[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07691463":3,"trial-entities:NCT07691463":92,"trial-summary:NCT07691463":96},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":23,"study_type":29,"primary_purpose":30,"phases":31,"enrollment_info":33,"interventions":36,"primary_outcomes":42,"secondary_outcomes":50,"sex":51,"minimum_age":52,"maximum_age":53,"healthy_volunteers":54,"eligibility_criteria":55,"std_ages":66,"locations":69,"central_contacts":87,"overall_officials":89,"references":90,"see_also_links":91},"NCT07691463","IRB0000131-Exp1","Evaluating How Well Different Types of Light-sensitive Cells in the Eye Contribute to Its Focusing Ability","A Randomized, Repeated-measures Study to Evaluate the Contributions of Different Cone Photoreceptor Classes to a Step Ocular Accommodation Task","RECRUITING","2026-12-15","2026-07","2026-07-17","2026-07-02","Rochester Institute of Technology","OTHER",false,"In this experiment, subjects will view shapes on a screen with varying colors and be asked to focus their eyes on the shapes. The shapes will look as though they are jumping to random distances away from the eye. As the subjects focus their eyes on the shapes, the investigators will measure the focus of their eyes using a device called a wavefront sensor. This device uses infrared light to measure the optical properties of the eye in real time. Our goal is to find out how well the eye focuses on different colors. Our broad goal is to better understand how the eye focuses because that process is a major part of having clear and good vision.","In this experiment, subjects will view Gabor patterns on a display through a Badal relay. The Gabor patterns will vary in their color. The colors will be picked to selectively modulate cone photoreceptor activity in different directions in cone contrast space. Subjects will be instructed to accommodate to the patterns while the virtual distance of the screen is manipulated with a focus-adjustable lens. As they do so, the investigators will measure the wavefronts of their eyes using a Shack-Hartmann wavefront sensor.",[19,20,21,22],"Monochromatic","L- and S-cone Modulation Only","L- and M-cone Modulation Only","M and S-cone Modulation Only",[24,25,26,27,28],"Ocular accommodation","Visual acuity","Physiological optics","Visual psychophysics","Color science","INTERVENTIONAL","BASIC_SCIENCE",[32],"NA",{"count":34,"type":35},20,"ESTIMATED",[37],{"type":14,"name":38,"description":39,"armGroupLabels":40},"Color","Each intervention involves showing a participant a stimulus with a particular color on a screen display, and asking the participant to focus their eyes on the stimulus. The 4 colors are: 1) grayscale (L, M, and S-cone modulation), 2) L and S cone modulation only, 3) L and M cone modulation only, and 4) M and S cone modulation only.",[41],"Color variation in visual stimulus",[43,47],{"measure":44,"description":45,"timeFrame":46},"Accuracy of ocular accommodation","Ocular accommodation is the focusing response of the lens in the eye. When the stimulus viewed by the participant changes in distance, the eye automatically refocuses. The investigators measure this refocusing using a device called a wavefront sensor. The investigators are particularly interested in how accurate this refocusing is, which is measured in units of diopters.","Because this is a basic science experiment, each measurement takes place at the same time as the intervention. There will be two sessions, each lasting approximately 1 hour, on separate days (day 1 and day 2).",{"measure":48,"description":49,"timeFrame":46},"Speed of ocular accommodation","The investigators are interested in how quickly the eye refocuses when a near object moves farther away. Typically, this process takes around 1 second, but it can take longer or shorter depending on the individual and on the object being viewed. By analyzing data collected by the wavefront sensor, the investigators will calculate how long it took for the eye to refocus during each measurement.",[],"ALL",null,"35 Years",true,{"inclusion":56,"exclusion":59,"raw_text":65},[57,58],"Between 18-35 years of age","Normal or corrected-to-normal (glasses\u002Fcontact lenses) vision.",[60,61,62,63,64],"Vision worse than 20\u002F20 while wearing glasses \u002F contact lenses.","Fragile or loose teeth (participants need to bite a piece of dental clay to stabilize their heads so that measurements can be taken from their eyes)","Current pregnancy (experiment requires sitting down without moving for stretches of time)","Heart disease","Personal\u002Ffamilial history of epilepsy","Inclusion Criteria:\n\n* Between 18-35 years of age\n* Normal or corrected-to-normal (glasses\u002Fcontact lenses) vision.\n\nExclusion Criteria:\n\n* Vision worse than 20\u002F20 while wearing glasses \u002F contact lenses.\n* Fragile or loose teeth (participants need to bite a piece of dental clay to stabilize their heads so that measurements can be taken from their eyes)\n* Current pregnancy (experiment requires sitting down without moving for stretches of time)\n* Heart disease\n* Personal\u002Ffamilial history of epilepsy",[67,68],"CHILD","ADULT",[70],{"facility":71,"status":8,"city":72,"state":73,"zip":74,"country":75,"contacts":76,"geoPoint":84},"Chester F. Carlson Center for Imaging Science","Rochester","New York","14623","United States",[77,82],{"name":78,"role":79,"phone":80,"email":81},"Benjamin M Chin, Doctorate","CONTACT","8454534320","bmccis@rit.edu",{"name":78,"role":83},"PRINCIPAL_INVESTIGATOR",{"lat":85,"lon":86},43.15478,-77.61556,[88],{"name":78,"role":79,"phone":80,"email":81},[],[],[],{"nct_id":4,"conditions":93,"biomarkers":95},[94],"Normal vision",[],{"nct_id":4,"found":54,"summary":97,"prompt_version":106},{"design":98,"status":99,"heading":6,"summary":100,"follow_up":101,"word_count":102,"commitments":103,"compensation":104,"drugs_mentioned":105},"This is an interventional study planning to enroll 20 participants. It is not specified if it is randomized or blinded.","completed","This study is looking at how different colors affect your eye's ability to focus. You would view shapes on a screen that change color, and your eye's focusing ability will be measured using a special device called a wavefront sensor. The colors used are grayscale, L and S cone modulation only, and L and M cone modulation only. The study aims to understand how your eye focuses on different colors, which is important for clear vision. To join, you need to be between 18 and 35 years old with normal or corrected-to-normal vision (20\u002F20 or better with glasses\u002Fcontacts). The study is currently unclear on its recruitment status.","Measurements are taken during the two 1-hour sessions, with no follow-up specified after the second session.",107,"You would participate in two sessions, each lasting about 1 hour, on separate days. You will need to bite a piece of dental clay to stabilize your head during measurements.","Not stated in the trial record.",[38],"v2"]