[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07339423":3,"trial-entities:NCT07339423":669,"trial-summary:NCT07339423":672},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":25,"interventions":28,"primary_outcomes":39,"secondary_outcomes":44,"sex":110,"minimum_age":111,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":112,"std_ages":122,"locations":125,"central_contacts":657,"overall_officials":663,"references":667,"see_also_links":668},"NCT07339423","NN9490-8021","AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight","Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Obesity (AMAZE 1)","RECRUITING","2029-08-21","2026-07","2026-07-09","2026-02-24","Novo Nordisk A\u002FS","INDUSTRY",false,"The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.",null,[19],"Obesity",[],"INTERVENTIONAL","TREATMENT",[24],"PHASE3",{"count":26,"type":27},1150,"ESTIMATED",[29,34],{"type":30,"name":31,"description":32,"armGroupLabels":33},"DRUG","NNC0487-0111","NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.",[31],{"type":30,"name":35,"description":36,"armGroupLabels":37},"Placebo (matched to NNC0487-0111)","Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.",[38],"Placebo",[40],{"measure":41,"description":42,"timeFrame":43},"Relative change in body weight","Measured as percentage of body weight.","From baseline (week 0) to week 84",[45,49,52,55,58,61,64,67,70,73,76,79,82,85,87,89,91,93,95,97,99,103,105,107],{"measure":46,"description":47,"timeFrame":48},"Change in waist circumference","Measured as centimetre (cm).","From baseline (week 0) to week 84 and week 136",{"measure":50,"description":51,"timeFrame":48},"Change in systolic blood pressure (SBP)","Measured as millimetre of mercury (mmHg).",{"measure":53,"description":54,"timeFrame":48},"Change in Impact of Weight on Quality of Life-Lite Clinical Trials Version (IWQOL-Lite-CT) physical function score","Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Higher scores indicate better levels of functioning. The physical function score ranges from 0-100.",{"measure":56,"description":57,"timeFrame":48},"Change in SF-36v2® Health Survey Acute (SF-36v2 Acute) physical functioning score","Measured as score on a scale. SF-36v2 Acute measures Health-Related Quality of Life (HRQOL). The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 Acute scores are norm-based scores, i.e. transformed to a scale where the 2009 US general population has a mean of 50 and a standard deviation (SD) of 10. Higher scores indicate better functional health and well-being. The physical functioning ranges from 19.0 to 57.6.",{"measure":59,"description":60,"timeFrame":48},"Change in body weight","Measured as kilogram (kg).",{"measure":62,"description":63,"timeFrame":48},"Change in body mass index (BMI)","Measured as kilograms per meter squared (kg\u002Fm\\^2).",{"measure":65,"description":66,"timeFrame":48},"Change in IWQOL-Lite-CT physical composite score","Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Higher scores indicate better levels of functioning. The physical composite score ranges from 0-100.",{"measure":68,"description":69,"timeFrame":48},"Change in IWQOL-Lite-CT psychosocial composite score","Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Higher scores indicate better levels of functioning. The psychosocial composite score ranges from 0-100.",{"measure":71,"description":72,"timeFrame":48},"Change in IWQOL-Lite-CT total score","Measured as score on a scale. IWQOL-Lite-CT measures weight-related physical and psychosocial functioning. The measure consists of 20 items yielding 