[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07713849":3,"trial-entities:NCT07713849":235,"trial-summary:NCT07713849":242},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":24,"study_type":31,"primary_purpose":32,"phases":33,"enrollment_info":34,"interventions":37,"primary_outcomes":43,"secondary_outcomes":48,"sex":61,"minimum_age":62,"maximum_age":63,"healthy_volunteers":15,"eligibility_criteria":64,"std_ages":76,"locations":78,"central_contacts":110,"overall_officials":114,"references":118,"see_also_links":234},"NCT07713849","IRB25-1866","Transition Care for FEP","Adapting and Improving Transition Care for First Episode Psychosis","RECRUITING","2029-05-06","2026-07","2026-07-20","2026-05-06","University of Chicago","OTHER",false,"This study is testing a new approach to help people with first episode psychosis transition successfully from the hospital to outpatient mental health care. Many patients lose contact with services after they leave the hospital, which can lead to worse outcomes. The investigators have developed a Transition Care Team (TCT) that works with patients while they are in the hospital and continues to support them after discharge. The team provides therapy, case management, and coordination with community programs that offer ongoing care. The main goal of the study is to find out if this new program increases the number of patients who successfully begin outpatient treatment after hospitalization, compared to usual care. The investigators will also look at whether the program improves symptoms, functioning, and overall well-being.","For individuals experiencing the onset of a psychotic disorder such as schizophrenia, the period of time around their first hospitalization and subsequent stabilization in outpatient care is a critical juncture for establishing the trajectory of their recovery. Engaging early and consistently in care not only yields more rapid stabilization of symptoms, but it is also associated with improved long-term prognosis and better quality of life. In recent years, the field has focused on developing a gold standard outpatient treatment model for individuals experiencing their first episode of psychosis (FEP), called Coordinated Specialty Care (CSC). This model features wraparound services, shared decision making with the young adult experiencing FEP, peer support, and caregiver engagement. It has been consistently shown to improve outcomes for these individuals. Unfortunately, however, many patients who would qualify for enrollment in CSC programs are unable to benefit from this effective treatment. That is, there is a vulnerable period in between the initial diagnosis and stabilization of a psychotic disorder-often occurring on inpatient care units-and successful engagement in the CSC program. In this vulnerable care transition time, many patients are lost to follow-up, thus losing the treatment gains of acute inpatient care and failing to take advantage of progressing further into recovery via CSCs. The barriers to effective transition between these two treatment settings are numerous: poor insight regarding the need for continued care, inadequate caregiver support, insufficient knowledge of the healthcare system, practical\u002Fstructural constraints such as lack of transportation, long wait times for the initial appointment, and more. In our own preliminary data from one inpatient unit, 76% of qualifying FEP individuals did not successfully attend an outpatient CSC appointment. Accordingly, there is a significant clinical care gap in practice: CSC may be the best outpatient treatment program for individuals with FEP, but many are unable to benefit as a result of being lost to follow-up. In this project, the investigators will pilot an intervention designed to close this gap. The investigators have adapted the concept of transitional care, used in other medical settings, for hospitalized FEP individuals to facilitate engagement in outpatient CSC care. A Transition Care Team (TCT) will engage with FEP patients before and after hospitalization, incorporating CSC elements such as family engagement, peer support, and case management. Importantly, it will also be resourced to provide interim medication management, transportation, etc., which will be offered until the patient engages with CSC for the next stage of their care. This integrates two established care models-transitional care and CSC-for FEP populations. The investigators expect this approach will be successful by addressing targets at the patient, provider, and system levels.