[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07637331":3,"trial-entities:NCT07637331":96,"trial-summary:NCT07637331":100},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":21,"phases":22,"enrollment_info":24,"interventions":27,"primary_outcomes":35,"secondary_outcomes":43,"sex":47,"minimum_age":48,"maximum_age":49,"healthy_volunteers":50,"eligibility_criteria":51,"std_ages":70,"locations":72,"central_contacts":89,"overall_officials":92,"references":94,"see_also_links":95},"NCT07637331","28083","The Effect of Respiratory Muscle Training on Cognitive Performance","RECRUITING","2027-04","2026-06","2026-06-26","2026-03-27","Indiana University","OTHER",false,"Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance.",null,[18],"Respiratory Muscle Training",[],"INTERVENTIONAL","PREVENTION",[23],"NA",{"count":25,"type":26},32,"ESTIMATED",[28],{"type":29,"name":30,"description":31,"armGroupLabels":32},"DEVICE","Inspiratory muscle training","8 weeks of active or sham inspiratory muscle training",[33,34],"Active IMT","Sham IMT",[36,40],{"measure":37,"description":38,"timeFrame":39},"Diaphragm thickness","ultrasound measurements of diaphragm thickness","Baseline and after 8 weeks of training",{"measure":41,"description":42,"timeFrame":39},"Cognitive performance","CAAPES performance with the higher percentage correct corresponding to a better performance.",[44],{"measure":45,"description":46,"timeFrame":39},"Dyspnea","Measure of breathing discomfort and pleasantness using a visual analog scale, the higher the value the more discomfort and unpleasant the subject's breathing is.","ALL","18 Years","40 Years",true,{"inclusion":52,"exclusion":58,"raw_text":69},[53,54,55,56,57],"18-40 years old","Body mass index \\\u003C30 kg\u002Fm2","Naïve to IMT","\\>75% of predicted forced expiratory volume in 1 second (FEV1) \u002F forced vital capacity (FVC) (FEV1\u002FFVC)","Access to smart phone or tablet with internet",[59,60,61,62,63,64,65,66,67,68],"Diagnosed:","Cardiovascular disease","Respiratory disease (including asthma)","Metabolic disease","Currently pregnant","Unable to adhere to the IMT protocol","Answering 'yes' to any of the questions on page one of the PAR-Q+","Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)","Self-reported color blindness","Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and\u002For compromise the objectives of the study","Inclusion Criteria:\n\n* 18-40 years old\n* Body mass index \\\u003C30 kg\u002Fm2\n* Naïve to IMT\n* \\>75% of predicted forced expiratory volume in 1 second (FEV1) \u002F forced vital capacity (FVC) (FEV1\u002FFVC)\n* Access to smart phone or tablet with internet\n\nExclusion Criteria:\n\n* Diagnosed:\n\n  * Cardiovascular disease\n  * Respiratory disease (including asthma)\n  * Metabolic disease\n  * Currently pregnant\n  * Unable to adhere to the IMT protocol\n* Answering 'yes' to any of the questions on page one of the PAR-Q+\n* Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)\n* Self-reported color blindness\n* Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and\u002For compromise the objectives of the study",[71],"ADULT",[73],{"facility":12,"status":7,"city":74,"state":75,"zip":76,"country":77,"contacts":78,"geoPoint":86},"Bloomington","Indiana","47405","United States",[79,84],{"name":80,"role":81,"phone":82,"email":83},"Blair Johnson, PhD","CONTACT","812-855-8699","bj33@iu.edu",{"name":80,"role":85},"PRINCIPAL_INVESTIGATOR",{"lat":87,"lon":88},39.16533,-86.52639,[90],{"name":91,"role":81,"phone":82,"email":83},"Blair Johnson",[93],{"name":80,"affiliation":12,"role":85},[],[],{"nct_id":4,"conditions":97,"biomarkers":99},[98],"Healthy Volunteers",[],{"nct_id":4,"found":14,"summary":16,"prompt_version":16}]