[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07638384":3,"trial-entities:NCT07638384":90,"trial-summary:NCT07638384":94},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":39,"secondary_outcomes":44,"sex":48,"minimum_age":49,"maximum_age":50,"healthy_volunteers":51,"eligibility_criteria":52,"std_ages":62,"locations":64,"central_contacts":82,"overall_officials":86,"references":88,"see_also_links":89},"NCT07638384","STUDY-26-00124","Evaluation of Muscle Oxygen With MRI","Effect of External Pressure and Muscle Contraction on Soft Tissue Oxygenation Measured With Functional MRI","RECRUITING","2029-05-07","2026-07","2026-07-13","2026-08","Icahn School of Medicine at Mount Sinai","OTHER",false,"Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.","Participant will undergo a single MRI examination. Standard orthopedic Sarmiento brace\u002F shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a standard brace soft foam attached; blood pressure cuff will be partially inflated. Participant will also be asked to lift MRI compatible 10 lb. weight. Muscle oxygenation will be actively measured using MRI. No medications are being given, and no invasive devices are being used.",[19],"Muscle Oxygenation",[21,22,23,24],"muscle","magnetic resonance imaging","external pressure","muscle contraction","INTERVENTIONAL","BASIC_SCIENCE",[28],"NA",{"count":30,"type":31},75,"ESTIMATED",[33],{"type":34,"name":35,"description":36,"armGroupLabels":37},"PROCEDURE","Compression and Contraction","Standard orthopedic Sarmiento brace\u002F shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a soft foam attached. Pressure will be applied intermittently with blood pressure cuff. Participant will also be asked to lift MRI compatible 10 lb. weight.",[38],"MRI",[40],{"measure":41,"description":42,"timeFrame":43},"Muscle oxygen level","Using functional MRI to evaluate effect of muscle compression on muscle oxygen. Demonstrating statistically significant change in muscle oxygen in tissues with application of tissue compression and muscle contraction compared to the same, non-compressed tissues with only muscle contraction","Day 1, during procedure",[45],{"measure":46,"description":47,"timeFrame":43},"Deep tissue oxygen level","Using functional MRI to evaluate the effect of muscle compression and contraction on deep tissue oxygen. Demonstrate statistically greater decreased tissue oxygenation in the deep soft tissues compared to the superficial tissues below the deforming element, during application of tissue compression, during muscle contraction as well during application of tissue compression and muscle contraction.","ALL","20 Years","64 Years",true,{"inclusion":53,"exclusion":58,"raw_text":61},[54,55,56,57],"Alert and oriented.","Able to lift 10lbs. and hold for 30 seconds","Not claustrophobic.","Intact sensation in right upper extremity.",[59,60],"Latex allergy or allergy to isopropyl alcohol.","Skin injury or decreased sensation on right upper extremity.","Inclusion Criteria:\n\n* Alert and oriented.\n* Able to lift 10lbs. and hold for 30 seconds\n* Not claustrophobic.\n* Intact sensation in right upper extremity.\n\nExclusion Criteria:\n\n* Latex allergy or allergy to isopropyl alcohol.\n* Skin injury or decreased sensation on right upper extremity.",[63],"ADULT",[65],{"facility":66,"status":8,"city":67,"state":67,"zip":68,"country":69,"contacts":70,"geoPoint":79},"Mount Sinai Hess Center","New York","10029","United States",[71,76],{"name":72,"role":73,"phone":74,"email":75},"Christopher Cannistraci, MA","CONTACT","(212) 824-8466","Christopher.Cannistraci@mssm.org",{"name":77,"role":78},"Yudell Edelstein, MD","PRINCIPAL_INVESTIGATOR",{"lat":80,"lon":81},40.71427,-74.00597,[83],{"name":77,"role":73,"phone":84,"email":85},"212-244-8864","yudell.edelstein@mountsinai.org",[87],{"name":77,"affiliation":13,"role":78},[],[],{"nct_id":4,"conditions":91,"biomarkers":93},[92],"Physiological Study",[],{"nct_id":4,"found":15,"summary":95,"prompt_version":95},null]