3 composite scores, and 1 total score. Higher scores indicate better levels of functioning. The total score ranges from 0-100.",{"measure":74,"description":75,"timeFrame":48},"Change in glycated haemoglobin (HbA1c)","Measured as percentage of HbA1c.",{"measure":77,"description":78,"timeFrame":48},"Change in fasting plasma glucose (FPG)","Measured as millimole per liter (mmol\u002FL).",{"measure":80,"description":81,"timeFrame":48},"Ratio to baseline: change in fasting insulin","Measured as ratio.",{"measure":83,"description":84,"timeFrame":43},"Change in diastolic blood pressure (DBP)","Measured as mmHg.",{"measure":86,"description":81,"timeFrame":48},"Ratio to baseline: change in total cholesterol",{"measure":88,"description":81,"timeFrame":48},"Ratio to baseline: change in high-density lipoprotein (HDL) cholesterol",{"measure":90,"description":81,"timeFrame":48},"Ratio to baseline: change in low-density lipoprotein (LDL) cholesterol",{"measure":92,"description":81,"timeFrame":48},"Ratio to baseline: change in very low-density lipoprotein (VLDL) cholesterol",{"measure":94,"description":81,"timeFrame":48},"Ratio to baseline: change in non-HDL cholesterol",{"measure":96,"description":81,"timeFrame":48},"Ratio to baseline: change in triglycerides",{"measure":98,"description":81,"timeFrame":48},"Ratio to baseline: change in high-sensitivity C-reactive protein (hsCRP)",{"measure":100,"description":101,"timeFrame":102},"Number of treatment emergent adverse events (TEAEs)","Measured as events.","From baseline (week 0) to week 84 and week 140",{"measure":104,"description":101,"timeFrame":102},"Number of treatment emergent serious adverse events (TESAEs)",{"measure":106,"description":101,"timeFrame":102},"Number of TEAEs leading to permanent treatment discontinuation",{"measure":41,"description":108,"timeFrame":109},"Measured as % of body weight.","From baseline (week 0) to week 136","ALL","18 Years",{"inclusion":113,"exclusion":117,"raw_text":121},[114,115,116],"Male or female (sex at birth).","Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.","History of at least one self-reported unsuccessful dietary effort to lose body weight.",[118,119,120],"HbA1c ≥ 6.5% (48 millimole per mole \\[mmol\u002Fmol\\]) as measured by the central laboratory at screening.","History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.","Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.","Key Inclusion Criteria:\n\n* Male or female (sex at birth).\n* Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study.\n* History of at least one self-reported unsuccessful dietary effort to lose body weight.\n\nKey Exclusion Criteria:\n\n* HbA1c ≥ 6.5% (48 millimole per mole \\[mmol\u002Fmol\\]) as measured by the central laboratory at screening.\n* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.\n* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.",[123,124],"ADULT","OLDER_ADULT",[126,135,142,150,158,166,174,181,189,196,203,211,219,227,234,241,249,256,263,271,278,285,293,302,309,316,320,327,334,343,350,357,365,373,380,387,394,401,408,417,425,433,441,449,458,465,473,480,487,493,501,508,515,522,529,537,544,551,558,565,572,581,589,597,604,611,615,622,629,636,643,650],{"facility":127,"status":8,"city":128,"state":129,"zip":130,"country":131,"geoPoint":132},"South Broward Research LLC","Miramar","Florida","33027","United States",{"lat":133,"lon":134},25.98731,-80.23227,{"facility":136,"status":8,"city":137,"state":129,"zip":138,"country":131,"geoPoint":139},"Clinical Neuroscience