[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07528742":3,"trial-entities:NCT07528742":87,"trial-summary:NCT07528742":91},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":25,"interventions":28,"primary_outcomes":34,"secondary_outcomes":39,"sex":40,"minimum_age":41,"maximum_age":17,"healthy_volunteers":42,"eligibility_criteria":43,"std_ages":53,"locations":56,"central_contacts":77,"overall_officials":80,"references":81,"see_also_links":86},"NCT07528742","2026-218","Vagus Nerve Stimulation for Reaction Time","Enhancing Reaction Time Through Non-Invasive Vagus Nerve Stimulation","RECRUITING","2027-04-05","2026-04","2026-04-14","2026-04-06","Youngstown State University","OTHER",false,"Non-Invasive Vagus Nerve Stimulation will be provided to the participants using a transcutaneous electrical nerve stimulation (TENS) unit, a routine physical therapy intervention by the faculty researcher who is a licensed physical therapist. The electrodes will be clipped to ear over the vagus nerve distribution area. The parameters will be 30 Hz, 250 us, 5 minutes, at tolerance (no pain). Reaction time will test collected pre and post the stimulation using online reaction time testing platform.",null,[19],"Healthy Subjects (HS)",[],"INTERVENTIONAL","BASIC_SCIENCE",[24],"NA",{"count":26,"type":27},30,"ESTIMATED",[29],{"type":30,"name":31,"description":32,"armGroupLabels":33},"DEVICE","vagus nerve stimulation","Non-Invasive Vagus Nerve Stimulation will be provided to the participants using a transcutaneous electrical nerve stimulation (TENS) unit, a routine physical therapy intervention by the faculty researcher who is a licensed physical therapist. The electrodes will be clipped to ear over the vagus nerve distribution area. The parameters will be 30 Hz, 250 us, 5 minutes, at tolerance (no pain)",[31],[35],{"measure":36,"description":37,"timeFrame":38},"Reaction time","Reaction time will test collected pre and post the stimulation using online platform. The subjects will press a key when setting a color change in the computer screen.","Baseline and immediately after the intervention.",[],"ALL","18 Years",true,{"inclusion":44,"exclusion":47,"raw_text":52},[45,46],"Healthy participants over the age of 18","did not receive vagus nerve stimulation previously",[48,49,50,51],"alcohol or drug abuse","metal in the skull","implanted cardiac or cranial devices","Women during 3 trimester of pregnancy","Inclusion Criteria:\n\n* Healthy participants over the age of 18\n* did not receive vagus nerve stimulation previously\n\nExclusion Criteria:\n\n* alcohol or drug abuse\n* metal in the skull\n* implanted cardiac or cranial devices\n* Women during 3 trimester of pregnancy",[54,55],"ADULT","OLDER_ADULT",[57],{"facility":13,"status":8,"city":58,"state":59,"zip":60,"country":61,"contacts":62,"geoPoint":74},"Youngstown","Ohio","44555","United States",[63,68,72],{"name":64,"role":65,"phone":66,"email":67},"Weiqing Ge, DPT, PhD","CONTACT","330-941-2702","wge@ysu.edu",{"name":69,"role":65,"phone":70,"email":71},"Cathy Parrott, PhD","330 941-2559","cbieberparrott@ysu.edu",{"name":64,"role":73},"PRINCIPAL_INVESTIGATOR",{"lat":75,"lon":76},41.09978,-80.64952,[78],{"name":79,"role":65,"phone":66,"email":67},"Weiqing Ge Ge, DPT, PhD",[],[82],{"pmid":83,"type":84,"citation":85},"41044114","RESULT","Camargo L, Gianlorenco AC, Pacheco-Barrios K, Pichardo E, Costa V, Choi H, Song JJ, Fregni F. The effects of non-invasive transcutaneous auricular vagus nerve stimulation on resting-state delta oscillation: a randomized, double-blinded, sham-control trial. Sci Rep. 2025 Oct 3;15(1):34531. doi: 10.1038\u002Fs41598-025-17821-5.",[],{"nct_id":4,"conditions":88,"biomarkers":90},[89],"Healthy Subjects",[],{"nct_id":4,"found":42,"summary":92,"prompt_version":101},{"design":93,"status":94,"heading":6,"summary":95,"follow_up":96,"word_count":97,"commitments":98,"compensation":99,"drugs_mentioned":100},"This interventional study plans to enroll 30 healthy participants.","completed","This study is looking at how non-invasive vagus nerve stimulation (using a transcutaneous electrical nerve stimulation or TENS unit, a routine physical therapy treatment) affects reaction time. You might be able to join if you are a healthy adult over 18 and have not had vagus nerve stimulation before. The study will measure your reaction time before and right after the stimulation to see if it changes. The current status of this study is unclear.","Your reaction time will be measured immediately after the intervention.",75,"You would receive non-invasive vagus nerve stimulation on your ear for 5 minutes and have your reaction time tested before and immediately after the stimulation.","Not stated in the trial record.",[31],"v2"]