[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07607678":3,"trial-entities:NCT07607678":202,"trial-summary:NCT07607678":206},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":26,"interventions":29,"primary_outcomes":45,"secondary_outcomes":49,"sex":80,"minimum_age":81,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":82,"std_ages":99,"locations":102,"central_contacts":192,"overall_officials":196,"references":197,"see_also_links":198},"NCT07607678","2012-0001","A Study in People With Advanced Cancer to Test How Well Different Doses of BI 3819026 Are Tolerated When Taken Alone and Together With Ezabenlimab","A First-in-human Phase I, Open-label, Multicentre, Dose Escalation Trial of BI 3819026 in Combination With Ezabenlimab in Patients With Unresectable Advanced or Metastatic Solid Cancers to Determine the Maximum Tolerated Dose (MTD) and Recommended Dose for Expansion (RDE)","RECRUITING","2030-10-15","2026-08","2026-08-04","2026-05-01","Boehringer Ingelheim","INDUSTRY",false,"This study is open to adults with advanced cancer. The purpose of this study is to find the highest dose of BI 3819026 that people with advanced cancer can tolerate when taken alone and together with ezabenlimab. BI 3819026 and ezabenlimab are study medicines that may fight cancer.\n\nParticipants first receive one treatment of BI 3819026 alone, followed by treatment with a combination of BI 3819026 and ezabenlimab. Different doses of BI3819026 are given to small groups of participants, starting with the lowest dose. Treatment with the next higher dose of BI 3819026 starts only if the previous dose was tolerated. Each participant remains on the same dose of BI 3819026 throughout the study.\n\nParticipants are in the study for up to 2 years as long as they can tolerate the treatment and their condition does not get worse. During this time, they visit the study site regularly. The doctors look at the occurrence of certain health problems. They also regularly take blood samples, image participants' tumours, and take note of any unwanted effects.",null,[19,20],"Advanced Solid Cancer","Metastatic Solid Cancer",[],"INTERVENTIONAL","TREATMENT",[25],"PHASE1",{"count":27,"type":28},60,"ESTIMATED",[30,42],{"type":31,"name":32,"description":32,"armGroupLabels":33},"DRUG","BI 3819026",[34,35,36,37,38,39,40,41],"BI 3819026 + Ezabenlimab (BI 754091) dose group 1","BI 3819026 + Ezabenlimab (BI 754091) dose group 2","BI 3819026 + Ezabenlimab (BI 754091) dose group 3","BI 3819026 + Ezabenlimab (BI 754091) dose group 3 backfill","BI 3819026 + Ezabenlimab (BI 754091) dose group 4","BI 3819026 + Ezabenlimab (BI 754091) dose group 4 backfill","BI 3819026 + Ezabenlimab (BI 754091) dose group 5","BI 3819026 + Ezabenlimab (BI 754091) dose group 5 backfill",{"type":31,"name":43,"description":43,"armGroupLabels":44},"Ezabenlimab (BI 754091)",[34,35,36,37,38,39,40,41],[46],{"measure":47,"timeFrame":48},"Occurrence of dose-limiting toxicities (DLTs) in the primary DLT evaluation period","Up to 30 days",[50,53,55,58,60,62,65,67,69,71,73,77],{"measure":51,"timeFrame":52},"Occurrence of adverse events (AEs) with onset during the on-treatment period","Up to 2 years",{"measure":54,"timeFrame":52},"Occurrence of DLTs with onset during the on-treatment period",{"measure":56,"timeFrame":57},"Occurrence of AEs with onset during Cycle 1","Up to 15 days",{"measure":59,"timeFrame":57},"Occurrence of DLTs with onset during Cycle 1",{"measure":61,"timeFrame":57},"Maximum measured concentration of BI 3819026 alone (C max) in cycle 1",{"measure":63,"timeFrame":64},"Maximum measured concentration of BI 3819026 alone (C max) in cycle 3","Up to Day 30",{"measure":66,"timeFrame":64},"Maximum measured concentration of BI 3819026 + ezabenlimab combination (C max) in cycle 3",{"measure":68,"timeFrame":57},"Area under concentration-time curve of BI 3819026 alone over a uniform dosing interval 0 - 504 h (AUC 0-504) in cycle 1",{"measure":70,"timeFrame":64},"Area under concentration-time curve of BI 3819026 alone over a uniform dosing interval 0 - 504 h (AUC 0-504) in cycle 3",{"measure":72,"timeFrame":64},"Area under concentration-time curve of BI 3819026 + ezabenlimab