[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07499232":3,"trial-entities:NCT07499232":1164,"trial-summary:NCT07499232":1167},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":25,"interventions":28,"primary_outcomes":40,"secondary_outcomes":45,"sex":70,"minimum_age":71,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":72,"std_ages":86,"locations":89,"central_contacts":1152,"overall_officials":1158,"references":1162,"see_also_links":1163},"NCT07499232","CNTO1959CRD3009","A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease","A Phase 3b, Multicenter, Randomized, Open-Label, Active-Controlled Study to Compare the Efficacy and Safety of Guselkumab Versus Risankizumab in the Treatment of Participants With Moderately to Severely Active Crohn's Disease","RECRUITING","2030-12-11","2026-08","2026-08-28","2026-04-21","Janssen Research & Development, LLC","INDUSTRY",false,"The purpose of this study is to assess how well guselkumab works when compared to risankizumab in participants with moderately to severely active Crohn's Disease (CD; a long-term condition causing severe inflammation of the intestinal tract).",null,[19],"Crohn Disease",[],"INTERVENTIONAL","TREATMENT",[24],"PHASE3",{"count":26,"type":27},530,"ESTIMATED",[29,36],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","Guselkumab","Guselkumab will be administered.",[31],[35],"CNTO1959",{"type":30,"name":37,"description":38,"armGroupLabels":39},"Risankizumab","Risankizumab will be administered.",[37],[41],{"measure":42,"description":43,"timeFrame":44},"Number of Participants with Deep Remission at Week 52","Deep remission is a composite endpoint defined as achieving both clinical remission and endoscopic remission at the participant level. Clinical remission is defined as Crohn's Disease Activity Index (CDAI) score less than (\\\u003C) 150-point. CDAI will be assessed by collecting information on 8 different CD-related variables: extra-intestinal manifestations, abdominal mass, weight, hematocrit, total number of liquid stools, abdominal pain\u002Fcramping, use of antidiarrheal drug(s), and\u002For opiates, and general well-being. In general, CDAI score ranges from 0 to approximately 600. Higher score indicates higher disease activity. Endoscopic remission is defined as Simple Endoscopic Score for Crohn's Disease (SES-CD) less than or equal to (\\\u003C=) 4 with at least a 2-point reduction from baseline and no sub score greater than (\\>) 1 in any individual component and score can range from 0 to 56. Higher scores indicating severe disease.","At Week 52",[46,49,52,55,58,62,66],{"measure":47,"description":48,"timeFrame":44},"Composite Endpoint of Number of Participants with Clinical Remission and Endoscopic Response at Week 52","Clinical remission is defined as CDAI score \\\u003C 150-point. CDAI will be assessed by collecting information on 8 different CD-related variables: extra-intestinal manifestations, abdominal mass, weight, hematocrit, total number of liquid stools, abdominal pain\u002Fcramping, use of antidiarrheal drug(s), and\u002For opiates, and general well-being. In general, CDAI score ranges from 0 to approximately 600. Higher score indicates higher disease activity. Endoscopic response is defined as \\>50 percent (%) improvement from baseline in the SES CD or SES-CD score \\\u003C= 2 or a decrease of at least 2 points in participants with a baseline score of 4 and isolated ileal disease. This is a composite endpoint defined to measure achievement of both clinical remission and endoscopic response.",{"measure":50,"description":51,"timeFrame":44},"Number of Participants with Endoscopic Remission at Week 52","Endoscopic remission is defined as SES-CD \\\u003C= 4 with at least a 2-point reduction from baseline and no sub score \\> 1 in any individual component and score can range from 0 to 56. Higher scores indicating severe disease.",{"measure":53,"description":54,"timeFrame":44},"Number of Participants