\n\nGiven the emphasis on transitional care between acute and outpatient settings, this intervention will begin on the inpatient unit itself shortly after the FEP individual begins to stabilize. In preparation for discharge, the TCT will meet individually with the FEP patient and their caregivers to conduct a needs assessment for the transition period. This team will then continue following the patient after discharge, maintaining contact with the individual, their caregivers, and the CSC program they are referred to, for up to 6 weeks or until attendance of the CSC appointment.",[19,20,21,22,23],"Schizoaffective Disorders","Bipolar Disorder With Psychotic Features","Schizophrenia Disorders","Major Depressive Disorder With Psychotic Features","Psychosis NOS",[25,26,27,28,29,30],"First Episode Psychosis","Bipolar","Inpatient Unit","Transition Care Team","Schizophrenia","Coordinated Specialty Care","OBSERVATIONAL",null,[],{"count":35,"type":36},75,"ESTIMATED",[38],{"type":39,"name":28,"description":40,"armGroupLabels":41},"BEHAVIORAL","The novel intervention is the Transition Care Team (TCT), a multidisciplinary clinical support model designed to improve continuity of care for individuals experiencing a first episode of psychosis. The TCT provides short-term post-discharge services, including psychoeducation, case management, peer support, and coordination with outpatient programs until participants are established in Coordinated Specialty Care (CSC). This differs from standard care, where patients typically receive discharge referrals without structured follow-up. The intervention itself uses evidence-based clinical practices but applies them in a new, transitional format for this population, which is not currently part of standard inpatient-to-outpatient care at UChicago or Ingalls.",[42],"Individuals with First Episode Psychosis",[44],{"measure":45,"description":46,"timeFrame":47},"Effectiveness of Transition Care Team for First Episode Psychosis","Attendance at 1 or more than 1 CSC appointment within 6 weeks of discharge","6 weeks post-discharge",[49,53,57],{"measure":50,"description":51,"timeFrame":52},"Demographic Factors affecting CSC Engagement","Assessing mechanisms underlying effectiveness of CSC engagement by dividing subjects into those that did attend CSC and those that did not and compare the demographic \\[sex, age, socioeconomic status\\] data of patients.","From enrollment to the end of intervention at 6 week follow up",{"measure":54,"description":55,"timeFrame":56},"Symptom Severity\u002FBPRS Score","Assessing mechanisms underlying the effectiveness of CSC engagement by dividing subjects into those that did attend CSC and those that did not attend and compare the symptom severity (BPRS score) at the patient-level.","From enrollment to the 6 week timepoint.",{"measure":58,"description":59,"timeFrame":60},"Barriers to Engagement","Assessing mechanisms underlying effectiveness of CSC engagement by dividing subjects into those that did attend CSC and those that did not attend and compare the needs (family support) and system-level variables including transportation, insurance, etc. that are barriers that can affect attendance.","From the baseline to 6 week timepoint.","ALL","18 Years","40 Years",{"inclusion":65,"exclusion":72,"raw_text":75},[66,67,68,69,70,71],"Diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depressive disorder with psychotic features, schizophreniform disorder, or psychosis NOS","The diagnosis of one