[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07393503":3,"trial-entities:NCT07393503":98,"trial-summary:NCT07393503":101},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":14,"conditions":16,"keywords":18,"study_type":19,"primary_purpose":13,"phases":20,"enrollment_info":22,"interventions":25,"primary_outcomes":46,"secondary_outcomes":51,"sex":55,"minimum_age":56,"maximum_age":14,"healthy_volunteers":57,"eligibility_criteria":58,"std_ages":81,"locations":84,"central_contacts":94,"overall_officials":95,"references":96,"see_also_links":97},"NCT07393503","STUDY00009423","Musculoskeletal Outcomes Using Tylenol\u002FIbuprofen vs. Oral Steroids in New Injuries","ENROLLING_BY_INVITATION","2027-01","2026-02","2026-02-18","2025-09-17","State University of New York at Buffalo","OTHER",null,"In this pilot study, the investigators aim to compare two short-term pain relief methods administered over the course of 6 days in the setting of acute musculoskeletal (MSK) pain:\n\n1. Methylprednisolone((Medrol)dose pack- standard taper per dose pack instructions\n2. Standard of Care (SOC) which includes a combination of Acetaminophen (Tylenol)+Ibuprofen (Motrin)\n\nThe investigators are interested in studying pain relief regimens for acute injury of any body part among an adult orthopaedic urgent care population.",[17],"Musculoskeletal Pain",[],"INTERVENTIONAL",[21],"PHASE4",{"count":23,"type":24},60,"ESTIMATED",[26,34,41],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":32},"DRUG","Methylprednisolone 4Mg Tab","Participants follow standard 6- day taper dosing schedule.",[31],"Methylprednisolone",[33],"Medrol",{"type":27,"name":35,"description":36,"armGroupLabels":37,"otherNames":39},"Acetaminophen 500Mg Tab","Participants follow a 6- day taper dosing schedule.",[38],"Oral Acetaminophen and Ibuprofen",[40],"Tylenol",{"type":27,"name":42,"description":36,"armGroupLabels":43,"otherNames":44},"Ibuprofen 200Mg Oral Tablet",[38],[45],"Motrin",[47],{"measure":48,"description":49,"timeFrame":50},"Change in Pain","Pain as self-reported by the patient, following pain medication treatment for an acute musculoskeletal (MSK) injury as measured with the Visual Analog Scale (VAS) where 0 is no pain at all and 10 is the worst pain imaginable. Lower scores indicate less pain.","1 week, 1 month",[52],{"measure":53,"description":54,"timeFrame":50},"Change in Function","Function as self-reported by the patient following pain medication treatment for an acute musculoskeletal (MSK) injury as measured with the musculoskeletal health questionnaire (MSK-HQ) scale which sums 14 health domains on a 5-point scale from 4 being not at all and 0 to very severe. Higher scores indicate better overall MSK health.","ALL","18 Years",false,{"inclusion":59,"exclusion":64,"raw_text":80},[60,61,62,63],"Adults 18+","Able to answer survey questions in English","MSK pain \\> 3 on the VAS scale in any body part","Invited to participate by and enrolling clinician",[65,66,67,68,69,70,71,72,73,74,75,76,77,78,79],"\\> 2 weeks from pain onset","Fractures","Active infections","Anaphylactic reaction to either medication (Oral Steroids, Ibuprofen, and\u002For Acetaminophen)","Currently taking anti-platelet agents (aspirin \\\u003C\u002F= 100\u002Fmg a day, clopidogrel, etc.)","Chronic Kidney Disease Stage 3 or worse","Uncontrolled diabetes (A1C above 9)","Currently taking oral anti-coagulants","History of bleeding ulcer","Cirrhosis","Taking daily prednisone","Chronic pain syndrome","Chronic pain medication (gabapentin, Lyrica, narcotics, etc.)","Pregnant Patients","Worker's Compensation Patients","Inclusion Criteria:\n\n* Adults 18+\n* Able to answer survey questions in English\n* MSK pain \\> 3 on the VAS scale in any body part\n* Invited to participate by and enrolling clinician\n\nExclusion Criteria:\n\n* \\> 2 weeks from pain onset\n* Fractures\n* Active infections\n* Anaphylactic reaction to either medication (Oral Steroids, Ibuprofen, and\u002For Acetaminophen)\n* Currently taking anti-platelet agents (aspirin \\\u003C\u002F= 100\u002Fmg a day, clopidogrel, etc.)\n* Chronic Kidney Disease Stage 3 or worse\n* Uncontrolled diabetes (A1C above 9)\n* Currently taking oral anti-coagulants\n* History of bleeding ulcer\n* Cirrhosis\n* Taking daily prednisone\n* Chronic pain syndrome\n* Chronic pain medication (gabapentin, Lyrica, narcotics, etc.)\n* Pregnant Patients\n* Worker's Compensation Patients",[82,83],"ADULT","OLDER_ADULT",[85],{"facility":86,"city":87,"state":88,"zip":89,"country":90,"geoPoint":91},"UBMD Orthopaedics and Sports Medicine (716 Health)","Buffalo","New York","14221","United States",{"lat":92,"lon":93},42.88645,-78.87837,[],[],[],[],{"nct_id":4,"conditions":99,"biomarkers":100},[17],[],{"nct_id":4,"found":57,"summary":14,"prompt_version":14}]