with Clinical Remission at Week 52","Clinical remission is defined as CDAI score \\\u003C 150-point. CDAI will be assessed by collecting information on 8 different CD-related variables: extra-intestinal manifestations, abdominal mass, weight, hematocrit, total number of liquid stools, abdominal pain\u002Fcramping, use of antidiarrheal drug(s), and\u002For opiates, and general well-being. In general, CDAI score ranges from 0 to approximately 600. Higher score indicates higher disease activity.",{"measure":56,"description":57,"timeFrame":44},"Number of Participants with Steroid-Free Clinical Remission at Week 52","Steroid-free clinical remission is defined as clinical remission at Week 52 and not receiving corticosteroids for at least 90 days prior to Week 52. Clinical remission is defined as CDAI score \\\u003C 150-point.",{"measure":59,"description":60,"timeFrame":61},"Number of Participants with Abnormalities in Laboratory Parameters","Number of participants with abnormalities in laboratory parameters (hematology and chemistry) will be reported.","Up to Week 148",{"measure":63,"description":64,"timeFrame":65},"Number of Participants With Change From Baseline in Laboratory Abnormalities","Number of participants with change from baseline in laboratory abnormalities (hematology and chemistry) will be reported.","Up to week 148",{"measure":67,"description":68,"timeFrame":69},"Number of Participants with Adverse Events (AEs), Serious AEs and AEs Leading to Discontinuation of Study Intervention","An AE is any untoward medical occurrence in a participant administered a pharmaceutical (investigational or non investigational) product. An AE does not necessarily have a causal relationship with the treatment. An SAE is any untoward medical occurrence that at any dose results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability\u002Fincapacity, is a congenital anomaly\u002Fbirth defect, is a suspected transmission of any infectious agent via a medicinal product and is medically important.","Up to Week 165","ALL","18 Years",{"inclusion":73,"exclusion":79,"raw_text":85},[74,75,76,77,78],"Has CD or fistulizing Crohn's Disease (CD) of at least 12 weeks' duration, with colitis, ileitis, or ileocolitis, confirmed at some time in the past by radiography, histology, and\u002For endoscopy","Have moderately to severely active CD, defined as baseline Crohn's Disease Activity Index (CDAI) score greater than or equal to (\\>=) 220 but less than or equal to (\\\u003C=) 450","Baseline endoscopic evidence of active ileal and\u002For colonic CD as assessed by central endoscopy reading at the screening endoscopy defined as a screening Simple Endoscopic Score for Crohn's Disease (SES CD) \\>= 4 (for participants with isolated ileal disease) or \\>= 6 (for participants with colonic or ileocolonic disease), based on the presence of ulceration in any 1 of the 5 ileocolonic segments, resulting in the following specified ulceration component scores:","In the opinion of the investigator, participant's disease is appropriate to treat with the maintenance dosing regimens utilized in the study","Adhere to the requirements for concomitant medications for the treatment of CD as mentioned in the protocol",[80,81,82,83,84],"Has complications of CD such as symptomatic strictures or stenoses, short gut syndrome, active draining stoma or significant fistulizing disease or any other manifestation anticipated to require surgery within the next year, could preclude the use of the CDAI to assess response to therapy, or would possibly confound the ability to assess the effect of treatment with guselkumab or risankizumab","Currently has or is suspected to have an abscess","Has an active fistula during screening or at Week 0 with an anticipated need for surgery","Has had any kind of bowel resection within 24 weeks, or any other intra-abdominal or other major surgery within 12 weeks, before first dose of study intervention","Currently has