[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07617649":3,"trial-entities:NCT07617649":148,"trial-summary:NCT07617649":151},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":25,"interventions":28,"primary_outcomes":43,"secondary_outcomes":47,"sex":48,"minimum_age":49,"maximum_age":50,"healthy_volunteers":15,"eligibility_criteria":51,"std_ages":70,"locations":72,"central_contacts":86,"overall_officials":87,"references":91,"see_also_links":147},"NCT07617649","86182","Laboratory Heat Biomarker and Cooling Interventions","Laboratory Based Identification of Heat Stress Biomarkers and Effective Cooling Interventions","NOT_YET_RECRUITING","2028-06","2026-05","2026-06-01","2026-06","Stanford University","OTHER",true,"Our study has two goals. The first goal is to find a blood test that can detect signs of strain from heat in the body (\"a biomarker\"). Second, the study team wants to identify types of devices that can help people cool down quickly.\n\nBy identifying biomarkers for heat strain, scientists can better track and treat the health effects of heat. The study team will identify such biomarkers by simulating, in a laboratory-based environment, the heat and physical work that real-world workers experience.\n\nIn addition, the study team plans to test two cooling technologies that might keep people cool during physical activity.",null,[19],"Hyperthermia",[],"INTERVENTIONAL","PREVENTION",[24],"NA",{"count":26,"type":27},30,"ESTIMATED",[29,39],{"type":14,"name":30,"description":31,"armGroupLabels":32},"Hand cooling table","A participant can rest their hand on the cooling table after the one hour exercise session, and this should cool their body quickly. Cold water is pumped throughout the cooling table.",[33,34,35,36,37,38],"Biomarker testing (A), Cooling bandana (B), Hand cooling table (C)","Biomarker testing (A), Hand cooling table (C), Cooling bandana (B)","Cooling bandana (B), Biomarker testing (A), Hand cooling table (C)","Cooling bandana (B), Hand cooling table (C), Biomarker testing (A)","Hand cooling table (C), Biomarker testing (A), Cooling bandana (B)","Hand cooling table (C), Cooling bandana (B), Biomarker testing (A)",{"type":14,"name":40,"description":41,"armGroupLabels":42},"Cooling bandana","A participant will tie a bandana that has been soaked in cold water onto their forehead. They will wear this bandana during the one hour exercise session.",[33,34,35,36,37,38],[44],{"measure":45,"timeFrame":46},"Core body temperature","Baseline through end of study (approximately 2 months).",[],"ALL","18 Years","50 Years",{"inclusion":52,"exclusion":58,"raw_text":69},[53,54,55,56,57],"Age 18-50","Able to communicate in English or Spanish","General good health","A lifestyle that includes regular patterns of modest exercise","Body weight over 80 pounds",[59,60,61,62,63,64,65,66,67,68],"Cannot provide informed consent","Known history of cardiac arrhythmias or having a pacemaker","Difficulty swallowing pills","Planned upcoming X-ray tests or MRI","Known history of gastroparesis, diverticulosis or diverticulitis, or inflammatory bowel disease","Previous surgery on stomach or intestines (except for appendix or gallbladder)","Pregnancy","Self-reported cardiac, kidney, or pulmonary disease, or diabetes","Concurrent use of temperature- or inflammation-modulating medications such as steroids or non-steroidal anti-inflammatory