[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07699848":3,"trial-entities:NCT07699848":111,"trial-summary:NCT07699848":115},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":26,"interventions":29,"primary_outcomes":38,"secondary_outcomes":62,"sex":63,"minimum_age":64,"maximum_age":65,"healthy_volunteers":66,"eligibility_criteria":67,"std_ages":76,"locations":79,"central_contacts":99,"overall_officials":104,"references":109,"see_also_links":110},"NCT07699848","20260691","Active Versus Passive Sitting, Cognition and Energy","Differences in Muscle Utilization, Tissue Pressure, Cognitive Performance, and Caloric Output Among Active and Passive Sitting Positions.","RECRUITING","2027-09-30","2026-07","2026-07-13","2026-07-07","University of Miami","OTHER",false,"The study will compare cognitive capacity, muscle utilization patterns, soft tissue seated pressure and caloric output during four seated conditions:\n\n1. passive sitting in a regular chair;\n2. passive sitting in an exercise chair;\n3. sitting in the exercise chair during active dynamic exercise; and,\n4. sitting in the chair during active static exercise.",null,[19,20],"Electromyography","Pressure Injury of Back",[],"INTERVENTIONAL","BASIC_SCIENCE",[25],"NA",{"count":27,"type":28},35,"ESTIMATED",[30],{"type":31,"name":32,"description":33,"armGroupLabels":34},"BEHAVIORAL","Chaircise","A chair-based exercise program using a specialized chair with a foot lever that allows participants to lift their body weight.",[35,36,37],"Experimental: Dynamic Leg Exercise in Exercise Chair","Experimental: Static Leg Exercise in Exercise Chair","Passive Comparator: Exercise Chair",[39,43,47,50,54,58],{"measure":40,"description":41,"timeFrame":42},"Differences in cognitive performance among chair conditions as measured by the Psychomotor Vigilance Test in number of key depressions","Cognitive performance will be assessed using the 3-minute Psychomotor Vigilance Test (PVT). During the test, participants will press the space bar as quickly as possible in response to the appearance of a visual stimulus on a computer screen. Performance will be measured as the total number of valid responses recorded during the test. Higher values indicate greater alertness, sustained attention, and reaction speed.","Approximately 3 minutes",{"measure":44,"description":45,"timeFrame":46},"Executive function among chair conditions as measured by the Stroop Test using words counted.","Executive function will be assessed using the Stroop Test, a cognitive task requiring participants to respond to color word stimuli. The outcome will be measured by total words counted, reported as the number of words.","Approximately 5 minutes.",{"measure":48,"description":49,"timeFrame":46},"Executive function among chair conditions as measured by the Stroop Test using error rate.","Executive function will be assessed using the Stroop Test, a cognitive task requiring participants to respond to color word stimuli. The outcome will be measured by error rate, reported as the percentage of errors.",{"measure":51,"description":52,"timeFrame":53},"Muscle activity among chair conditions using electromyography","Muscle activity will be assessed using surface electromyography (EMG). Muscle activation will be quantified as EMG amplitude, measured in microvolts (µV) from EMG recordings. Higher values indicate greater muscle activity.","Approximately 45 minutes",{"measure":55,"description":56,"timeFrame":57},"Peak seated tissue pressure among chair conditions using a pressure sensitive mat","Seated tissue pressure will be assessed using a pressure-sensitive mat placed on the seat surface of each chair. Peak pressure will be recorded to quantify the highest pressure exerted at the seating interface during each chair condition, measured in kilopascals. Higher values indicate greater localized pressure on seated tissues.","Approximately 15 minutes",{"measure":59,"description":60,"timeFrame":61},"Metabolic cost of sitting among the chair conditions using a portable oxygen consumption unit","Metabolic cost during sitting will be assessed under each chair condition using a portable indirect calorimetry device. Participants will wear a facemask that measures oxygen consumption (VO₂) and carbon dioxide production (VCO₂). These measurements will be used to estimate energy expenditure during the sitting period. Higher values indicate greater metabolic cost.","Approximately 25 minutes",[],"ALL","18 Years","70 Years",true,{"inclusion":68,"exclusion":70,"raw_text":75},[69],"Adult (18-70)",[71,72,73,74],"Any current injury in the lower limb or trunk.","Use of prescription drugs or supplements that may affect cardiovascular or neuromuscular responses.","Reported lack of sleep or stress that may affect physiological responses to exercise.","Cardiovascular, respiratory, neurologic, balance, metabolic, or musculoskeletal conditions that could increase risk during exercise testing","Inclusion Criteria:\n\n* Adult (18-70)\n\nExclusion Criteria:\n\n* Any current injury in the lower limb or trunk.\n* Use of prescription drugs or supplements that may affect cardiovascular or neuromuscular responses.\n* Reported lack of sleep or stress that may affect physiological responses to exercise.\n* Cardiovascular, respiratory, neurologic, balance, metabolic, or musculoskeletal conditions that could increase risk during exercise testing",[77,78],"ADULT","OLDER_ADULT",[80],{"facility":81,"status":8,"city":82,"state":83,"zip":84,"country":85,"contacts":86,"geoPoint":96},"Laboratory of Neuromuscular Research and Active Aging","Coral Gables","Florida","33146","United States",[87,92],{"name":88,"role":89,"phone":90,"email":91},"Joseph Signorile Joseph Signorile, PhD","CONTACT","305-898-1458","jsignorile@miami.edu",{"name":93,"role":89,"phone":94,"email":95},"Ethan J Elkins, MS","3052844173","exe453@miami.edu",{"lat":97,"lon":98},25.72149,-80.26838,[100,103],{"name":101,"role":89,"phone":102,"email":91},"Joseph Signorile J Joseph Signorile, PhD","3058981458",{"name":93,"role":89,"phone":94,"email":95},[105],{"name":106,"affiliation":107,"role":108},"Joseph J Signorile, PhD","University of Miami - Coral Gables Campus","PRINCIPAL_INVESTIGATOR",[],[],{"nct_id":4,"conditions":112,"biomarkers":114},[113],"Healthy Volunteers",[],{"nct_id":4,"found":66,"summary":116,"prompt_version":126},{"design":117,"status":118,"heading":119,"summary":120,"follow_up":121,"word_count":122,"commitments":123,"compensation":124,"drugs_mentioned":125},"This interventional study plans to include 35 participants. It will compare four different sitting conditions.","completed","Chaircise for Cognition and Energy","This study is looking at how different ways of sitting, including using a special exercise chair called Chaircise, affect your thinking abilities and energy use. Researchers will compare sitting in a regular chair to sitting in the Chaircise chair, both passively and while doing exercises. They want to see if there are differences in how well you perform on thinking tests (like the Psychomotor Vigilance Test and Stroop Test) depending on how you are sitting. You might be able to join if you are an adult between 18 and 70 years old, and do not have any current injuries in your legs or back, or take medications that could affect your body's response to exercise. The study is currently unclear on its recruitment status.","Not specified.",124,"You will participate in different sitting conditions, including using a specialized Chaircise chair. Your cognitive performance will be measured using tests like the Psychomotor Vigilance Test (approximately 3 minutes) and the Stroop Test (approximately 5 minutes).","Not stated in the trial record.",[32],"v2"]