a malignancy or has a history of malignancy within 5 years before screening","Inclusion criteria:\n\n* Has CD or fistulizing Crohn's Disease (CD) of at least 12 weeks' duration, with colitis, ileitis, or ileocolitis, confirmed at some time in the past by radiography, histology, and\u002For endoscopy\n* Have moderately to severely active CD, defined as baseline Crohn's Disease Activity Index (CDAI) score greater than or equal to (\\>=) 220 but less than or equal to (\\\u003C=) 450\n* Baseline endoscopic evidence of active ileal and\u002For colonic CD as assessed by central endoscopy reading at the screening endoscopy defined as a screening Simple Endoscopic Score for Crohn's Disease (SES CD) \\>= 4 (for participants with isolated ileal disease) or \\>= 6 (for participants with colonic or ileocolonic disease), based on the presence of ulceration in any 1 of the 5 ileocolonic segments, resulting in the following specified ulceration component scores:\n\n  1. a minimum score of 1 for the component of \"size of ulcers\" AND\n  2. a minimum score of 1 for the component of \"ulcerated surface\"\n* In the opinion of the investigator, participant's disease is appropriate to treat with the maintenance dosing regimens utilized in the study\n* Adhere to the requirements for concomitant medications for the treatment of CD as mentioned in the protocol\n\nExclusion criteria\n\n* Has complications of CD such as symptomatic strictures or stenoses, short gut syndrome, active draining stoma or significant fistulizing disease or any other manifestation anticipated to require surgery within the next year, could preclude the use of the CDAI to assess response to therapy, or would possibly confound the ability to assess the effect of treatment with guselkumab or risankizumab\n* Currently has or is suspected to have an abscess\n* Has an active fistula during screening or at Week 0 with an anticipated need for surgery\n* Has had any kind of bowel resection within 24 weeks, or any other intra-abdominal or other major surgery within 12 weeks, before first dose of study intervention\n* Currently has a malignancy or has a history of malignancy within 5 years before screening",[87,88],"ADULT","OLDER_ADULT",[90,99,106,114,121,128,135,139,147,154,162,170,178,185,189,196,203,211,215,222,230,238,246,254,262,270,278,284,292,299,307,315,323,331,339,346,353,360,363,370,378,385,392,399,406,413,420,428,432,439,446,453,460,467,476,484,492,499,506,513,521,525,533,540,547,551,558,564,572,576,580,587,591,598,602,610,617,624,631,635,642,649,656,664,671,678,685,692,699,706,713,717,724,731,738,746,750,757,764,771,778,785,792,799,807,811,815,819,823,827,834,841,849,856,863,870,877,884,891,899,906,913,921,928,932,939,946,953,960,964,972,979,986,993,1000,1003,1010,1018,1025,1032,1039,1046,1053,1057,1064,1071,1079,1086,1093,1097,1101,1108,1113,1116,1120,1126,1130,1134,1138,1145],{"facility":91,"status":8,"city":92,"state":93,"zip":94,"country":95,"geoPoint":96},"Digestive Health Specialists of the Southeast","Dothan","Alabama","36305","United States",{"lat":97,"lon":98},31.22323,-85.39049,{"facility":100,"status":8,"city":101,"state":93,"zip":102,"country":95,"geoPoint":103},"East View Medical Research","Mobile","36608",{"lat":104,"lon":105},30.69436,-88.04305,{"facility":107,"status":8,"city":108,"state":109,"zip":110,"country":95,"geoPoint":111},"Clinnova Research","Anaheim","California","92805",{"lat":112,"lon":113},33.83529,-117.9145,{"facility":115,"status":8,"city":116,"state":109,"zip":117,"country":95,"geoPoint":118},"Gastro Care Institute","Lancaster","93534",{"lat":119,"lon":120},34.69804,-118.13674,{"facility":122,"status":8,"city":123,"state":109,"zip":124,"country":95,"geoPoint":125},"United Gastroenterologists","Los Alamitos","90720",{"lat":126,"lon":127},33.80307,-118.07256,{"facility":129,"status":8,"city":130,"state":109,"zip":131,"country":95,"geoPoint":132},"TLC Clinical Research Inc","Los