[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07308873":3,"trial-entities:NCT07308873":95,"trial-summary:NCT07308873":99},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":21,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":25,"interventions":28,"primary_outcomes":29,"secondary_outcomes":34,"sex":38,"minimum_age":39,"maximum_age":40,"healthy_volunteers":41,"eligibility_criteria":42,"std_ages":68,"locations":71,"central_contacts":81,"overall_officials":90,"references":93,"see_also_links":94},"NCT07308873","STUDY25080027","Individual Differences in Gait and Osteoarthritis Pain","RECRUITING","2030-08-01","2026-01","2026-01-29","2026-01-07","University of Pittsburgh","OTHER",true,"The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are:\n\nWhy do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar?\n\nWhat are the factors that contribute to walking pain in people with knee osteoarthritis?\n\nParticipants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing.","This observational study will identify biopsychosocial factors that contribute to inter-individual differences in walking pain and pain limiting walking with the hypothesis that neural processes play a key role. This study's objective is to elucidate \"whole person\" biopsychosocial mechanisms of movement-evoked pain and pain limitations on function in knee OA, helping to determine why some patients have severe disabling pain while others do not despite similar degenerative changes of the knee joint. Three hundred participants with knee OA will undergo a comprehensive data collection over two study visits, including surveys, exercise tasks, non-invasive brain and joint imaging, and biomechanics assessments during mobility. Using advanced analysis, this dataset will be used to identify factors contributing to walking-evoked pain and functional limitations in knee osteoarthritis.These results will identify new therapeutic targets to maintain or improve physical activity in patients with knee osteoarthritis, leading to better outcomes of physical therapy and improved overall health and well-being.",[18,19,20],"Knee Osteoarthritis (OA)","Chronic Pain","Chronic Knee Pain",[],"OBSERVATIONAL",null,[],{"count":26,"type":27},300,"ESTIMATED",[],[30],{"measure":31,"description":32,"timeFrame":33},"6 minute walk test pain intensity","Pain intensity on numeric rating scale (0-10) during and around the time of the 6-minute walk test.","6 minutes",[35],{"measure":36,"description":37,"timeFrame":33},"Distance walked in the 6-minute walking test","Distance walked during 6 minute walking task","ALL","45 Years","80 Years",false,{"inclusion":43,"exclusion":48,"raw_text":67},[44,45,46,47],"Knee pain for greater than 6 months.","Moderate-to-severe knee pain (\\>3\u002F10) due to osteoarthritis, as defined by American College of Rheumatology and EULAR diagnostic criteria, on \\>50% of days in the past month.","KL grade 2-4 indicating significant degenerative changes on knee X-ray.","45-80 years old",[49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66],"Inflammatory arthritis (e.g. rheumatoid arthritis).","More intense pain due to another chronic pain syndrome (e.g. fibromyalgia, hip osteoarthritis)","Significant pain or weakness in the lower extremities due to a neurological condition (e.g. lumbar radiculopathy, paresis due to stroke)","Acute pain that is more intense than knee osteoarthritis pain","Current routine use of more than 15 mg oral morphine equivalents per day (use of \\\u003C15 mg OME does not exclude the participant).","Recent new medication, exercise, behavioral, or complementary and integrative treatment started in the last month. Stable use of these treatments for greater than 1 month does not exclude the participant.","Recent intra-articular injection of steroid or other agent (greater than 1 month does not exclude the participant)","Recent knee radiofrequency ablation (greater than 3 months does not exclude the participant)","Recent knee arthroscopic surgery (greater than 3 months does not exclude the participant)","History of knee replacement or open knee surgery on the index knee, defined as the more painful knee on average over the last month.","Inability to walk or climb stairs without significant assistance (e.g. a one-person assist, use a wheel chair; however, the use of a cane does not exclude the participant).","Inability to participate in study procedures (e.g. cognitive impairment limiting ability to understand directions, inability to understand and read English)","Uncontrolled or unstable medical disorder preventing participation in study procedures","History of brain surgery","Tattoos on sensory testing sites","Pregnancy","Breastfeeding","Inability to under knee MRI scan due to incompatible devices or foreign bodies.","Inclusion Criteria:\n\n* Knee pain for greater than 6 months.