Solution","Orlando","32801",{"lat":140,"lon":141},28.53834,-81.37924,{"facility":143,"status":8,"city":144,"state":145,"zip":146,"country":131,"geoPoint":147},"Hope Clin Res & Wellness","Conyers","Georgia","30094",{"lat":148,"lon":149},33.66761,-84.01769,{"facility":151,"status":8,"city":152,"state":153,"zip":154,"country":131,"geoPoint":155},"Endeavor Health","Skokie","Illinois","60077",{"lat":156,"lon":157},42.03336,-87.73339,{"facility":159,"status":8,"city":160,"state":161,"zip":162,"country":131,"geoPoint":163},"Midwest Inst For Clin Res","Indianapolis","Indiana","46260",{"lat":164,"lon":165},39.76838,-86.15804,{"facility":167,"status":8,"city":168,"state":169,"zip":170,"country":131,"geoPoint":171},"StudyMetrix Research LLC","City of Saint Peters","Missouri","63303",{"lat":172,"lon":173},38.80033,-90.62651,{"facility":175,"status":8,"city":176,"state":176,"zip":177,"country":131,"geoPoint":178},"New York Gastroenterology Associates","New York","10075",{"lat":179,"lon":180},40.71427,-74.00597,{"facility":182,"status":8,"city":183,"state":184,"zip":185,"country":131,"geoPoint":186},"UNC Eastowne Medical Office","Chapel Hill","North Carolina","27514",{"lat":187,"lon":188},35.9132,-79.05584,{"facility":190,"status":8,"city":191,"state":184,"zip":192,"country":131,"geoPoint":193},"PharmQuest Life Sciences LLC","Greensboro","27408",{"lat":194,"lon":195},36.07264,-79.79198,{"facility":197,"status":8,"city":198,"state":184,"zip":199,"country":131,"geoPoint":200},"Accellacare and KDCILM, LLC","Wilmington","28401",{"lat":201,"lon":202},34.23556,-77.94604,{"facility":204,"status":8,"city":205,"state":206,"zip":207,"country":131,"geoPoint":208},"UPA Ctr Weight and Eating Dis","Philadelphia","Pennsylvania","19104",{"lat":209,"lon":210},39.95238,-75.16362,{"facility":212,"status":8,"city":213,"state":214,"zip":215,"country":131,"geoPoint":216},"Clinical Res Collaborative","Cumberland","Rhode Island","02864",{"lat":217,"lon":218},41.96677,-71.43284,{"facility":220,"status":8,"city":221,"state":222,"zip":223,"country":131,"geoPoint":224},"Medical Uni of SC Charleston","Charleston","South Carolina","29425",{"lat":225,"lon":226},32.77632,-79.93275,{"facility":228,"status":8,"city":229,"state":222,"zip":230,"country":131,"geoPoint":231},"Coastal Carolina Research Ctr","North Charleston","29405",{"lat":232,"lon":233},32.85462,-79.97481,{"facility":235,"status":8,"city":236,"state":222,"zip":237,"country":131,"geoPoint":238},"Hillcrest Clinical Research","Simpsonville","29681-1538",{"lat":239,"lon":240},34.73706,-82.25428,{"facility":242,"status":8,"city":243,"state":244,"zip":245,"country":131,"geoPoint":246},"Amarillo Medical Specialists","Amarillo","Texas","79124",{"lat":247,"lon":248},35.222,-101.8313,{"facility":250,"status":8,"city":251,"state":244,"zip":252,"country":131,"geoPoint":253},"Velocity Clinical Res-Dallas","Dallas","75230-6855",{"lat":254,"lon":255},32.78306,-96.80667,{"facility":257,"status":8,"city":258,"state":244,"zip":259,"country":131,"geoPoint":260},"Care United Research, LLC","Forney","75126",{"lat":261,"lon":262},32.74818,-96.47193,{"facility":264,"status":8,"city":265,"state":266,"zip":267,"country":131,"geoPoint":268},"Washington Cntr Weight Mgmt","Arlington","Virginia","22206",{"lat":269,"lon":270},38.88101,-77.10428,{"facility":272,"status":8,"city":273,"state":266,"zip":274,"country":131,"geoPoint":275},"Health Res of Hampton Roads","Newport News","23606",{"lat":276,"lon":277},36.98038,-76.42975,{"facility":279,"status":8,"city":280,"state":266,"zip":281,"country":131,"geoPoint":282},"Selma Medical Associates","Winchester","22601-3834",{"lat":283,"lon":284},39.18566,-78.16333,{"facility":286,"status":8,"city":287,"state":288,"zip":289,"country":131,"geoPoint":290},"Rainier