[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07654296":3,"trial-entities:NCT07654296":130,"trial-summary:NCT07654296":136},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":24,"study_type":28,"primary_purpose":29,"phases":30,"enrollment_info":32,"interventions":35,"primary_outcomes":47,"secondary_outcomes":52,"sex":87,"minimum_age":88,"maximum_age":89,"healthy_volunteers":15,"eligibility_criteria":90,"std_ages":98,"locations":101,"central_contacts":122,"overall_officials":127,"references":128,"see_also_links":129},"NCT07654296","2026P000126","Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery","Multimodal Analgesia Pathway Assessing Role of Suzetrigine for the Reduction of Opioid Use Following Ureteroscopic Surgery","NOT_YET_RECRUITING","2027-03-31","2026-06","2026-06-17","2026-08-01","Brigham and Women's Hospital","OTHER",false,"Urologic surgery has advanced with new technologies to allow less invasive management of common afflictions such as kidney stones, these procedures are notoriously painful as the ureter must be dilated to accommodate any instruments, and a ureteral stent is often left following surgery to allow for adequate healing. Unfortunately, stents are poorly tolerated by a significant number of patients, with up to 100% complaining of bothersome pain and 10% of patients with unplanned healthcare visits. Further complicating kidney stone management is the frequency of concurrent chronic kidney disease (CKD) or acute kidney injury (AKI) that prohibits many patients from taking NSAIDs which limits pain management options. There is now a push to treat these patients with multimodal analgesia to provide better care and reduce opioid use. Suzetrigine is a new a first-in-class selective inhibitor of the NaV1.8 sodium channel that functions as a non-opioid analgesic developed to treat acute pain and neuropathic pain. This study assesses the addition of suzetrigine to standard-of-care multimodal analgesia. We hypothesize a demonstrated decrease in opioid use, decrease Emergency Room visits within 30 days, decrease the number of unplanned care encounters.","Urologic surgery has advanced with new technologies to allow less invasive management of common afflictions such as kidney stones, these procedures are notoriously painful as the ureter must be dilated to accommodate any instruments, and a ureteral stent is often left following surgery to allow for adequate healing. Unfortunately, stents are poorly tolerated by a significant number of patients, with up to 100% complaining of bothersome pain and 10% of patients with unplanned healthcare visits. Further complicating kidney stone management is the frequency of concurrent chronic kidney disease (CKD) or acute kidney injury (AKI) that prohibits many patients from taking NSAIDs which limits pain management options. There is now a push to treat these patients with multimodal analgesia to provide better care and reduce opioid use. Suzetrigine is a new a first-in-class selective inhibitor of the NaV1.8 sodium channel that functions as a non-opioid analgesic developed to treat acute pain and neuropathic pain. This study assesses the addition of suzetrigine to standard-of-care multimodal analgesia. We hypothesize a demonstrated decrease in opioid use, decrease Emergency Room visits within 30 days, decrease the number of unplanned care encounters. This prospective open-label interventional single-center study will compare 30-day postoperative patient reported outcomes and pain medication use between a pre-implementation cohort of patients managed with standard-of-care multimodal analgesia after ureteroscopy with a post-implementation cohort of patient with this regimen and addition of suzetrigine. The primary outcome will be opioid usage after discharge with standard of care multimodal analgesia (historical control) vs opioid usage after discharge with suzetrigine included with the standard of care\n\nmultimodal analgesia regimen (intervention). Secondary outcomes will include unplanned care encounters within 30 days (Emergency Room, unplanned clinic visits) and surveyed patient reported outcomes measured on a post-operative survey including PROMIS (Patient-Reported Outcomes Measurement Information System) questions as well as an end of study administration of WISQOL (The Wisconsin Stone Quality of Life Questionnaire). The study will be conducted within a single academic institution including the primary hospital (Brigham and Women's Hospital) and satellite sites (Brigham and Women's Faulkner Hospital).",[19,20,21,22,23],"Opioid Consumption, Postoperative","Multimodal Analgesia","Ureteroscopy","Ureteral Stents","Ureteral Stent-Related Symptoms",[20,25,26,27],"Postoperative Opioid Consumption","ureteroscopy","ureteral stents","INTERVENTIONAL","TREATMENT",[31],"PHASE3",{"count":33,"type":34},100,"ESTIMATED",[36,42],{"type":37,"name":38,"description":39,"armGroupLabels":40},"DRUG","multimodal analgesia regimen without suzetrigine","multimodal