[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07509307":3,"trial-entities:NCT07509307":678,"trial-summary:NCT07509307":682},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":23,"primary_purpose":24,"phases":25,"enrollment_info":27,"interventions":30,"primary_outcomes":41,"secondary_outcomes":49,"sex":122,"minimum_age":123,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":124,"std_ages":139,"locations":142,"central_contacts":666,"overall_officials":672,"references":676,"see_also_links":677},"NCT07509307","NN9490-8294","AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain","Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 6)","RECRUITING","2028-08-14","2026-08","2026-08-17","2026-04-20","Novo Nordisk A\u002FS","INDUSTRY",false,"This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.",null,[19,20,21],"Obesity","Overweight","Osteoarthritis, Knee",[],"INTERVENTIONAL","TREATMENT",[26],"PHASE3",{"count":28,"type":29},400,"ESTIMATED",[31,36],{"type":32,"name":33,"description":34,"armGroupLabels":35},"DRUG","NNC0487-0111","NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.",[33],{"type":32,"name":37,"description":38,"armGroupLabels":39},"Placebo (matched to NNC0487-0111)","Placebo matched to NNC0487-0111 will be administered subcutaneously using PDS290 pre-filled pen-injectors to one of the body parts: thigh, abdomen or upper arm.",[40],"Placebo",[42,46],{"measure":43,"description":44,"timeFrame":45},"Relative change in body weight","Measured as percentage change in body weight.","From baseline (week 0) to week 80",{"measure":47,"description":48,"timeFrame":45},"Change in Western Ontario and McMaster Universities Osteoarthritis Index Numerical Rating Scale (NRS) 3.1 (24-hour) (WOMAC) pain score","WOMAC is a participant reported outcome (PRO) measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and\u002For knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Subscale score for pain ranges 0-100, where higher score indicates worse pain. Measured as score on a scale.",[50,53,56,59,62,65,68,71,74,77,80,82,84,86,88,90,92,95,98,101,104,106,109,111,114,118,120],{"measure":51,"description":52,"timeFrame":45},"Change in WOMAC physical function score","WOMAC is a PRO measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and\u002For knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Subscale score for physical function ranges 0-100, where higher score indicates worse physical function. Measured as score on a scale.",{"measure":54,"description":55,"timeFrame":45},"Change in SF-36v2® Health Survey Acute (SF-36v2 Acute) physical functioning score","SF-36v2 Acute measures Health-Related Quality of Life (HRQOL). The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 Acute scores are norm-based scores, i.e. transformed to a scale where the 2009 US general population has a mean of 50 and a standard deviation (SD) of 10. Higher scores indicate better functional health and well-being. The physical functioning ranges from 19.0 to 57.6. Measured as score on a scale.",{"measure":57,"description":58,"timeFrame":45},"Change in body weight","Measured as kilograms (kg).",{"measure":60,"description":61,"timeFrame":45},"Change in body mass index (BMI)","Measured as kilograms per meter squared (kg\u002Fm\\^2).",{"measure":63,"description":64,"timeFrame":45},"Change in WOMAC stiffness score","WOMAC is a PRO measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and\u002For knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Subscale score for stiffness ranges 0-100, where higher score indicates worse stiffness. Measured as score on a scale.",{"measure":66,"description":67,"timeFrame":45},"Change in WOMAC total score","WOMAC is a PRO measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and\u002For knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Total score ranges 0-100, where higher score indicates worse pain, stiffness, physical function and overall osteoarthritis related disability. Measured as score on a scale.",{"measure":69,"description":70,"timeFrame":45},"Change in waist circumference","Measured as centimetres (cm).",{"measure":72,"description":73,"timeFrame":45},"Change in systolic blood pressure (SBP)","Measured as millimetre of mercury (mmHg).",{"measure":75,"description":76,"timeFrame":45},"Change in diastolic blood pressure (DBP)","Measured as mmHg.",{"measure":78,"description":79,"timeFrame":45},"Ratio to baseline: change in total cholesterol","Measured as ratio.",{"measure":81,"description":79,"timeFrame":45},"Ratio to baseline: change in high-density lipoprotein (HDL) cholesterol",{"measure":83,"description":79,"timeFrame":45},"Ratio to baseline: change in low-density lipoprotein (LDL) cholesterol",{"measure":85,"description":79,"timeFrame":45},"Ratio to baseline: change in very low-density lipoprotein (VLDL) cholesterol",{"measure":87,"description":79,"timeFrame":45},"Ratio to baseline: change in non-HDL cholesterol",{"measure":89,"description":79,"timeFrame":45},"Ratio to baseline: change in triglycerides",{"measure":91,"description":79,"timeFrame":45},"Ratio to baseline: change in high-sensitivity C-reactive protein (hsCRP)",{"measure":93,"description":94,"timeFrame":45},"Change in glycated haemoglobin (HbA1c)","Measured as percentage of HbA1c.",{"measure":96,"description":97,"timeFrame":45},"Change in fasting plasma glucose (FPG)","Measured as millimole per litre (mmol\u002FL).",{"measure":99,"description":100,"timeFrame":45},"Number of participants with use of allowed rescue analgesics during washout period (yes\u002Fno)","Measured as count of participants.",{"measure":102,"description":103,"timeFrame":45},"Amount of allowed rescue analgesics used during washout period","Measured as dose of analgesics.",{"measure":105,"description":100,"timeFrame":45},"Number of participants with use of pain medication (yes\u002Fno)",{"measure":107,"description":108,"timeFrame":45},"Amount of pain medication used","Measured as dose of pain medication.",{"measure":110,"description":100,"timeFrame":45},"Number of participants with change in pain medication (decrease\u002Fno change\u002Fincrease)",{"measure":112,"description":113,"timeFrame":45},"Change in knee pain intensity score (NRS)","NRS item is PRO measures knee pain at its worst. The measure consists of 1 item. The response scale is an 11-point numeric rating scale from 0 (No knee pain) to 10 (Worst possible knee pain). Higher scores indicate worse pain. Measured as score on a scale.",{"measure":115,"description":116,"timeFrame":117},"Number of treatment emergent adverse events (TEAEs)","Measured as events.","From baseline (week 0) to week 84",{"measure":119,"description":116,"timeFrame":117},"Number of treatment emergent serious adverse events (TESAEs)",{"measure":121,"description":116,"timeFrame":117},"Number of TEAEs leading to permanent treatment discontinuation","ALL","18 Years",{"inclusion":125,"exclusion":131,"raw_text":138},[126,127,128,129,130],"Male or female (sex at birth)","Age 18 years or above at the time of signing the informed consent","Clinical diagnosis of knee osteoarthritis (OA) (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence \\[KL\\] grades 2 to 4 as per central reading) in target knee. Target knee joint is defined as most symptomatic knee at screening. If pain in knees is equal, the target knee joint will be the dominant leg","Symptomatic knee OA with first appearance of pain in the target knee \\> 90 days prior to screening and pain in the target knee for \\> 15 days over the prior 30 