[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07332598":3,"trial-entities:NCT07332598":77,"trial-summary:NCT07332598":83},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":20,"study_type":21,"primary_purpose":16,"phases":22,"enrollment_info":23,"interventions":26,"primary_outcomes":27,"secondary_outcomes":31,"sex":32,"minimum_age":33,"maximum_age":16,"healthy_volunteers":34,"eligibility_criteria":35,"std_ages":47,"locations":50,"central_contacts":60,"overall_officials":61,"references":65,"see_also_links":76},"NCT07332598","25-005869","Mayo Clinic Precure - Prospective Study","ENROLLING_BY_INVITATION","2035-12","2026-02","2026-03-16","2026-01-19","Mayo Clinic","OTHER",false,"The goal of this observational study is to 1) better understand and predict biological processes before disease begins or is identified, 2) study genomic and environmental contributors to disease, 3) identify ways to stop disease advancement before it becomes serious or complex, and 4) identify potential targets for disease therapy.\n\nParticipants will be asked to:\n\n* collect biological samples,\n* download a mobile app,\n* collect speech (voice) recordings, and\n* complete surveys",null,[18,19],"Genetic Predisposition","Exposure, Environmental",[],"OBSERVATIONAL",[],{"count":24,"type":25},100000,"ESTIMATED",[],[28],{"measure":29,"timeFrame":30},"Build a comprehensive, multi-omics and phenotype dataset","Up to 5 years",[],"ALL","18 Years",true,{"inclusion":36,"exclusion":42,"raw_text":46},[37,38,39,40,41],"Age ≥ 18 years","Registered Mayo Clinic patient","Able to provide informed written consent","Able to receive mail and packages within a United States (US) state","Able to collect and ship samples within a US state via FedEx for overnight delivery",[43,44,45],"Active hematological cancer or history of a hematological cancer","Allogeneic Bone Marrow Transplant (autologous bone marrow transplant recipients are acceptable if collected at least one month after transplant)","Other co-morbidity that, in physician's opinion, would interfere with patient's ability to participate in the study (e.g., reduced ability to comprehend, i.e., dementia, intellectual disability, etc.)","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Registered Mayo Clinic patient\n* Able to provide informed written consent\n* Able to receive mail and packages within a United States (US) state\n* Able to collect and ship samples within a US state via FedEx for overnight delivery\n\nExclusion Criteria:\n\n* Active hematological cancer or history of a hematological cancer\n* Allogeneic Bone Marrow Transplant (autologous bone marrow transplant recipients are acceptable if collected at least one month after transplant)\n* Other co-morbidity that, in physician's opinion, would interfere with patient's ability to participate in the study (e.g., reduced ability to comprehend, i.e., dementia, intellectual disability, etc.)",[48,49],"ADULT","OLDER_ADULT",[51],{"facility":52,"city":53,"state":54,"zip":55,"country":56,"geoPoint":57},"Mayo Clinic in Rochester","Rochester","Minnesota","55905","United States",{"lat":58,"lon":59},44.02163,-92.4699,[],[62],{"name":63,"affiliation":12,"role":64},"Konstantinos N. Lazaridis, M.D.","PRINCIPAL_INVESTIGATOR",[66,70,73],{"pmid":67,"type":68,"citation":69},"16906051","BACKGROUND","Thomas DC. High-volume \"-omics\" technologies and the future of molecular epidemiology. Epidemiology. 2006 Sep;17(5):490-1. doi: 10.1097\u002F01.ede.0000229950.29674.68. No abstract available.",{"pmid":71,"type":68,"citation":72},"18441400","Ramos RG, Olden K. Gene-environment interactions in the development of complex disease phenotypes. Int J Environ Res Public Health. 2008 Mar;5(1):4-11. doi: 10.3390\u002Fijerph5010004.",{"pmid":74,"type":68,"citation":75},"16103423","Wild CP. Complementing the genome with an \"exposome\": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50. doi: 10.1158\u002F1055-9965.EPI-05-0456. No abstract available.",[],{"nct_id":4,"conditions":78,"biomarkers":82},[79,80,81],"Environmental","Exposure","Genetic Predisposition to Disease",[],{"nct_id":4,"found":14,"summary":16,"prompt_version":16}]