of the psychotic disorders has a duration of less than two years.","Able to read, speak, and understand English, which will be assessed through observation.","Able and willing to provide written informed consent or assent, in cases where caregivers are considered legal guardians. Dr. Shima, co-I of the study, is a forensic psychiatrist, and particularly adept at judging such ability. Drs. Erickson and Keedy have conducted studies in individuals with psychotic disorders, including FEP and in the context of clinical trials, for years, and are similarly competent to judge whether individuals can provide informed consent. Finally, we will also use an Evaluation to Sign Consent form that documents subjects' verbalized understanding of key aspects of the study.","have an estimated IQ of \\> 65, assessed by the Wechsler Test of Adult Reading","Eligible caregivers\u002Fproxy informants must be identified by the participant or clinical team as being involved in the participant's discharge planning or follow-up care, be able to provide informed verbal consent, and be able to speak and read English sufficiently to complete study questionnaires. Caregivers may include family members, close supports, or legally authorized representatives.",[73,74],"Individuals with substance-induced psychosis or psychosis due to a medical condition will not be included in the study. We will use the Structured Clinical Interview for DSM-5 as well as medical records, and if the subject gives permission, caregiver information in this process","Individuals who do not meet criteria for a first episode of psychosis","Inclusion Criteria:\n\n* Diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depressive disorder with psychotic features, schizophreniform disorder, or psychosis NOS\n* The diagnosis of one of the psychotic disorders has a duration of less than two years.\n* Able to read, speak, and understand English, which will be assessed through observation.\n* Able and willing to provide written informed consent or assent, in cases where caregivers are considered legal guardians. Dr. Shima, co-I of the study, is a forensic psychiatrist, and particularly adept at judging such ability. Drs. Erickson and Keedy have conducted studies in individuals with psychotic disorders, including FEP and in the context of clinical trials, for years, and are similarly competent to judge whether individuals can provide informed consent. Finally, we will also use an Evaluation to Sign Consent form that documents subjects' verbalized understanding of key aspects of the study.\n* have an estimated IQ of \\> 65, assessed by the Wechsler Test of Adult Reading\n* Eligible caregivers\u002Fproxy informants must be identified by the participant or clinical team as being involved in the participant's discharge planning or follow-up care, be able to provide informed verbal consent, and be able to speak and read English sufficiently to complete study questionnaires. Caregivers may include family members, close supports, or legally authorized representatives.\n\nExclusion Criteria:\n\n* Individuals with substance-induced psychosis or psychosis due to a medical condition will not be included in the study. We will use the Structured Clinical Interview for DSM-5 as well as medical records, and if the subject gives permission, caregiver information in this process\n* Individuals who do not meet criteria for a first episode of psychosis",[77],"ADULT",[79,89],{"facility":80,"status":81,"city":82,"state":83,"zip":84,"country":85,"geoPoint":86},"University of Chicago Medical Center, Biological Science Division","ACTIVE_NOT_RECRUITING","Chicago","Illinois","60637","United States",{"lat":87,"lon":88},41.85003,-87.65005,{"facility":90,"status":8,"city":91,"state":83,"zip":92,"country":85,"contacts":93,"geoPoint":107},"University of Chicago Ingalls Memorial Hospital","Harvey","60426",[94,99,102,105],{"name":95,"role":96,"phone":97,"email":98},"Madeline Perez, B.S","CONTACT","773-712-9178","maddieg@bsd.uchicago.edu",{"name":100,"role":101},"Carolyn