days","Willingness to complete a 72-hour washout period of analgesics before all visits involving WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) questionnaire (acetaminophen 4 grams (g)\u002Fday is allowed as rescue medication up until 24 hours before those visits)",[132,133,134,135,136,137],"Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol\u002Fmol) as measured by the central laboratory at screening","History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records","Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening","Any joint prosthesis or joint replacement in target knee","Arthroscopy or injections into target knee within the last 90 days prior to screening","Any other joint disease in target knee including gout and pseudogout","Key Inclusion Criteria:\n\n* Male or female (sex at birth)\n* Age 18 years or above at the time of signing the informed consent\n* Clinical diagnosis of knee osteoarthritis (OA) (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence \\[KL\\] grades 2 to 4 as per central reading) in target knee. Target knee joint is defined as most symptomatic knee at screening. If pain in knees is equal, the target knee joint will be the dominant leg\n* Symptomatic knee OA with first appearance of pain in the target knee \\> 90 days prior to screening and pain in the target knee for \\> 15 days over the prior 30 days\n* Willingness to complete a 72-hour washout period of analgesics before all visits involving WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) questionnaire (acetaminophen 4 grams (g)\u002Fday is allowed as rescue medication up until 24 hours before those visits)\n\nKey Exclusion Criteria:\n\n* Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol\u002Fmol) as measured by the central laboratory at screening\n* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records\n* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening\n* Any joint prosthesis or joint replacement in target knee\n* Arthroscopy or injections into target knee within the last 90 days prior to screening\n* Any other joint disease in target knee including gout and pseudogout",[140,141],"ADULT","OLDER_ADULT",[143,152,159,166,174,182,186,193,201,208,216,224,232,240,244,252,260,268,276,284,293,300,307,315,322,330,337,341,345,349,353,362,370,378,385,391,398,406,413,420,429,436,440,444,451,458,462,471,479,482,490,494,501,509,518,522,529,531,538,540,544,546,553,561,569,576,583,590,597,604,611,618,625,629,636,641,645,647,654,658,662],{"facility":144,"status":8,"city":145,"state":146,"zip":147,"country":148,"geoPoint":149},"Neighborhood Healthcare","Escondido","California","92025","United States",{"lat":150,"lon":151},33.11921,-117.08642,{"facility":153,"status":8,"city":154,"state":146,"zip":155,"country":148,"geoPoint":156},"First Valley Medical Group","Lancaster","93534",{"lat":157,"lon":158},34.69804,-118.13674,{"facility":160,"status":8,"city":161,"state":146,"zip":162,"country":148,"geoPoint":163},"Desert Oasis Healthcare","Palm Springs","92262",{"lat":164,"lon":165},33.8303,-116.54529,{"facility":167,"status":8,"city":168,"state":169,"zip":170,"country":148,"geoPoint":171},"Chase Medical Research LLC","Waterbury","Connecticut","06708",{"lat":172,"lon":173},41.55815,-73.0515,{"facility":175,"status":8,"city":176,"state":177,"zip":178,"country":148,"geoPoint":179},"Westside Center For Clinical Research","Jacksonville","Florida","32205",{"lat":180,"lon":181},30.33218,-81.65565,{"facility":183,"status":8,"city":176,"state":177,"zip":184,"country":148,"geoPoint":185},"Clinical Neuroscience Solutions, LLC","32256",{"lat":180,"lon":181},{"facility":187,"status":8,"city":188,"state":177,"zip":189,"country":148,"geoPoint":190},"Advanced Res for Health