[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07701733":3,"trial-entities:NCT07701733":131,"trial-summary:NCT07701733":135},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":15,"conditions":17,"keywords":19,"study_type":20,"primary_purpose":15,"phases":21,"enrollment_info":22,"interventions":25,"primary_outcomes":32,"secondary_outcomes":37,"sex":38,"minimum_age":39,"maximum_age":40,"healthy_volunteers":41,"eligibility_criteria":42,"std_ages":46,"locations":49,"central_contacts":118,"overall_officials":124,"references":127,"see_also_links":128},"NCT07701733","26-239","A Study of Lung Cancer Risk","ARISE: Assessing Lung Cancer Risk in Never-Smoking Women","RECRUITING","2029-06","2026-07","2026-07-17","2026-06-30","Memorial Sloan Kettering Cancer Center","OTHER",null,"The researchers are doing this study to learn more about factors that may increase the risk of lung cancer in people who have never smoked. This information may help predict which people who have never smoked may be more likely to get lung cancer.",[18],"Lung Cancer",[5],"OBSERVATIONAL",[],{"count":23,"type":24},500,"ESTIMATED",[26],{"type":14,"name":27,"description":28,"armGroupLabels":29},"Questionnaire","The study questionnaire will be administered at a regular treatment visit for case patients and at a study-specific visit for control participants. At the same visit, 1 vial of blood will be collected for genomic analysis for research purposes from both case patients and control participants. Collection of demographic information and exposure data.",[30,31],"Case patients","Control participants",[33],{"measure":34,"description":35,"timeFrame":36},"Identify factors associated with the risk of NSCLC","analyses will include all participants who completed the demographic and exposure assessment and whole-exome sequencing","3 years",[],"ALL","40 Years","74 Years",true,{"inclusion":43,"exclusion":44,"raw_text":45},[],[],"Criteria:\n\n* Female at birth\n* Age 40-74 years\n* No smoking history\n\n  * Participants must be never-smokers, defined as having smoked \\\u003C100 cigarettes in their lifetime\n* Documentation of disease - case patients\n\n  o Case patients must have pathologically confirmed primary lung adenocarcinoma. New and prevalent cases will be eligible. Case patients with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.\n* Criteria for control participants\n\n  * Control participants must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules. Participants recruited as controls and found on imaging to have lesions suspicious for lung cancer will be excluded from analysis and followed prospectively. Data regarding these participants will be reported in a sensitivity analysis. Additional control participants will be recruited to ensure balanced age- and race-matched enrollment by frequency matching. Control participants with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.",[47,48],"ADULT","OLDER_ADULT",[50,64,73,82,92,101,109],{"facility":51,"status":8,"city":52,"state":53,"zip":54,"country":55,"contacts":56,"geoPoint":61},"Memorial Sloan Kettering Basking Ridge (All Protocol Activities)","Basking Ridge","New Jersey","07920","United States",[57],{"name":58,"role":59,"phone":60},"Alexis Chidi, MD, PhD","CONTACT","929-829-0677",{"lat":62,"lon":63},40.70621,-74.54932,{"facility":65,"status":8,"city":66,"state":53,"zip":67,"country":55,"contacts":68,"geoPoint":70},"Memorial Sloan Kettering Monmouth (All Protocol Activities)","Middletown","07748",[69],{"name":58,"role":59,"phone":60},{"lat":71,"lon":72},40.39428,-74.11709,{"facility":74,"status":8,"city":75,"state":53,"zip":76,"country":55,"contacts":77,"geoPoint":79},"Memorial Sloan Kettering Bergen (All Protocol Activities)","Montvale","07645",[78],{"name":58,"role":59,"phone":60},{"lat":80,"lon":81},41.04676,-74.02292,{"facility":83,"status":8,"city":84,"state":85,"zip":86,"country":55,"contacts":87,"geoPoint":89},"Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)","Commack","New York","11725",[88],{"name":58,"role":59,"phone":60},{"lat":90,"lon":91},40.84288,-73.29289,{"facility":93,"status":8,"city":94,"state":85,"zip":95,"country":55,"contacts":96,"geoPoint":98},"Memorial Sloan Kettering Westchester (All Protocol Activities)","Harrison","10604",[97],{"name":58,"role":59,"phone":60},{"lat":99,"lon":100},40.96899,-73.71263,{"facility":102,"status":8,"city":85,"state":85,"zip":103,"country":55,"contacts":104,"geoPoint":106},"Memorial Sloan Kettering Cancer Center (All Protocol Activities)","10065",[105],{"name":58,"role":59,"phone":60},{"lat":107,"lon":108},40.71427,-74.00597,{"facility":110,"status":8,"city":111,"state":85,"zip":112,"country":55,"contacts":113,"geoPoint":115},"Memorial Sloan Kettering Nassau (All Protocol Activities)","Uniondale","11553",[114],{"name":58,"role":59,"phone":60},{"lat":116,"lon":117},40.70038,-73.59291,[119,122],{"name":58,"role":59,"phone":120,"email":121},"(929) 829-0677","arisestudy@mskcc.org",{"name":123,"role":59,"phone":120},"Tafadzwa Chaunzwa, MD",[125],{"name":58,"affiliation":13,"role":126},"PRINCIPAL_INVESTIGATOR",[],[129],{"label":13,"url":130},"https:\u002F\u002Fwww.mskcc.org\u002F",{"nct_id":4,"conditions":132,"biomarkers":134},[133],"Lung Adenocarcinoma",[],{"nct_id":4,"found":41,"summary":136,"prompt_version":146},{"design":137,"status":138,"heading":139,"summary":140,"follow_up":141,"word_count":142,"commitments":143,"compensation":144,"drugs_mentioned":145},"This is an observational study planning to enroll 500 participants. It is not specified if it is randomized or blinded.","completed","A Study of Lung Cancer Risk in Never-Smokers","This study aims to understand what factors might increase the risk of lung cancer in people who have never smoked. Researchers will use a questionnaire and collect a blood sample for genetic analysis. The goal is to identify factors linked to non-small cell lung cancer (NSCLC) risk over three years. This information could help predict who might be more likely to develop lung cancer even without a smoking history. The study is looking for 500 participants, specifically women aged 40-74 who have smoked fewer than 100 cigarettes in their lifetime. The current recruitment status is unclear.","The primary goal is to identify risk factors measured at 3 years, suggesting a follow-up period.",96,"You would complete a questionnaire and have one vial of blood collected for genomic analysis during a regular treatment visit (if you have lung cancer) or a study-specific visit (if you don't).","Not stated in the trial record.",[27],"v2"]