[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07706595":3,"trial-entities:NCT07706595":94,"trial-summary:NCT07706595":98},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":25,"primary_purpose":26,"phases":27,"enrollment_info":29,"interventions":32,"primary_outcomes":47,"secondary_outcomes":56,"sex":61,"minimum_age":62,"maximum_age":15,"healthy_volunteers":63,"eligibility_criteria":64,"std_ages":70,"locations":73,"central_contacts":90,"overall_officials":91,"references":92,"see_also_links":93},"NCT07706595","#810809","A Randomized Controlled Trial Comparing Posterior Nasal Nerve Ablation Procedures for Chronic Rhinitis","Radiofrequency Ablation (RhinAer, Neuromark) vs. Cryoablation (ClariFix) of the Posterior Nasal Nerve for Chronic Rhinitis: A Randomized Controlled Trial","ENROLLING_BY_INVITATION","2027-08-31","2026-07","2026-07-16","2024-07-18","University of California, San Diego","OTHER",null,"The goal of this clinical trial is to learn which procedural intervention most effectively reduces symptoms of chronic rhinitis (non-allergic rhinitis) in adult patients (18 years and older). The main questions it aims to answer are:\n\n* Which procedural intervention leads to the greatest reduction in total nasal symptom scores (TNSS)?\n* Which procedural intervention leads to the greatest improvement in sinonasal quality of life as measured by the SNOT-22?\n\nResearchers will compare radiofrequency ablation (RhinAer or Neuromark) and cryotherapy (ClariFix) to see if there are differences in symptom reduction and durability of response across treatments. Participants will:\n\n* Be randomly assigned to one of three FDA-cleared posterior nasal nerve ablation procedures (RhinAer, Neuromark, or ClariFix)\n* Complete validated symptom questionnaires (TNSS and SNOT-22) before and after their procedure\n* Have their relevant medical records reviewed (demographics, clinical history, prior rhinitis treatments)","Chronic rhinitis (non-allergic\u002Fvasomotor rhinitis) affects an estimated 14 million Americans and is characterized by nasal inflammation in the absence of infectious or allergic triggers. When medical management fails, patients may pursue procedural intervention to ablate the posterior nasal nerves. Currently available FDA-cleared standard-of-care options include in-office radiofrequency ablation (RhinAer, Neuromark) and cryotherapy (ClariFix). Despite the availability of these modalities, comparative effectiveness data are lacking. This randomized controlled trial will enroll adult patients and randomly assign them to one of the three treatment arms to compare symptom reduction and durability of response across the three procedures.",[19,20],"Chronic Rhinitis","Non-allergic Rhinitis",[22,23,24],"Radiofrequency ablation","Cryotherapy","Chronic rhinitis","INTERVENTIONAL","TREATMENT",[28],"NA",{"count":30,"type":31},50,"ESTIMATED",[33,38,42],{"type":34,"name":35,"description":36,"armGroupLabels":37},"DEVICE","RhinAer","RhinAer is an in-office radiofrequency ablation device that delivers targeted thermal energy to the posterior nasal nerve along the lateral nasal wall. The procedure is performed under local anesthesia without the need for general anesthesia or sedation, and aims to reduce parasympathetic nerve signaling to decrease rhinorrhea, postnasal drip, and nasal congestion in patients with chronic rhinitis.",[35],{"type":34,"name":39,"description":40,"armGroupLabels":41},"Neuromark","Neuromark is an in-office radiofrequency ablation device that delivers targeted thermal energy to the posterior nasal nerve along the lateral nasal wall. The procedure is performed under local anesthesia without the need for general anesthesia or sedation, and aims to reduce parasympathetic nerve signaling to decrease rhinorrhea, postnasal drip, and nasal congestion in patients with chronic rhinitis.",[39],{"type":34,"name":43,"description":44,"armGroupLabels":45},"Clarifix","ClariFix