drugs (NSAIDs)","Staff under the direct supervision of any project directors or employed in the laboratory of the study investigators","Inclusion Criteria:\n\n* Age 18-50\n* Able to communicate in English or Spanish\n* General good health\n* A lifestyle that includes regular patterns of modest exercise\n* Body weight over 80 pounds\n\nExclusion Criteria:\n\n* Cannot provide informed consent\n* Known history of cardiac arrhythmias or having a pacemaker\n* Difficulty swallowing pills\n* Planned upcoming X-ray tests or MRI\n* Known history of gastroparesis, diverticulosis or diverticulitis, or inflammatory bowel disease\n* Previous surgery on stomach or intestines (except for appendix or gallbladder)\n* Pregnancy\n* Self-reported cardiac, kidney, or pulmonary disease, or diabetes\n* Concurrent use of temperature- or inflammation-modulating medications such as steroids or non-steroidal anti-inflammatory drugs (NSAIDs)\n* Staff under the direct supervision of any project directors or employed in the laboratory of the study investigators",[71],"ADULT",[73],{"facility":13,"city":74,"state":75,"zip":76,"country":77,"contacts":78,"geoPoint":83},"Stanford","California","94305","United States",[79],{"name":80,"role":81,"email":82},"Astrid Elliott, MS","CONTACT","astride@stanford.edu",{"lat":84,"lon":85},37.42411,-122.16608,[],[88],{"name":89,"affiliation":13,"role":90},"Julie Parsonnet, MD","PRINCIPAL_INVESTIGATOR",[92,96,99,102,105,108,111,114,117,120,123,126,129,132,135,138,141,144],{"pmid":93,"type":94,"citation":95},"31836035","BACKGROUND","Ray SC, Mason J, O'Connor PM. Ischemic Renal Injury: Can Renal Anatomy and Associated Vascular Congestion Explain Why the Medulla and Not the Cortex Is Where the Trouble Starts? Semin Nephrol. 2019 Nov;39(6):520-529. doi: 10.1016\u002Fj.semnephrol.2019.10.002.",{"pmid":97,"type":94,"citation":98},"31566903","Evans RG, Smith DW, Lee CJ, Ngo JP, Gardiner BS. What Makes the Kidney Susceptible to Hypoxia? Anat Rec (Hoboken). 2020 Oct;303(10):2544-2552. doi: 10.1002\u002Far.24260. Epub 2019 Sep 30.",{"pmid":100,"type":94,"citation":101},"11219501","Febbraio MA. Alterations in energy metabolism during exercise and heat stress. Sports Med. 2001;31(1):47-59. doi: 10.2165\u002F00007256-200131010-00004.",{"pmid":103,"type":94,"citation":104},"34682351","Hymczak H, Golab A, Mendrala K, Plicner D, Darocha T, Podsiadlo P, Hudziak D, Gocol R, Kosinski S. Core Temperature Measurement-Principles of Correct Measurement, Problems, and Complications. Int J Environ Res Public Health. 2021 Oct 10;18(20):10606. doi: 10.3390\u002Fijerph182010606.",{"pmid":106,"type":94,"citation":107},"25649311","Mazloumi A, Golbabaei F, Mahmood Khani S, Kazemi Z, Hosseini M, Abbasinia M, Farhang Dehghan S. Evaluating Effects of Heat Stress on Cognitive Function among Workers in a Hot Industry. Health Promot Perspect. 2014 Dec 30;4(2):240-6. doi: 10.5681\u002Fhpp.2014.031. eCollection 2014.",{"pmid":109,"type":94,"citation":110},"38518609","Yin B, Fang W, Liu L, Guo Y, Ma X, Di Q. Effect of extreme high temperature on cognitive function at different time scales: A national difference-in-differences analysis. Ecotoxicol Environ Saf. 2024 Apr 15;275:116238. doi: 10.1016\u002Fj.ecoenv.2024.116238. Epub 2024 Mar 21.",{"pmid":112,"type":94,"citation":113},"41047384","Alahmad B, Kessler W, Alwadi Y, Schwartz J, Wagner GR, Michaels D. A nationwide analysis of heat and workplace injuries in the United States. Environ Health. 