Angeles","90048",{"lat":133,"lon":134},34.05223,-118.24368,{"facility":136,"status":8,"city":130,"state":109,"zip":137,"country":95,"geoPoint":138},"GastroIntestinal Bioscience","90067",{"lat":133,"lon":134},{"facility":140,"status":141,"city":142,"state":109,"zip":143,"country":95,"geoPoint":144},"Hoag Memorial Hospital","SUSPENDED","Newport Beach","92663",{"lat":145,"lon":146},33.61891,-117.92895,{"facility":148,"status":8,"city":149,"state":109,"zip":150,"country":95,"geoPoint":151},"Medical Associates Research Group, Inc.","San Diego","92123",{"lat":152,"lon":153},32.71571,-117.16472,{"facility":155,"status":8,"city":156,"state":157,"zip":158,"country":95,"geoPoint":159},"Peak Gastroenterology Associates","Colorado Springs","Colorado","80907",{"lat":160,"lon":161},38.83388,-104.82136,{"facility":163,"status":8,"city":164,"state":165,"zip":166,"country":95,"geoPoint":167},"Medical Research Center of Connecticut","Hamden","Connecticut","06518",{"lat":168,"lon":169},41.39593,-72.89677,{"facility":171,"status":8,"city":172,"state":173,"zip":174,"country":95,"geoPoint":175},"Green Leaf Clinical Trials","Jacksonville","Florida","32258",{"lat":176,"lon":177},30.33218,-81.65565,{"facility":179,"status":8,"city":180,"state":173,"zip":181,"country":95,"geoPoint":182},"Sanchez Clinical Research, Inc","Miami","33157-6575",{"lat":183,"lon":184},25.77427,-80.19366,{"facility":186,"status":8,"city":180,"state":173,"zip":187,"country":95,"geoPoint":188},"Biodax Medical Research Trials","33186",{"lat":183,"lon":184},{"facility":190,"status":8,"city":191,"state":173,"zip":192,"country":95,"geoPoint":193},"GI Pros Research","Naples","34102",{"lat":194,"lon":195},26.14234,-81.79596,{"facility":197,"status":8,"city":198,"state":173,"zip":199,"country":95,"geoPoint":200},"GCP Clinical Research","Tampa","33609",{"lat":201,"lon":202},27.94752,-82.45843,{"facility":204,"status":8,"city":205,"state":206,"zip":207,"country":95,"geoPoint":208},"Morehouse School of Medicine","Atlanta","Georgia","30310",{"lat":209,"lon":210},33.749,-84.38798,{"facility":212,"status":141,"city":205,"state":206,"zip":213,"country":95,"geoPoint":214},"Atlanta Gastroenterology Associates","30342",{"lat":209,"lon":210},{"facility":216,"status":8,"city":217,"state":206,"zip":218,"country":95,"geoPoint":219},"Gastroenterology Associates of Central GA","Macon","31201",{"lat":220,"lon":221},32.84069,-83.6324,{"facility":223,"status":141,"city":224,"state":225,"zip":226,"country":95,"geoPoint":227},"Comprehensive Gastrointestinal Health Libertyville","Northbrook","Illinois","60062",{"lat":228,"lon":229},42.12753,-87.82895,{"facility":231,"status":8,"city":232,"state":233,"zip":234,"country":95,"geoPoint":235},"Cotton-O'Neil Clinical Research Center","Topeka","Kansas","66606",{"lat":236,"lon":237},39.04833,-95.67804,{"facility":239,"status":8,"city":240,"state":241,"zip":242,"country":95,"geoPoint":243},"Gastroenterology Clinic of Acadiana","Lafayette","Louisiana","70503",{"lat":244,"lon":245},30.22409,-92.01984,{"facility":247,"status":8,"city":248,"state":249,"zip":250,"country":95,"geoPoint":251},"Woodholme Gastroenterology Associates","Glen Burnie","Maryland","21061",{"lat":252,"lon":253},39.16261,-76.62469,{"facility":255,"status":8,"city":256,"state":257,"zip":258,"country":95,"geoPoint":259},"Lucida Clinical Trials","New Bedford","Massachusetts","02740",{"lat":260,"lon":261},41.63526,-70.92701,{"facility":263,"status":8,"city":264,"state":265,"zip":266,"country":95,"geoPoint":267},"Michigan Center of Medical Research","Farmington Hills","Michigan","48334",{"lat":268,"lon":269},42.48531,-83.37716,{"facility":271,"status":8,"city":272,"state":273,"zip":274,"country":95,"geoPoint":275},"Westchester Putnam Gastroenterology","Carmel","New York","10512",{"lat":276,"lon":277},41.43009,-73.68013,{"facility":279,"status":8,"city":273,"state":273,"zip":280,"country":95,"geoPoint":281},"New York Gastroenterology