Clin Res Ctr Inc","Renton","Washington","98057",{"lat":291,"lon":292},47.48288,-122.21707,{"facility":294,"status":8,"city":295,"state":296,"zip":297,"country":298,"geoPoint":299},"Fundación CESIM","Santa Rosa","La Pampa Province","6300","Argentina",{"lat":300,"lon":301},-36.61617,-64.28991,{"facility":303,"status":8,"city":304,"zip":305,"country":298,"geoPoint":306},"Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli","Buenos Aires","C1425AGC",{"lat":307,"lon":308},-34.61315,-58.37723,{"facility":310,"status":8,"city":311,"zip":312,"country":298,"geoPoint":313},"Instituto de Investigaciones Clínicas Córdoba","Córdoba","5000",{"lat":314,"lon":315},-31.40648,-64.18853,{"facility":317,"status":8,"city":318,"zip":319,"country":298},"Sanatorio Esperanza","Esperanza, Santa Fe","S3080BQV",{"facility":321,"status":8,"city":322,"zip":323,"country":298,"geoPoint":324},"CIPADI","Godoy Cruz","M5501ARP",{"lat":325,"lon":326},-32.92533,-68.84428,{"facility":328,"status":8,"city":329,"zip":330,"country":298,"geoPoint":331},"Instituto de Investigaciones Clinicas San Nicolás","San Nicolás","B2900",{"lat":332,"lon":333},-31.43628,-64.45288,{"facility":335,"status":8,"city":336,"state":337,"zip":338,"country":339,"geoPoint":340},"Sydney Clinical Trials","Campbelltown","New South Wales","2560","Australia",{"lat":341,"lon":342},-34.06667,150.81667,{"facility":344,"status":8,"city":345,"state":337,"zip":346,"country":339,"geoPoint":347},"Sydney Cardiometabolic Centre","Liverpool","2170",{"lat":348,"lon":349},-33.91938,150.92588,{"facility":351,"status":8,"city":352,"state":337,"zip":353,"country":339,"geoPoint":354},"Hunter Diabetes Centre","Merewether","2291",{"lat":355,"lon":356},-32.94801,151.74325,{"facility":358,"status":8,"city":359,"state":360,"zip":361,"country":339,"geoPoint":362},"Heart of Australia","Chelmer","Queensland","4068",{"lat":363,"lon":364},-27.51326,152.97524,{"facility":366,"status":8,"city":367,"zip":368,"country":369,"geoPoint":370},"HUB - Hôpital Erasme","Brussels","1070","Belgium",{"lat":371,"lon":372},50.85045,4.34878,{"facility":374,"status":8,"city":375,"zip":376,"country":369,"geoPoint":377},"UZA - UZ Antwerpen - Department of Endocrinology","Edegem","2650",{"lat":378,"lon":379},51.15662,4.44504,{"facility":381,"status":8,"city":382,"zip":383,"country":369,"geoPoint":384},"Universitair Ziekenhuis Gent","Ghent","9000",{"lat":385,"lon":386},51.05,3.71667,{"facility":388,"status":8,"city":389,"zip":390,"country":369,"geoPoint":391},"UZ Leuven - Endocrinology","Leuven","3000",{"lat":392,"lon":393},50.87959,4.70093,{"facility":395,"status":8,"city":396,"zip":397,"country":369,"geoPoint":398},"MECLINAS","Mechelen","2800",{"lat":399,"lon":400},51.02574,4.47762,{"facility":402,"status":8,"city":403,"zip":404,"country":369,"geoPoint":405},"AZ Delta - Roeselare","Roeselare","8800",{"lat":406,"lon":407},50.94653,3.12269,{"facility":409,"status":8,"city":410,"state":411,"zip":412,"country":413,"geoPoint":414},"C-Health Partners","Calgary","Alberta","T2V 4J2","Canada",{"lat":415,"lon":416},51.05011,-114.08529,{"facility":418,"status":8,"city":419,"state":420,"zip":421,"country":413,"geoPoint":422},"Ocean West Research Clinic","Surrey","British Columbia","V3Z 2N6",{"lat":423,"lon":424},49.10635,-122.82509,{"facility":426,"status":8,"city":427,"state":428,"zip":429,"country":413,"geoPoint":430},"G.A. Research Associates Ltd.","Moncton","New Brunswick","E1G 1A7",{"lat":431,"lon":432},46.09454,-64.7965,{"facility":434,"status":8,"city":435,"state":436,"zip":437,"country":413,"geoPoint":438},"Nova