\u002FEXCLUSION CRITERIA\n\nInclusion Criteria:\n\n1. Age 18 years or older\n2. Designated by the control subject as someone who knows the subject well enough to comment on their health and functional starus (e.g., may be family member, friend, caregiver, case manager, etc.)\n3. Ability to read, write and speak English\u002FChinese (UCSF only)\n4. Ability to provide informed consent for self\n\nExclusion Criteria:\n\n1. Pre-existing and major disabling medical, psychiatric, or other neurological disease (e.g. dementia) that interferes with ability to provide evaluation of control subject's health and functional status.\n2. Prisoners or in custody\n3. On psychiatric hold (e.g. 5150, 5250)",[40],"OLDER_ADULT",[42,50,54],{"facility":12,"city":43,"state":44,"zip":45,"country":46,"geoPoint":47},"San Francisco","California","94110","United States",{"lat":48,"lon":49},37.77493,-122.41942,{"facility":51,"city":43,"state":44,"zip":52,"country":46,"geoPoint":53},"San Francisco Veterans Affairs Medical Center","94121",{"lat":48,"lon":49},{"facility":55,"city":56,"state":57,"zip":58,"country":46,"geoPoint":59},"University of Pittsburgh","Pittsburgh","Pennsylvania","15213",{"lat":60,"lon":61},40.44062,-79.99589,[],[64],{"name":65,"affiliation":12,"role":66},"Geoffrey Manley, MD, PhD","PRINCIPAL_INVESTIGATOR",[68],{"pmid":69,"type":70,"citation":71},"42428125","DERIVED","Rosen-Lang Y, Puccio AM, Yuh EL, Lombardi D, Kuang K, Nelson MD, Boscardin WJ, Huie JR, Yaffe K, Okonkwo DO, Arrastia RD, Manley GT, Gardner RC; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) investigators. 6-Month Recovery after Mild Traumatic Brain Injury in Older Adults: A TRACK-GERI Study. medRxiv [Preprint]. 2026 Jun 29:2026.06.25.26356520. doi: 10.64898\u002F2026.06.25.26356520.",[73,76,78],{"label":74,"url":75},"Related Info","https:\u002F\u002Ftracktbi.ucsf.edu\u002F",{"label":74,"url":77},"https:\u002F\u002Ftracktbi.ucsf.edu\u002Fpublications",{"label":74,"url":79},"https:\u002F\u002Ftracktbinet.ucsf.edu\u002F",{"nct_id":4,"conditions":81,"biomarkers":83},[82],"Traumatic Encephalopathy",[],{"nct_id":4,"found":14,"summary":16,"prompt_version":16}]