[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07635329":3,"trial-entities:NCT07635329":96,"trial-summary:NCT07635329":101},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":28,"study_type":34,"primary_purpose":35,"phases":36,"enrollment_info":38,"interventions":41,"primary_outcomes":53,"secondary_outcomes":61,"sex":62,"minimum_age":63,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":64,"std_ages":68,"locations":71,"central_contacts":89,"overall_officials":93,"references":94,"see_also_links":95},"NCT07635329","STUDY00010314","Home-based Vision Rehabilitation Guided by Brain Imaging","Behavioral Rehabilitation Through Image-Guided Home-based Training","RECRUITING","2030-03-31","2026-06","2026-06-09","2026-07-01","Georgetown University","OTHER",false,"The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.\n\nUsing a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.",null,[19,20,21,22,23,24,25,26,27],"Visual Field Defect","Stroke","Hemianopia Homonymous","Quadrantanopia","Cortical Blindness","Visual Field Defect, Peripheral","Visual Field Loss","Traumatic Brain Injury","Brain Tumor",[29,30,31,32,33],"neuroplasticity","stroke","vision","TBI","brain tumor","INTERVENTIONAL","TREATMENT",[37],"NA",{"count":39,"type":40},100,"ESTIMATED",[42,48],{"type":43,"name":44,"description":45,"armGroupLabels":46},"BEHAVIORAL","High-level perceptual learning-based training","Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing",[47],"Perceptual learning-based training using high-level visual stimuli",{"type":43,"name":49,"description":50,"armGroupLabels":51},"Low-level perceptual learning-based training","behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing",[52],"Perceptual learning-based training using low-level visual stimuli",[54,58],{"measure":55,"description":56,"timeFrame":57},"Change in high-level perceptual discrimination performance","Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up\u002F1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.","Week 2-4 or Week 7-9 of the study (depending on the order)",{"measure":59,"description":60,"timeFrame":57},"Change in low-level perceptual discrimination performance","Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up\u002F1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.",[],"ALL","18 Years",{"inclusion":65,"exclusion":66,"raw_text":67},[],[],"Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Capable of providing informed consent and complying with study procedures.\n3. Unilateral or bilateral focal brain damage causing visual field loss.\n4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.\n5. Eligible for MRI based on standard safety screening.\n\nExclusion Criteria:\n\n1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.\n2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.\n3. Ocular disease or disorder.",[69,70],"ADULT","OLDER_ADULT",[72],{"facility":73,"status":8,"city":74,"state":75,"zip":76,"country":77,"contacts":78,"geoPoint":86},"Georgetown University Medical Center","Washington D.C.","District of Columbia","20057","United States",[79,84],{"name":80,"role":81,"phone":82,"email":83},"Tina Liu, PhD","CONTACT","202-784-9949","vpplab@georgetown.edu",{"name":80,"role":85},"PRINCIPAL_INVESTIGATOR",{"lat":87,"lon":88},38.89511,-77.03637,[90],{"name":80,"role":81,"phone":91,"email":92},"2027849920","tina.liu@georgetown.edu",[],[],[],{"nct_id":4,"conditions":97,"biomarkers":100},[98,23,20,99,19],"Brain Neoplasm","Traumatic Encephalopathy",[],{"nct_id":4,"found":15,"summary":17,"prompt_version":17}]