Shima, PhD","SUB_INVESTIGATOR",{"name":103,"role":104},"Sarah Keedy, PhD","PRINCIPAL_INVESTIGATOR",{"name":106,"role":101},"Molly Erickson, PhD",{"lat":108,"lon":109},41.61003,-87.64671,[111],{"name":112,"role":96,"phone":97,"email":113},"Madeline Perez Lab Manager, B.S","keedylab@gmail.com",[115,116,117],{"name":106,"affiliation":13,"role":104},{"name":100,"affiliation":13,"role":104},{"name":103,"affiliation":13,"role":104},[119,123,126,129,132,135,138,141,144,147,150,153,156,159,162,165,168,171,174,177,180,183,186,189,192,195,198,201,204,207,210,213,216,219,222,225,228,231],{"pmid":120,"type":121,"citation":122},"33568244","BACKGROUND","Ma CF, Chan SKW, Chung YL, Ng SM, Hui CLM, Suen YN, Chen EYH. The predictive power of expressed emotion and its components in relapse of schizophrenia: a meta-analysis and meta-regression. Psychol Med. 2021 Feb;51(3):365-375. doi: 10.1017\u002FS0033291721000209. Epub 2021 Feb 11.",{"pmid":124,"type":121,"citation":125},"39779465","Keegan C, Brown K, Gaynor K. A Systematic Review Exploring the Relationship Between Family Factors and Symptom Severity, Relapse and Social or Occupational Functioning in First-Episode Psychosis. Early Interv Psychiatry. 2025 Mar;19(3):e13643. doi: 10.1111\u002Feip.13643. Epub 2025 Jan 8.",{"pmid":127,"type":121,"citation":128},"30173041","Villagonzalo KA, Leitan N, Farhall J, Foley F, McLeod B, Thomas N. Development and validation of a scale for self-efficacy for personal recovery in persisting mental illness. Psychiatry Res. 2018 Nov;269:354-360. doi: 10.1016\u002Fj.psychres.2018.08.093. Epub 2018 Aug 25.",{"pmid":130,"type":121,"citation":131},"8494061","Amador XF, Strauss DH, Yale SA, Flaum MM, Endicott J, Gorman JM. Assessment of insight in psychosis. Am J Psychiatry. 1993 Jun;150(6):873-9. doi: 10.1176\u002Fajp.150.6.873.",{"pmid":133,"type":121,"citation":134},"10264257","Schneider LC, Struening EL. SLOF: a behavioral rating scale for assessing the mentally ill. Soc Work Res Abstr. 1983 Fall;19(3):9-21. doi: 10.1093\u002Fswra\u002F19.3.9.",{"pmid":136,"type":121,"citation":137},"33244410","Humensky JL, Bello I, Malinovsky I, Nossel I, Patel S, Jones G, Cabassa LJ, Radigan M, Sobeih T, Tobey C, Basaraba C, Scodes J, Smith T, Wall M, Labouliere C, Stanley B, Dixon LB. OnTrackNY's learning healthcare system. J Clin Transl Sci. 2020 Apr 6;4(4):301-306. doi: 10.1017\u002Fcts.2020.35.",{"pmid":139,"type":121,"citation":140},"40247900","Vohs JL, Srihari V, Vinson AH, Lapidos A, Cahill J, Taylor SF, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso IF, Breitborde NJK, Breier A. The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states. Learn Health Syst. 2024 Nov 17;9(2):e10471. doi: 10.1002\u002Flrh2.10471. eCollection 2025 Apr.",{"pmid":142,"type":121,"citation":143},"39543502","Tryon VL, Nye KE, Savill M, Loewy R, Miles MJ, Tully LM, Padovani AJ, Tancredi DJ, Melnikow J, Ereshefsky S, Sharma N, McNamara AP, Kado-Walton M, Hakusui CK, Miller C, Nguyen KLH, Safdar M, Padilla VE, Smith L, Wilcox AB, Banks LM, Hayes SL, Pierce KM, Muro K, Shapiro DI, Bolden-Thompson KA, Botello RM, Grattan RE, Zhang Y, Hotz B, Dixon L, Carter CS, Niendam TA. The California collaborative network to promote data driven care and improve outcomes in early psychosis (EPI-CAL) project: rationale, background, design and methodology. BMC Psychiatry. 2024 Nov 14;24(1):800. doi: 10.1186\u002Fs12888-024-06245-6.",{"pmid":145,"type":121,"citation":146},"40056755","Dow JF, Cerundolo N, Konstas K, Carol EE, Johnson KA, Keshavan MS, Ongur D. Implementing early psychosis services: Experiences from the laboratory for early psychosis center. Schizophr Res. 2025 Mar;277:124-129. doi: 10.1016\u002Fj.schres.2025.02.016. Epub 2025 Mar 7.",{"pmid":148,"type":121,"citation":149},"40175161","Calkins ME, Jumper M, Ered A, Dong F, Sarpal DK, Baker KK, Bencivengo DJ, Margolis RL, Buchanan RW, Boumaiz Y, Burris E, Campbell PD, Chengappa KNR, Conroy C, Cooke A, Dickerson F, Flowers N, Fauble M, Goldberg RW, Harvin A, Howell C, Kelly C, Kreyenbuhl J, Li L, Lucksted A, Marsteller JA, Moxam A, Namowicz D, Nayar S, Oko J, Riggs J, Saravana A, Scheinberg R, Smith WR, States R, Suhail-Sindhu T, Taylor J, Vatza CL, Wolcott M, Kohler CG, Bennett ME. Connection Learning Healthcare System Hub of the Early Psychosis Intervention Network: Program and Participant Characteristics. Early Interv Psychiatry. 