[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07653464":3,"trial-entities:NCT07653464":102,"trial-summary:NCT07653464":106},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":20,"study_type":21,"primary_purpose":22,"phases":23,"enrollment_info":25,"interventions":28,"primary_outcomes":36,"secondary_outcomes":47,"sex":48,"minimum_age":49,"maximum_age":50,"healthy_volunteers":14,"eligibility_criteria":51,"std_ages":76,"locations":79,"central_contacts":97,"overall_officials":99,"references":100,"see_also_links":101},"NCT07653464","2134707","Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity","NOT_YET_RECRUITING","2032-06","2026-07","2026-07-28","2026-10","University of Missouri-Columbia","OTHER",true,"Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.",null,[18,19],"Obesity (BMI>30)","Insulin Resistance",[],"INTERVENTIONAL","BASIC_SCIENCE",[24],"EARLY_PHASE1",{"count":26,"type":27},64,"ESTIMATED",[29],{"type":30,"name":31,"description":32,"armGroupLabels":33},"DRUG","human insulin","Participants will be administered human insulin (160 IU) using an intra-nasal device.",[34,35],"Insulin (Doppler)","Insulin (MRI)",[37,41,44],{"measure":38,"description":39,"timeFrame":40},"Amount of muscle sympathetic nerve activity (MSNA)","MSNA burst incidence (bursts\u002F100 heart beats)","Change from baseline at minute 30",{"measure":42,"description":43,"timeFrame":40},"Amount of cerebral blood flow","Measured with arterial spin labeling (mL\u002F100 g\u002Fmin)",{"measure":45,"description":46,"timeFrame":40},"Amount of leg blood flow","Measured with Doppler ultrasound (mL\u002Fmin)",[],"ALL","18 Years","65 Years",{"inclusion":52,"exclusion":60,"raw_text":75},[53,54,55,56,57,58,59],"18 to 65 years of age","BMI 30-45 kg\u002Fm2","Waist circumference ≥102 cm (men) or ≥88 cm (women)","HOMA-IR ≥2.5","BMI 18-25 kg\u002Fm2","Waist circumference \\\u003C94 cm (men) and \\\u003C80 cm (women)","HOMA-IR \\\u003C2",[61,62,63,64,65,66,67,68,69,70,71,72,73,74],"Pregnancy, breastfeeding","Unable to provide consent","Diabetes or polycystic ovarian syndrome","Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke","Nerve\u002Fneurologic disease","Uncontrolled hypertension (systolic blood pressure \\>180 mmHg and\u002For diastolic blood pressure \\>100 mmHg)","Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)","Current smoking, tobacco, nicotine use","Use of pharmacological therapy for weight loss","Body weight change \\>10% within the last 6 months","Adherence to \\>150 min\u002Fweek of moderate-to-vigorous physical activity\u002Fexercise","Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months","Claustrophobia","Non-MRI compatible metal implants","Inclusion Criteria:\n\n* 18 to 65 years of age\n\nIndividuals with obesity and comorbid IR\n\n* BMI 30-45 kg\u002Fm2\n* Waist circumference ≥102 cm (men) or ≥88 cm (women)\n* HOMA-IR ≥2.5\n\nHealthy normal weight adults\n\n* BMI 18-25 kg\u002Fm2\n* Waist circumference \\\u003C94 cm (men) and \\\u003C80 cm (women)\n* HOMA-IR \\\u003C2\n\nExclusion Criteria:\n\n* Pregnancy, breastfeeding\n* Unable to provide consent\n* Diabetes or polycystic ovarian syndrome\n* Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke\n* Nerve\u002Fneurologic disease\n* Uncontrolled hypertension (systolic blood pressure \\>180 mmHg and\u002For diastolic blood pressure \\>100 mmHg)\n* Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)\n* Current smoking, tobacco, nicotine use\n* Use of pharmacological therapy for weight loss\n* Body weight change \\>10% within the last 6 months\n* Adherence to \\>150 min\u002Fweek of moderate-to-vigorous physical activity\u002Fexercise\n* Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months\n* Claustrophobia\n* Non-MRI compatible metal implants",[77,78],"ADULT","OLDER_ADULT",[80],{"facility":81,"city":82,"state":83,"zip":84,"country":85,"contacts":86,"geoPoint":94},"University of Missouri","Columbia","Missouri","65211","United States",[87,92],{"name":88,"role":89,"phone":90,"email":91},"Jacqueline Limberg","CONTACT","573-882-2544","limberglab@missouri.edu",{"name":88,"role":93},"PRINCIPAL_INVESTIGATOR",{"lat":95,"lon":96},38.95171,-92.33407,[98],{"name":88,"role":89,"phone":90,"email":91},[],[],[],{"nct_id":4,"conditions":103,"biomarkers":105},[19,104],"Obesity",[],{"nct_id":4,"found":107,"summary":16,"prompt_version":16},false]