[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07660250":3,"trial-entities:NCT07660250":106,"trial-summary:NCT07660250":110},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":28,"primary_purpose":29,"phases":30,"enrollment_info":32,"interventions":35,"primary_outcomes":48,"secondary_outcomes":53,"sex":57,"minimum_age":58,"maximum_age":17,"healthy_volunteers":59,"eligibility_criteria":60,"std_ages":74,"locations":77,"central_contacts":99,"overall_officials":102,"references":104,"see_also_links":105},"NCT07660250","VNS","Vagus Nerve Stimulation for Myelopathy","Vagus Nerve Stimulation to Improve Post-operative Outcomes of Degenerative Cervical Myelopathy","RECRUITING","2028-05","2026-06","2026-06-22","2026-04-14","Washington University School of Medicine","OTHER",false,"The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative cervical myelopathy (DCM)",null,[19],"Degenerative Cervical Myelopathy",[21,22,23,24,25,26,27],"degenerative cervical myelopathy","myelopathy","cervical myelopathy","degenerative myelopathy","vagus nerve","vagus nerve stimulation","ear stimulation","INTERVENTIONAL","TREATMENT",[31],"NA",{"count":33,"type":34},36,"ESTIMATED",[36,43],{"type":37,"name":38,"description":39,"armGroupLabels":40},"DEVICE","Vagus nerve stimulation (taVNS)","Vagus nerve stimulation - clip is attached to ear",[41,42],"Post Group","Pre-Post Group (P-P)",{"type":37,"name":44,"description":45,"armGroupLabels":46},"Sham Stimulation","Clip will be attached to the ear, but no stimulation will be given.",[41,47],"Sham Group",[49],{"measure":50,"description":51,"timeFrame":52},"mJOA - Modified Japanese Orthopedics Association","Measures neurological impairment in degenerative cervical myelopathy","through study completion, an average of 1 year",[54],{"measure":55,"description":56,"timeFrame":52},"Neck Disability Index (NDI)","NDI measures activity limitations associated with neck pain","ALL","18 Years",true,{"inclusion":61,"exclusion":65,"raw_text":73},[62,63,64],"18 years of age or older","Moderate or severe degenerative cervical myelopathy according to the mJOA","Decompression surgery planned",[66,67,68,69,70,71,72],"• Pregnancy","Electrically active implants (e.g. pacemaker)","Known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and\u002For lumbar stenosis, spine tumor, HIV-related myelopathy","Ongoing cancer therapy","Ongoing use of immunomodulating or suppressive medication","Sustained bradycardia with a heartrate \\\u003C50 beats per minute for \\> 5 minutes following admission.","Prior cervical spine surgery","Inclusion Criteria:\n\n* 18 years of age or older\n* Moderate or severe degenerative cervical myelopathy according to the mJOA\n* Decompression surgery planned\n\nExclusion Criteria:\n\n* • Pregnancy\n\n  * Electrically active implants (e.g. pacemaker)\n  * Known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and\u002For lumbar stenosis, spine tumor, HIV-related myelopathy\n  * Ongoing cancer therapy\n  * Ongoing use of immunomodulating or suppressive medication\n  * Sustained bradycardia with a heartrate \\\u003C50 beats per minute for \\> 5 minutes following admission.\n  * Prior cervical spine surgery",[75,76],"ADULT","OLDER_ADULT",[78],{"facility":79,"status":8,"city":80,"state":81,"zip":82,"country":83,"contacts":84,"geoPoint":96},"Washington University","St Louis","Missouri","63110","United States",[85,90,93],{"name":86,"role":87,"phone":88,"email":89},"Linda Z Koester, BS","CONTACT","314-362-7368","koesterl@wustl.edu",{"name":91,"role":87,"email":92},"Wilson Z Ray, MD","rayz@wustl.edu",{"name":94,"role":95},"Wilson Z. Ray, MD","PRINCIPAL_INVESTIGATOR",{"lat":97,"lon":98},38.62727,-90.19789,[100],{"name":101,"role":87,"phone":88,"email":89},"Linda Koester, BS",[103],{"name":91,"affiliation":13,"role":95},[],[],{"nct_id":4,"conditions":107,"biomarkers":109},[108],"Myelopathy due to cervical spondylosis",[],{"nct_id":4,"found":59,"summary":111,"prompt_version":121},{"design":112,"status":113,"heading":114,"summary":115,"follow_up":116,"word_count":117,"commitments":118,"compensation":119,"drugs_mentioned":120},"This is an interventional study comparing active vagus nerve stimulation to a sham stimulation. It plans to enroll 36 participants.","completed","Vagus Nerve Stimulation for Degenerative Cervical Myelopathy","This study is testing if transauricular vagus nerve stimulation (taVNS) can improve recovery after surgery for moderate to severe degenerative cervical myelopathy (DCM). DCM is a condition where the spinal cord in your neck is compressed. taVNS involves attaching a clip to your ear to deliver stimulation. Some participants will receive actual stimulation, while others will receive a sham (inactive) stimulation. The study aims to enroll 36 participants who are 18 years or older, have moderate or severe DCM, and are planning to have decompression surgery. We will measure success by looking at your mJOA score (Modified Japanese Orthopedics Association), which assesses your neurological function, for about one year after surgery. The current recruitment status is unclear.","Participants will be followed through study completion, which is an average of 1 year, to measure their mJOA score.",117,"Not specified in the trial record.","Not stated in the trial record.",[38],"v2"]