Scotia Hlth Halifax","Halifax","Nova Scotia","B3H1V7",{"lat":439,"lon":440},44.64269,-63.57688,{"facility":442,"status":8,"city":443,"state":444,"zip":445,"country":413,"geoPoint":446},"Milestone Research","London","Ontario","N5W 6A2",{"lat":447,"lon":448},42.98339,-81.23304,{"facility":450,"status":8,"city":451,"state":452,"zip":453,"country":454,"geoPoint":455},"Sanos Clinic - Vejle","Vejle","Region Syddanmark","7100","Denmark",{"lat":456,"lon":457},55.70927,9.5357,{"facility":459,"status":8,"city":460,"zip":461,"country":454,"geoPoint":462},"Sanos Clinic - Gandrup","Gandrup","9362",{"lat":463,"lon":464},57.05744,10.18137,{"facility":466,"status":467,"city":468,"zip":469,"country":454,"geoPoint":470},"Steno Diabetes Center Nordjylland","COMPLETED","Gistrup","9260",{"lat":471,"lon":472},56.9943,9.99085,{"facility":474,"status":8,"city":475,"zip":476,"country":454,"geoPoint":477},"Gentofte Hospital - Center for Klinisk Metabolisk Forskning","Hellerup","2900",{"lat":478,"lon":479},55.73204,12.57093,{"facility":481,"status":8,"city":482,"zip":483,"country":454,"geoPoint":484},"Hillerød Endokrinologisk amb. H0652","Hillerød","3400",{"lat":485,"lon":486},55.92791,12.30081,{"facility":488,"status":8,"city":489,"zip":376,"country":454,"geoPoint":490},"Hvidovre Hospital Endokrinologisk forsknings afsnit 159","Hvidovre",{"lat":491,"lon":492},55.64297,12.47708,{"facility":494,"status":8,"city":495,"zip":496,"country":497,"geoPoint":498},"HOPITAL EUROPEEN GEORGES POMPIDOU_Service de nutrition et diabétologie","Paris","75015","France",{"lat":499,"lon":500},48.85341,2.3488,{"facility":502,"status":8,"city":503,"zip":504,"country":497,"geoPoint":505},"HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition","Pierre-Bénite","69310",{"lat":506,"lon":507},45.70359,4.82424,{"facility":509,"status":8,"city":510,"zip":511,"country":497,"geoPoint":512},"CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition","Saint-Herblain","44800",{"lat":513,"lon":514},47.21154,-1.651,{"facility":516,"status":8,"city":517,"zip":518,"country":497,"geoPoint":519},"CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE-HOPITAL RANGUEIL-Service de diabétologie et nutrition","Toulouse","31059",{"lat":520,"lon":521},43.60426,1.44367,{"facility":523,"status":8,"city":524,"zip":525,"country":497,"geoPoint":526},"CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques","Vénissieux","69200",{"lat":527,"lon":528},45.69706,4.88593,{"facility":530,"status":8,"city":531,"zip":532,"country":533,"geoPoint":534},"Herz- und Diabeteszentrum NRW - Bad Oeynhausen","Bad Oeynhausen","32545","Germany",{"lat":535,"lon":536},52.20699,8.80365,{"facility":538,"status":8,"city":539,"zip":540,"country":533,"geoPoint":541},"Zentrum für klinische Studien Südbrandenburg GmbH","Elsterwerda","04910",{"lat":542,"lon":543},51.46043,13.52001,{"facility":545,"status":8,"city":546,"zip":547,"country":533,"geoPoint":548},"MVZ im Altstadt-Carree Fulda GmbH - Zentrum für klinische Studien","Fulda","36037",{"lat":549,"lon":550},50.55162,9.67518,{"facility":552,"status":8,"city":553,"zip":554,"country":533,"geoPoint":555},"SMO.MD GmbH - Zentrum für klinische Studien","Magdeburg","39120",{"lat":556,"lon":557},52.13129,11.63189,{"facility":559,"status":8,"city":560,"zip":561,"country":533,"geoPoint":562},"Institut für Diabetesforschung Osnabrück","Osnabrück","49080",{"lat":563,"lon":564},52.27264,8.0498,{"facility":566,"status":8,"city":567,"zip":568,"country":533,"geoPoint":569},"Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann","Witten","58455",{"lat":570,"lon":571},51.44362,7.35258,{"facility":573,"status":8,"city":574,"state":575,"zip":576,"country":577,"geoPoint":578},"Fowey