2025 Apr;19(4):e70031. doi: 10.1111\u002Feip.70031.",{"pmid":151,"type":121,"citation":152},"39854977","Gleeson JFM, Ludwig K, Stiles BJ, Piantella S, McNab C, Cotton S, Fraser MI, Alvarez-Jimenez M, Watson A, Fraser E, Penn DL. Systematic review and meta-analysis of family-based interventions for early psychosis: Carer and patient outcomes. Schizophr Res. 2025 Feb;276:57-78. doi: 10.1016\u002Fj.schres.2025.01.006. Epub 2025 Jan 23.",{"pmid":154,"type":121,"citation":155},"7991753","Bebbington P, Kuipers L. The predictive utility of expressed emotion in schizophrenia: an aggregate analysis. Psychol Med. 1994 Aug;24(3):707-18. doi: 10.1017\u002Fs0033291700027860.",{"pmid":157,"type":121,"citation":158},"39133712","Sheehan KJ, Bastas D, Guerra S, Creanor S, Hulme C, Lamb S, Martin FC, Sackley C, Smith T, Bell P, Hillsdon M, Pope S, Cook H, Godfrey E. Protocol for a feasibility randomised controlled trial of the 'Outdoor' mobility intervention for older adults after hip fracture. PLoS One. 2024 Aug 12;19(8):e0306871. doi: 10.1371\u002Fjournal.pone.0306871. eCollection 2024.",{"pmid":160,"type":121,"citation":161},"41037739","Unick JL, Duffy C, Dizon D, Fenton MA, Cao Z, Oselinsky K, Tobin SY, Wing RR. Evaluation of a Translatable Web-Based Intervention for Increasing Physical Activity Among Cancer Survivors: Pilot Randomized Trial. JMIR Cancer. 2025 Oct 2;11:e79610. doi: 10.2196\u002F79610.",{"pmid":163,"type":121,"citation":164},"36401993","Brown H, Ongur D, Smurawska L, Valcourt S. Inpatient - Outpatient transitions in first episode psychosis care. Schizophr Res. 2022 Dec;250:123-124. doi: 10.1016\u002Fj.schres.2022.10.014. Epub 2022 Nov 17. No abstract available.",{"pmid":166,"type":121,"citation":167},"36553890","Peritogiannis V, Ninou A, Samakouri M. Mortality in Schizophrenia-Spectrum Disorders: Recent Advances in Understanding and Management. Healthcare (Basel). 2022 Nov 25;10(12):2366. doi: 10.3390\u002Fhealthcare10122366.",{"pmid":169,"type":121,"citation":170},"19343456","Snow V, Beck D, Budnitz T, Miller DC, Potter J, Wears RL, Weiss KB, Williams MV; American College of Physicians; Society of General Internal Medicine; Society of Hospital Medicine; American Geriatrics Society; American College of Emergency Physicians; Society of Academic Emergency Medicine. Transitions of Care Consensus Policy Statement American College of Physicians-Society of General Internal Medicine-Society of Hospital Medicine-American Geriatrics Society-American College of Emergency Physicians-Society of Academic Emergency Medicine. J Gen Intern Med. 2009 Aug;24(8):971-6. doi: 10.1007\u002Fs11606-009-0969-x. Epub 2009 Apr 3.",{"pmid":172,"type":121,"citation":173},"39212182","Roson Rodriguez P, Chen X, Arancibia M, Garegnani L, Escobar Liquitay CM, Mohammad HA, Franco JV. Transitional discharge interventions for people with schizophrenia. Cochrane Database Syst Rev. 2024 Aug 30;8(8):CD009788. doi: 10.1002\u002F14651858.CD009788.pub3.",{"pmid":175,"type":121,"citation":176},"32038320","Hegedus A, Kozel B, Richter D, Behrens J. Effectiveness of Transitional Interventions in Improving Patient Outcomes and Service Use After Discharge From Psychiatric Inpatient Care: A Systematic Review and Meta-Analysis. Front Psychiatry. 