Improve","Naples","34102",{"lat":191,"lon":192},26.14234,-81.79596,{"facility":194,"status":8,"city":195,"state":196,"zip":197,"country":148,"geoPoint":198},"Clinical Investigation Spec Gurnee","Gurnee","Illinois","60031",{"lat":199,"lon":200},42.3703,-87.90202,{"facility":202,"status":8,"city":203,"state":196,"zip":204,"country":148,"geoPoint":205},"Evanston Premier Hlthcr Res","Skokie","60077",{"lat":206,"lon":207},42.03336,-87.73339,{"facility":209,"status":8,"city":210,"state":211,"zip":212,"country":148,"geoPoint":213},"Monroe Biomedical Research, LLC","Louisville","Kentucky","40213",{"lat":214,"lon":215},38.25424,-85.75941,{"facility":217,"status":8,"city":218,"state":219,"zip":220,"country":148,"geoPoint":221},"Arcturus Healthcare, PLC.","Troy","Michigan","48098-6368",{"lat":222,"lon":223},42.60559,-83.14993,{"facility":225,"status":8,"city":226,"state":227,"zip":228,"country":148,"geoPoint":229},"Clinvest Research","Springfield","Missouri","65807",{"lat":230,"lon":231},37.21533,-93.29824,{"facility":233,"status":234,"city":235,"state":235,"zip":236,"country":148,"geoPoint":237},"NYU Langone Orthopedic Center","NOT_YET_RECRUITING","New York","10016",{"lat":238,"lon":239},40.71427,-74.00597,{"facility":241,"status":8,"city":235,"state":235,"zip":242,"country":148,"geoPoint":243},"Hospital For Special Surgery","10021",{"lat":238,"lon":239},{"facility":245,"status":8,"city":246,"state":247,"zip":248,"country":148,"geoPoint":249},"Piedmont Healthcare\u002FResearch","Statesville","North Carolina","28625",{"lat":250,"lon":251},35.78264,-80.8873,{"facility":253,"status":8,"city":254,"state":255,"zip":256,"country":148,"geoPoint":257},"Northwest Research Center","Portland","Oregon","97202",{"lat":258,"lon":259},45.52345,-122.67621,{"facility":261,"status":8,"city":262,"state":263,"zip":264,"country":148,"geoPoint":265},"Mercy Family Clinic","Dallas","Texas","75208",{"lat":266,"lon":267},32.78306,-96.80667,{"facility":269,"status":8,"city":270,"state":271,"zip":272,"country":148,"geoPoint":273},"Health Res of Hampton Roads","Newport News","Virginia","23606",{"lat":274,"lon":275},36.98038,-76.42975,{"facility":277,"status":8,"city":278,"state":279,"zip":280,"country":148,"geoPoint":281},"Northwest Clinical Research Center","Bellevue","Washington","98007",{"lat":282,"lon":283},47.61038,-122.20068,{"facility":285,"status":8,"city":286,"state":287,"zip":288,"country":289,"geoPoint":290},"Emeritus Research Sydney","Botany","New South Wales","2019","Australia",{"lat":291,"lon":292},-33.94599,151.19591,{"facility":294,"status":8,"city":295,"state":287,"zip":296,"country":289,"geoPoint":297},"Momentum Clinical Research Darlinghurst","Darlinghurst","2010",{"lat":298,"lon":299},-33.87939,151.21925,{"facility":301,"status":8,"city":302,"state":287,"zip":303,"country":289,"geoPoint":304},"Kolling Institute","St Leonards","2065",{"lat":305,"lon":306},-33.82344,151.19836,{"facility":308,"status":8,"city":309,"state":310,"zip":311,"country":289,"geoPoint":312},"Heart of Australia","Chelmer","Queensland","4068",{"lat":313,"lon":314},-27.51326,152.97524,{"facility":316,"status":8,"city":317,"state":310,"zip":318,"country":289,"geoPoint":319},"Coastal Digestive Health","Maroochydore","4558",{"lat":320,"lon":321},-26.66008,153.09953,{"facility":323,"status":8,"city":324,"zip":325,"country":326,"geoPoint":327},"UMHAT Sveti Georgi EAD, Plovdiv","Plovdiv","4002","Bulgaria",{"lat":328,"lon":329},42.15387,24.75001,{"facility":331,"status":8,"city":332,"zip":333,"country":326,"geoPoint":334},"MC Dr. Atanasov EOOD","Sofia","1231",{"lat":335,"lon":336},42.69751,23.32415,{"facility":338,"status":8,"city":332,"zip":339,"country":326,"geoPoint":340},"MC Excelsior