[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07544576":3,"trial-entities:NCT07544576":107,"trial-summary:NCT07544576":15},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":15,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":40,"secondary_outcomes":48,"sex":53,"minimum_age":54,"maximum_age":15,"healthy_volunteers":55,"eligibility_criteria":56,"std_ages":77,"locations":80,"central_contacts":99,"overall_officials":100,"references":105,"see_also_links":106},"NCT07544576","1402691","Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance","Non-Inferiority Study Comparing Treatment of Primary Knee Osteoarthritis With Intra-Articular Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance: The PRECISION-Knee Trial (PRospective Evaluation of the Clinical Impact of Steroid Injection Options iN Knee Osteoarthritis)","ENROLLING_BY_INVITATION","2026-12-08","2026-04","2026-04-22","2025-12-12","Sosi Dzhugarian","OTHER",null,"The purpose of this study is to determine whether a lower dose of corticosteroid injection with ultrasound-guidance for the treatment of knee osteoarthritis can be as effective as a higher dose that is landmark-guided. With landmark-guided dosing, it may be reasonable to use a higher amount of corticosteroid in order to ensure a sufficient amount of the medication is administered, however these injections carry the risk of side effects. Alternatively, with the use of ultrasound, it may be reasonable to use less corticosteroid, possibly decreasing the risk of side effects and increasing patient satisfaction.",[18],"Knee Arthritis Osteoarthritis",[],"INTERVENTIONAL","TREATMENT",[23],"PHASE4",{"count":25,"type":26},140,"ESTIMATED",[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32},"DRUG","Triamcinolone knee injection without ultrasound guidance","3mL lidocaine (without epinephrine) 1% solution combined with 1mL triamcinolone acetonide injectable solution, USP (40mg per mL)",[33],"40mg landmark-guided triamcinolone knee joint injection",{"type":35,"name":36,"description":37,"armGroupLabels":38},"COMBINATION_PRODUCT","Triamcinolone knee injection with ultrasound guidance","3mL lidocaine (without epinephrine) 1% solution combined with 0.5mL triamcinolone acetonide injectable solution, USP (40mg per mL)",[39],"20mg ultrasound-guided triamcinolone knee injection",[41,45],{"measure":42,"description":43,"timeFrame":44},"Western Ontario and McMaster Universities Index","Scores are on a scale of 0 through 96, with a higher score indicating a worse function level.","From enrollment to 3 months",{"measure":46,"description":47,"timeFrame":44},"Pain Visual Analog Scale","scale of 0 through 10, with 10 being the highest pain level.",[49],{"measure":50,"description":51,"timeFrame":52},"Immediate change in pVAS (Pain Visual Analog Scale)","pVAS scores from baseline and immediately after injection will be compared. pVAS is on a scale of 0 through 10, with 10 being the highest pain level.","From enrollment to immediately after intervention","ALL","50 Years",false,{"inclusion":57,"exclusion":65,"raw_text":76},[58,59,60,61,62,63,64],"Subjects who have already been evaluated within at least one of the 4 study clinics with any of the 3 providers who will be administering the treatment","Males or females age 50 and older","Already had completion of imaging of the affected knee(s) via radiography and\u002For MRI","Imaging demonstrates osteoarthritis of any severity","Diagnosis of primary osteoarthritis of one or both knees","One or more symptoms associated with the osteoarthritis of at least one knee","Patients able to provide informed consent in English and\u002For Spanish",[66,67,68,69,70,71,72,73,74,75],"Skin infection at or near area of injection site","Recent fracture of the same knee joint within past 6 months","Uncontrolled bleeding disorder","Intra-articular corticosteroid injection within past 3 months","Intra-articular HA injection within the past 3 months","Intra-articular PRP injection within the past 3 months","Presence of prosthetic knee joint in symptomatic knee","Inability to report symptoms due to cognitive impairment","Complete inability to ambulate, even with assistive device","Any person who is pregnant or less than 1 year post-menopause","Inclusion Criteria:\n\n* Subjects who have already been evaluated within at least one of the 4 study clinics with any of the 3 providers who will be administering the treatment\n* Males or females age 50 and older\n* Already had completion of imaging of the affected knee(s) via radiography and\u002For MRI\n* Imaging demonstrates osteoarthritis of any severity\n* Diagnosis of primary osteoarthritis of one or both knees\n* One or more symptoms associated with the osteoarthritis of at least one knee\n* Patients able to provide informed consent in English and\u002For Spanish\n\nExclusion Criteria:\n\n* Skin infection at or near area of injection site\n* Recent fracture of the same knee joint within past 6 months\n* Uncontrolled bleeding disorder\n* Intra-articular corticosteroid injection within past 3 months\n* Intra-articular HA injection within the past 3 months\n* Intra-articular PRP injection within the past 3 months\n* Presence of prosthetic knee joint in symptomatic knee\n* Inability to report symptoms due to cognitive impairment\n* Complete inability to ambulate, even with assistive device\n* Any person who is pregnant or less than 1 year post-menopause",[78,79],"ADULT","OLDER_ADULT",[81,90,93,96],{"facility":82,"city":83,"state":84,"zip":85,"country":86,"geoPoint":87},"Community Memorial Health Center - North Brent Street, 168 North Brent Street, Suite 302, Orthopedic Surgery Clinic, Ventura, California 93003","Ventura","California","93003","United States",{"lat":88,"lon":89},34.27834,-119.29317,{"facility":91,"city":83,"state":84,"zip":85,"country":86,"geoPoint":92},"Community Memorial Health Center - North Brent Street, 168 North Brent Street, Suite 302, Sports Medicine Clinic, Ventura, California 93003",{"lat":88,"lon":89},{"facility":94,"city":83,"state":84,"zip":85,"country":86,"geoPoint":95},"Community Memorial Health Center - Pirie Road, 117 Pirie Road, Orthopedic Surgery Clinic, Ojai, California 93023",{"lat":88,"lon":89},{"facility":97,"city":83,"state":84,"zip":85,"country":86,"geoPoint":98},"Community Memorial Health Center, 1320 Maricopa Highway, Ojai, California 93023",{"lat":88,"lon":89},[],[101],{"name":102,"affiliation":103,"role":104},"Griffin Elbert, DO","Community Memorial Healthcare","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":108,"biomarkers":110},[109],"Osteoarthritis of knee",[]]