2025 Oct 6;24(1):65. doi: 10.1186\u002Fs12940-025-01231-1.",{"pmid":115,"type":94,"citation":116},"29074166","McTavish RK, Richard L, McArthur E, Shariff SZ, Acedillo R, Parikh CR, Wald R, Wilk P, Garg AX. Association Between High Environmental Heat and Risk of Acute Kidney Injury Among Older Adults in a Northern Climate: A Matched Case-Control Study. Am J Kidney Dis. 2018 Feb;71(2):200-208. doi: 10.1053\u002Fj.ajkd.2017.07.011. Epub 2017 Oct 23.",{"pmid":118,"type":94,"citation":119},"31773783","Moyce S, Armitage T, Mitchell D, Schenker M. Acute kidney injury and workload in a sample of California agricultural workers. Am J Ind Med. 2020 Mar;63(3):258-268. doi: 10.1002\u002Fajim.23076. Epub 2019 Nov 26.",{"pmid":121,"type":94,"citation":122},"18474113","Grahn DA, Murray JV, Heller HC. Cooling via one hand improves physical performance in heat-sensitive individuals with multiple sclerosis: a preliminary study. BMC Neurol. 2008 May 12;8:14. doi: 10.1186\u002F1471-2377-8-14.",{"pmid":124,"type":94,"citation":125},"15879169","Grahn DA, Cao VH, Heller HC. Heat extraction through the palm of one hand improves aerobic exercise endurance in a hot environment. J Appl Physiol (1985). 2005 Sep;99(3):972-8. doi: 10.1152\u002Fjapplphysiol.00093.2005. Epub 2005 May 5.",{"pmid":127,"type":94,"citation":128},"25771030","Lissoway JB, Lipman GS, Grahn DA, Cao VH, Shaheen M, Phan S, Weiss EA, Heller HC. Novel application of chemical cold packs for treatment of exercise-induced hyperthermia: a randomized controlled trial. Wilderness Environ Med. 2015 Jun;26(2):173-9. doi: 10.1016\u002Fj.wem.2014.11.006. Epub 2015 Mar 12.",{"pmid":130,"type":94,"citation":131},"22076097","Grahn DA, Cao VH, Nguyen CM, Liu MT, Heller HC. Work volume and strength training responses to resistive exercise improve with periodic heat extraction from the palm. J Strength Cond Res. 2012 Sep;26(9):2558-69. doi: 10.1519\u002FJSC.0b013e31823f8c1a.",{"pmid":133,"type":94,"citation":134},"29708853","Grahn D, Makam M, Craig Heller H. A method to reduce heat strain while clad in encapsulating outerwear. J Occup Environ Hyg. 2018 Aug;15(8):573-579. doi: 10.1080\u002F15459624.2018.1470635.",{"pmid":136,"type":94,"citation":137},"29700064","Kellogg RA, Dunn J, Snyder MP. Personal Omics for Precision Health. Circ Res. 2018 Apr 27;122(9):1169-1171. doi: 10.1161\u002FCIRCRESAHA.117.310909.",{"pmid":139,"type":94,"citation":140},"36658343","Shen X, Kellogg R, Panyard DJ, Bararpour N, Castillo KE, Lee-McMullen B, Delfarah A, Ubellacker J, Ahadi S, Rosenberg-Hasson Y, Ganz A, Contrepois K, Michael B, Simms I, Wang C, Hornburg D, Snyder MP. Multi-omics microsampling for the profiling of lifestyle-associated changes in health. Nat Biomed Eng. 2024 Jan;8(1):11-29. doi: 10.1038\u002Fs41551-022-00999-8. Epub 2023 Jan 19.",{"pmid":142,"type":94,"citation":143},"14514731","Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 2003 Oct;14(10):2534-43. doi: 10.1097\u002F01.asn.0000088027.54400.c6.",{"pmid":145,"type":94,"citation":146},"11960972","Kregel KC. Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J Appl Physiol (1985). 2002 May;92(5):2177-86. doi: 10.1152\u002Fjapplphysiol.01267.2001.",[],{"nct_id":4,"conditions":149,"biomarkers":150},[19],[],{"nct_id":4,"found":152,"summary":17,"prompt_version":17},false]