OOD","1407",{"lat":335,"lon":336},{"facility":342,"status":8,"city":332,"zip":343,"country":326,"geoPoint":344},"UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology","1527",{"lat":335,"lon":336},{"facility":346,"status":8,"city":332,"zip":347,"country":326,"geoPoint":348},"MMA MHAT - Sofia, Rheumatology clinic","1606",{"lat":335,"lon":336},{"facility":350,"status":8,"city":332,"zip":351,"country":326,"geoPoint":352},"UMHAT Sveti Ivan Rilski EAD, Rheumatology","1612",{"lat":335,"lon":336},{"facility":354,"status":234,"city":355,"state":356,"zip":357,"country":358,"geoPoint":359},"TLC Diabetes and Endocrinology","Surrey","British Columbia","V3T 2V6","Canada",{"lat":360,"lon":361},49.10635,-122.82509,{"facility":363,"status":8,"city":364,"state":365,"zip":366,"country":358,"geoPoint":367},"Your Research Network","Niagara Falls","Ontario","L2H 1H5",{"lat":368,"lon":369},43.10012,-79.06627,{"facility":371,"status":8,"city":372,"state":373,"zip":374,"country":358,"geoPoint":375},"ALPHA Recherche Clinique","Lévis","Quebec","G6V 0C9",{"lat":376,"lon":377},46.80326,-71.17793,{"facility":379,"status":8,"city":380,"state":373,"zip":381,"country":358,"geoPoint":382},"Centre Medical Acadie","Montreal","H4N 2W2",{"lat":383,"lon":384},45.50884,-73.58781,{"facility":371,"status":8,"city":386,"state":373,"zip":387,"country":358,"geoPoint":388},"Québec","G3K 2P8",{"lat":389,"lon":390},46.81228,-71.21454,{"facility":392,"status":8,"city":393,"state":373,"zip":394,"country":358,"geoPoint":395},"Centre de Recherche du CHUS","Sherbrooke","J1H 5N4",{"lat":396,"lon":397},45.40008,-71.89908,{"facility":399,"status":8,"city":400,"zip":401,"country":402,"geoPoint":403},"Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme","Aarhus N","8200","Denmark",{"lat":404,"lon":405},56.20367,10.17317,{"facility":407,"status":8,"city":408,"zip":409,"country":402,"geoPoint":410},"Frederiksberg Hospital - Parker Institutet (Artrose)","Frederiksberg","2000",{"lat":411,"lon":412},55.67938,12.53463,{"facility":414,"status":8,"city":415,"zip":416,"country":402,"geoPoint":417},"Sanos Clinic - Herlev","Herlev","2730",{"lat":418,"lon":419},55.72366,12.43998,{"facility":421,"status":8,"city":422,"state":423,"zip":424,"country":425,"geoPoint":426},"University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine","Chaïdári","Attica","12461","Greece",{"lat":427,"lon":428},38.01135,23.66597,{"facility":430,"status":8,"city":431,"zip":432,"country":425,"geoPoint":433},"Evangelismos S.A. - Endocrinology department","Athens","10676",{"lat":434,"lon":435},37.98376,23.72784,{"facility":437,"status":8,"city":431,"zip":438,"country":425,"geoPoint":439},"Laiko General Hospital Of Athens - 1st department of Internal Medicine","115 27",{"lat":434,"lon":435},{"facility":441,"status":8,"city":431,"zip":442,"country":425,"geoPoint":443},"Athens Medical Center S.A. (Iatriko Psychikou) - Department of Internal Medicine & Metabolic Diseases","11525",{"lat":434,"lon":435},{"facility":445,"status":8,"city":446,"zip":447,"country":425,"geoPoint":448},"Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit","Marousi","15125",{"lat":449,"lon":450},38.05,23.8,{"facility":452,"status":8,"city":453,"zip":454,"country":425,"geoPoint":455},"NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes","Thessaloniki","54635",{"lat":456,"lon":457},40.64072,22.93493,{"facility":459,"status":8,"city":453,"zip":460,"country":425,"geoPoint":461},"Thermi Clinic S.A. - Diabetes and Internal Medicine Department","57001",{"lat":456,"lon":457},{"facility":463,"status":8,"city":464,"state":465,"zip":466,"country":467,"geoPoint":468},"Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo","Udine","Friuli Venezia Giulia","33100","Italy",{"lat":469,"lon":470},46.0693,13.23715,{"facility":472,"status":8,"city":473,"state":474,"zip":475,"country":467,"geoPoint":476},"Casa della Salute