[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07351318":3,"trial-entities:NCT07351318":82,"trial-summary:NCT07351318":86},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":28,"primary_purpose":29,"phases":30,"enrollment_info":31,"interventions":34,"primary_outcomes":35,"secondary_outcomes":40,"sex":47,"minimum_age":48,"maximum_age":29,"healthy_volunteers":15,"eligibility_criteria":49,"std_ages":57,"locations":60,"central_contacts":78,"overall_officials":79,"references":80,"see_also_links":81},"NCT07351318","20254424","Estimating Insulin Sensitivity in Pregnancies With Type 1 Diabetes","Estimating Insulin Sensitivity Fluctuations Across Pregnancies With Type 1 Diabetes","ENROLLING_BY_INVITATION","2027-03","2026-02","2026-03-02","2026-02-01","University of Virginia","OTHER",false,"The investigators want to learn how the body's response to insulin changes during pregnancy in people with Type 1 Diabetes.\n\nIn this study, the investigators will look at information from people who used a Dexcom continuous glucose monitor (CGM) and a Tandem insulin pump while they were pregnant. Participants will fill out an online survey and agree to share their device data. The investigators will use this information to see how insulin sensitivity changes from three months before pregnancy to six months after the baby is born.","The aim of this retrospective observational study is to collect continuous glucose monitor (CGM) and insulin pump data from pregnant individuals with Type 1 Diabetes, from 3 months before conception to 6 months after delivery. This data will be used to estimate how insulin sensitivity (IS) changes across gestation, with the goal of better understanding glucose-insulin dynamics during pregnancy and develop algorithms for adapting insulin administration across gestational ages.\n\nParticipants will complete an online survey where they will provide their insulin pump serial number, date of delivery, gestational week at delivery, date of last menstrual cycle (if known), and other optional demographic information. The study team will use this information to retrieve participants' CGM and insulin infusion data from 3 months before conception to 6 months after delivery.\n\nUp to 200 participants will be screened, with the goal of reaching 100 screened participants.",[19,20],"Pregnancy","Type 1 Diabetes (T1D)",[22,23,24,25,26,27],"pregnancy","type 1 diabetes","diabetes","insulin","insulin sensitivity","gestation","OBSERVATIONAL",null,[],{"count":32,"type":33},100,"ESTIMATED",[],[36],{"measure":37,"description":38,"timeFrame":39},"Percent Time in Target Range","Percentage of time blood glucose was 70mg\u002FdL and 180mg\u002FdL as per CGM","Assessed every 2 weeks from 4 weeks pre-conception to 6 months post partum",[41,44],{"measure":42,"description":43,"timeFrame":39},"Percent Time Below Range","Percentage of time blood glucose was below 70mg\u002FdL as per CGM",{"measure":45,"description":46,"timeFrame":39},"Percent Time Above Range","Percentage of time blood glucose was above 180 mg\u002Fdl as per CGM","FEMALE","18 Years",{"inclusion":50,"exclusion":55,"raw_text":56},[51,52,53,54],"Age \\>=18 years old","Pregnant within the last 8 years","Diagnosed with type 1 diabetes for at least one year at the time of pregnancy","Use of a Dexcom CGM system (Dexcom, Inc., CA) and Tandem insulin infusion pump (Tandem Diabetes Care, CA) across gestation, and willing to share data from this pregnancy with study staff.",[],"Inclusion Criteria:\n\n* Age \\>=18 years old\n* Pregnant within the last 8 years\n* Diagnosed with type 1 diabetes for at least one year at the time of pregnancy\n* Use of a Dexcom CGM system (Dexcom, Inc., CA) and Tandem insulin infusion pump (Tandem Diabetes Care, CA) across gestation, and willing to share data from this pregnancy with study staff.",[58,59],"ADULT","OLDER_ADULT",[61,70],{"facility":62,"city":63,"state":64,"zip":65,"country":66,"geoPoint":67},"Northwestern Memorial Hospital","Chicago","Illinois","60611","United States",{"lat":68,"lon":69},41.85003,-87.65005,{"facility":71,"city":72,"state":73,"zip":74,"country":66,"geoPoint":75},"UVA Health","Charlottesville","Virginia","22903",{"lat":76,"lon":77},38.02931,-78.47668,[],[],[],[],{"nct_id":4,"conditions":83,"biomarkers":85},[19,84],"Type 1 Diabetes Mellitus",[],{"nct_id":4,"found":15,"summary":29,"prompt_version":29}]