is an in-office cryoablation device that applies freezing (cold thermal) energy to the posterior nasal nerve in the posterior nasal cavity. The procedure is performed under local anesthesia without the need for general anesthesia or sedation, and aims to reduce parasympathetic nerve signaling to decrease rhinorrhea, postnasal drip, and nasal congestion in patients with chronic rhinitis.",[46],"ClariFix",[48,52],{"measure":49,"description":50,"timeFrame":51},"Sino-Nasal Outcome Test-22 (SNOT-22)","SNOT-22 is a validated 22-item patient-reported outcome measure assessing sinonasal-specific quality of life across domains including nasal symptoms (nasal blockage, rhinorrhea, loss of smell\u002Ftaste), ear and facial symptoms (ear pain, facial pressure), sleep dysfunction (difficulty falling asleep, waking up tired), and psychological and functional impairment (reduced productivity, fatigue, sadness).","SNOT-22 will be administered at baseline and at 1, 3, and 6 months post-procedure.",{"measure":53,"description":54,"timeFrame":55},"Total Nasal Symptom Score (TNSS)","TNSS is a validated 4-item patient-reported scoring instrument measuring severity of rhinorrhea, nasal congestion, nasal itching, and sneezing.","TNSS will be administered at baseline and at 1, 3, and 6 months post-procedure.",[57],{"measure":58,"description":59,"timeFrame":60},"Visual Analog Scale (VAS) Patient Satisfaction","A 0-10 visual analog scale on which patients rate their overall satisfaction with the procedure and its effect on their chronic rhinitis symptoms, with higher scores indicating greater satisfaction.","VAS patient satisfaction will be administered at 1, 3, and 6 months post-procedure.","ALL","18 Years",false,{"inclusion":65,"exclusion":68,"raw_text":69},[66,67],"Age 18 years or older","Diagnosis of chronic rhinitis (non-allergic rhinitis)",[],"Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of chronic rhinitis (non-allergic rhinitis)\n\nExclusion Criteria:\n\n\\- Under 18 years of age",[71,72],"ADULT","OLDER_ADULT",[74,83],{"facility":75,"city":76,"state":77,"zip":78,"country":79,"geoPoint":80},"Perlman Medical Office at UC San Diego","La Jolla","California","92037","United States",{"lat":81,"lon":82},32.84727,-117.2742,{"facility":84,"city":85,"state":77,"zip":86,"country":79,"geoPoint":87},"Veterans Affairs San Diego Healthcare System","San Diego","92161",{"lat":88,"lon":89},32.71571,-117.16472,[],[],[],[],{"nct_id":4,"conditions":95,"biomarkers":97},[96],"Non-allergic rhinitis",[],{"nct_id":4,"found":99,"summary":100,"prompt_version":110},true,{"design":101,"status":102,"heading":103,"summary":104,"follow_up":105,"word_count":106,"commitments":107,"compensation":108,"drugs_mentioned":109},"This is an interventional study that will randomly assign 50 adult participants to one of three treatment groups: RhinAer, Neuromark, or ClariFix.","completed","Comparing Procedures for Chronic Rhinitis","This study is comparing three different in-office procedures for adults with chronic rhinitis (non-allergic rhinitis), a condition causing ongoing nasal inflammation without allergies or infection. The procedures being tested are RhinAer, Neuromark (both use heat), and ClariFix (uses freezing). All are performed under local anesthesia. Researchers want to find out which procedure best reduces your nasal symptoms and improves your quality of life. They will measure your symptoms and quality of life at the start, and then at 1, 3, and 6 months after the procedure. The study aims to enroll 50 participants, but its current status is unclear.","Participants will be followed for 6 months after their procedure to assess symptom reduction and quality of life.",99,"You would undergo one of the three procedures. Your nasal symptoms and quality of life will be measured at the start, and then at 1, 3, and 6 months after the procedure.","Not stated in the trial record.",[35,39,43],"v2"]