di Ceccano - Ambulatori Campus Biomedico","Rome","Lazio","00128",{"lat":477,"lon":478},41.89193,12.51133,{"facility":480,"status":8,"city":473,"state":474,"zip":475,"country":467,"geoPoint":481},"Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia",{"lat":477,"lon":478},{"facility":483,"status":8,"city":484,"state":485,"zip":486,"country":467,"geoPoint":487},"Auxologico San Luca - Endocrinologia e Malattie del Metabolismo","Milan","Lombardy","20149",{"lat":488,"lon":489},45.46427,9.18951,{"facility":491,"status":8,"city":484,"state":485,"zip":492,"country":467,"geoPoint":493},"Ospedale Galeazzi S.p.A. - INCO - Istituto Nazionale per la Cura dell'Obesità","20157",{"lat":488,"lon":489},{"facility":495,"status":8,"city":496,"state":485,"zip":497,"country":467,"geoPoint":498},"Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica","San Donato Milanese","20097",{"lat":499,"lon":500},45.41047,9.26838,{"facility":502,"status":234,"city":503,"state":504,"zip":505,"country":467,"geoPoint":506},"Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia","Verona","Veneto","37126",{"lat":507,"lon":508},45.43854,10.9938,{"facility":510,"status":8,"city":511,"state":512,"zip":513,"country":514,"geoPoint":515},"\"Zdrowie Osteo-Medic\" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik","Bialystok","Podlaskie Voivodeship","15-351","Poland",{"lat":516,"lon":517},53.13333,23.16433,{"facility":519,"status":8,"city":511,"zip":520,"country":514,"geoPoint":521},"ClinicMed Daniluk, Nowak Spółka Komandytowa","15-879",{"lat":516,"lon":517},{"facility":523,"status":8,"city":524,"zip":525,"country":514,"geoPoint":526},"Centrum Medyczne Intercor Sp. z o.o.","Bydgoszcz","85-605",{"lat":527,"lon":528},53.1235,18.00762,{"facility":523,"status":234,"city":524,"zip":525,"country":514,"geoPoint":530},{"lat":527,"lon":528},{"facility":532,"status":8,"city":533,"zip":534,"country":514,"geoPoint":535},"CenterMed Kraków Sp. z o.o.","Krakow","31-530",{"lat":536,"lon":537},50.06143,19.93658,{"facility":532,"status":234,"city":533,"zip":534,"country":514,"geoPoint":539},{"lat":536,"lon":537},{"facility":541,"status":8,"city":533,"zip":542,"country":514,"geoPoint":543},"Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.","31-826",{"lat":536,"lon":537},{"facility":541,"status":234,"city":533,"zip":542,"country":514,"geoPoint":545},{"lat":536,"lon":537},{"facility":547,"status":8,"city":548,"zip":549,"country":514,"geoPoint":550},"Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher","Warsaw","02-637",{"lat":551,"lon":552},52.22977,21.01178,{"facility":554,"status":8,"city":555,"zip":556,"country":557,"geoPoint":558},"Latin Clinical Trial Center Puerto Rico","San Juan","00909","Puerto Rico",{"lat":559,"lon":560},18.46633,-66.10572,{"facility":562,"status":8,"city":563,"zip":564,"country":565,"geoPoint":566},"Instituto Medico Quirurgico San Rafael","A Coruña","15006","Spain",{"lat":567,"lon":568},43.37135,-8.396,{"facility":570,"status":8,"city":571,"zip":572,"country":565,"geoPoint":573},"Hospital Germans Trias i Pujol","Badalona","08916",{"lat":574,"lon":575},41.45004,2.24741,{"facility":577,"status":8,"city":578,"zip":579,"country":565,"geoPoint":580},"Hospital Naval Ferrol","Ferrol","15405",{"lat":581,"lon":582},43.48451,-8.23293,{"facility":584,"status":234,"city":585,"zip":586,"country":565,"geoPoint":587},"Centro Especialidades Hermanos Sangro","Madrid","28038",{"lat":588,"lon":589},40.4165,-3.70256,{"facility":591,"status":8,"city":592,"zip":593,"country":565,"geoPoint":594},"Hospital Quirónsalud Málaga","Málaga","29004",{"lat":595,"lon":596},36.72016,-4.42034,{"facility":598,"status":8,"city":599,"zip":600,"country":565,"geoPoint":601},"Hospital Infanta Sofía","San Sebastián de Los Reyes (Madrid)","28702",{"lat":602,"lon":603},40.55555,-3.62733,{"facility":605,"status":8,"city":606,"zip":607,"country":565,"geoPoint":608},"Hospital Universitario Marqués de Valdecilla","Santander","39008",{"lat":609,"lon":610},43.46589,-3.80493,{"facility":612,"status":8,"city":613,"zip":614,"country":565,"geoPoint":615},"Hospital HM La Esperanza","Santiago de Compostela","15705",{"lat":616,"lon":617},42.88052,-8.54569,{"facility":619,"status":8,"city":620,"zip":621,"country":565,"geoPoint":622},"Clínica Nuevas Tecnologías en Diabetes y Endocrinología","Seville","41003",{"lat":623,"lon":624},37.38283,-5.97317,{"facility":626,"status":8,"city":620,"zip":627,"country":565,"geoPoint":628},"H. Infanta Luisa_Endocrino y Obesidad","41010",{"lat":623,"lon":624},{"facility":630,"status":8,"city":631,"zip":632,"country":565,"geoPoint":633},"Hospital General de Valencia","Valencia","46014",{"lat":634,"lon":635},39.47391,-0.37966,{"facility":637,"status":8,"city":638,"zip":639,"country":640},"İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi","Bahçelievler\u002Fİstanbul","34186","Turkey (Türkiye)",{"facility":642,"status":8,"city":643,"zip":644,"country":640},"Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon","Çankaya\u002FAnkara","06800",{"facility":646,"status":8,"city":643,"zip":644,"country":640},"SBÜ Ankara Gaziler Fizik Tedavi Ve Rehabilitasyon Eğitim Ve Araştırma Hastanesi",{"facility":648,"status":8,"city":649,"zip":650,"country":640,"geoPoint":651},"Trakya Üniversitesi Tıp Fakültesi Hastanesi-Fizik Tedavi ve Rehabilitasyon","Edirne","22030",{"lat":652,"lon":653},41.67719,26.55597,{"facility":655,"status":8,"city":656,"zip":657,"country":640},"Istanbul Üniversitesi- Istanbul Tıp Fakültesi Esnaf Hastanesi Poliklinikleri Fiziksel Tıp Ve Rehabilitasyon Anabilim Dalı","Fatih\u002Fİstanbul","34116",{"facility":659,"status":8,"city":660,"zip":661,"country":640},"Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon","Yuregir\u002FAdana","01060",{"facility":663,"status":8,"city":664,"zip":665,"country":640},"Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon","Yıldırım\u002FBursa","16310",[667],{"name":668,"role":669,"phone":670,"email":671},"Novo Nordisk","CONTACT","(+1) 866-867-7178","clinicaltrials@novonordisk.com",[673],{"name":674,"affiliation":13,"role":675},"Clinical Transparency (dept. 2834)","STUDY_DIRECTOR",[],[],{"nct_id":4,"conditions":679,"biomarkers":681},[19,680,20],"Osteoarthritis",[],{"nct_id":4,"found":683,"summary":684,"prompt_version":694},true,{"design":685,"status":686,"heading":687,"summary":688,"follow_up":689,"word_count":690,"commitments":691,"compensation":692,"drugs_mentioned":693},"This is an interventional study where participants are randomly assigned to receive either NNC0487-0111 or a placebo. Approximately 400 people are planned to participate.","completed","AMAZE 6: NNC0487-0111 for Weight Loss and Knee Pain","This study, called AMAZE 6, is looking at how well a medicine called NNC0487-0111 helps people with excess body weight and knee osteoarthritis (a condition where joint cartilage wears down) to lose weight and reduce pain. You would receive weekly injections under your skin of either NNC0487-0111 or a placebo (a substance with no active medicine). The study aims to see if NNC0487-0111 can lead to a change in body weight and a reduction in knee pain over 80 weeks. To join, you must be at least 18 years old and have a diagnosis of knee osteoarthritis with specific radiographic changes. The study is currently recruiting about 400 participants.","Your body weight and knee pain will be measured from the start of the study (week 0) up to week 80.",109,"You would receive weekly injections under your skin in your thigh, abdomen, or upper arm for 80 weeks.","Not stated in the trial record.",[33],"v2"]