[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07526766":3,"trial-entities:NCT07526766":103,"trial-summary:NCT07526766":106},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":26,"interventions":29,"primary_outcomes":36,"secondary_outcomes":58,"sex":59,"minimum_age":60,"maximum_age":61,"healthy_volunteers":15,"eligibility_criteria":62,"std_ages":72,"locations":75,"central_contacts":94,"overall_officials":96,"references":98,"see_also_links":99},"NCT07526766","25-011057","A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia","Cardiopulmonary, Hemodynamic, And Symptom Responses To Aerobic And Resistance Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia: A Single-center, Single-arm Prospective Clinical Trial.","RECRUITING","2027-07-01","2026-07","2026-07-10","2026-08-01","Mayo Clinic","OTHER",false,"The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD) and\u002For Fibromuscular Dysplasia (FMD).",null,[19,20],"Fibromuscular Dysplasia","Spontaneous Coronary Artery Dissection",[],"INTERVENTIONAL","HEALTH_SERVICES_RESEARCH",[25],"NA",{"count":27,"type":28},28,"ESTIMATED",[30],{"type":31,"name":32,"description":33,"armGroupLabels":34},"BEHAVIORAL","Aerobic and resistance exercises","Subjects will undergo three exercise tests, each separated by at least 48 hours:\n\n* Symptom-limited cardiopulmonary exercise test (CPET): Patients will cycle upright starting at 0W (3 min) before the workload is increased by 10-35W·min-1 in a ramp fashion (like cycling up a progressively steeper hill) until volitional exhaustion for the determination of V̇O2peak and Wpeak\n* Two-stage submaximal constant power exercise test: Following a 5-minute warm-up (10-20 W), participants will cycle in the moderate intensity domain for 25 minutes followed by 25 minutes in the heavy intensity domain.\n* Six different resistance exercises of varying intensities: Participants will perform three sets of six different resistance exercises: chest press; lateral raises; abdominal crunches; planks; leg press; weighted lunges",[35],"Aerobic and resistance exercise",[37,41,45,48,51,55],{"measure":38,"description":39,"timeFrame":40},"Change in blood pressure in response to aerobic exercise","Systemic blood pressure will be measured at rest, at peak exercise, and for 5 minutes of recovery after exercise via finger photoplethysmography and reported as mmHg","Baseline, 5 minutes, 25 minutes, 50 minutes and 55 minutes",{"measure":42,"description":43,"timeFrame":44},"Dartmouth COOP Functional Assessment Chart score","The Dartmouth COOP Functional Assessment Charts are a set of patient-reported, pictorial tools used to measure physical, mental, and social functioning. The tool includes 9 questions that are rated on scores from 1-5, with higher scores indicating worse function.","Baseline",{"measure":46,"description":47,"timeFrame":44},"Duke Activity Index Status (DASI) score","The Duke Activity Status Index (DASI) is a self-administered questionnaire that measures a patient's functional capacity. It consists of 12 yes\u002Fno questions. Scores range from 0 to 58.2, with higher scores indicating better exercise capacity.",{"measure":49,"description":50,"timeFrame":44},"International Physical Activity Questionnaire Short Form (IPAQ-SF) score","The International Physical Activity Questionnaire Short Form (IPAQ-SF) is a 7-item self-reported questionnaire where subjects report time spent being physically active in the last 7 days reported hours per day or minutes per day.",{"measure":52,"description":53,"timeFrame":54},"Change in perceived exertion","Perceived exertion (breathlessness and leg fatigue) will be obtained using the Borg 0-10 scale.","Baseline, 25 minutes, and 50 minutes",{"measure":56,"description":57,"timeFrame":54},"Change in blood lactate concentration [La-]b","Blood lactate concentration \\[La-\\]b will be measured via analysis of a pinprick point-of-care lactate test (via the earlobe) at rest, during exercise, and at peak exercise.",[],"ALL","21 Years","65 Years",{"inclusion":63,"exclusion":66,"raw_text":71},[64,65],"History of Spontaneous Coronary Artery Dissection (SCAD) and\u002For Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain.","Able to provide written informed consent",[67,68,69,70],"Individuals who are clinically obese (BMI ≥36) and\u002For who suffer from musculoskeletal or other conditions that would limit exercise participation.","Individuals who are deemed medically unstable","Participants who are unable to comply with study requirements.","Pregnancy","Inclusion criteria:\n\n* History of Spontaneous Coronary Artery Dissection (SCAD) and\u002For Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain.\n* Able to provide written informed consent\n\nExclusion criteria:\n\n* Individuals who are clinically obese (BMI ≥36) and\u002For who suffer from musculoskeletal or other conditions that would limit exercise participation.\n* Individuals who are deemed medically unstable\n* Participants who are unable to comply with study requirements.\n* Pregnancy",[73,74],"ADULT","OLDER_ADULT",[76],{"facility":77,"status":8,"city":78,"state":79,"zip":80,"country":81,"contacts":82,"geoPoint":91},"Mayo Clinic in Florida","Jacksonville","Florida","32224","United States",[83,88],{"name":84,"role":85,"phone":86,"email":87},"Armia R. Habil, MD","CONTACT","904-953-0859","habil.armia@mayo.edu",{"name":89,"role":90},"Elizabeth H. Dineen, DO","PRINCIPAL_INVESTIGATOR",{"lat":92,"lon":93},30.33218,-81.65565,[95],{"name":84,"role":85,"phone":86,"email":87},[97],{"name":89,"affiliation":13,"role":90},[],[100],{"label":101,"url":102},"Mayo Clinic Clinical Trials","https:\u002F\u002Fwww.mayo.edu\u002Fresearch\u002Fclinical-trials",{"nct_id":4,"conditions":104,"biomarkers":105},[19,20],[],{"nct_id":4,"found":107,"summary":108,"prompt_version":118},true,{"design":109,"status":110,"heading":111,"summary":112,"follow_up":113,"word_count":114,"commitments":115,"compensation":116,"drugs_mentioned":117},"This is an interventional study, meaning participants will receive specific exercises. It plans to enroll 28 participants, but the phase is not specified.","completed","Exercise Study for SCAD and FMD","This study is looking at how different types of exercise, specifically aerobic (like cycling) and resistance exercises, affect people who have experienced Spontaneous Coronary Artery Dissection (SCAD) and\u002For Fibromuscular Dysplasia (FMD). Researchers want to understand how your heart and body respond to these exercises, and if they impact your symptoms. You might be able to join if you are between 21 and 65 years old, have a history of SCAD or FMD (at least 2 months ago and no chest pain), and are not clinically obese or have conditions that limit exercise. The study aims to see changes in your blood pressure and how well you can do daily activities after exercise. The current status of this study is unclear, and it plans to enroll 28 participants.","Blood pressure will be measured at baseline, 5 minutes, 25 minutes, 50 minutes, and 55 minutes. Other scores are measured at baseline.",127,"You will undergo three exercise tests, each at least 48 hours apart. These tests include a symptom-limited cardiopulmonary exercise test (CPET) on a bike.","Not stated in the trial record.",[],"v2"]