Associates","10075",{"lat":282,"lon":283},40.71427,-74.00597,{"facility":285,"status":8,"city":286,"state":287,"zip":288,"country":95,"geoPoint":289},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27599 7080",{"lat":290,"lon":291},35.9132,-79.05584,{"facility":293,"status":8,"city":294,"state":287,"zip":295,"country":95,"geoPoint":296},"Charlotte Gastroenterology and Hepatology, PLLC","Charlotte","28207",{"lat":297,"lon":298},35.22709,-80.84313,{"facility":300,"status":8,"city":301,"state":302,"zip":303,"country":95,"geoPoint":304},"Great Lakes Gastroenterology Research, LLC","Mentor","Ohio","44060",{"lat":305,"lon":306},41.66616,-81.33955,{"facility":308,"status":8,"city":309,"state":310,"zip":311,"country":95,"geoPoint":312},"Digestive Disease Specialists Inc","Oklahoma City","Oklahoma","73114",{"lat":313,"lon":314},35.46756,-97.51643,{"facility":316,"status":8,"city":317,"state":318,"zip":319,"country":95,"geoPoint":320},"Frontier Clinical Research","Uniontown","Pennsylvania","15401",{"lat":321,"lon":322},39.90008,-79.71643,{"facility":324,"status":8,"city":325,"state":326,"zip":327,"country":95,"geoPoint":328},"Palmetto Primary and Specialty Care Physicians, Charleston","Summerville","South Carolina","29486",{"lat":329,"lon":330},33.0185,-80.17565,{"facility":332,"status":8,"city":333,"state":334,"zip":335,"country":95,"geoPoint":336},"DFW Clinical Trials","Carrollton","Texas","75010",{"lat":337,"lon":338},32.95373,-96.89028,{"facility":340,"status":141,"city":341,"state":334,"zip":342,"country":95,"geoPoint":343},"UT Southwestern","Dallas","75390",{"lat":344,"lon":345},32.78306,-96.80667,{"facility":347,"status":8,"city":348,"state":334,"zip":349,"country":95,"geoPoint":350},"Lubbock Gastroenterology","Lubbock","79424",{"lat":351,"lon":352},33.57786,-101.85517,{"facility":354,"status":8,"city":355,"state":334,"zip":356,"country":95,"geoPoint":357},"Gastroenterology Research of America, LLC","San Antonio","78229",{"lat":358,"lon":359},29.42412,-98.49363,{"facility":361,"status":8,"city":355,"state":334,"zip":356,"country":95,"geoPoint":362},"Southern Star Research Institute, LLC",{"lat":358,"lon":359},{"facility":364,"status":8,"city":365,"state":334,"zip":366,"country":95,"geoPoint":367},"The University of Texas Health Science Center at Tyler","Tyler","75708",{"lat":368,"lon":369},32.35126,-95.30106,{"facility":371,"status":8,"city":372,"zip":373,"country":374,"geoPoint":375},"LKH-Univ. Klinikum Graz","Graz","8036","Austria",{"lat":376,"lon":377},47.06733,15.44197,{"facility":379,"status":8,"city":380,"zip":381,"country":374,"geoPoint":382},"Medizinische Universitatsklinik Innsbruck","Innsbruck","6020",{"lat":383,"lon":384},47.26266,11.39454,{"facility":386,"status":8,"city":387,"zip":388,"country":374,"geoPoint":389},"Kepler Universitatsklinikum GmbH","Linz","4021",{"lat":390,"lon":391},48.30639,14.28611,{"facility":393,"status":8,"city":394,"zip":395,"country":374,"geoPoint":396},"LKH - Universitätsklinikum der PMU Salzburg","Salzburg","5020",{"lat":397,"lon":398},47.79941,13.04399,{"facility":400,"status":8,"city":401,"zip":402,"country":374,"geoPoint":403},"Krankenhaus der Barmherzigen Brüder","Vienna","1020",{"lat":404,"lon":405},48.20849,16.37208,{"facility":407,"status":8,"city":408,"zip":409,"country":374,"geoPoint":410},"Klinikum Wels Grieskirchen","Wels","4600",{"lat":411,"lon":412},48.16667,14.03333,{"facility":414,"status":8,"city":415,"zip":416,"country":374,"geoPoint":417},"Universitatsklinikum Wiener Neustadt","Wiener Neustadt","2700",{"lat":418,"lon":419},47.80485,16.23196,{"facility":421,"status":8,"city":422,"zip":423,"country":424,"geoPoint":425},"ULB Erasme Ziekenhuis","Brussels","1070","Belgium",{"lat":426,"lon":427},50.85045,4.34878,{"facility":429,"status":8,"city":422,"zip":430,"country":424,"geoPoint":431},"Cliniques Universitaires Saint Luc","1200",{"lat":426,"lon":427},{"facility":433,"status":8,"city":434,"zip":435,"country":424,"geoPoint":436},"Ziekenhuis