combination over a uniform dosing interval 0 - 504 h (AUC 0-504) in cycle 3",{"measure":74,"description":75,"timeFrame":76},"Treatment-induced changes in target cells as compared with baseline","Backfill cohorts only: only patients in whom sequential biopsies are technically feasible and deemed safe by the investigator will be eligible","At baseline and up to 2 years",{"measure":78,"description":79,"timeFrame":76},"Treatment-induced changes in target cells ratio as compared with baseline","Backfill cohorts only","ALL","18 Years",{"inclusion":83,"exclusion":87,"raw_text":98},[84,85,86],"Brain metastases have adequately been treated and are without progression or haemorrhage and are considered stable and asymptomatic by the investigator,","Radiotherapy and\u002For surgery for brain metastases was completed at least 14 and 28 days, respectively, prior to the first administration of BI 3819026,","Patient is off steroids and anti-convulsive drugs for at least 7 days prior to the first administration of BI 3819026 and has no requirement for such therapy at the time of initiating trial treatment. 4. Availability of archived formalin-fixed and paraffin embedded (FFPE) tumour tissue. Patients who do not have archived FFPE tumour tissue available may be allowed to enrol without archival tumour tissue upon agreement between the investigator and the Sponsor 5. All toxicities related to previous anti-cancer therapies have resolved to Grade ≤1 or baseline prior to trial treatment administration (except for alopecia, peripheral neuropathy and endocrinopathies considered irreversible \\[like hypothyroidism\\], and amenorrhea\u002Fmenstrual disorders which can be any grade)",[88,89,90,91,92,93,94,95,96,97],"Effectively treated non-melanoma skin cancers","Effectively treated carcinoma in situ of the cervix","Effectively treated ductal carcinoma in situ of the breast","Other effectively treated malignancy that is considered cured by local treatment 2. Has received prior therapy with an immune-checkpoint inhibitor that was discontinued due to immune-related adverse events (AE) 3. Prior treatment with systemic anti-cancer drugs (including any agents or investigational medicinal products) within 3 weeks or 5 half-lives (whichever is shorter) before the first dose of trial treatment 4. Radiotherapy within 4 weeks prior to start of the trial treatment except as follows:","Palliative radiotherapy to regions other than the chest is allowed if completed at least 2 weeks prior and is not on the target lesion (which should be outside of the radiation field)","Single dose palliative radiotherapy for symptomatic metastasis that is not the target lesion (which should be outside of the radiation field) within 2 weeks prior may be allowed 5. Active\u002Fprevious history of interstitial lung disease, pulmonary fibrosis, organising pneumonia or non-infectious pneumonitis (any grade) 6. Patients with active autoimmune disease or a documented history of autoimmune disease, that requires systemic treatment, e.g. corticosteroids or immunosuppressive drugs, except patients with vitiligo, resolved childhood asthma\u002Fatopy, alopecia, or any chronic skin condition that does not require systemic therapy; patients with autoimmune-related hypothyroidism on a stable dose of thyroid replacement hormone and\u002For controlled Type 1 diabetes mellitus on a stable insulin regimen are eligible 7. Patient has a diagnosis of immunodeficiency other than human immunodeficiency virus (HIV) 8. Patients with history of HIV infection who meet one or more of the following criteria:","CD4+ count \\\u003C350 cells\u002FµL","Viral load \\>400 copies\u002FmL","Not receiving antiretroviral therapy","Receiving established antiretroviral therapy for less than four weeks prior to the start of trial treatment","Inclusion Criteria :\n\n1. Participants with histologically confirmed unresectable advanced or metastatic solid tumours who have documented progression after or are refractory to or ineligible for established and available therapies with proven clinical benefit, or have declined such therapy.