River Practice","Fowey","Cornwall","PL23 1DT","United Kingdom",{"lat":579,"lon":580},50.33634,-4.6386,{"facility":582,"status":8,"city":583,"state":584,"zip":585,"country":577,"geoPoint":586},"The Adam Practice","Poole","Dorset","BH16 5PW",{"lat":587,"lon":588},50.71429,-1.98458,{"facility":590,"status":8,"city":591,"state":592,"zip":593,"country":577,"geoPoint":594},"Pickering Medical Practice","Pickering","North Yorkshire","YO18 8BL",{"lat":595,"lon":596},54.25,-0.76667,{"facility":598,"status":8,"city":599,"state":419,"zip":600,"country":577,"geoPoint":601},"The Crouch Oak Family Practice","Addlestone","KT15 2BH",{"lat":602,"lon":603},51.37135,-0.49353,{"facility":605,"status":8,"city":606,"zip":607,"country":577,"geoPoint":608},"The Health Centre","Bradford-on-Avon","BA15 1DQ",{"lat":609,"lon":610},51.34772,-2.25065,{"facility":612,"status":8,"city":613,"zip":614,"country":577},"EMS Healthcare","Cheshire","CH65 4LE",{"facility":616,"status":8,"city":617,"zip":618,"country":577,"geoPoint":619},"HMC Health - Heston - The Meadows Centre for Health","Hounslow","TW4 7NJ",{"lat":620,"lon":621},51.46839,-0.36092,{"facility":623,"status":8,"city":624,"zip":625,"country":577,"geoPoint":626},"Kiltearn Medical Centre","Nantwich","CW5 5NX",{"lat":627,"lon":628},53.06878,-2.52051,{"facility":630,"status":8,"city":631,"zip":632,"country":577,"geoPoint":633},"Knowle House Surgery","Plymouth","PL5 3JB",{"lat":634,"lon":635},50.37153,-4.14305,{"facility":637,"status":8,"city":638,"zip":639,"country":577,"geoPoint":640},"Clifton Medical Centre","Rotherham","S65 1DA",{"lat":641,"lon":642},53.43012,-1.35678,{"facility":644,"status":8,"city":645,"zip":646,"country":577,"geoPoint":647},"Staploe Medical Centre","Soham","CB7 5JD",{"lat":648,"lon":649},52.33543,0.33654,{"facility":651,"status":8,"city":652,"zip":653,"country":577,"geoPoint":654},"Albany House Medical Centre","Wellingborough","NN8 4RW",{"lat":655,"lon":656},52.30273,-0.69446,[658],{"name":659,"role":660,"phone":661,"email":662},"Novo Nordisk","CONTACT","(+1) 866-867-7178","clinicaltrials@novonordisk.com",[664],{"name":665,"affiliation":13,"role":666},"Clinical Transparency (dept. 2834)","STUDY_DIRECTOR",[],[],{"nct_id":4,"conditions":670,"biomarkers":671},[19],[],{"nct_id":4,"found":673,"summary":674,"prompt_version":684},true,{"design":675,"status":676,"heading":677,"summary":678,"follow_up":679,"word_count":680,"commitments":681,"compensation":682,"drugs_mentioned":683},"This is an interventional study where participants are randomly assigned to receive either NNC0487-0111 or a placebo. It aims to enroll 1150 participants.","completed","AMAZE 1: NNC0487-0111 for Excess Body Weight","This study, called AMAZE 1, is looking into whether a medicine called NNC0487-0111 is safe and effective for people who have excess body weight. You would receive weekly injections under the skin, either of NNC0487-0111 or a placebo (a treatment with no active medicine). The study aims to see how much your body weight changes over 84 weeks. To join, you must be at least 18 years old, of any gender, and have tried to lose weight unsuccessfully before. Your blood sugar levels (HbA1c) must be below 6. The study plans to enroll about 1150 people.","The primary endpoint measures body weight change from baseline to week 84.",96,"Participants will receive weekly subcutaneous injections in the thigh, abdomen, or upper arm for 84 weeks.","Not stated in the trial record.",[31],"v2"]