[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07621757":3,"trial-entities:NCT07621757":63,"trial-summary:NCT07621757":68},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":22,"study_type":23,"primary_purpose":17,"phases":24,"enrollment_info":25,"interventions":28,"primary_outcomes":29,"secondary_outcomes":33,"sex":36,"minimum_age":37,"maximum_age":38,"healthy_volunteers":39,"eligibility_criteria":40,"std_ages":47,"locations":50,"central_contacts":59,"overall_officials":60,"references":61,"see_also_links":62},"NCT07621757","IRB2026-0064","The Implementation of Genetic Risk for Colorectal Cancer Screening","Prospective Trial for the Implementation of Genetic Risk for Colorectal Cancer Screening","ENROLLING_BY_INVITATION","2027-05-31","2026-05","2026-06-02","2026-06-01","Endeavor Health","OTHER",false,"The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are:\n\n1. How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies?\n2. How do colonoscopy outcomes compare between genetic risk groups?",null,[19,20,21],"Colorectal Cancer","Colorectal Adenoma","Colorectal Polyp",[],"OBSERVATIONAL",[],{"count":26,"type":27},100,"ESTIMATED",[],[30],{"measure":31,"timeFrame":32},"Number of scheduled colonoscopies in each genetic risk group","One year following enrollment",[34],{"measure":35,"timeFrame":32},"Number of polyps and\u002For adenomas found through colonoscopy in each genetic risk group","ALL","45 Years","75 Years",true,{"inclusion":41,"exclusion":42,"raw_text":46},[],[43,44,45],"Prior colonoscopy","Prior personal history of colorectal cancer or inflammatory bowel disease","Medical contraindications to colonoscopy\u002Fsedation","Inclusion Criteria:\n\n\\- Due for initial screening colonoscopy per current guidelines\n\nExclusion Criteria:\n\n* Prior colonoscopy\n* Prior personal history of colorectal cancer or inflammatory bowel disease\n* Medical contraindications to colonoscopy\u002Fsedation",[48,49],"ADULT","OLDER_ADULT",[51],{"facility":13,"city":52,"state":53,"zip":54,"country":55,"geoPoint":56},"Evanston","Illinois","60201","United States",{"lat":57,"lon":58},42.04114,-87.69006,[],[],[],[],{"nct_id":4,"conditions":64,"biomarkers":66},[20,65,21],"Colorectal Carcinoma",[67],"Polygenic Risk Score",{"nct_id":4,"found":15,"summary":17,"prompt_version":17}]