\n2. At least one measurable disease lesion outside of the central nervous system (CNS) defined per Response Evaluation Criteria in Solid Tumours (RECIST) v1.1\n3. Patients with brain metastases are eligible provided they meet the following criteria:\n\n   * Brain metastases have adequately been treated and are without progression or haemorrhage and are considered stable and asymptomatic by the investigator,\n   * Radiotherapy and\u002For surgery for brain metastases was completed at least 14 and 28 days, respectively, prior to the first administration of BI 3819026,\n   * Patient is off steroids and anti-convulsive drugs for at least 7 days prior to the first administration of BI 3819026 and has no requirement for such therapy at the time of initiating trial treatment.\n4. Availability of archived formalin-fixed and paraffin embedded (FFPE) tumour tissue. Patients who do not have archived FFPE tumour tissue available may be allowed to enrol without archival tumour tissue upon agreement between the investigator and the Sponsor\n5. All toxicities related to previous anti-cancer therapies have resolved to Grade ≤1 or baseline prior to trial treatment administration (except for alopecia, peripheral neuropathy and endocrinopathies considered irreversible \\[like hypothyroidism\\], and amenorrhea\u002Fmenstrual disorders which can be any grade)\n6. Adequate liver, bone marrow and renal organ function Further inclusion criteria apply.\n\nExclusion Criteria :\n\n1. Previous or concomitant malignancies other than the one treated in this trial within the last 3 years except:\n\n   * Effectively treated non-melanoma skin cancers\n   * Effectively treated carcinoma in situ of the cervix\n   * Effectively treated ductal carcinoma in situ of the breast\n   * Other effectively treated malignancy that is considered cured by local treatment\n2. Has received prior therapy with an immune-checkpoint inhibitor that was discontinued due to immune-related adverse events (AE)\n3. Prior treatment with systemic anti-cancer drugs (including any agents or investigational medicinal products) within 3 weeks or 5 half-lives (whichever is shorter) before the first dose of trial treatment\n4. Radiotherapy within 4 weeks prior to start of the trial treatment except as follows:\n\n   * Palliative radiotherapy to regions other than the chest is allowed if completed at least 2 weeks prior and is not on the target lesion (which should be outside of the radiation field)\n   * Single dose palliative radiotherapy for symptomatic metastasis that is not the target lesion (which should be outside of the radiation field) within 2 weeks prior may be allowed\n5. Active\u002Fprevious history of interstitial lung disease, pulmonary fibrosis, organising pneumonia or non-infectious pneumonitis (any grade)\n6. Patients with active autoimmune disease or a documented history of autoimmune disease, that requires systemic treatment, e.g. corticosteroids or immunosuppressive drugs, except patients with vitiligo, resolved childhood asthma\u002Fatopy, alopecia, or any chronic skin condition that does not require systemic therapy; patients with autoimmune-related hypothyroidism on a stable dose of thyroid replacement hormone and\u002For controlled Type 1 diabetes mellitus on a stable insulin regimen are eligible\n7. Patient has a diagnosis of immunodeficiency other than human immunodeficiency virus (HIV)\n8. Patients with history of HIV infection who meet one or more of the following criteria:\n\n   * CD4+ count \\\u003C350 cells\u002FµL\n   * Viral load \\>400 copies\u002FmL\n   * Not receiving antiretroviral therapy\n   * Receiving established antiretroviral therapy for less than four weeks prior to the start of trial treatment\n   * History of acquired immunodeficiency syndrome (AIDS)-defining opportunistic infections within 12 months prior to start of trial treatment Patients with a history of HIV who do not meet any of the exclusion criteria above are eligible to participate but the patient must be under the care of an HIV\u002FInfectious Diseases specialist, or an HIV\u002FInfectious Diseases specialist must be consulted prior to inclusion Further exclusion criteria