[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07673198":3,"trial-entities:NCT07673198":84,"trial-summary:NCT07673198":87},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":20,"study_type":26,"primary_purpose":27,"phases":28,"enrollment_info":30,"interventions":33,"primary_outcomes":39,"secondary_outcomes":44,"sex":45,"minimum_age":46,"maximum_age":47,"healthy_volunteers":15,"eligibility_criteria":48,"std_ages":57,"locations":60,"central_contacts":76,"overall_officials":78,"references":82,"see_also_links":83},"NCT07673198","4526.3","Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia","Word Retrieval in Aphasia","NOT_YET_RECRUITING","2028-08","2026-07","2026-07-13","2026-08","Albert Einstein Healthcare Network","OTHER",false,"Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and\u002For comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.","This study examines a retrieval practice-based naming treatment termed criterion learning. In criterion learning, each item's assigned criterion level dictates the number of times that item is correctly retrieved before it is dropped from further training within a session. Criterion learning optimally incorporates potent learning experiences, including spaced retrieval practice with emphasis on correct retrievals during training. The present study will provide critical observations for optimizing criterion learning for treating word processing deficits in people with aphasia. This study will recruit 12 community-dwelling individuals with aphasia, who will undergo comprehensive neuropsychological characterization. Subsequently, participants will engage in an experimental treatment designed to promote improvements in word retrieval deficits.\n\nThis study will examine whether making retrieval practice more effortful by increasing semantically-driven lexical competition enhances naming treatment benefit in a multiple-session naming treatment. This involves training items amidst related (e.g., for \"dog,\" horse, cow, zebra) or unrelated items (e.g., for \"dog,\" ambulance, pencil, rose). Each PWA will complete multiple training\u002Ftest rounds--a round refers to the two training sessions separated by one or more days, and a retention test for those items. In some sessions, a desk-mounted eyetracker will be used to track eyegaze patterns as participants name pictures.",[19],"Aphasia",[21,22,23,24,25],"anomia","retrieval practice","word-finding problem","communication disorder","naming impairment","INTERVENTIONAL","TREATMENT",[29],"NA",{"count":31,"type":32},12,"ESTIMATED",[34],{"type":35,"name":36,"description":37,"armGroupLabels":38},"BEHAVIORAL","Criterion-learning practice","The experiments will be presented on a computer. On each criterion-learning trial, a picture is presented and the participant is asked to try to produce the name for the object with or without a cue. Correct-answer feedback is provided. Criterion learning involves presenting a block of items in fixed order, and on each trial, the experimenter or a voice-recognition component will code the response during the trial as correct\u002Fincorrect. When the item reaches its assigned criterion level, it is dropped from further training in a session.",[36],[40],{"measure":41,"description":42,"timeFrame":43},"Trained naming items","Confrontation naming task that involves trained items","approximately one-week following treatment",[],"ALL","18 Years","89 Years",{"inclusion":49,"exclusion":52,"raw_text":56},[50,51],"English as a native or primary language","Adults with stroke who are at least 6 months post-onset",[53,54,55],"History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease","History of a learning disability that significantly impacted language development, such as developmental language disorder","Insufficient stamina to participate in the protocol","Inclusion Criteria:\n\n* English as a native or primary language\n* Adults with stroke who are at least 6 months post-onset\n\nExclusion Criteria:\n\n* History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease\n* History of a learning disability that significantly impacted language development, such as developmental language disorder\n* Insufficient stamina to participate in the protocol",[58,59],"ADULT","OLDER_ADULT",[61],{"facility":62,"city":63,"state":64,"zip":65,"country":66,"contacts":67,"geoPoint":73},"Jefferson Moss Rehabilitation Research Institute","Elkins Park","Pennsylvania","19027","United States",[68],{"name":69,"role":70,"phone":71,"email":72},"Kelly Horel, CCC-SLP","CONTACT","215-663-6017","kelly.horel@jefferson.edu",{"lat":74,"lon":75},40.07706,-75.12684,[77],{"name":69,"role":70,"phone":71,"email":72},[79],{"name":80,"affiliation":13,"role":81},"Erica Middleton, PhD","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":85,"biomarkers":86},[19],[],{"nct_id":4,"found":88,"summary":89,"prompt_version":99},true,{"design":90,"status":91,"heading":92,"summary":93,"follow_up":94,"word_count":95,"commitments":96,"compensation":97,"drugs_mentioned":98},"This is an interventional study with 12 participants. It is not specified if it is randomized or blinded.","completed","Criterion-learning Naming Treatment for Aphasia","This study is looking at a behavioral treatment called \"criterion-learning practice\" for people with aphasia (a language disorder often caused by stroke). The goal is to improve word retrieval, which is difficulty finding the right words. You would practice naming pictures on a computer, receiving feedback on your answers. Researchers want to see if making this practice more challenging by including similar words (like \"horse\" and \"cow\" when learning \"dog\") helps more than using unrelated words. This study will enroll 12 adults with aphasia who are at least 6 months past their stroke. Success will be measured by how well you can name the practiced items about one week after the treatment.","Your ability to name trained items will be measured approximately one week after treatment.",112,"You would undergo comprehensive neuropsychological characterization and then participate in multiple training and test rounds, with each round including two training sessions separated by one or more days.","Not stated in the trial record.",[36],"v2"]