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(ACCLAIM-CTA)","https:\u002F\u002Ftrials.lilly.com\u002Fen-US\u002Ftrial\u002F723885",{"nct_id":4,"conditions":757,"biomarkers":759},[19,758],"Coronary Artery Disease",[],{"nct_id":4,"found":761,"summary":762,"prompt_version":772},true,{"design":763,"status":764,"heading":765,"summary":766,"follow_up":767,"word_count":768,"commitments":769,"compensation":770,"drugs_mentioned":771},"This interventional study is designed to compare lepodisiran to a placebo. It plans to enroll 252 participants.","completed","A Study of Lepodisiran for Plaque Reduction in Adults with High Lp(a)","This study is looking at how a drug called lepodisiran might help reduce plaque in the heart's arteries for adults aged 45 to 80. You could be eligible if you have high levels of Lipoprotein(a) (Lp(a)), which is a protein linked to a higher risk of heart disease, and have either had heart events or are at high risk. Researchers will compare lepodisiran to a placebo (an inactive substance) to see how it affects the amount and type of plaque using a special imaging scan (Coronary Computed Tomography Angiography or CCTA). The main goal is to measure changes in noncalcified plaque volume over about 104 weeks. The study aims to enroll 252 participants.","The primary endpoint measures changes in plaque volume at Week 104, suggesting follow-up for at least this duration.",113,"Participation in this study will last about 120 weeks. You would receive either lepodisiran or a placebo, both given as an injection under the skin (SC).","Not stated in the trial record.",[35,41],"v2"]