2020 Jan 21;10:969. doi: 10.3389\u002Ffpsyt.2019.00969. eCollection 2019.",{"pmid":178,"type":121,"citation":179},"26834024","Rosenheck R, Leslie D, Sint K, Lin H, Robinson DG, Schooler NR, Mueser KT, Penn DL, Addington J, Brunette MF, Correll CU, Estroff SE, Marcy P, Robinson J, Severe J, Rupp A, Schoenbaum M, Kane JM. Cost-Effectiveness of Comprehensive, Integrated Care for First Episode Psychosis in the NIMH RAISE Early Treatment Program. Schizophr Bull. 2016 Jul;42(4):896-906. doi: 10.1093\u002Fschbul\u002Fsbv224. Epub 2016 Jan 31.",{"pmid":181,"type":121,"citation":182},"15485934","Craig TK, Garety P, Power P, Rahaman N, Colbert S, Fornells-Ambrojo M, Dunn G. The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis. BMJ. 2004 Nov 6;329(7474):1067. doi: 10.1136\u002Fbmj.38246.594873.7C. Epub 2004 Oct 14.",{"pmid":184,"type":121,"citation":185},"26937191","Chong HY, Teoh SL, Wu DB, Kotirum S, Chiou CF, Chaiyakunapruk N. Global economic burden of schizophrenia: a systematic review. Neuropsychiatr Dis Treat. 2016 Feb 16;12:357-73. doi: 10.2147\u002FNDT.S96649. eCollection 2016.",{"pmid":187,"type":121,"citation":188},"35524619","Correll CU, Solmi M, Croatto G, Schneider LK, Rohani-Montez SC, Fairley L, Smith N, Bitter I, Gorwood P, Taipale H, Tiihonen J. Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors. World Psychiatry. 2022 Jun;21(2):248-271. doi: 10.1002\u002Fwps.20994.",{"pmid":190,"type":121,"citation":191},"31427170","Nowak M, Lee S, Karbach U, Pfaff H, Gross SE. Short length of stay and the discharge process: Preparing breast cancer patients appropriately. Patient Educ Couns. 2019 Dec;102(12):2318-2324. doi: 10.1016\u002Fj.pec.2019.08.012. Epub 2019 Aug 10.",{"pmid":193,"type":121,"citation":194},"35661429","Mao H, Xie Y, Shen Y, Wang M, Luo Y. Effectiveness of nurse-led discharge service on adult surgical inpatients: A meta-analysis of randomized controlled trials. Nurs Open. 2022 Sep;9(5):2250-2262. doi: 10.1002\u002Fnop2.1268. Epub 2022 Jun 6.",{"pmid":196,"type":121,"citation":197},"19577834","Jones IR, Ahmed N, Catty J, McLaren S, Rose D, Wykes T, Burns T; Echo group. Illness careers and continuity of care in mental health services: a qualitative study of service users and carers. Soc Sci Med. 2009 Aug;69(4):632-9. doi: 10.1016\u002Fj.socscimed.2009.06.015. Epub 2009 Jul 3.",{"pmid":199,"type":121,"citation":200},"11007712","Boyer CA, McAlpine DD, Pottick KJ, Olfson M. Identifying risk factors and key strategies in linkage to outpatient psychiatric care. Am J Psychiatry. 2000 Oct;157(10):1592-8. doi: 10.1176\u002Fappi.ajp.157.10.1592.",{"pmid":202,"type":121,"citation":203},"35524616","Fusar-Poli P, Estrade A, Stanghellini G, Venables J, Onwumere J, Messas G, Gilardi L, Nelson B, Patel V, Bonoldi I, Aragona M, Cabrera A, Rico J, Hoque A, Otaiku J, Hunter N, Tamelini MG, Maschiao LF, Puchivailo MC, Piedade VL, Keri P, Kpodo L, Sunkel C, Bao J, Shiers D, Kuipers E, Arango C, Maj M. The lived experience of psychosis: a bottom-up review co-written by experts by experience and academics. World Psychiatry. 2022 Jun;21(2):168-188. doi: 10.1002\u002Fwps.20959.",{"pmid":205,"type":121,"citation":206},"40174484","Bello I, Stefancic A, Florence AC, Wall M, Radigan M, Malinovsky I, Nossel I, Mathai C, Cabassa L, Fidaleo K, Sheitman A, Montague E, McGuire W, Smith TE, Dixon L, Patel S. OnTrackNY: A public sector learning healthcare system for youth and young adults with early psychosis. Schizophr Res. 2025 May;279:50-58. doi: 10.1016\u002Fj.schres.2025.03.033. Epub 2025 Apr 1.",{"pmid":208,"type":121,"citation":209},"29800949","Correll CU, Galling B, Pawar A, Krivko A, Bonetto C, Ruggeri M, Craig TJ, Nordentoft M, Srihari VH, Guloksuz S, Hui CLM, Chen EYH, Valencia M, Juarez F, Robinson DG, Schooler NR, Brunette MF, Mueser KT, Rosenheck RA, Marcy P, Addington J, Estroff SE, Robinson J, Penn D, Severe JB, Kane JM. Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression. JAMA Psychiatry. 2018 Jun 1;75(6):555-565. doi: 10.1001\u002Fjamapsychiatry.2018.0623.",{"pmid":211,"type":121,"citation":212},"25639994","Srihari VH, Tek C, Kucukgoncu S, Phutane VH, Breitborde NJ, Pollard J, Ozkan B, Saksa J, Walsh BC, Woods SW. First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial. Psychiatr Serv. 2015 Jul;66(7):705-12. doi: 10.1176\u002Fappi.ps.201400236. Epub 2015 Feb 2.",{"pmid":214,"type":121,"citation":215},"26511605","Breitborde NJ, Bell EK, Dawley D, Woolverton C, Ceaser A, Waters AC, Dawson SC, Bismark AW, Polsinelli AJ, Bartolomeo L, Simmons J, Bernstein B, Harrison-Monroe P. The Early Psychosis Intervention Center (EPICENTER): development and six-month outcomes of an American first-episode psychosis clinical service. BMC Psychiatry. 