analgesia regimen",[41],"multimodal analgesia pathway (standard, no suzetrigine)",{"type":37,"name":43,"description":44,"armGroupLabels":45},"Suzetrigine","suzetrigine with multimodal analgesia regimen",[46],"suzetrigine with multimodal analgesia pathway",[48],{"measure":49,"description":50,"timeFrame":51},"Post-discharge opioid consumption (MME)","assessed at post-operative visit","1-2 weeks",[53,56,59,63,64,67,68,71,72,74,75,77,78,80,81,83,84,86],{"measure":49,"description":54,"timeFrame":55},"assessed at 30 days after surgery","30 days",{"measure":57,"description":58,"timeFrame":55},"Rate of unplanned care encounters","Emergency Room visits",{"measure":60,"description":61,"timeFrame":62},"patient reported outcomes: pain score","measured on a 0 to 10 analog scale on post-operative survey","2 weeks",{"measure":60,"description":61,"timeFrame":55},{"measure":65,"description":66,"timeFrame":62},"patient reported outcomes: PROMIS composite score","total score where each of the following is rated from 0 to 4 then aggregated into a total value:\n\n1. How much did pain interfere with your day-to-day activities?\n2. How much did pain interfere with work around the home?\n3. How much did pain interfere with your ability to participate in social activities?\n4. How much did pain interfere with your household chores?\n5. How much did pain interfere with things you usually do for fun?\n6. How much did pain interfere with your enjoyment of social activities?",{"measure":65,"description":66,"timeFrame":55},{"measure":69,"description":70,"timeFrame":62},"patient reported outcomes (PROMIS) pain interfere with your day-to-day activities","rated from 0 to 4",{"measure":69,"description":70,"timeFrame":55},{"measure":73,"description":70,"timeFrame":62},"patient reported outcomes (PROMIS) pain interfere with work around the home",{"measure":73,"description":70,"timeFrame":55},{"measure":76,"description":70,"timeFrame":62},"patient reported outcomes (PROMIS) pain interfere with your ability to participate in social activities",{"measure":76,"description":70,"timeFrame":55},{"measure":79,"description":70,"timeFrame":62},"patient reported outcomes (PROMIS) pain interfere with your household chores",{"measure":79,"description":70,"timeFrame":55},{"measure":82,"description":70,"timeFrame":62},"patient reported outcomes (PROMIS) pain interfere with things you usually do for fun",{"measure":82,"description":70,"timeFrame":55},{"measure":85,"description":70,"timeFrame":62},"patient reported outcomes (PROMIS) pain interfere with your enjoyment of social activities",{"measure":85,"description":70,"timeFrame":55},"ALL","21 Years","80 Years",{"inclusion":91,"exclusion":94,"raw_text":97},[92,93],"Patients undergoing ureteroscopy between ages 21 to 80 at BWFH (Brigham \\& Women's Faulkner Hospital) by one of the department's high volume endoscopic surgeons. Patient who are or not pre-stented prior to surgery will be included (these will be assessed via stratification within a secondary analysis).","Patients able to consent for their own medical care (i.e. consent able to be obtained directly from patient and does not require a healthcare proxy or guardian)",[95,96],"Regular opioid use prior to surgery or significant substance abuse concerns.","Inability of patient to provide their own consent (i.e. lack capacity).","Inclusion Criteria:\n\n* Patients undergoing ureteroscopy between ages 21 to 80 at BWFH (Brigham \\& Women's Faulkner Hospital) by one of the department's high volume endoscopic surgeons. Patient who are or not pre-stented prior to surgery will be included (these will be assessed via stratification within a secondary analysis).\n* Patients able to consent for their own medical care (i.e. consent able to be obtained directly from patient and does not require a healthcare proxy or guardian)\n\nExclusion Criteria:\n\n* Regular opioid use prior to surgery or significant substance abuse concerns.\n* Inability of patient to provide their own consent (i.e. lack capacity).",[99,100],"ADULT","OLDER_ADULT",[102,116],{"facility":13,"city":103,"state":104,"zip":105,"country":106,"contacts":107,"geoPoint":113},"Boston","Massachusetts","02115","United States",[108],{"name":109,"role":110,"phone":111,"email":112},"Daniel A Wollin, MD, MS","CONTACT","617 732 6354","dwollin@mgb.org",{"lat":114,"lon":115},42.35843,-71.05977,{"facility":117,"city":103,"state":104,"zip":118,"country":106,"contacts":119,"geoPoint":121},"Brigham and Women's Faulkner Hospital","02130",[120],{"name":109,"role":110,"phone":111,"email":112},{"lat":114,"lon":115},[123,124],{"name":109,"role":110,"phone":111,"email":112},{"name":125,"role":110,"email":126},"Christopher Magnani, MD, MS, MPhil","CMAGNANI@BWH.HARVARD.EDU",[],[],[],{"nct_id":4,"conditions":131,"biomarkers":134},[132,133,21],"Disorder caused by ureteric stent","Post-Operative Pain",[135],"SODIUM VOLTAGE-GATED CHANNEL, ALPHA SUBUNIT 10",{"nct_id":4,"found":15,"summary":137,"prompt_version":137},null]