[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07641335":3,"trial-entities:NCT07641335":134,"trial-summary:NCT07641335":137},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":23,"study_type":34,"primary_purpose":35,"phases":36,"enrollment_info":38,"interventions":41,"primary_outcomes":51,"secondary_outcomes":56,"sex":82,"minimum_age":83,"maximum_age":84,"healthy_volunteers":85,"eligibility_criteria":86,"std_ages":107,"locations":109,"central_contacts":127,"overall_officials":130,"references":132,"see_also_links":133},"NCT07641335","SLU-CHESS-CAFF-2026","Effects of Caffeine on Chess Performance and Cognitive Function in Professional Chess Players","GRANDMASTER: Gauging the Role of Alertness and Neurostimulation With Dietary Caffeine in Master-Level Chess; A Double-Blind Randomized Crossover Trial","NOT_YET_RECRUITING","2027-08","2026-06","2026-06-11","2026-06-15","St. Louis University","OTHER",false,"This study will examine whether caffeine improves cognitive and competitive performance in professional chess players during tournament-style games. In a randomized double-blind crossover design, participants will complete two experimental sessions in which they consume either caffeinated coffee or decaffeinated coffee before playing a standardized chess match. Cognitive performance will be assessed using attention and reaction-time tests, including the Stroop Test, Trail Making Test, and Puzzle Rush task. Chess performance outcomes such as move accuracy, time management, and error rates will also be evaluated. The study aims to determine whether moderate caffeine intake enhances focus, alertness, and decision-making during prolonged competitive chess play.","This randomized double-blind crossover trial will evaluate the effects of moderate caffeine intake on cognitive and competitive performance in professional chess players. Twelve FIDE-rated chess players will complete two experimental conditions in randomized order: caffeinated coffee and decaffeinated coffee placebo. During each visit, participants will complete standardized cognitive assessments and a tournament-style chess game under controlled laboratory conditions.\n\nPrimary outcomes will include objective chess performance metrics derived from chess engine analysis, including move accuracy, centipawn loss, error rates, and time management. Secondary outcomes will include cognitive test performance, tactical reaction time, and self-reported alertness and fatigue. Chess games will be analyzed using standardized software-based evaluation methods.\n\nThe crossover design allows each participant to serve as their own control, minimizing variability related to individual differences in skill level, caffeine tolerance, and playing style. The study aims to determine whether caffeine enhances sustained attention, decision-making, and competitive chess performance during prolonged gameplay. Findings may provide insight into nutritional strategies for cognitive performance optimization in mentally demanding competitive environments.",[19,20,21,22],"Cognitive Performance","Attention","Reaction Time","Caffeine",[22,24,19,20,25,26,27,28,29,30,31,32,33],"Chess Performance","Mental Fatigue","Professional Chess Players","Decision Making","Neurocognitive Performance","Randomized Crossover Trial","Coffee","Alertness","Executive Function","Cognitive Fatigue","INTERVENTIONAL","BASIC_SCIENCE",[37],"NA",{"count":39,"type":40},12,"ESTIMATED",[42,47],{"type":43,"name":44,"description":45,"armGroupLabels":46},"DIETARY_SUPPLEMENT","Caffeinated Coffee","Black caffeinated coffee prepared from 15 g of ground coffee brewed in 200 g of water, providing approximately 100 mg of caffeine. The beverage will be consumed approximately 30 minutes before cognitive testing and tournament-style chess gameplay.",[44],{"type":43,"name":48,"description":49,"armGroupLabels":50},"Decaffeinated Coffee Placebo","Black decaffeinated coffee prepared from the same batch of coffee beans and matched for taste and appearance to the caffeinated condition. The beverage will be consumed approximately 30 minutes before cognitive testing and tournament-style chess gameplay.",[48],[52],{"measure":53,"description":54,"timeFrame":55},"Chess Performance Accuracy","Chess performance accuracy will be assessed using engine-based analysis of tournament-style chess games. The primary reported metric will be average centipawn loss per move, with lower values indicating better chess performance accuracy.","30 minutes after beverage consumption through completion of the tournament-style chess game at each experimental visit.",[57,61,64,68,71,75,78],{"measure":58,"description":59,"timeFrame":60},"Puzzle Rush Correct Responses","Tactical accuracy will be assessed using the 3-minute Puzzle Rush task on Chess.com. The outcome will be the total number of correctly solved