Oost-Limburg","Genk","3600",{"lat":437,"lon":438},50.965,5.50082,{"facility":440,"status":8,"city":441,"zip":442,"country":424,"geoPoint":443},"Ghent University Hospital","Ghent","9000",{"lat":444,"lon":445},51.05,3.71667,{"facility":447,"status":8,"city":448,"zip":449,"country":424,"geoPoint":450},"Universitair Ziekenhuis Leuven","Leuven","3000",{"lat":451,"lon":452},50.87959,4.70093,{"facility":454,"status":8,"city":455,"zip":456,"country":424,"geoPoint":457},"CHU de Liege","Liège","4000",{"lat":458,"lon":459},50.63373,5.56749,{"facility":461,"status":8,"city":462,"zip":463,"country":424,"geoPoint":464},"Algemeen Ziekenhuis Delta","Roeselare","8800",{"lat":465,"lon":466},50.94653,3.12269,{"facility":468,"status":8,"city":469,"state":470,"zip":471,"country":472,"geoPoint":473},"Gastroenterology and Internal Medicine Research Institute (GIRI)","Edmonton","Alberta","T5R 1W2","Canada",{"lat":474,"lon":475},53.55014,-113.46871,{"facility":477,"status":8,"city":478,"state":479,"zip":480,"country":472,"geoPoint":481},"GIRI Gastrointestinal Research Institute","Vancouver","British Columbia","V6Z 2K5",{"lat":482,"lon":483},49.24966,-123.11934,{"facility":485,"status":8,"city":486,"state":487,"zip":488,"country":472,"geoPoint":489},"Charlton Digestive Disease Centre","Hamilton","Ontario","L8N1Y2",{"lat":490,"lon":491},43.25011,-79.84963,{"facility":493,"status":8,"city":494,"state":487,"zip":495,"country":472,"geoPoint":496},"London Digestive Disease Institute","London","N6K 1M6",{"lat":497,"lon":498},42.98339,-81.23304,{"facility":500,"status":8,"city":501,"state":487,"zip":502,"country":472,"geoPoint":503},"Taunton Surgical Centre","Oshawa","L1J 0C7",{"lat":504,"lon":505},43.90012,-78.84957,{"facility":507,"status":8,"city":508,"state":487,"zip":509,"country":472,"geoPoint":510},"Toronto Immune and Digestive Health Institute Inc","Toronto","M6A 3B4",{"lat":511,"lon":512},43.70643,-79.39864,{"facility":514,"status":8,"city":515,"state":516,"zip":517,"country":472,"geoPoint":518},"Centre Hospitalier de l'Universite de Montreal","Montreal","Quebec","H2X 0C1",{"lat":519,"lon":520},45.50884,-73.58781,{"facility":522,"status":8,"city":515,"state":516,"zip":523,"country":472,"geoPoint":524},"Clinique IMD","H3H1E3",{"lat":519,"lon":520},{"facility":526,"status":8,"city":527,"zip":528,"country":529,"geoPoint":530},"Changzhou No 2 Peoples Hospital","Changzhou","213018","China",{"lat":531,"lon":532},31.77359,119.95401,{"facility":534,"status":8,"city":535,"zip":536,"country":529,"geoPoint":537},"Chongqing General Hospital","Chongqing","400014",{"lat":538,"lon":539},29.56026,106.55771,{"facility":541,"status":8,"city":542,"zip":543,"country":529,"geoPoint":544},"The Second Affiliated Hospital of Guangzhou Medical University","Guangzhou","510261",{"lat":545,"lon":546},23.11667,113.25,{"facility":548,"status":8,"city":542,"zip":549,"country":529,"geoPoint":550},"The Sixth Affiliated Hospital Sun Yat sen University","510655",{"lat":545,"lon":546},{"facility":552,"status":8,"city":553,"zip":554,"country":529,"geoPoint":555},"Zhongda Hospital Southeast 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It compares guselkumab to risankizumab.","completed","A Study of Guselkumab Versus Risankizumab for Crohn's Disease","This study is comparing two approved medications, guselkumab and risankizumab, to see which works better for people with moderately to severely active Crohn's disease (a long-term condition causing severe inflammation of the intestinal tract). Researchers want to find out how many participants achieve \"deep remission\" (a significant improvement in symptoms and gut healing) after 52 weeks. You may be able to join if you are 18 or older and have had Crohn's disease for at least 12 weeks, confirmed by tests like X-rays or endoscopy. The study aims to enroll about 530 participants. The current recruitment status is unclear.","Participants will be assessed for deep remission at Week 52.",99,"Not specified in the trial record.","Not stated in the trial record.",[31,37],"v2"]