[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07483164":3,"trial-entities:NCT07483164":122,"trial-summary:NCT07483164":126},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":14,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":44,"secondary_outcomes":49,"sex":86,"minimum_age":87,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":88,"std_ages":99,"locations":102,"central_contacts":112,"overall_officials":113,"references":117,"see_also_links":118},"NCT07483164","25-014117","A Study Of T1\u002FTref Intubating Conditions","Intubating Conditions Based On The Ratio Between The Twitch Amplitude And Reference Twitch Amplitude: A Randomized, Prospective, Clinical Trial","ENROLLING_BY_INVITATION","2026-12-31","2026-07","2026-07-20","2026-08-31","Mayo Clinic","OTHER",false,"The purpose of this study is to determine the maximum ratio of the twitch amplitude (T1) to the reference twitch (Tref) amplitude (T1\u002FTref) that provides excellent intubating conditions.",null,[19],"Intubation",[],"INTERVENTIONAL",[23],"NA",{"count":25,"type":26},108,"ESTIMATED",[28,34,39],{"type":29,"name":30,"description":31,"armGroupLabels":32},"DEVICE","Twitch amplitude \u003C0.1","(T1\u002FTref) \\\u003C0.1",[33],"T1\u002FTref \u003C0.1",{"type":14,"name":35,"description":36,"armGroupLabels":37},"Twitch amplitude \u003C0.3","(T1\u002FTref) \\\u003C0.3",[38],"T1\u002FTref \u003C0.3",{"type":14,"name":40,"description":41,"armGroupLabels":42},"Twitch amplitude \u003C0.5","(T1\u002FTref) \\\u003C0.5",[43],"T1\u002FTref \u003C0.5",[45],{"measure":46,"description":47,"timeFrame":48},"Maximum T1\u002FTref ratio associated with excellent intubating conditions","The T1\u002FTref ratio that leads to the highest proportion of patients being intubated under excellent conditions: T1\u002FTref \\\u003C0.1, T1\u002FTref \\\u003C0.3, or T1\u002FTref \\\u003C0.5","Baseline",[50,53,56,59,62,65,68,71,74,77,80,83],{"measure":51,"description":52,"timeFrame":48},"Proportion of patients with excellent intubating conditions at predefined T1\u002FTred threshold: \u003C0.1","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.1 arm, considered to have excellent intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":54,"description":55,"timeFrame":48},"Proportion of patients with good intubating conditions at predefined T1\u002FTred threshold: \u003C0.1","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.1 arm considered to have good intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":57,"description":58,"timeFrame":48},"Proportion of patients with poor intubating conditions at predefined T1\u002FTred threshold: \u003C0.1","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.1 arm, considered to have poor intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":60,"description":61,"timeFrame":48},"Proportion of patients with excellent intubating conditions at predefined T1\u002FTred threshold: \u003C0.3","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.3 arm, considered to have excellent intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":63,"description":64,"timeFrame":48},"Proportion of patients with good intubating conditions at predefined T1\u002FTred threshold: \u003C0.3","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.3 arm, considered to have good intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":66,"description":67,"timeFrame":48},"Proportion of patients with poor intubating conditions at predefined T1\u002FTred threshold: \u003C0.3","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.3 arm, considered to have poor intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":69,"description":70,"timeFrame":48},"Proportion of patients with excellent intubating conditions at predefined T1\u002FTred threshold: \u003C0.5","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.5 arm, considered to have excellent intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":72,"description":73,"timeFrame":48},"Proportion of patients with good intubating conditions at predefined T1\u002FTred threshold: \u003C0.5","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.5 arm, considered to have good intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":75,"description":76,"timeFrame":48},"Proportion of patients with poor intubating conditions at predefined T1\u002FTred threshold: \u003C0.5","Percentage of patients, out of total patients in the T1\u002FTref \\\u003C0.5 arm, considered to have poor intubation conditions (using Copenhagen Consensus Conference Intubation Score)",{"measure":78,"description":79,"timeFrame":48},"Time to reach specific neuromuscular block level from rocuronium administration to achieving T1\u002FTref \u003C0.1","Time to reach specific neuromuscular block level from rocuronium administration to achieving T1\u002FTref \\\u003C0.1 will be reported in seconds",{"measure":81,"description":82,"timeFrame":48},"Time to reach specific neuromuscular block level from rocuronium administration to achieving T1\u002FTref \u003C0.3","Time to reach specific neuromuscular block level from rocuronium administration to achieving T1\u002FTref \\\u003C0.3 will be reported in seconds",{"measure":84,"description":85,"timeFrame":48},"Time to reach specific neuromuscular block level from rocuronium administration to achieving T1\u002FTref \u003C0.5","Time to reach specific neuromuscular block level from rocuronium administration to achieving T1\u002FTref \\\u003C0.5 will be reported in seconds","ALL","18 Years",{"inclusion":89,"exclusion":92,"raw_text":98},[90,91],"Age \\> or = 18 years old","Patients willing to participate and provide an integrated, informed consent",[93,94,95,96,97],"Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.","Patients with systemic neuromuscular diseases such as myasthenia gravis.","Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents, i.e., severe renal impairment requiring dialysis or end-stage liver disease.","Patients requiring a rapid sequence induction for airway protection.","Patients deemed ineligible for surgery, including pregnancy (as determined by standard of care testing).","Inclusion Criteria:\n\n* Age \\> or = 18 years old\n* Patients willing to participate and provide an integrated, informed consent\n\nExclusion Criteria\n\n* Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.\n* Patients with systemic neuromuscular diseases such as myasthenia gravis.\n* Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents, i.e., severe renal impairment requiring dialysis or end-stage liver disease.\n* Patients requiring a rapid sequence induction for airway protection.\n* Patients deemed ineligible for surgery, including pregnancy (as determined by standard of care testing).",[100,101],"ADULT","OLDER_ADULT",[103],{"facility":104,"city":105,"state":106,"zip":107,"country":108,"geoPoint":109},"Mayo Clinic in Florida","Jacksonville","Florida","32224","United States",{"lat":110,"lon":111},30.33218,-81.65565,[],[114],{"name":115,"affiliation":13,"role":116},"J. Ross Renew, MD","PRINCIPAL_INVESTIGATOR",[],[119],{"label":120,"url":121},"Mayo Clinic Clinical Trials","https:\u002F\u002Fwww.mayo.edu\u002Fresearch\u002Fclinical-trials",{"nct_id":4,"conditions":123,"biomarkers":125},[124],"Intubation Procedure",[],{"nct_id":4,"found":15,"summary":17,"prompt_version":17}]