tactical puzzles, with higher scores indicating better tactical accuracy.","Approximately 30 minutes after beverage consumption at each experimental visit.",{"measure":62,"description":63,"timeFrame":60},"Puzzle Rush Response Speed","Response speed will be assessed using the 3-minute Puzzle Rush task on Chess.com. The outcome will be average response time per puzzle, with lower values indicating faster response speed.",{"measure":65,"description":66,"timeFrame":67},"Stroop Test Performance","Selective attention will be assessed using the Stroop Test. The outcome will be the change in Stroop Test completion time from before gameplay to immediately after gameplay, with lower completion time indicating better performance.","Before gameplay and immediately after gameplay at each experimental visit.",{"measure":69,"description":70,"timeFrame":67},"Trail Making Test Performance","Cognitive flexibility and processing speed will be assessed using the Trail Making Test. The outcome will be the change in Trail Making Test completion time from before gameplay to immediately after gameplay, with lower completion time indicating better performance.",{"measure":72,"description":73,"timeFrame":74},"Self-Reported Alertness","Self-reported alertness will be assessed using a study-specific visual analog questionnaire. Higher scores will indicate greater perceived alertness.","Pre-game and immediately post-game at each experimental visit.",{"measure":76,"description":77,"timeFrame":74},"Self-Reported Mental Fatigue","Self-reported mental fatigue will be assessed using a study-specific visual analog questionnaire. Higher scores will indicate greater perceived mental fatigue.",{"measure":79,"description":80,"timeFrame":81},"Average Time Per Move","Chess time management will be assessed as the average time used per move during each tournament-style chess game. This value will be calculated from the total game time divided by the number of moves completed by the participant.","From the start of the tournament-style chess game until game completion, assessed over approximately 3 to 4 hours at each experimental visit.","ALL","18 Years","50 Years",true,{"inclusion":87,"exclusion":93,"raw_text":106},[88,89,90,91,92],"Male and female professional chess players aged 18-50 years","Current Fédération Internationale des Échecs (FIDE) standard rating between 2300 and 2600 Elo, or achievement of a standard FIDE rating within this range during the previous 12 months","Habitual caffeine consumers consuming ≤2 cups of coffee per day","Willingness to comply with all study procedures and study visits","Ability to provide written informed consent",[94,95,96,97,98,99,100,101,102,103,104,105],"Non-caffeine users","Habitual caffeine intake exceeding 2 cups of coffee per day","Cardiovascular disorders","Metabolic disorders","Psychiatric disorders","Pregnancy or breastfeeding","Current smoking","Shift workers","Use of psychoactive medications","Participation in another clinical trial within the previous 3 months","Known allergy or intolerance to milk proteins, dairy products, or soy","Known red-green color blindness or other color vision deficiencies that may interfere with Stroop Test performance","Inclusion Criteria:\n\n* Male and female professional chess players aged 18-50 years\n* Current Fédération Internationale des Échecs (FIDE) standard rating between 2300 and 2600 Elo, or achievement of a standard FIDE rating within this range during the previous 12 months\n* Habitual caffeine consumers consuming ≤2 cups of coffee per day\n* Willingness to comply with all study procedures and study visits\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Non-caffeine users\n* Habitual caffeine intake exceeding 2 cups of coffee per day\n* Cardiovascular disorders\n* Metabolic disorders\n* Psychiatric disorders\n* Pregnancy or breastfeeding\n* Current smoking\n* Shift workers\n* Use of psychoactive medications\n* Participation in another clinical trial within the previous 3 months\n* Known allergy or intolerance to milk proteins, dairy products, or soy\n* Known red-green color blindness or other color vision deficiencies that may interfere with Stroop Test performance",[108],"ADULT",[110],{"facility":111,"city":112,"state":113,"zip":114,"country":115,"contacts":116,"geoPoint":124},"Saint Louis University","St Louis","Missouri","63104","United States",[117,122],{"name":118,"role":119,"phone":120,"email":121},"Hossein Rafiei, PhD","CONTACT","1314-977-8675","hossein.rafiei@health.slu.edu",{"name":118,"role":123},"PRINCIPAL_INVESTIGATOR",{"lat":125,"lon":126},38.62727,-90.19789,[128],{"name":118,"role":119,"phone":129,"email":121},"13149778675",[131],{"name":118,"affiliation":13,"role":123},[],[],{"nct_id":4,"conditions":135,"biomarkers":136},[24,19],[],{"nct_id":4,"found":15,"summary":138,"prompt_version":138},null]