\n* Moderate-to-severe knee pain (\\>3\u002F10) due to osteoarthritis, as defined by American College of Rheumatology and EULAR diagnostic criteria, on \\>50% of days in the past month.\n* KL grade 2-4 indicating significant degenerative changes on knee X-ray.\n* 45-80 years old\n\nExclusion Criteria:\n\n* Inflammatory arthritis (e.g. rheumatoid arthritis).\n* More intense pain due to another chronic pain syndrome (e.g. fibromyalgia, hip osteoarthritis)\n* Significant pain or weakness in the lower extremities due to a neurological condition (e.g. lumbar radiculopathy, paresis due to stroke)\n* Acute pain that is more intense than knee osteoarthritis pain\n* Current routine use of more than 15 mg oral morphine equivalents per day (use of \\\u003C15 mg OME does not exclude the participant).\n* Recent new medication, exercise, behavioral, or complementary and integrative treatment started in the last month. Stable use of these treatments for greater than 1 month does not exclude the participant.\n* Recent intra-articular injection of steroid or other agent (greater than 1 month does not exclude the participant)\n* Recent knee radiofrequency ablation (greater than 3 months does not exclude the participant)\n* Recent knee arthroscopic surgery (greater than 3 months does not exclude the participant)\n* History of knee replacement or open knee surgery on the index knee, defined as the more painful knee on average over the last month.\n* Inability to walk or climb stairs without significant assistance (e.g. a one-person assist, use a wheel chair; however, the use of a cane does not exclude the participant).\n* Inability to participate in study procedures (e.g. cognitive impairment limiting ability to understand directions, inability to understand and read English)\n* Uncontrolled or unstable medical disorder preventing participation in study procedures\n* History of brain surgery\n* Tattoos on sensory testing sites\n* Pregnancy\n* Breastfeeding\n* Inability to under knee MRI scan due to incompatible devices or foreign bodies.",[69,70],"ADULT","OLDER_ADULT",[72],{"facility":73,"status":7,"city":74,"state":75,"zip":76,"country":77,"geoPoint":78},"UPMC Pain Medicine at Centre Commons","Pittsburgh","Pennsylvania","15206","United States",{"lat":79,"lon":80},40.44062,-79.99589,[82,87],{"name":83,"role":84,"phone":85,"email":86},"Benedict Alter, MD, PhD","CONTACT","412-665-8052","bea51@pitt.edu",{"name":88,"role":84,"email":89},"Emma Racunas, BS","ecr79@pitt.edu",[91],{"name":83,"affiliation":12,"role":92},"PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":96,"biomarkers":98},[97],"Osteoarthritis of knee",[],{"nct_id":4,"found":14,"summary":100,"prompt_version":110},{"design":101,"status":102,"heading":103,"summary":104,"follow_up":105,"word_count":106,"commitments":107,"compensation":108,"drugs_mentioned":109},"This is an observational study planning to enroll 300 participants. It is not testing a specific treatment.","completed","Observational Study on Gait and Osteoarthritis Pain","This study is looking at why some people with knee osteoarthritis (OA), a condition causing joint pain and stiffness, experience more severe walking pain than others, even with similar knee damage. Researchers want to understand the different factors that contribute to this pain. You might be able to join if you are 45-80 years old, have had knee pain for over six months, and have moderate-to-severe knee pain due to OA. The study will involve surveys, physical tasks, X-rays, MRI scans, non-invasive brain imaging, and sensory testing. The main goal is to measure your pain intensity during a 6-minute walk test. This is an observational study, meaning no specific interventions are being tested, and the current recruitment status is unclear.","The primary endpoint, 6-minute walk test pain intensity, is measured at 6 minutes. No further follow-up is specified.",120,"You will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing over two study visits.","Not stated in the trial record.",[],"v2"]