[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07563387":3,"trial-entities:NCT07563387":89,"trial-summary:NCT07563387":95},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":28,"primary_purpose":29,"phases":30,"enrollment_info":32,"interventions":35,"primary_outcomes":46,"secondary_outcomes":54,"sex":58,"minimum_age":59,"maximum_age":60,"healthy_volunteers":15,"eligibility_criteria":61,"std_ages":72,"locations":75,"central_contacts":85,"overall_officials":86,"references":87,"see_also_links":88},"NCT07563387","IRB202501105","taVNS for Speech and Language Recovery in Aphasia","Non-invasive Vagus Nerve Stimulation for Language Recovery in Aphasia","ENROLLING_BY_INVITATION","2028-01-01","2026-01","2026-05-04","2026-01-01","University of Florida","OTHER",false,"The goal of this research study is to evaluate a novel approach to improving speech recovery in those with acquired apraxia of speech. We will enroll participants with apraxia of speech resulting from stroke or brain injury to complete several tasks and intervention. Testing will take place four times over the course of the study and intervention will take place 5 days a week for 16 weeks. Overall, you can expect to spend up to 17 weeks participating in this study.",null,[19,20],"Aphasia","Apraxia of Speech",[22,23,24,25,26,27],"taVNS","vagus nerve stimulation","stroke","traumatic brain injury","language","speech","INTERVENTIONAL","TREATMENT",[31],"NA",{"count":33,"type":34},12,"ESTIMATED",[36,41],{"type":37,"name":22,"description":38,"armGroupLabels":39},"DEVICE","active vagus nerve stimulation",[40],"Treatment A",{"type":37,"name":42,"description":43,"armGroupLabels":44},"sham taVNS","sham vagus nerve stimulation",[45],"Treatment B",[47,51],{"measure":48,"description":49,"timeFrame":50},"Adverse events","Frequency and severity of adverse events will be monitored and evaluated for severity and impact on attrition.","6 months",{"measure":52,"description":53,"timeFrame":50},"Compliance","Percentage of the population that remains engaged in the study and completes all stimulation sessions.",[55],{"measure":56,"description":57,"timeFrame":50},"Change in speech production scores","Primary outcomes for this aim include the learning trajectory over 8 weeks of speech therapy as measured by weekly probes and the WAB when intervention is combined with taVNS versus control stimulation to determine the effect of taVNS on re-learning motor speech plans and the trajectory of motor speech recovery.","ALL","18 Years","80 Years",{"inclusion":62,"exclusion":67,"raw_text":71},[63,64,65,66],"Adults between 18-80","Native speakers of English or simultaneous bilinguals","At least 6 months post stroke or TBI","Diagnosed production type aphasia or apraxia of speech",[68,69,70],"Additional cognitive or neurological impairments (Autism, schizophrenia, seizures, etc)","Language comprehension deficits","Medications that influence key neurotransmitters","Inclusion Criteria:\n\n* Adults between 18-80\n* Native speakers of English or simultaneous bilinguals\n* At least 6 months post stroke or TBI\n* Diagnosed production type aphasia or apraxia of speech\n\nExclusion Criteria:\n\n* Additional cognitive or neurological impairments (Autism, schizophrenia, seizures, etc)\n* Language comprehension deficits\n* Medications that influence key neurotransmitters",[73,74],"ADULT","OLDER_ADULT",[76],{"facility":77,"city":78,"state":79,"zip":80,"country":81,"geoPoint":82},"Brooks Rehabilitation Clinical Research Center","Jacksonville","Florida","32216","United States",{"lat":83,"lon":84},30.33218,-81.65565,[],[],[],[],{"nct_id":4,"conditions":90,"biomarkers":94},[19,91,92,93],"Apraxic aphonia","Stroke","Traumatic Encephalopathy",[],{"nct_id":4,"found":15,"summary":17,"prompt_version":17}]