2015 Oct 28;15:266. doi: 10.1186\u002Fs12888-015-0650-3.",{"pmid":217,"type":121,"citation":218},"26481174","Kane JM, Robinson DG, Schooler NR, Mueser KT, Penn DL, Rosenheck RA, Addington J, Brunette MF, Correll CU, Estroff SE, Marcy P, Robinson J, Meyer-Kalos PS, Gottlieb JD, Glynn SM, Lynde DW, Pipes R, Kurian BT, Miller AL, Azrin ST, Goldstein AB, Severe JB, Lin H, Sint KJ, John M, Heinssen RK. Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program. Am J Psychiatry. 2016 Apr 1;173(4):362-72. doi: 10.1176\u002Fappi.ajp.2015.15050632. Epub 2015 Oct 20.",{"pmid":220,"type":121,"citation":221},"30826261","Hall MH, Holton KM, Ongur D, Montrose D, Keshavan MS. Longitudinal trajectory of early functional recovery in patients with first episode psychosis. Schizophr Res. 2019 Jul;209:234-244. doi: 10.1016\u002Fj.schres.2019.02.003. Epub 2019 Feb 28.",{"pmid":223,"type":121,"citation":224},"29571751","Lappin JM, Heslin M, Lomas B, Jones PB, Doody GA, Reininghaus UA, Croudace T, Craig T, Fearon P, Murray RM, Dazzan P, Morgan C. Early sustained recovery following first episode psychosis: Evidence from the AESOP10 follow-up study. Schizophr Res. 2018 Sep;199:341-345. doi: 10.1016\u002Fj.schres.2018.03.014. Epub 2018 Mar 20.",{"pmid":226,"type":121,"citation":227},"28982659","Lally J, Ajnakina O, Stubbs B, Cullinane M, Murphy KC, Gaughran F, Murray RM. Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies. Br J Psychiatry. 2017 Dec;211(6):350-358. doi: 10.1192\u002Fbjp.bp.117.201475. Epub 2017 Oct 5.",{"pmid":229,"type":121,"citation":230},"16756689","Menezes NM, Arenovich T, Zipursky RB. A systematic review of longitudinal outcome studies of first-episode psychosis. Psychol Med. 2006 Oct;36(10):1349-62. doi: 10.1017\u002FS0033291706007951. Epub 2006 Jun 7.",{"pmid":232,"type":121,"citation":233},"28941089","Fusar-Poli P, McGorry PD, Kane JM. Improving outcomes of first-episode psychosis: an overview. World Psychiatry. 2017 Oct;16(3):251-265. doi: 10.1002\u002Fwps.20446.",[],{"nct_id":4,"conditions":236,"biomarkers":241},[237,25,23,238,29,239,240],"Bipolar Disorder","Schizoaffective Disorder","Schizophreniform Disorder","Unipolar Depression",[],{"nct_id":4,"found":243,"summary":244,"prompt_version":254},true,{"design":245,"status":246,"heading":247,"summary":248,"follow_up":249,"word_count":250,"commitments":251,"compensation":252,"drugs_mentioned":253},"This is an observational study with a planned enrollment of 75 participants. It is looking at the effectiveness of the Transition Care Team (TCT) intervention.","completed","Transition Care for First Episode Psychosis","This study is looking at a new way to help people who have experienced a first episode of psychosis (FEP) – conditions like schizophrenia or bipolar disorder with psychotic features – move from hospital care to regular outpatient mental health services. Many people lose touch with care after leaving the hospital, which can make recovery harder. This study is testing a new program called the Transition Care Team (TCT). The TCT is a group of healthcare professionals who support patients both in the hospital and for a short time after they go home. They offer education, help with managing care, and connect patients with ongoing community programs. The main goal is to see if the TCT helps more patients successfully start outpatient treatment after their hospital stay. You might be able to join if you are 18-40 years old, speak English, and have been diagnosed with a psychotic disorder for less than two years. The study status is currently unclear.","The effectiveness of the Transition Care Team is measured at 6 weeks post-discharge.",160,"Not specified in the trial record.","Not stated in the trial record.",[28],"v2"]