apply.",[100,101],"ADULT","OLDER_ADULT",[103,117,128,137,147,156,162,174,183],{"facility":104,"status":8,"city":105,"state":106,"zip":107,"country":108,"contacts":109,"geoPoint":114},"Yale Cancer Center","New Haven","Connecticut","06511","United States",[110],{"name":13,"role":111,"phone":112,"email":113},"CONTACT","833-602-2368","unitedstates@bitrialsupport.com",{"lat":115,"lon":116},41.30815,-72.92816,{"facility":118,"status":119,"city":120,"state":121,"zip":122,"country":108,"contacts":123,"geoPoint":125},"Hackensack University Medical Center","NOT_YET_RECRUITING","Hackensack","New Jersey","07601",[124],{"name":13,"role":111,"phone":112,"email":113},{"lat":126,"lon":127},40.88593,-74.04347,{"facility":129,"status":119,"city":130,"state":130,"zip":131,"country":108,"contacts":132,"geoPoint":134},"New York University Langone Medical Center","New York","10016",[133],{"name":13,"role":111,"phone":112,"email":113},{"lat":135,"lon":136},40.71427,-74.00597,{"facility":138,"status":8,"city":139,"state":140,"zip":141,"country":108,"contacts":142,"geoPoint":144},"SCRI Oncology Partners","Nashville","Tennessee","37203",[143],{"name":13,"role":111,"phone":112,"email":113},{"lat":145,"lon":146},36.16589,-86.78444,{"facility":148,"status":8,"city":149,"zip":150,"country":151,"contacts":152},"National Cancer Center Hospital East","Chiba, Kashiwa","277-8577","Japan",[153],{"name":13,"role":111,"phone":154,"email":155},"05050508862","nippon@bitrialsupport.com",{"facility":157,"status":8,"city":158,"zip":159,"country":151,"contacts":160},"National Cancer Center Hospital","Tokyo, Chuo-ku","104-0045",[161],{"name":13,"role":111,"phone":154,"email":155},{"facility":163,"status":8,"city":164,"zip":165,"country":166,"contacts":167,"geoPoint":171},"Hospital Universitari Vall d'Hebron","Barcelona","08035","Spain",[168],{"name":13,"role":111,"phone":169,"email":170},"900876092","espana@bitrialsupport.com",{"lat":172,"lon":173},41.38879,2.15899,{"facility":175,"status":8,"city":176,"zip":177,"country":166,"contacts":178,"geoPoint":180},"Clínica Universidad de Navarra","Pamplona","31008",[179],{"name":13,"role":111,"phone":169,"email":170},{"lat":181,"lon":182},42.81687,-1.64323,{"facility":184,"status":8,"city":185,"zip":186,"country":166,"contacts":187,"geoPoint":189},"Hospital Clinico Universitario de Valencia","Valencia","46010",[188],{"name":13,"role":111,"phone":169,"email":170},{"lat":190,"lon":191},39.47391,-0.37966,[193],{"name":13,"role":111,"phone":194,"email":195},"1-800-243-0127","clintriage.rdg@boehringer-ingelheim.com",[],[],[199],{"label":200,"url":201},"Related Info","https:\u002F\u002Fwww.clinicalstudies.boehringer-ingelheim.com\u002Fmsw\u002Fdatatransparency",{"nct_id":4,"conditions":203,"biomarkers":205},[204],"Solid Neoplasm",[],{"nct_id":4,"found":207,"summary":208,"prompt_version":218},true,{"design":209,"status":210,"heading":211,"summary":212,"follow_up":213,"word_count":214,"commitments":215,"compensation":216,"drugs_mentioned":217},"This is an interventional study with an unspecified phase, enrolling about 60 participants. It tests different doses of BI 3819026 alone and in combination with ezabenlimab.","completed","Study of BI 3819026 Alone and With Ezabenlimab for Advanced Cancer","This study is for adults with advanced or metastatic solid cancers that have progressed or are not suitable for standard treatments. It aims to find the highest dose of BI 3819026 that can be safely tolerated, both when given alone and when combined with another study medicine called ezabenlimab. Both BI 3819026 and ezabenlimab are being studied for their potential to fight cancer by targeting the RAF mechanism. Participants will first receive BI 3819026 alone, then in combination with ezabenlimab. Doses of BI 3819026 will gradually increase in small groups, with safety being the main focus. The study plans to enroll about 60 people, but its current recruitment status is unclear.","The primary safety measure, dose-limiting toxicities (DLTs), is evaluated for up to 30 days.",111,"Participants will first receive BI 3819026 alone, then in combination with ezabenlimab. They will remain on the same dose of BI 3819026 throughout the study.","Not stated in the trial record.",[32],"v2"]